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公开(公告)号：US4076947A
公开(公告)日：1978-02-28
申请号：US758743
申请日：1977-01-12
IPC分类号： C07C31/133 , C07C33/44 , C07C405/00 , C07D303/40 , C07D309/12 , C07F7/18 , C07C177/00
CPC分类号： C07D309/12 , C07C31/1333 , C07C33/44 , C07C405/00 , C07D303/40 , C07F7/1804 , C07F7/1896 , Y10S514/826
摘要： This disclosure describes novel 15-hydroxy prostanoic acids and derivatives thereof useful as bronchodilators, hypotensive agents and gastric acid secretion inhibitors (anti-ulcer).
摘要翻译： 本公开描述了可用作支气管扩张剂，降血压药和胃酸分泌抑制剂（抗溃疡）的新型15-羟基前列腺酸及其衍生物。
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2.发明授权Novel 3-triphenylmethoxy-1-alkynes, 3-triphenyl-methoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates 失效3-三苯基甲氧基-1-炔烃，3-三苯基 - 甲氧基-1-反式链烯基 - 二烷基 - 烷烃和3-三苯基甲氧基-1-反式链烯基 - 二烷基铝酸锂
公开(公告)号：US4060540A
公开(公告)日：1977-11-29
申请号：US739174
申请日：1976-11-05
申请人： Karel Francis Bernady , Middleton Brawner Floyd, Jr. , John Frank Poletto , Robert Eugene Schaub , Martin Joseph Weiss
发明人： Karel Francis Bernady , Middleton Brawner Floyd, Jr. , John Frank Poletto , Robert Eugene Schaub , Martin Joseph Weiss
IPC分类号： C07C405/00 , C07D309/12 , C07D309/38 , C07F7/18
CPC分类号： C07D309/38 , C07C405/00 , C07D309/12
摘要： This disclosure describes 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
摘要翻译： 本公开描述了可用作制备某些11-羟基的3-三苯基甲氧基-1-炔烃，3-三苯基甲氧基-1-反式链烯基 - 二烷基 - 烷烃和3-三苯基甲氧基-1-反式链烯基 - 二烷基铝酸锂 - 和11-脱氧-9-酮（或羟基） - 前列环酸衍生物，其具有支气管扩张剂，降血压和抗溃疡活性。
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3.发明授权
公开(公告)号：US4018811A
公开(公告)日：1977-04-19
申请号：US240814
申请日：1972-04-03
IPC分类号： C07C405/00 , C07C177/00
CPC分类号： C07C405/00 , C07C405/0033
摘要： This disclosure describes compounds of the class of substituted 9-oxoprostanoic acids and the esters and cationic salts thereof, useful as antimicrobial agents, hypotensive agents, anti-ulcer agents, or as intermediates, and novel processes for preparing the same.
摘要翻译： 本公开内容描述了可用作抗微生物剂，降血压剂，抗溃疡剂或作为中间体的取代的9-氧代雄甾烷酸类及其酯和阳离子盐的化合物及其制备方法。
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4.发明授权Hydroxylated 15-deoxy derivatives of 9-hydroxy-13-trans-prostenoic acid 失效9-羟基-13-反式 - 前列宁酸的羟基化的15-脱氧衍生物
公开(公告)号：US3950406A
公开(公告)日：1976-04-13
申请号：US480989
申请日：1974-06-19
申请人： Middleton Brawner Floyd, Jr. , William James McGahren , Robert Eugene Schaub , Martin Joseph Weiss
发明人： Middleton Brawner Floyd, Jr. , William James McGahren , Robert Eugene Schaub , Martin Joseph Weiss
CPC分类号： C07C405/0016 , C07C405/00 , C07C405/0033 , C07F1/00 , C07F5/062 , C07F7/1856 , C07F9/54 , C12P31/00
摘要： This disclosure describes certain 15-deoxy prostanoic acid derivatives having a hydroxy group further along in the beta-chain, useful as bronchodilators, hypotensive agents, anti-ulcer agents, or as intermediates.
