公开(公告)号：US20210369792A1

公开(公告)日：2021-12-02

申请号：US17372614

申请日：2021-07-12

Applicant: Babita AGRAWAL ,  Rakesh KUMAR ,  Nancy GUPTA

Inventor： Babita AGRAWAL ,  Rakesh KUMAR ,  Nancy GUPTA

IPC: A61K35/74 ,  A61P37/06 ,  A61K45/06

Abstract: The present disclosure provides immunomodulatory compositions comprising live Caulobacter crescentus (CC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising live CC to the individual.

公开(公告)号：US20210340257A1

公开(公告)日：2021-11-04

申请号：US17267733

申请日：2019-08-22

Applicant: Lotfi Abou-Elkacem ,  Juergen Karl Willmann ,  Benjamin J. Hackel ,  Lawrence Arthur Stern ,  Patrick Samuel Lown ,  Amelie Margarete Marianne Lutz ,  Rakesh Kumar Bam ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Lotfi Abou-Elkacem ,  Juergen Karl Willmann ,  Benjamin J. Hackel ,  Lawrence Arthur Stern ,  Patrick Samuel Lown ,  Amelie Margarete Marianne Lutz ,  Rakesh Kumar Bam

IPC: C07K16/28 ,  A61K47/68 ,  A61K49/22 ,  A61K9/00 ,  A61P35/00

Abstract: Affibody polypeptides that specifically bind to B7-H3 are provided. Exemplary anti-B7-H3 affibodies are provided. The affibody polypeptides specifically recognize and bind to B7-H3 with high affinity. The affibodies can be conjugated to contrast agents, including without limitation microbubbles for contrast-enhanced ultrasound imaging

公开(公告)号：US08986822B2

公开(公告)日：2015-03-24

申请号：US13525408

申请日：2012-06-18

Applicant: Rakesh Kumar Gupta ,  Daniel Parker ,  Branden Michael Baer ,  Thomas Russell Downs

Inventor： Rakesh Kumar Gupta ,  Daniel Parker ,  Branden Michael Baer ,  Thomas Russell Downs

IPC: B32B5/02

CPC classification number: B32B5/02 ,  B32B5/022 ,  B32B5/024 ,  B32B5/026 ,  B32B5/26 ,  B32B2250/20 ,  B32B2262/0261 ,  B32B2262/0276 ,  B32B2262/04 ,  B32B2307/70 ,  B32B2307/726 ,  B32B2571/00 ,  E03F5/125 ,  E03F5/16 ,  Y10T442/3707 ,  Y10T442/488 ,  Y10T442/659

Abstract: A device or method to prevent penetration of oil and petroleum products while allowing high water flow rate is provided. Such device or method is beneficial in controlling the contamination of surrounding soil from accidental leak of hydrocarbons such as oil and other petroleum products from equipment or storage vessels containing such materials. The containment systems equipped with these devices will allow the rain water to flow through while providing barrier to oil and petroleum products.

Abstract translation: 提供了一种防止油和石油产品渗透同时允许高水流量的装置或方法。 这种装置或方法有利于控制周围土壤的污染，以防止从包含这种材料的设备或储存容器等烃类例如油和其他石油产品的意外泄漏。 配备这些设备的安全壳系统将允许雨水流过，同时为石油和石油产品提供屏障。

公开(公告)号：US08940616B2

公开(公告)日：2015-01-27

申请号：US13559626

申请日：2012-07-27

Applicant: Rama Krishna Kotlanka ,  Rakesh Kumar ,  Premachandran Chirayarikathuveedu Sankarapillai ,  Huamao Lin ,  Pradeep Yelehanka

Inventor： Rama Krishna Kotlanka ,  Rakesh Kumar ,  Premachandran Chirayarikathuveedu Sankarapillai ,  Huamao Lin ,  Pradeep Yelehanka

IPC: H01L21/30 ,  H01L21/46 ,  H01L21/76 ,  H01L21/00

CPC classification number: B81B7/0006 ,  B81C1/00269 ,  B81C3/001 ,  B81C2201/0115 ,  H01L21/50 ,  H01L23/481 ,  H01L23/5226 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A bonded device having at least one porosified surface is disclosed. The porosification process introduces nanoporous holes into the microstructure of the bonding surfaces of the devices. The material property of a porosified material is softer as compared to a non-porosified material. For the same bonding conditions, the use of the porosified bonding surfaces enhances the bond strength of the bonded interface as compared to the non-porosified material.

