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公开(公告)号：US20090071477A1
公开(公告)日：2009-03-19
申请号：US12275836
申请日：2008-11-21
申请人： Ron L. Hale , Soonho Song , Reynaldo J. Quintana , Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Soonho Song , Reynaldo J. Quintana , Joshua D. Rabinowitz , Alejandro C. Zaffaroni
CPC分类号： A61M15/06 , A24F47/006 , A61M11/041 , A61M11/042 , A61M11/047 , A61M2205/8268 , F24V30/00
摘要： Disclosed is a method and device for rapid heating of a substance. One embodiment includes a substance including a drug to be vaporized for inhalation therapy. A sealed fuel cell containing a combustible filament is placed in a heat exchange relationship with the substance. An igniter is operatively associated with the combustible element. The substance may be vaporized inside of a housing to allow the vaporized drug to aerosolize and be inhaled by a user.
摘要翻译： 公开了一种快速加热物质的方法和装置。 一个实施方案包括包含待蒸发的药物用于吸入治疗的物质。 将含有可燃灯丝的密封燃料电池置于与物质的热交换关系中。 点火器可操作地与可燃元件相关联。 物质可以在壳体内蒸发以允许蒸发的药物雾化并被使用者吸入。
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公开(公告)号：US07465435B2
公开(公告)日：2008-12-16
申请号：US11439475
申请日：2006-05-23
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to aerosols containing of atenolol, pindolol, esmolol, propranolol, or metoprolol that are used in inhalation therapy. In a method aspect of the present invention, of atenolol, pindolol, esmolol, propranolol, or metoprolol is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of atenolol, pindolol, esmolol, propranolol, or metoprolol, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering of atenolol, pindolol, esmolol, propranolol, or metoprolol through an inhalation route is provided which comprises: a) a thin coating of an atenolol, pindolol, esmolol, propranolol, or metoprolol composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及含有用于吸入治疗的阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的气溶胶。 在本发明的方法方面，将阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔通过吸入途径施用于患者。 该方法包括：a）在固体支持物上加热阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的薄层以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了用于通过吸入途径递送阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的试剂盒，其包括：a）将阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔 组合物和b）用于将所述薄涂层分配为冷凝气溶胶的装置。
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公开(公告)号：US07445768B2
公开(公告)日：2008-11-04
申请号：US11500735
申请日：2006-08-07
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of sedative-hypnotics through an inhalation route. Specifically, it relates to aerosols containing sedative-hypnotics that are used in inhalation therapy. In a method aspect of the present invention, a sedative-hypnotic drug is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of a sedative-hypnotic, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% sedative-hypnotic drug degradation products. In a kit aspect of the present invention, a kit for delivering a sedative-hypnotic through an inhalation route is provided which comprises: a) a thin layer of a sedative-hypnotic drug and b) a device for dispensing said thin layer a sedative-hypnotic drug as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送镇静催眠药。 具体地说，它涉及用于吸入治疗的含有镇静催眠药的气溶胶。 在本发明的方法方面，通过吸入途径向患者施用镇静催眠药物。 该方法包括：a）在固体支持物上加热镇静催眠剂的薄层以形成蒸气; 并且b）使空气通过加热的蒸气以产生具有小于5％镇静催眠药物降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送镇静催眠药物的试剂盒，其包括：a）镇静催眠药物的薄层，和b）用于分配所述薄层的镇静剂 - 催眠药物作为冷凝气溶胶。
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公开(公告)号：US07087218B2
公开(公告)日：2006-08-08
申请号：US10792013
申请日：2004-03-03
CPC分类号： A61K9/0073 , A61K9/007 , A61K31/5513 , Y10S514/958
摘要： The present invention relates to the delivery of compounds for the treatment of anxiety disorders and symptoms of such disorders through an inhalation route. Specifically, it relates to aerosols containing diazepam that are used in inhalation therapy. In a method aspect of the present invention, diazepam is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of diazepam on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering diazepam through an inhalation route is provided which comprises: a) a thin coating of a diazepam composition; and, b) a device for dispending said thin coating as a condensation aerosol.
