发明授权
- 专利标题： Delivery of beta-blockers through an inhalation route
- 专利标题（中）： 通过吸入途径递送β受体阻滞剂
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申请号： US11439475申请日： 2006-05-23
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公开(公告)号： US07465435B2公开(公告)日： 2008-12-16
- 发明人: Joshua D Rabinowitz , Alejandro C Zaffaroni
- 申请人： Joshua D Rabinowitz , Alejandro C Zaffaroni
- 申请人地址： US CA Mountain View
- 专利权人： Alexza Pharmaceuticals, Inc.
- 当前专利权人： Alexza Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Mountain View
- 代理机构： Swanson & Bratschun, L.L.C.
- 主分类号： A61K9/12
- IPC分类号： A61K9/12 ; A61K9/14 ; A61M15/00
摘要：
The present invention relates to aerosols containing of atenolol, pindolol, esmolol, propranolol, or metoprolol that are used in inhalation therapy. In a method aspect of the present invention, of atenolol, pindolol, esmolol, propranolol, or metoprolol is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of atenolol, pindolol, esmolol, propranolol, or metoprolol, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering of atenolol, pindolol, esmolol, propranolol, or metoprolol through an inhalation route is provided which comprises: a) a thin coating of an atenolol, pindolol, esmolol, propranolol, or metoprolol composition and b) a device for dispensing said thin coating as a condensation aerosol.
公开/授权文献
- US20060216243A1 Delivery of Beta-Blockers Through An Inhalation Route 公开/授权日：2006-09-28
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