Abstract translation: 公开了具有至少一个孔隙化表面的粘合装置。 孔化过程将纳米多孔孔引入装置的结合表面的微结构中。 与非孔隙化材料相比，孔化材料的材料性质更软。 对于相同的接合条件，与非孔隙化材料相比，使用孔隙化粘合表面增强了粘结界面的粘结强度。

公开(公告)号：US20140170679A1

公开(公告)日：2014-06-19

申请号：US14003215

申请日：2012-03-07

Applicant: James Stewart Aitchison ,  Lu Chen ,  James Jiahua Dou ,  Rakesh Kumar Nayyar

Inventor： James Stewart Aitchison ,  Lu Chen ,  James Jiahua Dou ,  Rakesh Kumar Nayyar

IPC: G01N33/569 ,  G01N33/58 ,  G01N21/64

CPC classification number: G01N33/56972 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2200/0647 ,  B01L2300/0877 ,  B01L2400/086 ,  G01N15/1459 ,  G01N15/1463 ,  G01N15/1484 ,  G01N21/6456 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/582 ,  G01N2015/1006 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2201/0221

Abstract: The present invention is a method and a system of cell detection and analysis. The present invention may incorporate at least an optical source, a fluidic chip and a detection module. Cells may be caused to flow within the fluidic chip and specifically past a detection window section accessible by the optical source. The flowing cells may be identified and/or analyzed. The detection module may specifically count the cells of interest as they flow past the detection window section of the chip. The detection module may further be operable to generate or otherwise capture images of the cells as they flow past the window and to use these images collectively for the purpose of analyzing the cells. The present invention may be portable and operable in remote locations.

Abstract translation: 本发明是细胞检测和分析的方法和系统。 本发明可以至少包括光源，流体芯片和检测模块。 可能使细胞在流体芯片内流动并且特别地通过可由光源访问的检测窗口部分。 可以识别和/或分析流动的细胞。 当检测模块流过芯片的检测窗口部分时，可以具体地对感兴趣的单元进行计数。 检测模块还可以用于在单元流过窗口时生成或以其他方式捕获单元的图像，并且为了分析单元的目的而集体使用这些图像。 本发明可以是便携式的并且可在远程位置操作。

公开(公告)号：US08589814B2

公开(公告)日：2013-11-19

申请号：US12762185

申请日：2010-04-16

Applicant: Gobinath Pandurangan ,  Pravin Wamanrao Shende ,  Chandrakanth Vittal ,  Rakesh Kumar C. Mehta

Inventor： Gobinath Pandurangan ,  Pravin Wamanrao Shende ,  Chandrakanth Vittal ,  Rakesh Kumar C. Mehta

IPC: G06F3/048

CPC classification number: G06F9/451 ,  G05B19/409 ,  G05B2219/32128

Abstract: Various graphical displays used for visualization of control techniques in a process control system can be provided to an operator. For example, the graphical display could include an image associated with a portion of a process and icons that are associated with corresponding process variables. At least some of the icons include a symbol that represents a change of one value of the associated process variable relative to another value of the process variable. Another graphical display could include a pigeonhole display that includes visual elements associated with corresponding process variables. Selection of a visual element could present the operator with a peephole display that includes information associated with process variables associated with the selected visual element. Each visual element displays layers of information that are associated with its process variable.

Abstract translation: 可以向操作者提供用于过程控制系统中的控制技术可视化的各种图形显示。 例如，图形显示可以包括与过程的一部分相关联的图像和与对应的过程变量相关联的图标。 至少一些图标包括表示相关过程变量的一个值相对于过程变量的另一值的变化的符号。 另一图形显示器可以包括包括与相应过程变量相关联的视觉元素的鸽子显示器。 视觉元素的选择可以向操作者呈现窥视孔显示，其包括与所选择的视觉元素相关联的过程变量相关联的信息。 每个可视元素显示与其过程变量相关联的信息层。

公开(公告)号：US08581931B2

公开(公告)日：2013-11-12

申请号：US12790428

申请日：2010-05-28

Applicant: Rakesh Kumar Arora ,  Keith William Paterson ,  Ming Zhao ,  Hong Albert Cai Wang ,  Dan Mihai Dumitru

Inventor： Rakesh Kumar Arora ,  Keith William Paterson ,  Ming Zhao ,  Hong Albert Cai Wang ,  Dan Mihai Dumitru

IPC: G09G5/00

CPC classification number: H04M1/72533 ,  G03B21/006 ,  G03B21/34 ,  H04M1/0272

Abstract: A system and method are set forth for remotely controlling a presentation from a portable electronic device so as to freeze a slide on a remote projector to permit searching for a desired slide on the portable electronic device and then continuing the presentation when searching is complete. In one embodiment, a switch is provided in a communication layer of a presentation application such that when the switch is turned off, communication is suspended between the portable electronic device and the projector, thereby permitting browsing on the portable electronic device without interrupting the presentation. When the switch is turned on the current slide information is transmitted from the portable electronic device to the projector.

