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    Thermal cycler for PCR including temperature control bladder
    2.
    发明授权
    Thermal cycler for PCR including temperature control bladder 有权
    热循环仪用于PCR，包括温度控制膀胱

    公开(公告)号：US07955840B2

    公开(公告)日：2011-06-07

    申请号：US11843843

    申请日：2007-08-23

    Applicant: Phil Belgrader

    Inventor： Phil Belgrader

    IPC: C12M1/38

    CPC classification number: C12M41/22 ,  B01L7/02 ,  B01L7/525 ,  B01L2300/0832 ,  B01L2300/0838 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2300/185 ,  C12Q1/686 ,  G05D23/185

    Abstract: Methods and devices for performing chemical reactions under controlled temperatures are described. In one embodiment, the devices provided by the invention comprise a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing. The reaction chamber has thermally conductive interior and exterior surfaces defining an internal volume therein at a first temperature. The device also includes at least one thermally conductive temperature-control bladder disposed therein, which bladder is configured to receive a temperature-control substance at a second temperature into said bladder and expel said temperature-control substance from said bladder. The bladder is further configured such that upon receiving the temperature-control substance, the bladder expands to abut substantially at least a portion of said exterior surfaces of said reaction chamber to enable thermal exchange between said temperature-control substance the said internal volume of reaction chamber.

    Abstract translation: 描述了在受控温度下进行化学反应的方法和装置。 在一个实施例中，由本发明提供的装置包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体。 反应室具有导热的内部和外部表面，在第一温度下限定内部体积。 该装置还包括设置在其中的至少一个导热温度控制囊，该囊被构造成在第二温度下将温度控制物质接纳到所述膀胱中并从所述膀胱排出所述温度控制物质。 气囊被进一步构造成使得在接收到温度控制物质时，气囊膨胀以基本上邻接所述反应室的所述外表面的至少一部分，以使所述温度控制物质与所述内部体积的反应室 。

    Devices for collection and preparation of biological agents
    4.
    发明申请
    Devices for collection and preparation of biological agents 审中-公开
    用于收集和制备生物制剂的装置

    公开(公告)号：US20090126514A1

    公开(公告)日：2009-05-21

    申请号：US11896701

    申请日：2007-09-05

    Applicant: Eric Gregory Burroughs ,  Kenneth Scott Damer ,  Phil Belgrader ,  Benjamin Raab

    Inventor： Eric Gregory Burroughs ,  Kenneth Scott Damer ,  Phil Belgrader ,  Benjamin Raab

    IPC: G01N1/04 ,  B01J19/00

    CPC classification number: G01N1/2208 ,  G01N1/2211 ,  G01N2001/022 ,  G01N2001/2223 ,  G01N2015/0069 ,  G01N2015/0088

    Abstract: A sample collection system and method for airborne biological agents is disclosed. The sample collection system comprises a sample collection module that collects particles in an air flow and transfer the collected particles into a sampling fluid, and a sample preparation module that is responsible for accepting the sampling fluid from the sample collection module, continuously aggregating or concentrating the collected particles in the sampling fluid during the sampling process and recycling a particle-lean sampling fluid back to the collection module.

    Abstract translation: 公开了一种用于空气传播生物制剂的样品收集系统和方法。 样品收集系统包括样品收集模块，其收集空气流中的颗粒并将收集的颗粒转移到采样流体中;以及样品制备模块，其负责接收来自样品采集模块的取样流体，连续聚集或浓缩 在采样过程中采样液中收集的颗粒，并将稀薄的样品回流回收集模块。

    Sample preparation device
    5.
    发明申请
    Sample preparation device 审中-公开
    样品制备装置

    公开(公告)号：US20090111193A1

    公开(公告)日：2009-04-30

    申请号：US12213942

    申请日：2008-06-26

    Applicant: Christopher G. Cooney ,  Phil Belgrader

    Inventor： Christopher G. Cooney ,  Phil Belgrader

    IPC: G01N1/34 ,  B01L11/00 ,  B01L3/02 ,  C12M1/33

    CPC classification number: G01N1/34 ,  B01L3/5025 ,  B01L2200/0631 ,  B01L2300/0681 ,  B01L2300/0832 ,  G01N1/405 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255

    Abstract: A sample preparation device is disclosed. The sample preparation device includes a housing defining a passage way between a first opening and a second opening; and a sample filter occupying a section of said passage way. The sample filter contains a monolith adsorbent that specifically binds to nucleic acids. Also disclosed are sample filters containing glass frit is coated with an capture agent that binds specifically to an analyte of interest, sample filters containing a hydrophilic matrix with impregnated chemicals that lyses cell membranes, a cartridge base and an integrated sample preparation cartridge.

