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公开(公告)号：US20090229600A1
公开(公告)日：2009-09-17
申请号：US12471070
申请日：2009-05-22
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
IPC分类号： A61M11/00
CPC分类号： A61M11/044 , A61K9/007 , A61K9/0073 , A61K31/235 , A61K31/4468 , A61K31/485 , A61K31/519 , A61M11/001 , A61M11/02 , A61M15/00 , A61M15/0028 , A61M16/109 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04
摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy
摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中涂覆的组合物为小于10μm厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶
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公开(公告)号：US08074644B2
公开(公告)日：2011-12-13
申请号：US12471070
申请日：2009-05-22
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
IPC分类号： A61L9/04
CPC分类号： A61M11/044 , A61K9/007 , A61K9/0073 , A61K31/235 , A61K31/4468 , A61K31/485 , A61K31/519 , A61M11/001 , A61M11/02 , A61M15/00 , A61M15/0028 , A61M16/109 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04
摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.
摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中所述涂覆的组合物为小于10μ厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。
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公开(公告)号：US07987846B2
公开(公告)日：2011-08-02
申请号：US12275836
申请日：2008-11-21
申请人： Ron L. Hale , Soonho Song , Reynaldo J. Quintana , Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Soonho Song , Reynaldo J. Quintana , Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61M11/00
CPC分类号： A61M15/06 , A24F47/006 , A61M11/041 , A61M11/042 , A61M11/047 , A61M2205/8268 , F24V30/00
摘要： Disclosed is a method and device for rapid heating of a substance. One embodiment includes a substance including a drug to be vaporized for inhalation therapy. A sealed fuel cell containing a combustible filament is placed in a heat exchange relationship with the substance. An igniter is operatively associated with the combustible element. The substance may be vaporized inside of a housing to allow the vaporized drug to aerosolize and be inhaled by a user.
摘要翻译： 公开了一种快速加热物质的方法和装置。 一个实施方案包括包含待蒸发的药物用于吸入治疗的物质。 将含有可燃灯丝的密封燃料电池置于与物质的热交换关系中。 点火器可操作地与可燃元件相关联。 物质可以在壳体内蒸发以允许蒸发的药物雾化并被使用者吸入。
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公开(公告)号：US20090301363A1
公开(公告)日：2009-12-10
申请号：US12485704
申请日：2009-06-16
申请人： Ramesh Damani , Ron L. Hale , Daniel J. Myers , Reynaldo J. Quintana , Dennis W. Solas , Soonho Song , Pravin Soni , Curtis Tom , Kirshnamohan Sharma
发明人： Ramesh Damani , Ron L. Hale , Daniel J. Myers , Reynaldo J. Quintana , Dennis W. Solas , Soonho Song , Pravin Soni , Curtis Tom , Kirshnamohan Sharma
IPC分类号： F23M5/00
CPC分类号： A61M11/00 , A61M11/041 , A61M11/042 , A61M11/047 , A61M11/048 , A61M15/06 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/36 , A61M2205/364 , A61M2205/3653 , A61M2205/8268 , B01B1/005 , B65B29/10 , C06B33/00 , C06B45/14 , C09K5/18 , F23B2900/00003 , F23C2900/99008 , F24V30/00 , Y02E20/346
摘要： Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
摘要翻译： 公开了能够快速加热的加热单元，药物供应单元和药物输送物品。 公开了一种加热单元，其包括基板和能够经受放置在基板内的放热金属氧化反应的固体燃料。 这些加热单元可以通过电阻，光学点火或敲击来致动。 还公开了药物供应单元和药物递送物品，其中固体燃料构造成将基底加热至足以快速热蒸发其上设置的药物的温度。
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公开(公告)号：US07347832B2
公开(公告)日：2008-03-25
申请号：US10686549
申请日：2003-10-14
IPC分类号： A61H31/00
CPC分类号： A61H31/005 , A61H31/006 , A61H31/008 , A61H2031/003 , A61H2201/0173 , A61H2201/5007 , Y10S601/06
摘要： A lightweight electro-mechanical chest compression device. The device is provided with a motor, a brake, a drive spool, a control system, and a metal channel beam to brace the device and guide a compression belt. The belt is provided in a belt cartridge that attaches to the channel beam. In use, the belt is secured around the patient and to the drive spool. The motor tightens the belt by turning the drive spool. The electro-mechanical chest compression device weighs less than 30 pounds when fully assembled with its power source.