Abstract translation: 提出了一种用于远程控制来自便携式电子设备的演示的系统和方法，以便冻结远程投影仪上的幻灯片以允许在便携式电子设备上搜索期望的幻灯片，然后在搜索完成时继续呈现。 在一个实施例中，在演示应用的通信层中提供开关，使得当开关断开时，在便携式电子设备和投影仪之间暂停通信，从而允许在便携式电子设备上浏览而不中断演示。 当开关打开时，当前的幻灯片信息从便携式电子设备发送到投影仪。

公开(公告)号：US20130232368A1

公开(公告)日：2013-09-05

申请号：US13782492

申请日：2013-03-01

Applicant: ERIC FETZER ,  REID RIEDLINGER ,  DON SOLTIS ,  WILLIAM BOWHILL ,  SATISH SHRIMALI ,  KRISHNAKANTH SISTLA ,  EFRAIM ROTEM ,  RAKESH KUMAR ,  VIVEK GARG ,  ALON NAVEH ,  LOKESH SHARMA

Inventor： ERIC FETZER ,  REID RIEDLINGER ,  DON SOLTIS ,  WILLIAM BOWHILL ,  SATISH SHRIMALI ,  KRISHNAKANTH SISTLA ,  EFRAIM ROTEM ,  RAKESH KUMAR ,  VIVEK GARG ,  ALON NAVEH ,  LOKESH SHARMA

IPC: G06F1/32

CPC classification number: G06F1/3296 ,  G06F1/324 ,  Y02D10/126 ,  Y02D10/172 ,  Y02D50/20

Abstract: A processor may include a core and an uncore area. The power consumed by the core area may be controlled by controlling the Cdyn of the processor such that the Cdyn is within an allowable Cdyn value irrespective of the application being processed by the core area. The power management technique includes measuring digital activity factor (DAF), monitoring architectural and data activity levels, and controlling power consumption by throttling the instructions based on the activity levels. As a result of throttling the instructions, throttling may be implemented in 3rd droop and thermal design point (TDP). Also, the idle power consumed by the uncore area while the core area is in deep power saving states may be reduced by varying the reference voltage VR and the VP provided to the uncore area. As a result, the idle power consumed by the uncore area may be reduced.

Abstract translation: 处理器可以包括核心和无孔区域。 可以通过控制处理器的Cdyn来控制核心区域消耗的功率，使得Cdyn处于可允许的Cdyn值内，而不管应用程序是否被核心区域处理。 电源管理技术包括测量数字活动因素（DAF），监控架构和数据活动级别，以及通过基于活动级别来限制指令来控制功耗。 作为节流指令的结果，节流可以在第3垂直和热设计点（TDP）中实现。 此外，通过改变提供给无孔区域的参考电压VR和VP，可以减少核心区域处于深功率节省状态时由无孔区域消耗的空闲功率。 结果，可以减少由无孔区域消耗的空闲功率。

公开(公告)号：US20130172378A1

公开(公告)日：2013-07-04

申请号：US13820834

申请日：2011-09-02

Applicant: Rakesh Kumar

Inventor： Rakesh Kumar

IPC: A61K31/506

CPC classification number: A61K31/506 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/4858 ,  A61K31/185 ,  A61P35/00 ,  A61K2300/00

Abstract: A novel combination comprising the VEGFR inhibitor 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, with a B-Raf inhibitor, particularly N-(3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl)-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of VEGFR and/or B-Raf is beneficial.

Abstract translation: 包含VEGFR抑制剂5 - [[4 - [（2,3-二甲基-2H-吲唑-6-基）甲基氨基] -2-嘧啶基]氨基] -2-甲基苯磺酰胺或其药学上可接受的盐的新型组合， 与B-Raf抑制剂，特别是N-（3- [5-（2-氨基-4-嘧啶基）-2-（1,1-二甲基乙基）-1,3-噻唑-4-基] -2-氟苯基 ）-2,6-二氟苯磺酰胺或其药学上可接受的盐，包含其的药物组合物以及在治疗VEGFR和/或B-Raf的抑制有益的条件下使用这些组合和组合物的方法。

公开(公告)号：US20130166472A1

公开(公告)日：2013-06-27

申请号：US13335430

申请日：2011-12-22

Applicant: Frank Brunswig ,  Rakesh Kumar ,  Preeta K ,  Vijay G

Inventor： Frank Brunswig ,  Rakesh Kumar ,  Preeta K ,  Vijay G

IPC: G06Q10/06

CPC classification number: G06Q10/10 ,  G06Q10/06 ,  H04L67/02

Abstract: A method to model a business object is disclosed. An analysis module analyzes elements of a business object. A modeling module models business object logic based on the elements of the business object. An implementation module implements the modeled business object logic. A repository stores the modeled business object logic. A business object runtime module executes the modeled business object logic.

Abstract translation: 公开了一种用于建模业务对象的方法。 分析模块分析业务对象的元素。 建模模块基于业务对象的元素来模拟业务对象逻辑。 实现模块实现建模的业务对象逻辑。 存储库存储建模的业务对象逻辑。 业务对象运行时模块执行建模的业务对象逻辑。