    Abstract translation: 公开了一种样品制备装置。 样品制备装置包括限定第一开口和第二开口之间的通道的壳体; 以及占据所述通道的一部分的样品过滤器。 样品过滤器包含与核酸特异性结合的整料吸附剂。 还公开了包含玻璃料的样品过滤器，其涂覆有特异性结合目的分析物的捕获剂，包含亲水基质的样品过滤器，其中浸渍的化学物质裂解细胞膜，滤筒基底和集成样品制备盒。

    Thermal Cycler for PCR Including Temperature Control Bladder
    8.
    发明申请
    Thermal Cycler for PCR Including Temperature Control Bladder 有权
    用于PCR的热循环仪包括温度控制膀胱

    公开(公告)号：US20090053772A1

    公开(公告)日：2009-02-26

    申请号：US11843843

    申请日：2007-08-23

    Applicant: Phil Belgrader

    Inventor： Phil Belgrader

    IPC: C12P19/34 ,  C12M1/00 ,  B01L7/00 ,  B01J19/18 ,  F28D15/00

    CPC classification number: C12M41/22 ,  B01L7/02 ,  B01L7/525 ,  B01L2300/0832 ,  B01L2300/0838 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2300/185 ,  C12Q1/686 ,  G05D23/185

    Abstract: Methods and devices for performing chemical reactions under controlled temperatures are described. In one embodiment, the devices provided by the invention comprise a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing. The reaction chamber has thermally conductive interior and exterior surfaces defining an internal volume therein at a first temperature. The device also includes at least one thermally conductive temperature-control bladder disposed therein, which bladder is configured to receive a temperature-control substance at a second temperature into said bladder and expel said temperature-control substance from said bladder. The bladder is further configured such that upon receiving the temperature-control substance, the bladder expands to abut substantially at least a portion of said exterior surfaces of said reaction chamber to enable thermal exchange between said temperature-control substance the said internal volume of reaction chamber.

    Abstract translation: 描述了在受控温度下进行化学反应的方法和装置。 在一个实施例中，由本发明提供的装置包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体。 反应室具有导热的内部和外部表面，在第一温度下限定内部体积。 该装置还包括设置在其中的至少一个导热温度控制囊，该囊被构造成在第二温度下将温度控制物质接纳到所述膀胱中并从所述膀胱排出所述温度控制物质。 气囊被进一步构造成使得在接收到温度控制物质时，气囊膨胀以基本上邻接所述反应室的所述外表面的至少一部分，以使所述温度控制物质与所述内部体积的反应室 。

    THERMAL CYCLER FOR PCR INCLUDING TEMPERATURE CONTROL BLADDER
    10.
    发明申请
    THERMAL CYCLER FOR PCR INCLUDING TEMPERATURE CONTROL BLADDER 有权
    用于PCR的热循环器，包括温度控制刮板

    公开(公告)号：US20110269191A1

    公开(公告)日：2011-11-03

    申请号：US13098336

    申请日：2011-04-29

    Applicant: Phil BELGRADER

    Inventor： Phil BELGRADER

    IPC: C12P19/34

    CPC classification number: C12M41/22 ,  B01L7/02 ,  B01L7/525 ,  B01L2300/0832 ,  B01L2300/0838 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2300/185 ,  C12Q1/686 ,  G05D23/185

    Abstract: Methods and devices for performing chemical reactions under controlled temperature are described. In one embodiment, the devices provided by the invention comprise a housing diminished hold a reaction chamber disposed within an interior volume of the housing. The reaction chamber has thermally conductive interior and exterior surfaces defining an internal volume therein at a first temperature. The device also includes at least one temperature-control substance at a second temperature into said bladder and expel said temperature-control substance, the bladder expands to about substantially at least a portion of said exterior surfaces of said reaction chamber to enable thermal exchange between said temperature-control substance the said internal volume of reaction chamber.

    Abstract translation: 描述了在受控温度下进行化学反应的方法和装置。 在一个实施例中，由本发明提供的装置包括减小的壳体，其保持设置在壳体的内部容积内的反应室。 反应室具有导热的内部和外部表面，在第一温度下限定内部体积。 该装置还包括在第二温度下的至少一个温度控制物质进入所述气囊并排出所述温度控制物质，所述气囊膨胀至所述反应室的所述外表面的基本上至少一部分，以使所述 温度控制物质反应室的所述内部体积。

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