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公开(公告)号：US07892247B2
公开(公告)日：2011-02-22
申请号：US10264741
申请日：2002-10-03
IPC分类号： A61B17/08
CPC分类号： A61F2/064 , A61B17/11 , A61B50/362 , A61B2050/364
摘要： The present invention provides implantable devices and associated methods for interconnecting human vessels in a side-to-side or an end-to-side arrangement rapidly, safely and in a minimally invasive manner. The devices comprise a vessel connector and a intravascular support mechanism for establishing fluid communication between two vessels. Certain embodiments further include a sealing member for further sealing the openings in the vessels created for inserting the subject devices.
摘要翻译： 本发明提供可植入装置和相关联的方法，用于将人血管以一对一侧或端对侧的排列方式快速，安全地并以微创方式相互连接。 所述装置包括血管连接器和用于在两个血管之间建立流体连通的血管内支撑机构。 某些实施例还包括用于进一步密封用于插入主体装置的容器中的开口的密封构件。
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公开(公告)号：US20090028953A1
公开(公告)日：2009-01-29
申请号：US12211001
申请日：2008-09-15
IPC分类号： A61K9/14 , A61K31/728 , A61P27/06
CPC分类号： A61K31/728
摘要： Compositions of microspheres formed of stabilized hyaluronic acid are disclosed. The unique biological properties of hyaluronic acid provide for very inert properties when exposed to tissues. Microsphere formulations of hyaluronic acid have medical utility due to the resultant properties of flowability, physical stability, and degradability. High concentration formulations of the microspheres have utility when injected to form a localized mass within tissues by providing physical stability and anti-fibrotic biological activity, especially suitable for certain surgical reconstructions. Low concentration formulation of the microspheres of the appropriate size range have utility when injected into the blood system to delivery diagnostic and therapeutic compounds.
摘要翻译： 公开了由稳定化的透明质酸形成的微球的组合物。 当暴露于组织时，透明质酸的独特生物学特性提供非常惰性的特性。 透明质酸的微球制剂由于所得到的流动性，物理稳定性和降解性的特性而具有医疗效用。 通过提供物理稳定性和抗纤维化生物活性，特别适用于某些外科重建，微注射剂的高浓度制剂在注射时可用于在组织内形成局部质量。 适当尺寸范围的微球的低浓度制剂在注射到血液系统中以递送诊断和治疗化合物时具有效用。
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公开(公告)号：US06458140B2
公开(公告)日：2002-10-01
申请号：US09771007
申请日：2001-01-26
申请人： Jodi Akin , Amr Salahieh , Michael Mack , Hani Shennib , Jackson Demond , Ronald K. Yamamoto , Stanley R. Conston
发明人： Jodi Akin , Amr Salahieh , Michael Mack , Hani Shennib , Jackson Demond , Ronald K. Yamamoto , Stanley R. Conston
IPC分类号： A61B1704
CPC分类号： A61F2/064 , A61B17/11 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61B2017/1139
摘要： The present invention provides implantable devices and associated methods forinterconnecting human vessels in a side-to-side or an end-to-side arrangement rapidly, safely and in a minimally invasive manner. The devices comprises at least a first segment, a second component, and a flow opening between the at least one segment and the second component when operatively used. The first segment is flexible and has physical and mechanical properties which allow it to be easily inserted into a vessel, to conformably seal with the inside wall of the vessel and to be resistant to dislodging from the vessel. The second component may comprise a second segment having the same or a similar configuration as the first segment or may be a tubular member which extends from the first segment. The first and second segments are flexible for easy insertion into an incision made within the side of each vessel. Upon release from a constricted state, each flexible segment subsequently conforms to the interior walls of a vessel to provide a sealing contact along the contact surface of the segment inserted within. The tubular member is configured to be inserted into a transected end of a vessel. The flow opening provides fluid interconnectivity between the vessels connected by the implanted devices. The devices are configured so as to: (1) not impede flow inside a vessel; (2) prevent leakage from the incisions within the vessels; and (3) apposition the vessels toward each other allowing the vessels to heal together so that flow in one vessel may flow to the other.
