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公开(公告)号：US20120022246A1
公开(公告)日：2012-01-26
申请号：US13269195
申请日：2011-10-07
申请人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： C07H21/04
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.
摘要翻译： 具有基本上无孔隙或具有小于10nm直径的孔的外部玻璃表面的磁性颗粒以及具有玻璃表面的铁磁颗粒优选用于从样品中分离生物材料。 它们提供快速可靠的净化。
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公开(公告)号：US06870047B2
公开(公告)日：2005-03-22
申请号：US09756743
申请日：2001-01-10
申请人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： G01N33/552 , B01J20/28 , B03C20060101 , B03C1/01 , C07H20060101 , C07H1/08 , C07H21/00 , C12N20060101 , C12N15/09 , C12N15/10 , C12N15/11 , C12Q20060101 , C12Q1/68 , G01N33/553 , H01F1/00 , H01F1/11 , H01F1/36 , C12N15/00 , C12N13/00 , C12P19/34
CPC分类号： C03C3/111 , B03C1/01 , B82Y25/00 , C03C3/078 , C03C3/083 , C03C3/085 , C03C3/087 , C03C3/089 , C03C3/091 , C03C3/102 , C03C3/105 , C03C3/108 , C07H21/00 , C12N15/1013 , C12Q1/6804 , C12Q1/6806 , C12Q1/6834 , H01F1/0063 , H01F1/112 , H01F1/36 , Y10S428/90 , Y10S435/814 , Y10T428/2996
摘要： Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free class surface or having pores with a diameter offices than 10 nm. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 μm. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3.
摘要翻译： 制备磁性颗粒，其包含涂覆有具有基本上无孔的等级表面或具有直径为10nm以上的孔的玻璃层的磁芯。 颗粒用于分离生物材料如核酸。 制备颗粒的优选方法是通过用由醇和金属醇盐形成的溶胶形成磁芯的混合物，喷雾干燥混合物以用一层凝胶溶胶涂覆芯，并加热涂覆的芯以获得 磁性玻璃颗粒。 优选地，颗粒的平均粒度小于100μm。 磁芯可以是包含固定在云母芯上的云母芯和磁铁矿颗粒的复合材料，并且玻璃层可以含有氧化硼。 磁芯材料包括磁铁矿（Fe3O4）和Fe2O3。
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3.发明授权Method for separating biological material from a fluid using magnetic particles 有权使用磁性颗粒从流体中分离生物材料的方法公开(公告)号：US07371830B2
公开(公告)日：2008-05-13
申请号：US11041750
申请日：2005-01-24
申请人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christop Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christop Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface or having pores with a diameter of less than 10 nm. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 μm. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3.
摘要翻译： 制备磁性颗粒，其包含涂覆有具有基本无孔玻璃表面或具有小于10nm直径的孔的玻璃层的磁芯。 颗粒用于分离生物材料如核酸。 制备颗粒的优选方法是通过用由醇和金属醇盐形成的溶胶形成磁芯的混合物，喷雾干燥混合物以用一层凝胶溶胶涂覆芯，并加热涂覆的芯以获得 磁性玻璃颗粒。 优选地，颗粒的平均粒度小于100μm。 磁芯可以是包含固定在云母芯上的云母芯和磁铁矿颗粒的复合材料，并且玻璃层可以含有氧化硼。 磁芯材料包括磁铁矿（Fe 3 O 4 O 4）和Fe 2 O 3 O 3。
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公开(公告)号：US20050266429A1
公开(公告)日：2005-12-01
申请号：US11041750
申请日：2005-01-24
申请人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.
摘要翻译： 具有基本上无孔隙或具有小于10nm直径的孔的外部玻璃表面的磁性颗粒以及具有玻璃表面的铁磁颗粒优选用于从样品中分离生物材料。 它们提供快速可靠的净化。
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公开(公告)号：US20050266462A1
公开(公告)日：2005-12-01
申请号：US11128024
申请日：2005-05-11
申请人： Kurt Weindel , Michael Riedling , Albert Geiger
发明人： Kurt Weindel , Michael Riedling , Albert Geiger
IPC分类号： B01J19/00 , B03C1/01 , C01B33/18 , C03B8/02 , C03B19/10 , C03C14/00 , C12M1/34 , C12N15/10 , C12Q1/68 , C23C26/00 , C23C30/00 , H01F1/00 , H01F1/06 , H01F1/44
CPC分类号： B82Y25/00 , B03C1/01 , C03B19/1065 , C03C1/006 , C03C3/091 , C03C3/093 , C03C12/00 , C03C14/004 , C03C2214/08 , C03C2214/32 , C12N15/1013 , C12Q1/6806 , C12Q1/6816 , C12Q1/6848 , C12Q2561/101 , C23C26/00 , C23C30/00 , H01F1/0054 , H01F1/0063 , H01F1/44 , C12Q2563/155 , C12Q2549/125 , C12Q2549/101
摘要： This invention relates to magnetic particles having a glass surface which are substantially spherical. This invention also relates to methods for making them, as well as to suspensions thereof and their uses for the purification of DNA or RNA in particular in automated processes.
