发明申请
- 专利标题： TSG101 as inhibitor of HIV production
- 专利标题（中）： TSG101作为艾滋病毒生产的抑制剂
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申请号： US10666997申请日： 2003-09-18
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公开(公告)号： US20050009745A1公开(公告)日： 2005-01-13
- 发明人: Carol Carter , Arthur Goff , Lorna Ehrlich , Stanley Cohen
- 申请人： Carol Carter , Arthur Goff , Lorna Ehrlich , Stanley Cohen
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/17 ; A61P31/12 ; A61P31/18 ; C07H21/04 ; C07K7/06 ; C07K7/08 ; C07K14/16 ; C07K14/47 ; C12N15/09 ; C12P21/02 ; C12Q1/02 ; C12Q1/68 ; G01N33/15 ; G01N33/50 ; G01N33/53 ; G01N33/569 ; G01N33/68 ; C12Q1/70
摘要：
The present invention provides methods for identifying peptides in a mammalian. Tsg101 protein that binds to the PTAPP motif or L domain of human immunodeficiency virus type I (HIV-1). Such peptides can be used to inhibit Tsg101-HIV Gag binding, and is therefore effective in reducing HIV particle production. The invention also provides the peptides identified by the method of the invention and to method of using such peptides for treating HIV infection.
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