摘要翻译： 本公开内容描述了具有进一步沿β链的羟基的某些15-脱氧前列腺酸衍生物，其可用作支气管扩张剂，降血压剂，抗溃疡剂或作为中间体。
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公开(公告)号：US3932479A
公开(公告)日：1976-01-13
申请号：US355350
申请日：1973-04-27
申请人： Karel Francis Bernady , Middleton Brawner Floyd, Jr. , John Frank Poletto , Robert Eugene Schaub , Martin Joseph Weiss
发明人： Karel Francis Bernady , Middleton Brawner Floyd, Jr. , John Frank Poletto , Robert Eugene Schaub , Martin Joseph Weiss
IPC分类号： C07C29/42 , C07C33/42 , C07C43/12 , C07C45/00 , C07C49/227 , C07C51/38 , C07C53/19 , C07C53/50 , C07C59/01 , C07C405/00 , C07D309/12 , C07D309/38 , C07F1/02 , C07F5/06 , C07F9/54
CPC分类号： C07F5/062 , C07C29/42 , C07C33/423 , C07C405/00 , C07C43/12 , C07C51/38 , C07C53/19 , C07C53/50 , C07C59/01 , C07D309/12 , C07D309/38 , C07F1/02 , C07F9/5407 , C07B2200/09 , Y10S514/814 , Y10S514/815 , Y10S514/826 , Y10S514/863 , Y10S514/927
摘要： This disclosure describes 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
摘要翻译： 本公开描述了可用作制备某些11-羟基的3-三苯基甲氧基-1-炔烃，3-三苯基甲氧基-1-反式链烯基 - 二烷基 - 烷烃和3-三苯基甲氧基-1-反式链烯基 - 二烷基铝酸锂 - 和11-脱氧-9-酮（或羟基） - 前列环酸衍生物，其具有支气管扩张剂，降血压和抗溃疡活性。
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公开(公告)号：US4110368A
公开(公告)日：1978-08-29
申请号：US806871
申请日：1977-06-15
申请人： Middleton Brawner Floyd, Jr. , Martin Joseph Weiss , John Frank Poletto , Robert Eugene Schaub , Karel Francis Bernady
发明人： Middleton Brawner Floyd, Jr. , Martin Joseph Weiss , John Frank Poletto , Robert Eugene Schaub , Karel Francis Bernady
IPC分类号： C07C45/00 , C07C51/60 , C07C53/19 , C07C59/01 , C07C59/205 , C07C59/82 , C07C59/86 , C07C59/88 , C07C59/90 , C07C405/00 , C07D303/38 , C07D305/12 , C07F1/02 , C07F5/06 , C07C177/00
CPC分类号： C07D303/38 , C07C405/00 , C07C51/60 , C07C53/19 , C07C59/01 , C07C59/205 , C07C59/82 , C07C59/86 , C07C59/88 , C07C59/90 , C07D305/12 , C07F1/02 , C07F5/062
摘要： This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto (or hydroxy)prostanoic acid derivatives useful as bronchodilators, anti-ulcer agents, or as intermediates.
摘要翻译： 本公开描述了可用作支气管扩张剂，抗溃疡剂或作为中间体的某些11-羟基和11-脱氧-9-酮（或羟基）前列腺烷酸衍生物。
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公开(公告)号：US4046787A
公开(公告)日：1977-09-06
申请号：US625406
申请日：1975-10-24
IPC分类号： C07C405/00 , C07C177/00
CPC分类号： C07C405/0041 , C07C405/00 , C07C405/0033
摘要： This disclosure describes compounds of the class of 15-substituted-9-keto(or 9-hydroxy)prostanoic acids and the esters and cationic salts thereof, useful as inhibitors of gastric acid secretion.
摘要翻译： 本公开内容描述了可用作胃酸分泌抑制剂的15-取代-9-酮（或9-羟基）前列腺烷酸类及其酯和阳离子盐的化合物。
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8.发明授权Novel 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenyl-methoxy-1-trans-alkenyl-dialkyl-alanates 失效3-三苯基甲氧基-1-炔烃，3-三苯基甲氧基-1-反式链烯基 - 二烷基 - 烷烃和3-三苯基 - 甲氧基-1-反式链烯基 - 二烷基 - 丙烷酸锂
公开(公告)号：US4007210A
公开(公告)日：1977-02-08
申请号：US613776
申请日：1975-09-18
申请人： Karel Francis Bernady , Middleton Brawner Floyd, Jr. , John Frank Poletto , Robert Eugene Schaub , Martin Joseph Weiss
发明人： Karel Francis Bernady , Middleton Brawner Floyd, Jr. , John Frank Poletto , Robert Eugene Schaub , Martin Joseph Weiss
IPC分类号： C07C405/00 , C07D309/12 , C07D309/38 , C09B11/06
CPC分类号： C07D309/12 , C07C405/00 , C07D309/38
摘要： This disclosure describes 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
摘要翻译： 本公开描述了可用作制备某些11-羟基的3-三苯基甲氧基-1-炔烃，3-三苯基甲氧基-1-反式链烯基 - 二烷基 - 烷烃和3-三苯基甲氧基-1-反式链烯基 - 二烷基铝酸锂 - 和11-脱氧-9-酮（或羟基） - 前列环酸衍生物，其具有支气管扩张剂，降血压和抗溃疡活性。
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公开(公告)号：US3993674A
公开(公告)日：1976-11-23
申请号：US555219
申请日：1975-03-04
IPC分类号： C07C405/00 , C09B11/00 , C09B11/06
CPC分类号： C07C405/00 , Y10S514/826 , Y10S514/925
摘要： This disclosure describes novel 15-hydroxy prostanoic acid derivatives having anti-ulcer, bronchodilator, and hypotensive activity.
摘要翻译： 本公开描述了具有抗溃疡，支气管扩张剂和降血压活性的新型15-羟基前列腺酸衍生物。
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公开(公告)号：US4028396A
公开(公告)日：1977-06-07
申请号：US592494
申请日：1975-07-02
IPC分类号： A61K31/557 , A61K31/19 , A61K31/5575 , A61P43/00 , C07C31/133 , C07C67/00 , C07C401/00 , C07C405/00 , C07D309/12 , C07D317/72 , C07D319/08 , C07F7/18 , C07F9/54 , C07C177/00
CPC分类号： C07D317/72 , C07C31/1333 , C07C405/00 , C07D309/12 , C07D319/08 , C07F7/1856 , C07F9/5407 , Y02P20/582 , Y10S514/826
摘要： This disclosure describes novel 15-hydroxy-16,16-spirocycloalkyl prostanoic acids and derivatives and congeners thereof which are useful as bronchodilators and gastric acid secretion inhibitors.
摘要翻译： 本公开描述了可用作支气管扩张剂和胃酸分泌抑制剂的新型15-羟基-16,16-螺环烷基前列腺酸及其衍生物和同系物。
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