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公开(公告)号：US20050042676A1
公开(公告)日：2005-02-24
申请号：US10479855
申请日：2002-06-07
Applicant: Christian Hamon , Andrew Thompson , Karsten Kuhn , Thomas Neumann , Richard Joubert , Robert Johnstone , Gunier Schmidt
Inventor： Christian Hamon , Andrew Thompson , Karsten Kuhn , Thomas Neumann , Richard Joubert , Robert Johnstone , Gunier Schmidt
IPC: C07D213/71 , C07D215/36 , C07D239/38 , C07D241/18 , C07D251/58 , C07K1/107 , C07K1/12 , C12Q1/02 , C12Q1/37 , G01N33/68 , G01N33/53
CPC classification number: G01N33/6848 , C07K1/12 , G01N33/6821
Abstract: Provided is a method for characterising a polypeptide or a population of polypeptides, which method comprises the steps of: (a) contacting a sample comprising one or more polypeptides with a lysine reactive agent to cap ε-amino groups; (b) optionally reacting the sample of polypeptides with an amine reactive reagent to block α-amino groups; (c) digesting the sample of polypeptides with a cleavage reagent to produce peptide fragments; (d) optionally deactivating the cleavage reagent; (e) removing those peptides having uncapped or unblocked amino groups; and (f) recovering the N-terminal peptides.
Abstract translation: 提供了表征多肽或多肽群体的方法，该方法包括以下步骤：（a）将包含一种或多种多肽的样品与赖氨酸反应剂接触以将ε-氨基封端; （b）任选地使多肽样品与胺反应试剂反应以阻断α-氨基; （c）用裂解试剂消化多肽样品以产生肽片段; （d）任选地使切割试剂失活; （e）除去具有未封端或未封闭的氨基的那些肽; 和（f）回收N-末端肽。
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公开(公告)号：US08021895B2
公开(公告)日：2011-09-20
申请号：US11850231
申请日：2007-09-05
Applicant: Stefan Kienle , Richard Joubert
Inventor： Stefan Kienle , Richard Joubert
IPC: G01N33/53
CPC classification number: G01N33/53 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/56911 , G01N33/6893 , G01N2800/245 , G01N2800/347 , Y10S436/811
Abstract: The present invention relates to methods of detecting renal transplant rejection and other forms of renal damage. Protein markers or renal damage are provided, along with assays for detecting said markers. Also provided are methods for identifying markers of renal damage.
Abstract translation: 本发明涉及检测肾移植排斥反应和其他形式的肾损伤的方法。 提供蛋白质标记物或肾损伤以及用于检测所述标记物的测定法。 还提供了用于鉴定肾损伤标记物的方法。
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公开(公告)号：US20090226905A1
公开(公告)日：2009-09-10
申请号：US12097703
申请日：2006-12-15
Applicant: Richard Joubert , Petra Prefot , Gitte Boehm , Juergen Arnhold , Claudia Hoehle , Erhard Neukum , Juergen Schaefer
Inventor： Richard Joubert , Petra Prefot , Gitte Boehm , Juergen Arnhold , Claudia Hoehle , Erhard Neukum , Juergen Schaefer
CPC classification number: A61K38/17 , G01N33/57419
Abstract: The invention relates to a method of diagnosis of colorectal cancer in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being: transforming growth factor-beta induced protein IG-H3 (SwissProt Acc. No. Q15582); suppressor of G2 allele of SKP1 homolog (isoform 2) (SwissProt Acc. No. Q9Y2Z0-2); hypothetical protein (part of URG4) (SwissProt Acc. No. Q9NWR7); calponin-2 (SwissProt Acc. No. Q99439); heat shock protein HSP90-beta (SwissProt Acc. No. P08238); phosphoglycerate mutase 1 (SwissProt Acc. No. P18669); serpin Cl protein (SwissProt Acc. No. P01008); or haptoglobin precursor (SwissProt Acc. No. P00738); or a decreased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being serotransferrin (SwissProt Acc. No. P02787); 26S proteasome subunit p40.5 (Swiss Prot Acc. No. Q9UNM7); aldo-keto reductase family 1 member B10 (SwissProt Acc. No. O60218); fructosamine-3-kinase (SwissProt Acc. No. Q9H479); peripherin (SwissProt Acc. No. P41219); alpha-2-macroglobulin (SwissProt Acc. No. P01023); serpin C1 protein (SwissProt Acc. No. P01008); or apolipoprotein A IV (SwissProt Acc. No. P06727). The same proteins can be used for prognosis by detecting changes in their concentration in the course of treatment for colorectal cancer.