摘要翻译： 本发明提供可植入装置和用于以快速，安全和微创的方式将人血管以一对侧或端对侧的排列方式相互连接的方法。 当操作使用时，这些装置至少包括第一部分，第二部分和至少一个部分和第二部件之间的流动开口。 第一段是柔性的并且具有物理和机械性质，其允许其容易地插入容器中，以与容器的内壁一致地密封并且抵抗从容器移出的阻力。 第二部件可以包括具有与第一部分相同或相似的构造的第二部分，或者可以是从第一部分延伸的管状部件。 第一和第二段是柔性的，以便于插入到在每个容器的侧面内形成的切口中。 当从收缩状态释放时，每个柔性段随后与容器的内壁一致，以沿着插入其中的段的接触表面提供密封接触。 管状构件被构造成插入到容器的横截面中。 流动开口在由注入装置连接的容器之间提供流体互连。 这些装置被配置为：（1）不妨碍容器内的流动; （2）防止血管内的切口渗漏; 和（3）将血管相互放置，使血管相互愈合，使一个血管中的流动流向另一个血管。
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公开(公告)号：US06207180B1
公开(公告)日：2001-03-27
申请号：US09525609
申请日：2000-03-14
IPC分类号： A61F202
CPC分类号： A61K9/0034 , A61K9/1647 , A61K9/70 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/44
摘要： Bioerodible, sustained release preparations are provided for placement into the bladder through the urethra which provide sustained release of drugs. Configurations are provided which are insertable through a catheter, such as a coiled filament, patch or a flowable gel. The device is bioeroded during or after the sustained release of the drug such that there is no blockage of the urinary tract while the device is in place within the bladder.
摘要翻译： 生物可降解的持续释放制剂被提供用于通过尿道放置到膀胱中，其提供药物的持续释放。 提供可通过导管插入的配置，例如卷绕长丝，贴片或可流动的凝胶。 该装置在药物持续释放期间或之后进行生物编码，使得在装置在膀胱内就位时不会阻塞尿道。
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公开(公告)号：US06187047B1
公开(公告)日：2001-02-13
申请号：US09110726
申请日：1998-07-07
IPC分类号： A61F228
CPC分类号： A61L24/0042 , A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30092 , A61F2002/30199 , A61F2002/30677 , A61F2210/0004 , A61F2210/0014 , A61F2230/0063 , A61F2310/00293 , A61F2310/00365 , A61F2310/00383 , A61L24/0036 , A61L24/0084 , A61L27/26 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/30 , A61L2300/406 , A61L2300/414 , A61L2300/602 , A61L2300/64 , A61L2430/02 , C08L89/06
摘要： A porous three-dimensional bone grafting matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium phosphate immobilized in the matrix and having a particle size of 5 microns or less.
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公开(公告)号：US6039967A
公开(公告)日：2000-03-21
申请号：US54154
申请日：1998-04-02
IPC分类号： A61K9/00 , A61K9/06 , A61K9/107 , A61K9/127 , A61K9/16 , A61K9/70 , A61K31/135 , A61K31/216 , A61K31/335 , A61K31/352 , A61K31/453 , A61K31/55 , A61K31/56 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/24 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/44 , A61P13/00 , A61F2/02 , A61F6/06 , A61K47/30
CPC分类号： A61K9/0034 , A61K47/12 , A61K47/36 , A61K9/70 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/44 , A61K9/1647
摘要： Bioerodible, sustained release preparations are provided for placement into the bladder through the urethra which provide sustained release of drugs. Configurations are provided which are insertable through a catheter, such as a coiled filament, patch or a flowable gel. The device is bioeroded during or after the sustained release of the drug such that there is no blockage of the urinary tract while the device is in place within the bladder.
摘要翻译： 生物可降解的持续释放制剂被提供用于通过尿道放置到膀胱中，其提供药物的持续释放。 提供可通过导管插入的配置，例如卷绕长丝，贴片或可流动的凝胶。 该装置在药物持续释放期间或之后进行生物编码，使得在装置在膀胱内就位时不会阻塞尿道。
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公开(公告)号：US5487895A
公开(公告)日：1996-01-30
申请号：US106342
申请日：1993-08-13
CPC分类号： A61K9/1658 , A61K9/5052
摘要： A method for forming a controlled release polymeric substrate is provided by contacting a polymeric substrate with a liquid mixture containing a cross-linking agent at least partially soluble therein comprising water and an organic liquid, for a period of time and at a temperature and concentration of the agent sufficient for the agent to penetrate the substrate to form cross-linking bridges in the substrate in a decreasing concentration gradient beneath the surface.
