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11 条记录 (耗时 0.021 秒)

    Methods and compositions for treating a subject having an anthrax toxin mediated condition
    2.
    发明申请
    Methods and compositions for treating a subject having an anthrax toxin mediated condition 有权
    用于治疗具有炭疽毒素介导病症的受试者的方法和组合物

    公开(公告)号：US20060257892A1

    公开(公告)日：2006-11-16

    申请号：US11356740

    申请日：2006-02-16

    申请人： Stanley Cohen ,  Wensheng Wei

    发明人： Stanley Cohen ,  Wensheng Wei

    IPC分类号： C12Q1/68

    CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/77

    摘要： Methods and compositions for treating a subject for an anthrax toxin mediated disease condition are provided. Aspects of the subject methods include administering to a subject an effective amount of an agent that inhibits cellular internalization of an anthrax toxin, e.g., such as a LRP6 modulatory agent. Also provided are active agents suitable for use in the subject methods, as well as pharmaceutical preparations thereof.

    摘要翻译： 提供了用于治疗受试者针对炭疽毒素介导的疾病状况的方法和组合物。 本发明方法的方面包括向受试者施用有效量的抑制炭疽毒素例如LRP6调节剂的细胞内化的药剂。 还提供了适用于本发明方法的活性剂及其药物制剂。

    Process for the preparation of epidermal growth factor and new derivative using cross-linked polyacrylamide gel at a pH of 1-3
    3.
    发明授权
    Process for the preparation of epidermal growth factor and new derivative using cross-linked polyacrylamide gel at a pH of 1-3 失效
    用pH为1-3的交联聚丙烯酰胺凝胶制备表皮生长因子和新衍生物的方法

    公开(公告)号：US3948875A

    公开(公告)日：1976-04-06

    申请号：US419231

    申请日：1973-11-27

    申请人： Stanley Cohen ,  C. Richard Savage, Jr.

    发明人： Stanley Cohen ,  C. Richard Savage, Jr.

    IPC分类号： C07K14/485 ,  C07G7/00

    CPC分类号： C07K14/485 ,  Y10S530/854

    摘要： A new procedure has been devised for the preparation of pure epidermal growth factor (EGF) in high yield which involves passing homogenates of submaxillary glands of adult male mice through a polyacrylamide gel column of a low acid pH. Preferably a two step procedure is used wherein the fraction obtained from the polyacrylamide gel chromatography is subjected to DEAE-cellulose chromatography.The new procedure also provides a new derivative of EGF, lacking the COOH-terminal Leu-Arg residues.

    摘要翻译： 已经设计了一种以高产率制备纯表皮生长因子（EGF）的新方法，其涉及通过低酸性pH的聚丙烯酰胺凝胶柱将成年雄性小鼠的下颌腺的匀浆通过。 优选使用两步法，其中从聚丙烯酰胺凝胶层析获得的级分进行DEAE-纤维素层析。

    Modulating SOS response induction by antimicrobial agents
    5.
    发明申请
    Modulating SOS response induction by antimicrobial agents 失效
    通过抗菌剂调节SOS反应诱导

    公开(公告)号：US20070031874A1

    公开(公告)日：2007-02-08

    申请号：US11498208

    申请日：2006-08-01

    申请人： Christine Miller ,  Ronen Mosseri ,  Stanley Cohen

    发明人： Christine Miller ,  Ronen Mosseri ,  Stanley Cohen

    IPC分类号： C12Q1/68 ,  C12Q1/18 ,  A61K31/43 ,  A61K31/545

    CPC分类号： C12Q1/18 ,  C12Q1/6897 ,  G01N2800/44

    摘要： Compositions and methods are provided for the use of SOS pathway targeted agents in antimicrobial formulations. The innate sensitivity of bacteria to antibiotics is increased by disrupting a mechanism that normally activates the bacterial SOS response or by inhibiting steps in the SOS response pathway itself. SOS response induction can result from exposure of bacteria to certain antibiotics, including β-lactam antibiotics and other agents that affect cell wall synthesis. By transiently delaying bacterial cell division, SOS response induction interferes with bacterial killing by ordinarily lethal concentrations of these drugs A pharmaceutical composition comprising an SOS targeted agent is administered to a patient suffering from a microbial infection, in combination with an antibiotic that induces an SOS response. The identification of the SOS pathway as a target for modulating antibiotic action provides a basis for further therapeutic development, through screening assays designed to detect molecules or genes that act on these pathways.