摘要翻译： 本发明涉及具有基本上球形的玻璃表面的磁性颗粒。 本发明还涉及制备它们的方法，以及其悬浮液及其用于纯化DNA或RNA的用途，特别是在自动化方法中。
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公开(公告)号：US06919444B2
公开(公告)日：2005-07-19
申请号：US10371375
申请日：2003-02-20
IPC分类号： C12N15/00 , B01D15/08 , B01J2/00 , B03C1/00 , B03C1/01 , B22F1/02 , C03B8/02 , C03C3/091 , C03C3/093 , C04B35/653 , C12M1/00 , C12N15/09 , C12N15/10 , C12Q1/68 , H01F1/00 , H01F1/11 , H01F1/24 , C07H21/04
CPC分类号： B82Y25/00 , B03C1/01 , C12N15/1006 , C12N15/1013 , C12Q1/6806 , H01F1/11 , H01F1/112 , Y10T428/2989 , Y10T428/2993 , Y10T428/2996
摘要： Preparations of particles having a glass surface, wherein more than 75% by weight of these particles have a particle size between 0.5 μm and 15 μm and a glass surface which contains between 2 and 6 mole % zinc oxide, have proven to be particularly advantageous in processes for the purification of nucleic acids. This in particular results in an increased nucleic acid yield.
摘要翻译： 具有玻璃表面的颗粒的制备，其中大于75重量％的这些颗粒具有0.5μm和15μm之间的粒度和含有2至6摩尔％氧化锌的玻璃表面，已被证明是特别有利的 核酸纯化方法。 这特别导致增加的核酸产量。
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公开(公告)号：US20110117561A1
公开(公告)日：2011-05-19
申请号：US12957157
申请日：2010-11-30
申请人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.
摘要翻译： 具有基本上无孔隙或具有小于10nm直径的孔的外部玻璃表面的磁性颗粒以及具有玻璃表面的铁磁颗粒优选用于从样品中分离生物材料。 它们提供快速可靠的净化。
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公开(公告)号：US20070082360A1
公开(公告)日：2007-04-12
申请号：US11638289
申请日：2006-12-12
申请人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.
摘要翻译： 具有基本上无孔隙或具有小于10nm直径的孔的外部玻璃表面的磁性颗粒以及具有玻璃表面的铁磁颗粒优选用于从样品中分离生物材料。 它们提供快速可靠的净化。
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公开(公告)号：US06545143B1
公开(公告)日：2003-04-08
申请号：US09856737
申请日：2002-01-09
IPC分类号： C07H2104
CPC分类号： B82Y25/00 , B03C1/01 , C12N15/1006 , C12N15/1013 , C12Q1/6806 , H01F1/11 , H01F1/112 , Y10T428/2989 , Y10T428/2993 , Y10T428/2996
摘要： Preparations of particles having a glass surface, wherein more than 75% by weight of these particles have a particle size between 0.5 &mgr;m and 15 &mgr;m and a glass surface which contains between 2 and 6 mole % zinc oxide, have proven to be particularly advantageous in processes for the purification of nucleic acids. This in particular results in an increased nucleic acid yield.
摘要翻译： 具有玻璃表面的颗粒的制备，其中大于75重量％的这些颗粒具有0.5μm和15μm之间的粒度和含有2至6摩尔％氧化锌的玻璃表面，已被证明是特别有利的 核酸纯化方法。 这特别导致增加的核酸产量。
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10.发明申请公开(公告)号：US20120247150A1
公开(公告)日：2012-10-04
申请号：US13372218
申请日：2012-02-13
申请人： Kurt Weindel , Michael Riedling , Albert Geiger
发明人： Kurt Weindel , Michael Riedling , Albert Geiger
IPC分类号： C03B19/10
CPC分类号： B82Y25/00 , B03C1/01 , C03B19/1065 , C03C1/006 , C03C3/091 , C03C3/093 , C03C12/00 , C03C14/004 , C03C2214/08 , C03C2214/32 , C12N15/1013 , C12Q1/6806 , C12Q1/6816 , C12Q1/6848 , C12Q2561/101 , C23C26/00 , C23C30/00 , H01F1/0054 , H01F1/0063 , H01F1/44 , C12Q2563/155 , C12Q2549/125 , C12Q2549/101
摘要： This invention relates to magnetic particles having a glass surface which are substantially spherical. This invention also relates to methods for making them, as well as to suspensions thereof and their uses for the purification of DNA or RNA in particular in automated processes.
摘要翻译： 本发明涉及具有基本上球形的玻璃表面的磁性颗粒。 本发明还涉及制备它们的方法，以及其悬浮液及其用于纯化DNA或RNA的用途，特别是在自动化方法中。
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