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公开(公告)号：US07319016B1
公开(公告)日：2008-01-15
申请号：US10646470
申请日：2003-08-22
Applicant: Ellen Chien , Douglas R. Dougan , Mark W. Knuth , Duncan E. McRee , Bi Ching Sang , Robert J. Skene , Ronald V. Swanson , Leslie W. Tari , Robert A. Wijnands
Inventor： Ellen Chien , Douglas R. Dougan , Mark W. Knuth , Duncan E. McRee , Bi Ching Sang , Robert J. Skene , Ronald V. Swanson , Leslie W. Tari , Robert A. Wijnands
CPC classification number: C12Y304/22027 , C07K2299/00 , C12N9/6472 , G01N2333/96466
Abstract: Provided are crystals relating to Cathepsin S and its various uses.
Abstract translation: 提供与组织蛋白酶S及其各种用途有关的晶体。
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公开(公告)号：US07294498B2
公开(公告)日：2007-11-13
申请号：US10121032
申请日：2002-04-09
Applicant: Edward J. Bylina , Ronald V. Swanson , Eric J. Mathur , David E. Lam
Inventor： Edward J. Bylina , Ronald V. Swanson , Eric J. Mathur , David E. Lam
CPC classification number: C12N9/2491 , C12N9/2402 , C12N9/2445 , C12N9/2454 , C12N9/2457 , C12N9/2465 , C12N9/2468 , C12N9/2494 , C12P19/02 , C12Y302/01021 , C12Y302/01022 , C12Y302/01023 , C12Y302/01025 , C12Y302/01041
Abstract: A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the food processing industry, pharmaceutical industry and in the textile industry, detergent industry and in the baking industry.
Abstract translation: 公开了衍生自各种热球菌属，葡萄球菌属和火球菌属的热稳定性糖苷酶。 酶由天然或重组宿主细胞产生，可用于食品加工业，制药工业，纺织工业，洗涤剂行业和烘焙行业。
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公开(公告)号：US07288400B2
公开(公告)日：2007-10-30
申请号：US09903410
申请日：2001-07-10
Applicant: Dan E. Robertson , Dennis Murphy , John Reid , Anthony M. Maffia , Steven Link , Ronald V. Swanson , Patrick V. Warren , Anna Kosmotka , Jay M. Short , Eric J. Mathur
Inventor： Dan E. Robertson , Dennis Murphy , John Reid , Anthony M. Maffia , Steven Link , Ronald V. Swanson , Patrick V. Warren , Anna Kosmotka , Jay M. Short , Eric J. Mathur
CPC classification number: C12N9/18 , A01K2217/05 , A61K38/00 , C12N9/16 , C12P13/04
Abstract: The invention relates to esterases and to polynucleotides encoding the esterases. In addition methods of designing new esterase method of use thereof are also provided. The esterases have increased activity and stability at increased pH and temperature.
Abstract translation: 本发明涉及酯酶和编码酯酶的多核苷酸。 此外，还提供了设计新的酯酶方法的方法。 酯酶在增加的pH和温度下具有增加的活性和稳定性。
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公开(公告)号：US07279316B2
公开(公告)日：2007-10-09
申请号：US10093037
申请日：2002-03-06
Applicant: Jay M. Short , Edward Bylina , Ronald V. Swanson , Eric J. Mathur , David E. Lam
Inventor： Jay M. Short , Edward Bylina , Ronald V. Swanson , Eric J. Mathur , David E. Lam
CPC classification number: C12N9/2468 , C12N9/2402 , C12N9/2437 , C12N9/2454 , C12N9/2457 , C12N9/2465 , C12N9/2494 , C12Y302/01004 , C12Y302/01022 , C12Y302/01025 , C12Y302/01041 , C12Y302/01078
Abstract: The invention relates to glycosidases and to polynucleotides encoding the glycosidases. In addition methods of designing new glycosidases and method of use thereof are also provided. The glycosidases have increased activity and stability at increased pH and temperature.
Abstract translation: 本发明涉及糖苷酶和编码糖苷酶的多核苷酸。 此外，还提供了设计新的糖苷酶的方法及其使用方法。 糖苷酶在增加的pH和温度下具有增加的活性和稳定性。
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公开(公告)号：US06632937B1
公开(公告)日：2003-10-14
申请号：US09408020
申请日：1999-09-29
Applicant: Ronald V. Swanson , Robert A. Feldman , Christa Schleper
Inventor： Ronald V. Swanson , Robert A. Feldman , Christa Schleper
IPC: C07H204
CPC classification number: C07K14/195
Abstract: The present application relates to nucleic acids and polypeptides from Cenarchaeum symbiosum. Methods of making the polypeptides and antibodies against the polypeptides are also described.