摘要翻译： 轻便的机电胸部按压装置。 该装置设置有马达，制动器，驱动卷轴，控制系统和金属通道梁，以支撑装置并引导压缩带。 带子设置在连接到通道梁的带盒中。 在使用中，皮带被固定在患者身体和驱动卷轴上。 电机通过转动驱动器卷轴来拧紧皮带。 机电式胸部压缩装置在与其电源完全组装时重量小于30磅。
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6.发明授权
公开(公告)号：US5362966A
公开(公告)日：1994-11-08
申请号：US103758
申请日：1993-08-10
IPC分类号： A61B5/00 , A61B5/024 , G01N21/35 , G01N33/487
CPC分类号： A61B5/1455 , A61B5/02422 , A61B5/02433 , A61B5/14532 , A61B5/14552 , G01N21/359 , A61B2560/0252
摘要： A near-infrared quantitative analysis instrument for measuring blood analytes in a finger of a subject includes a temperature-sensing thermistor-type ring worn around the base of the finger and connected to the instrument via a cable. A light shield glove may be provided with the thermistor-type ring attached thereto.
摘要翻译： 用于测量受试者手指中的血液分析物的近红外定量分析仪器包括在手指的基部周围佩戴的温度感测热敏电阻型环，并通过电缆连接到仪器。 遮光手套可以设置有附接到其上的热敏电阻型环。
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公开(公告)号：US08387612B2
公开(公告)日：2013-03-05
申请号：US12485704
申请日：2009-06-16
申请人： Ramesh Damani , Ron L. Hale , Daniel J. Myers , Reynaldo J. Quintana , Dennis W. Solas , Soonho Song , Pravin Soni , Curtis Tom , Kirshnamohan Sharma
发明人： Ramesh Damani , Ron L. Hale , Daniel J. Myers , Reynaldo J. Quintana , Dennis W. Solas , Soonho Song , Pravin Soni , Curtis Tom , Kirshnamohan Sharma
IPC分类号： F24J1/00
CPC分类号： A61M11/00 , A61M11/041 , A61M11/042 , A61M11/047 , A61M11/048 , A61M15/06 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/36 , A61M2205/364 , A61M2205/3653 , A61M2205/8268 , B01B1/005 , B65B29/10 , C06B33/00 , C06B45/14 , C09K5/18 , F23B2900/00003 , F23C2900/99008 , F24V30/00 , Y02E20/346
摘要： Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
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公开(公告)号：US07913688B2
公开(公告)日：2011-03-29
申请号：US10442385
申请日：2003-05-20
申请人： Stephen Cross , Craig C. Hodges , Ron L. Hale , Peter M. Lloyd , Daniel J. Myers , Reynaldo J. Quintana , Joshua D. Rabinowitz , Curtis Tom , Martin J. Wensley
发明人： Stephen Cross , Craig C. Hodges , Ron L. Hale , Peter M. Lloyd , Daniel J. Myers , Reynaldo J. Quintana , Joshua D. Rabinowitz , Curtis Tom , Martin J. Wensley
CPC分类号： A61M15/00 , A61M11/002 , A61M11/041 , A61M11/042 , A61M11/047
摘要： A device for delivering a drug by inhalation is disclosed. The device includes a body defining an interior flow-through chamber having upstream and downstream chamber openings, and a drug supply unit contained within the chamber for producing, upon actuation, a heated drug vapor in a condensation region of the chamber. Gas drawn through the chamber region at a selected gas-flow rate is effective to form drug condensation particles from the drug vapor having a selected MMAD between 0.02 and 0.1 MMAD or between 1 and 3.5 μm. A gas-flow control valve disposed upstream of the unit functions to limit gas-flow rate through the condensation region to the selected gas-flow rate. An actuation switch in the device activates the drug-supply unit, such that the drug-supply unit can be controlled to produce vapor when the gas-flow rate through the chamber is at the selected flow rate.