    摘要翻译： 提供了组合物和方法，用于在抗微生物制剂中使用SOS途径靶向剂。 通过破坏通常激活细菌SOS反应或通过抑制SOS反应途径本身的步骤的机制，细菌对抗生素的天生敏感性增加。 SOS反应诱导可能是由细菌暴露于某些抗生素，包括β-内酰胺抗生素和影响细胞壁合成的其他药物引起的。 通过暂时延迟细菌细胞分裂，SOS反应诱导通过这些药物的通常致死浓度干扰细菌杀伤。将包含SOS靶向药物的药物组合物施用于患有微生物感染的患者与引起SOS反应的抗生素组合 。 作为调节抗生素作用靶标的SOS途径的鉴定为进一步治疗发展提供了依据，通过设计用于检测作用于这些途径的分子或基因的筛选试验。

    Mammalian tumor susceptibility genes and their uses
    9.
    发明申请
    Mammalian tumor susceptibility genes and their uses 失效

    公开(公告)号：US20060193848A1

    公开(公告)日：2006-08-31

    申请号：US10697720

    申请日：2003-10-29

    申请人： Stanley Cohen ,  Limin Li

    发明人： Stanley Cohen ,  Limin Li

    IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06

    CPC分类号： G01N33/57415 ,  C07K14/4702 ,  C12N15/00 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136

    摘要： TSG101 is a tumor susceptibility gene whose homozygous functional knock out in fibroblasts leads to transformation and the ability of these cells to form metastatic tumors in nude mice. The cellular transformation that results from inactivation of TSG101 is reversible by restoration of TSG101 function. Decreased expression of TSG101 is associated with the occurrence of certain human cancers, including breast carcinomas. The TSG101 nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.

    Resuscitation assistive timer
    10.
    发明授权
    Resuscitation assistive timer 失效
    复苏辅助计时器

    公开(公告)号：US4491423A

    公开(公告)日：1985-01-01

    申请号：US545591

    申请日：1983-10-26

    申请人： Stanley Cohen

    发明人： Stanley Cohen

    IPC分类号： G04F5/02 ,  G09B23/28 ,  G04F8/00

    CPC分类号： G09B23/288 ,  G04F5/025

    摘要： A resuscitation-assistive timer is utilized to provide audio or visual signals which act as cues to aid pediatric and adult resuscitations by indicating timing for chest compression and respiratory effort in cardio-pulmonary resuscitation. Short audio and visual signals are utilized to indicate the compression period whereas an elongated audio and/or visual signal is used to indicate the period for respiratory effort. For infants a ratio of five compressions to each respiratory effort is utilized, with the respiratory effort taking approximately two times as long as the cardiac compression. In one embodiment short pulses to signal chest compression are provided by a one-shot multivibrator which is actuated by a series of counted-down pulses from a variable frequency oscillator which may be set in accordance with the age of the individual to whom resuscitation is applied. The counted-down signals may also be further counted down and utilized to actuate a second one-shot multivibrator for the production of an elongated pulse during which respiratory effort is applied to the patient.

    摘要翻译： 使用复苏辅助计时器来提供音频或视觉信号，其通过指示心脏 - 肺复苏中的胸部压缩和呼吸努力的时间来充当儿科和成人复苏的线索。 短的音频和视频信号用于指示压缩时段，而细长的音频和/或视觉信号用于指示呼吸努力的周期。 对于婴儿，利用每次呼吸努力的5次按压比例，呼吸力大约是心脏压缩的两倍。 在一个实施例中，用于信号胸部按压的短脉冲是由单稳态多谐振荡器提供的，其由来自可变频率振荡器的一系列计数脉冲脉冲启动，该可变频率振荡器可以根据应用复苏的个体的年龄设置 。 减数信号还可以进一步下降，并用于致动第二单脉冲多谐振荡器以产生延长的脉冲，在此期间向患者施加呼吸作用。