摘要翻译： 形成控释聚合物基质的方法是通过使聚合物基质与含有至少部分可溶于其中的包含水和有机液体的交联剂的液体混合物接触一段时间并且温度和浓度为 所述试剂足以使试剂穿透基底以在表面下方以递减的浓度梯度在基底中形成交联桥。
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公开(公告)号：US20120010702A1
公开(公告)日：2012-01-12
申请号：US13233986
申请日：2011-09-15
申请人： Robert STEGMANN , Stanley R. CONSTON , David J. KUPIECKI , John McKENZIE , Candice D. PINSON , Ronald K. YAMAMOTO
发明人： Robert STEGMANN , Stanley R. CONSTON , David J. KUPIECKI , John McKENZIE , Candice D. PINSON , Ronald K. YAMAMOTO
IPC分类号： A61F2/14
CPC分类号： A61F9/00781
摘要： An implant is placed within Schlemm's canal of the eye and provides tension to the trabecular meshwork. The tension is continuous and increases the aqueous outflow without the necessity of administering cholinergic drugs to treat glaucoma.
摘要翻译： 将植入物放置在眼睛的施莱姆的运河内，并向小梁网提供张力。 张力是连续的，并且增加水流出物，而不需要施用胆碱能药物治疗青光眼。
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公开(公告)号：US08034105B2
公开(公告)日：2011-10-11
申请号：US11305306
申请日：2005-12-16
申请人： Robert Stegmann , Stanley R. Conston , David J. Kupiecki , John McKenzie , Candice D. Pinson , Ronald K. Yamamoto
发明人： Robert Stegmann , Stanley R. Conston , David J. Kupiecki , John McKenzie , Candice D. Pinson , Ronald K. Yamamoto
CPC分类号： A61F9/00781
摘要： A method is provided for increasing the outflow of fluid through Schlemm's canal that is useful for treatment of glaucoma. The implant is placed in Schlemm's canal by use of a flexible delivery instrument attached to the implant. The instrument and implant are positioned within the canal, the implant is released and the distal and proximal ends of the implant are connected to apply sufficient axial tensioning force on the inner wall of the canal to increase fluid permeability. In another embodiment a delivery instrument attached to the implant is positioned in the canal securing one of the distal or proximal ends of the implant within the canal. The implant provides sufficient axial tensioning force on the inner wall of the canal to increase fluid permeability of the inner wall of the canal. The other of the distal or proximal ends may be secured to maintain the tensioning force on the inner wall of the canal.
摘要翻译： 提供了一种增加流体穿过施莱姆氏管的流出方法，可用于治疗青光眼。 通过使用附着在植入物上的柔性递送器械将植入物置于施莱姆氏管中。 仪器和植入物定位在管内，植入物被释放，并且植入物的远端和近端被连接以在管的内壁上施加足够的轴向张力以增加流体渗透性。 在另一个实施例中，附接到植入物的递送器械定位在将移植物的远端或近端中的一端固定在管内的运河中。 植入物在管道的内壁上提供足够的轴向张力，以增加管道内壁的流体渗透性。 远端或近端中的另一个可以被固定以保持在管的内壁上的张紧力。
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公开(公告)号：US20100179652A1
公开(公告)日：2010-07-15
申请号：US12587375
申请日：2009-10-05
CPC分类号： A61B8/10 , A61B8/0841 , A61F9/00781
摘要： The invention relates to a novel apparatus for the treatment of ocular disease, particularly glaucoma. The apparatus consists of a locating device to locate Schlemm's Canal within the anterior portion of the eye and a surgical tool to access the canal for treatment. The apparatus allows for guided, minimally invasive surgical access to Schlemm's Canal to enable surgical procedures to be performed on the canal and trabecular meshwork to reduce intraocular pressure. The apparatus may also deliver devices or substances to Schlemm's Canal in the treatment of glaucoma.
摘要翻译： 本发明涉及用于治疗眼部疾病，特别是青光眼的新型装置。 该装置包括一个定位装置，用于在眼前部位置定位Schlemm's运河，另外还有一个外科手术工具可以进入运河进行治疗。 该装置允许引导，微创手术进入施莱姆运河，使得能够在运河和小梁网上进行外科手术以降低眼内压。 该装置还可以将器械或物质运送到施莱姆运河治疗青光眼。
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