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公开(公告)号：US07070765B2
公开(公告)日：2006-07-04
申请号：US10768205
申请日：2004-01-29
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of drug esters through an inhalation route. Specifically, it relates to aerosols containing drug esters that are used in inhalation therapy. In a method aspect of the present invention, a drug ester is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of a drug ester, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug ester degradation product. In a kit aspect of the present invention, a kit for delivering a drug ester through an inhalation route is provided which comprises: a) a thin coating of a drug ester composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送药物酯。 具体地说，它涉及用于吸入治疗的含有药物酯的气溶胶。 在本发明的方法方面，通过吸入途径将药物酯递送至患者。 该方法包括：a）在固体支持物上加热药物酯的涂层以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物酯降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了用于通过吸入途径递送药物酯的试剂盒，其包括：a）药物酯组合物的薄涂层，以及b）用于分配所述薄涂层作为凝结气溶胶的装置。
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6.发明授权Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route 有权通过吸入途径递送阿普唑仑，艾司唑仑，咪达唑仑或三唑仑公开(公告)号：US07060255B2
公开(公告)日：2006-06-13
申请号：US10769157
申请日：2004-01-29
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , F24V30/00 , Y10S514/958
摘要： The present invention relates to the delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route. Specifically, it relates to aerosols containing alprazolam, estazolam, midazolam or triazolam that are used in inhalation therapy. In a method aspect of the present invention, alprazolam, estazolam, midazolam or triazolam is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of alprazolam, estazolam, midazolam or triazolam, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering alprazolam, estazolam, midazolam or triazolam through an inhalation route is provided which comprises: a) a thin coating of an alprazolam, estazolam, midazolam, or triazolam composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送阿普唑仑，艾司唑仑，咪达唑仑或三唑仑。 具体来说，它涉及用于吸入治疗的含有阿普唑仑，艾司唑仑，咪达唑仑或三唑仑的气溶胶。 在本发明的方法方面，通过吸入途径向患者施用阿普唑仑，艾司唑仑，咪达唑仑或三唑仑。 该方法包括：a）在固体支持物上加热阿普唑仑，艾司唑仑，咪达唑仑或三唑仑的薄层，形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了一种用于通过吸入途径输送阿普唑仑，艾司唑仑，咪达唑仑或三唑仑的试剂盒，其包括：a）阿普唑仑，咪达唑仑或三唑仑组合物的薄涂层，和b） 用于分配所述薄涂层作为凝结气溶胶。
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7.发明授权Delivery of compounds for the treatment of migraine through an inhalation route 有权输送化合物用于通过吸入途径治疗偏头痛公开(公告)号：US07045118B2
公开(公告)日：2006-05-16
申请号：US10766574
申请日：2004-01-27
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of a migraine headache drug through an inhalation route. Specifically, it relates to aerosols containing a migraine headache drug that are used in inhalation therapy. In a method aspect of the present invention, a migraine headache drug is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of a migraine headache drug, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering a migraine headache drug through an inhalation route is provided which comprises: a) a thin coating of an a migraine drug composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送偏头痛药物。 具体地说，它涉及含有用于吸入治疗的偏头痛药物的气溶胶。 在本发明的方法方面，偏头痛药物通过吸入途径给予患者。 该方法包括：a）在固体支持物上加热偏头痛药物的薄层以形成蒸汽; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送偏头痛药物的试剂盒，其包括：a）偏头痛药物组合物的薄涂层，以及b）用于分配所述薄涂层作为结露的装置 气雾剂。
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公开(公告)号：US07033575B2
公开(公告)日：2006-04-25
申请号：US10769051
申请日：2004-01-30
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of physiologically active compounds through an inhalation route. Specifically, it relates to aerosols containing physiologically active compounds that are used in inhalation therapy. In a method aspect of the present invention, the physiologically active compound is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of a physiologically active compound, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% physiologically active compound degradation products. In a kit aspect of the present invention, a kit for delivering a physiologically active compound through an inhalation route is provided which comprises: a) a thin coating of a physiologically active compound, and b) a device for dispensing said thin coating as a condensation aerosol.
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公开(公告)号：US07029658B2
公开(公告)日：2006-04-18
申请号：US10734902
申请日：2003-12-12
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antidepressants through an inhalation route. Specifically, it relates to aerosols containing an antidepressant that are used in inhalation therapy. In a method aspect of the present invention, an antidepressant is administered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an antidepressant to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% antidepressant degradation products. In a kit aspect of the present invention, a kit for delivering an antidepressant through an inhalation route to a mammal is provided which comprises: a) a thin coating of an antidepressant composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送抗抑郁剂。 具体地说，它涉及含有用于吸入治疗的抗抑郁药的气溶胶。 在本发明的方法方面，抗抑郁药通过吸入途径给予患者。 该方法包括：a）加热组合物，其中组合物包含抗抑郁剂以形成蒸汽; 和b）允许蒸汽冷却，从而形成包含具有小于5％抗抑郁降解产物的颗粒的冷凝气雾剂。 在本发明的试剂盒方面，提供了一种用于通过吸入途径将抗抑郁药递送至哺乳动物的试剂盒，其包括：a）抗抑郁组合物的薄涂层，以及b）用于将所述薄涂层分配为凝结气溶胶的装置 。
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公开(公告)号：US07011819B2
公开(公告)日：2006-03-14
申请号：US10792096
申请日：2004-03-03
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/192 , A61K31/196 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , F24V30/00 , Y10S514/958
摘要： The present invention relates to the delivery of headache and anti-migraine compounds through an inhalation route. Specifically, it relates to aerosols containing that are used in inhalation therapy. In a method aspect of the present invention, rizatriptan or zolmitriptan is administered to a patient through an inhalation route. The method comprises: a) heating a composition, comprising rizatriptan or zolmitriptan to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol with less than 5% of the drug degradation products. In a kit aspect of the present invention, a kit for delivering rizatriptan or zolmitriptan through an inhalation route is provided which comprises: a) a thin coating of a rizatriptan or zolmitriptan composition; and, b) a device for dispending said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送头痛和抗偏头痛化合物。 具体地说，它涉及含有用于吸入治疗的气溶胶。 在本发明的方法方面，利扎曲坦或佐米曲坦通过吸入途径给予患者。 该方法包括：a）加热包含利扎曲坦或佐米曲坦的组合物以形成蒸气; 和b）允许蒸气冷却，由此形成少于药物降解产物的5％的凝结气雾剂。 在本发明的试剂盒方面，提供了用于通过吸入途径输送利扎曲坦或佐米曲坦的试剂盒，其包括：a）利扎曲坦或唑来曲坦组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。
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