Abstract translation: 本发明涉及一种从人体受试者获得的有效身体组织的诊断样本中诊断结肠直肠癌的方法，其包括检测诊断样品中蛋白质浓度的增加，与正常人类样品相比， 蛋白质是：转化生长因子-β诱导的蛋白质IG-H3（SwissProt Acc。No.Q15582）; SKP1同源物（同种型2）（SwissProt Acc。No.Q9Y2Z0-2）的G2等位基因的抑制子; 假定蛋白（URG4的一部分）（SwissProt Acc。No.Q9NWR7）; calponin-2（SwissProt Acc。No.Q99439）; 热休克蛋白HSP90-β（SwissProt Acc。No.P08238）; 磷酸甘油酸变位酶1（SwissProt Acc。编号P18669）; 丝氨酸蛋白酶C1蛋白（SwissProt Acc。编号P01008）; 或触珠蛋白前体（SwissProt Acc.P00738）; 或者与正常人样品相比，该蛋白质是血清转铁蛋白（SwissProt Acc.No.P02787）; 26S蛋白酶体亚基p40.5（Swiss Prot Acc。No.Q9UNM7）; 醛醇还原酶家族1成员B10（SwissProt Acc.No.O60218）; 果糖胺-3-激酶（SwissProt Acc。No.Q9H479）; 外周蛋白（SwissProt Acc。No. P41219）; α-2-巨球蛋白（SwissProt Acc.Po1023）; 丝氨酸蛋白酶C1蛋白（SwissProt Acc。编号P01008）; 或载脂蛋白A IV（SwissProt Acc.Po6727）。 通过检测结肠直肠癌治疗过程中其浓度的变化可以将相同的蛋白质用于预后。
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公开(公告)号：US20080153092A1
公开(公告)日：2008-06-26
申请号：US11850231
申请日：2007-09-05
Applicant: Stefan Kienle , Richard Joubert
Inventor： Stefan Kienle , Richard Joubert
IPC: C12Q1/68 , G01N33/543 , G01N33/567
CPC classification number: G01N33/53 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/56911 , G01N33/6893 , G01N2800/245 , G01N2800/347 , Y10S436/811
Abstract: The present invention relates to methods of detecting renal transplant rejection and other forms of renal damage. Protein markers or renal damage are provided, along with assays for detecting said markers. Also provided are methods for identifying markers of renal damage.
Abstract translation: 本发明涉及检测肾移植排斥反应和其他形式的肾损伤的方法。 提供蛋白质标记物或肾损伤以及用于检测所述标记物的测定法。 还提供了用于鉴定肾损伤标记物的方法。
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公开(公告)号：US08741580B2
公开(公告)日：2014-06-03
申请号：US13237146
申请日：2011-09-20
Applicant: Stefan Kienle , Richard Joubert
Inventor： Stefan Kienle , Richard Joubert
IPC: G01N33/53
CPC classification number: G01N33/53 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/56911 , G01N33/6893 , G01N2800/245 , G01N2800/347 , Y10S436/811
Abstract: The present invention relates to methods of detecting renal transplant rejection and other forms of renal damage. Protein markers or renal damage are provided, along with assays for detecting said markers. Also provided are methods for identifying markers of renal damage.