Abstract translation: 本申请涉及来自
共生共生体的核酸和多肽。 还描述了制备针对多肽的多肽和抗体的方法。 -
Patent Agency Ranking
公开(公告)号：US4212577A
公开(公告)日：1980-07-15
申请号：US862865
申请日：1977-12-21
Applicant: Ronald V. Swanson
Inventor： Ronald V. Swanson
Abstract: A grapple attachment for the boom of a hoisting machine having a pair of arms movable between open and closed positions, the arms supporting an endless chain which, when the arms are closed, embrace a pole to be placed so that the pole can be lifted and then rotated about its own axis by a drive motor engaging the chain so that the fittings and the like attached to the pole can be aligned in a selected direction while the pole is held by the grapple.
Abstract translation: 一种用于曳引机的起重臂的抓斗附件，其具有可在打开和关闭位置之间移动的一对臂，所述臂支撑环状链，当臂关闭时，该臂环包括待放置的杆，使得杆能够被提升，并且 然后通过与链条啮合的驱动马达围绕其自身的轴线旋转，使得附接到杆的配件等可以在杆被抓斗保持的同时沿所选方向对齐。
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公开(公告)号：US20100130424A1
公开(公告)日：2010-05-27
申请号：US12612548
申请日：2009-11-04
Applicant: RONALD V. SWANSON , NIGEL P. SHANKLEY , VERONICA MORENO , PETER GENGO
Inventor： RONALD V. SWANSON , NIGEL P. SHANKLEY , VERONICA MORENO , PETER GENGO
CPC classification number: C07K14/57509 , A61K38/00
Abstract: The present invention relates to novel peptides that are selective corticotrophin releasing hormone receptor type 2 (CRHR2) agonists and compositions thereof for the treatment, amelioration or inhibition of cardiovascular conditions, including but not limited to heart failure. The novel peptide agonist preferably comprise modifications that include pegylated peptides. Furthermore, the present invention also relates to methods for the treatment and prevention of a disease or disorder related to CRHR2 activity.
Abstract translation: 本发明涉及用于治疗，改善或抑制心血管疾病（包括但不限于心力衰竭）的选择性促肾上腺皮质激素释放激素受体2型（CRHR2）激动剂及其组合物的新型肽。 该新颖的肽激动剂优选包括包含聚乙二醇化肽的修饰。 此外，本发明还涉及治疗和预防与CRHR2活性相关的疾病或病症的方法。
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公开(公告)号：US20080279985A1
公开(公告)日：2008-11-13
申请号：US11840149
申请日：2007-08-16
Applicant: Jay M. Short , Edward Bylina , Ronald V. Swanson , Eric J. Mathur , David E. Lam
Inventor： Jay M. Short , Edward Bylina , Ronald V. Swanson , Eric J. Mathur , David E. Lam
IPC: A23L1/30 , C12N9/44 , C12P21/04 , C12P19/02 , A62D3/02 , G06F19/00 , C09K8/60 , C10L1/10 , C40B50/06
CPC classification number: C12N9/2468 , C12N9/2402 , C12N9/2437 , C12N9/2454 , C12N9/2457 , C12N9/2465 , C12N9/2494 , C12Y302/01004 , C12Y302/01022 , C12Y302/01025 , C12Y302/01041 , C12Y302/01078
Abstract: The invention relates to a polypeptide having glycosidase activity. In addition methods of designing new glycosidases and method of use thereof are also provided. The glycosidases have increased activity and stability at increased pH and Temperature.
Abstract translation: 本发明涉及具有糖苷酶活性的多肽。 此外，还提供了设计新的糖苷酶的方法及其使用方法。 糖苷酶在增加的pH和温度下具有增加的活性和稳定性。
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公开(公告)号：US5814473A
公开(公告)日：1998-09-29
申请号：US599171
申请日：1996-02-09
Applicant: Patrick V. Warren , Ronald V. Swanson
Inventor： Patrick V. Warren , Ronald V. Swanson
CPC classification number: C12N9/1096
Abstract: Thermostable transaminase and aminotransferase enzymes derived from various ammonifex, aquifex and pyrobaculum organisms are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the pharmaceutical, agricultural and other industries.
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公开(公告)号：US10040838B2
公开(公告)日：2018-08-07
申请号：US12612548
申请日：2009-11-04
Applicant: Ronald V. Swanson , Nigel P. Shankley , Veronica Moreno , Peter Gengo
Inventor： Ronald V. Swanson , Nigel P. Shankley , Veronica Moreno , Peter Gengo
IPC: C07K14/57 , A61K38/00 , C07K14/575
Abstract: The present invention relates to novel peptides that are selective corticotrophin releasing hormone receptor type 2 (CRHR2) agonists and compositions thereof for the treatment, amelioration or inhibition of cardiovascular conditions, including but not limited to heart failure. The novel peptide agonist preferably comprise modifications that include pegylated peptides. Furthermore, the present invention also relates to methods for the treatment and prevention of a disease or disorder related to CRHR2 activity.
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