摘要翻译： 公开了一种通过吸入传送药物的装置。 该装置包括限定具有上游和下游室开口的内部流通室的主体，以及容纳在该室内的药物供应单元，用于在致动时产生在该室的冷凝区域中的加热的药物蒸气。 以选定的气体流速通过室区域抽吸的气体有效地从具有0.02至0.1MMAD的选定MMAD或1至3.5μm之间的药物蒸气形成药物凝结颗粒。 设置在单元上游的气体流量控制阀用于将通过冷凝区域的气体流量限制到所选择的气体流量。 装置中的致动开关激活药物供应单元，使得当通过腔室的气体流量处于所选择的流速时，可以控制药物供应单元产生蒸汽。
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公开(公告)号：US07645442B2
公开(公告)日：2010-01-12
申请号：US10633876
申请日：2003-08-04
申请人： Ron L. Hale , Peter M. Lloyd , Amy Lu , Daniel J. Myers , Reynaldo J. Quintana , Joshua D. Rabinowitz , Dennis W. Solas , Soonho Song , Curtis Tom , Martin J. Wensley
发明人： Ron L. Hale , Peter M. Lloyd , Amy Lu , Daniel J. Myers , Reynaldo J. Quintana , Joshua D. Rabinowitz , Dennis W. Solas , Soonho Song , Curtis Tom , Martin J. Wensley
CPC分类号： A61M11/041 , A61K9/007 , A61K9/0073 , A61M11/042 , A61M11/047 , A61M15/002 , A61M15/0028 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04 , Y10S514/958
摘要： A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300° C., and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.
摘要翻译： 公开了一种用于生产冷凝气雾剂的装置，方法和系统。 该装置包括具有允许气体流过腔室的上游开口和下游开口的腔室，以及位于上游和下游开口之间位置的导热基底。 在基质上形成药物组合物膜，当药物以气溶胶形式施用时，其含有治疗有效剂量的药物。 装置中的热源可操作以向衬底供应热量以产生大于300℃的衬底温度，并且在2秒或更短的时间内使药物组合物膜从衬底基本挥发。 该装置产生含有小于约10重量％的药物组合物降解产物和所述膜的药物组合物的至少50％的气溶胶。
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公开(公告)号：US20090071477A1
公开(公告)日：2009-03-19
申请号：US12275836
申请日：2008-11-21
申请人： Ron L. Hale , Soonho Song , Reynaldo J. Quintana , Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Soonho Song , Reynaldo J. Quintana , Joshua D. Rabinowitz , Alejandro C. Zaffaroni
CPC分类号： A61M15/06 , A24F47/006 , A61M11/041 , A61M11/042 , A61M11/047 , A61M2205/8268 , F24V30/00
摘要： Disclosed is a method and device for rapid heating of a substance. One embodiment includes a substance including a drug to be vaporized for inhalation therapy. A sealed fuel cell containing a combustible filament is placed in a heat exchange relationship with the substance. An igniter is operatively associated with the combustible element. The substance may be vaporized inside of a housing to allow the vaporized drug to aerosolize and be inhaled by a user.
摘要翻译： 公开了一种快速加热物质的方法和装置。 一个实施方案包括包含待蒸发的药物用于吸入治疗的物质。 将含有可燃灯丝的密封燃料电池置于与物质的热交换关系中。 点火器可操作地与可燃元件相关联。 物质可以在壳体内蒸发以允许蒸发的药物雾化并被使用者吸入。
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