Abstract translation: 本发明涉及检测肾移植排斥反应和其他形式的肾损伤的方法。 提供蛋白质标记物或肾损伤以及用于检测所述标记物的测定法。 还提供了用于鉴定肾损伤标记物的方法。
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Patent Agency Ranking
公开(公告)号：US07897361B2
公开(公告)日：2011-03-01
申请号：US11664076
申请日：2005-09-29
Applicant: Jules Westbrook , Helen Byers , Malcolm Ward , Simon Lovestone , Abdul Hye , Stephen Lynham , Richard Joubert , Petra Prefot , Karsten Kuhn , Christian Baumann , Juergen Schaefer , Thorsten Prinz , Stefan Kienle
Inventor： Jules Westbrook , Helen Byers , Malcolm Ward , Simon Lovestone , Abdul Hye , Stephen Lynham , Richard Joubert , Petra Prefot , Karsten Kuhn , Christian Baumann , Juergen Schaefer , Thorsten Prinz , Stefan Kienle
IPC: C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/567
CPC classification number: G01N33/6896 , G01N2800/2821 , G01N2800/52
Abstract: Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
Abstract translation: 提供了与阿尔茨海默病相关的方法和组合物。 具体地，提供了在阿尔茨海默病状态下相对于其在正常状态下的表达差异表达的蛋白质。 鉴定和描述与阿尔茨海默氏病相关的蛋白质。 还提供了使用差异表达的蛋白质来诊断阿尔茨海默氏病的方法，以及化合物的鉴定和治疗用途的预防和治疗阿尔茨海默病的方法。
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公开(公告)号：US09095549B2
公开(公告)日：2015-08-04
申请号：US12097703
申请日：2006-12-15
Applicant: Richard Joubert , Petra Prefot , Gitte Boehm , Juergen Arnhold , Claudia Hoehle , Erhard Neukum , Juergen Schaefer
Inventor： Richard Joubert , Petra Prefot , Gitte Boehm , Juergen Arnhold , Claudia Hoehle , Erhard Neukum , Juergen Schaefer
IPC: G01N33/53 , A61K38/17 , G01N33/574
CPC classification number: A61K38/17 , G01N33/57419
Abstract: The invention relates to a method of diagnosis of colorectal cancer in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being: transforming growth factor-beta induced protein IG-H3 (SwissProt Acc. No. Q15582); suppressor of G2 allele of SKP1 homolog (isoform 2) (SwissProt Acc. No. Q9Y2Z0-2); hypothetical protein (part of URG4) (SwissProt Acc. No. Q9NWR7); calponin-2 (SwissProt Acc. No. Q99439); heat shock protein HSP90-beta (SwissProt Acc. No. P08238); phosphoglycerate mutase 1 (SwissProt Acc. No. P18669); serpin C1 protein (SwissProt Acc. No. P01008); or haptoglobin precursor (SwissProt Acc. No. P00738); or a decreased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being serotransferrin (SwissProt Acc. No. P02787); 26S proteasome subunit p40.5 (Swiss Prot Acc. No. Q9UNM7); aldo-keto reductase family 1 member B10 (SwissProt Acc. No. O60218); fructosamine-3-kinase (SwissProt Acc. No. Q9H479); peripherin (SwissProt Acc. No. P41219); alpha-2-macroglobulin (SwissProt Acc. No. P01023); serpin C1 protein (SwissProt Acc. No. P01008); or apolipoprotein A IV (SwissProt Acc. No. P06727). The same proteins can be used for prognosis by detecting changes in their concentration in the course of treatment for colorectal cancer.
Abstract translation: 本发明涉及一种从人体受试者获得的有效身体组织的诊断样本中诊断结肠直肠癌的方法，其包括检测诊断样品中蛋白质浓度的增加，与正常人类样品相比， 蛋白质是：转化生长因子-β诱导的蛋白质IG-H3（SwissProt Acc。No.Q15582）; SKP1同源物（同种型2）（SwissProt Acc。No.Q9Y2Z0-2）的G2等位基因的抑制子; 假定蛋白（URG4的一部分）（SwissProt Acc。No.Q9NWR7）; calponin-2（SwissProt Acc。No.Q99439）; 热休克蛋白HSP90-β（SwissProt Acc。No.P08238）; 磷酸甘油酸变位酶1（SwissProt Acc。编号P18669）; 丝氨酸蛋白酶C1蛋白（SwissProt Acc。编号P01008）; 或触珠蛋白前体（SwissProt Acc.P00738）; 或者与正常人样品相比，该蛋白质是血清转铁蛋白（SwissProt Acc.No.P02787）; 26S蛋白酶体亚基p40.5（Swiss Prot Acc。No.Q9UNM7）; 醛醇还原酶家族1成员B10（SwissProt Acc.No.O60218）; 果糖胺-3-激酶（SwissProt Acc。No.Q9H479）; 外周蛋白（SwissProt Acc。No. P41219）; α-2-巨球蛋白（SwissProt Acc.Po1023）; 丝氨酸蛋白酶C1蛋白（SwissProt Acc。编号P01008）; 或载脂蛋白A IV（SwissProt Acc.Po6727）。 通过检测结肠直肠癌治疗过程中其浓度的变化可以将相同的蛋白质用于预后。
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公开(公告)号：US20120065095A1
公开(公告)日：2012-03-15
申请号：US13237146
申请日：2011-09-20
Applicant: Stefan KIENLE , Richard JOUBERT
Inventor： Stefan KIENLE , Richard JOUBERT
CPC classification number: G01N33/53 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/56911 , G01N33/6893 , G01N2800/245 , G01N2800/347 , Y10S436/811
Abstract: The present invention relates to methods of detecting renal transplant rejection and other forms of renal damage. Protein markers or renal damage are provided, along with assays for detecting said markers. Also provided are methods for identifying markers of renal damage.
Abstract translation: 本发明涉及检测肾移植排斥反应和其他形式的肾损伤的方法。 提供蛋白质标记物或肾损伤以及用于检测所述标记物的测定法。 还提供了用于鉴定肾损伤标记物的方法。
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公开(公告)号：US20110165146A1
公开(公告)日：2011-07-07
申请号：US13005121
申请日：2011-01-12
Applicant: Jules Westbrook , Helen Byers , Malcolm Ward , Simon Lovestone , Abdul Hye , Stephen Lynham , Richard Joubert , Petra Prefot , Karsten Kuhn , Christian Baumann , Juergen Schaefer , Thorsten Prinz , Stefan Kienle
Inventor： Jules Westbrook , Helen Byers , Malcolm Ward , Simon Lovestone , Abdul Hye , Stephen Lynham , Richard Joubert , Petra Prefot , Karsten Kuhn , Christian Baumann , Juergen Schaefer , Thorsten Prinz , Stefan Kienle
IPC: A61K39/395 , G01N33/53 , G01N33/00 , A61P25/28
CPC classification number: G01N33/6896 , G01N2800/2821 , G01N2800/52
Abstract: Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
Abstract translation: 提供了与阿尔茨海默病相关的方法和组合物。 具体地，提供了在阿尔茨海默病状态下相对于其在正常状态下的表达差异表达的蛋白质。 鉴定和描述与阿尔茨海默氏病相关的蛋白质。 还提供了使用差异表达的蛋白质来诊断阿尔茨海默氏病的方法，以及化合物的鉴定和治疗用途的预防和治疗阿尔茨海默病的方法。
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公开(公告)号：US20080070995A1
公开(公告)日：2008-03-20
申请号：US11664076
申请日：2005-09-29
Applicant: Jules Westbrook , Helen Byers , Malcolm Ward , Simon Lovestone , Abdul Hye , Stephen Lynham , Richard Joubert , Petra Prefot , Karsten Kuhn , Christian Baumann , Juergen Schaefer , Thorsten Prinz , Stefan Kienle
Inventor： Jules Westbrook , Helen Byers , Malcolm Ward , Simon Lovestone , Abdul Hye , Stephen Lynham , Richard Joubert , Petra Prefot , Karsten Kuhn , Christian Baumann , Juergen Schaefer , Thorsten Prinz , Stefan Kienle
CPC classification number: G01N33/6896 , G01N2800/2821 , G01N2800/52
Abstract: Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
Abstract translation: 提供了与阿尔茨海默病相关的方法和组合物。 具体地，提供了在阿尔茨海默病状态下相对于其在正常状态下的表达差异表达的蛋白质。 鉴定和描述与阿尔茨海默氏病相关的蛋白质。 还提供了使用差异表达的蛋白质来诊断阿尔茨海默氏病的方法，以及化合物的鉴定和治疗用途的预防和治疗阿尔茨海默病的方法。
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