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    Adherent device for sleep disordered breathing
    1.
    发明授权
    Adherent device for sleep disordered breathing 有权
    睡眠呼吸障碍的粘附装置

    公开(公告)号：US08688190B2

    公开(公告)日：2014-04-01

    申请号：US13543660

    申请日：2012-07-06

    申请人： Imad Libbus ,  Yatheendhar D. Manicka ,  Mark J. Bly

    发明人： Imad Libbus ,  Yatheendhar D. Manicka ,  Mark J. Bly

    IPC分类号： A61B5/053 ,  A61B5/113

    CPC分类号： A61B5/4818 ,  A61B5/0002 ,  A61B5/0205 ,  A61B5/02055 ,  A61B5/04085 ,  A61B5/0809 ,  A61B5/11 ,  A61B5/14551 ,  A61B5/6832 ,  A61B5/6833 ,  A61B5/7282 ,  A61B2560/0412 ,  A61B2562/164

    摘要： An adherent device is configured to adhere to the skin of the patient with an adherent patch, for example breathable tape, coupled to at least four electrodes. The device comprises impedance circuitry coupled to the at least four electrodes and configured to measure respiration of the patient to detect sleep apnea and/or hypopnea. The impedance circuitry may be used to measure hydration of the patient. An accelerometer can be mechanically coupled to the adherent patch such that the accelerometer can be coupled to and move with the skin of the patient. Electrocardiogram circuitry to generate an electrocardiogram signal may be coupled to at least two of the at least four electrodes to detect the sleep apnea and/or hypopnea.

    摘要翻译： 贴附装置被配置为使用与至少四个电极耦合的粘附贴片（例如透气带）粘附到患者的皮肤。 该装置包括耦合到至少四个电极的阻抗电路，并且被配置为测量患者的呼吸以检测睡眠呼吸暂停和/或呼吸不足。 阻抗电路可以用于测量患者的水合。 加速度计可以机械耦合到粘附贴片，使得加速度计可以耦合到患者皮肤并与患者的皮肤一起移动。 用于产生心电图信号的心电图电路可以耦合到至少四个电极中的至少两个，以检测睡眠呼吸暂停和/或呼吸不足。

    DIRECT DELIVERY SYSTEM FOR TRANSVASCULAR LEAD
    2.
    发明申请
    DIRECT DELIVERY SYSTEM FOR TRANSVASCULAR LEAD 有权
    直升机系统

    公开(公告)号：US20110178530A1

    公开(公告)日：2011-07-21

    申请号：US13079512

    申请日：2011-04-04

    申请人： Mark J. Bly

    发明人： Mark J. Bly

    IPC分类号： A61B19/00

    CPC分类号： A61N1/057 ,  A61N1/0558 ,  A61N1/36114

    摘要： A lead delivery system for delivering a neurostimulation lead to a patient's internal jugular vein using a percutaneous stick. The system comprises a neurostimulation lead adapted to stimulate a vagus nerve from the internal jugular vein. The lead includes a proximal end, a distal end, a generally spiral shaped retaining structure interposed between the proximal and distal ends and configured to retain the lead in the internal jugular vein, an electrode coupled to the retaining structure, and a side port interposed between the retaining structure and the proximal end. The side port provides access to a lumen extending from the distal end to the side port. A guidewire is sized to fit within the side port and lumen and reduce a force exerted by the retaining structure against the internal jugular vein, thereby allowing rotation of the lead and orientation of the electrode by applying a torque to the lead. A catheter has a lumen sized to slideably receive the medical electrical lead and configured to provide access to the internal jugular vein from the percutaneous stick site. A method of delivering a medical electrical lead to a patient's internal jugular vein.

    摘要翻译： 用于使用经皮棒递送神经刺激导致患者颈内静脉的引导递送系统。 该系统包括适于从颈内静脉刺激迷走神经的神经刺激引线。 引线包括近端，远端，插入在近端和远端之间的大致螺旋形的保持结构，并且构造成将引线保持在颈内静脉内，连接到保持结构的电极和插入在 保持结构和近端。 侧端口提供进入从远端延伸到侧端口的内腔。 导丝的尺寸设置成适合于侧端口和内腔，并且减小由保持结构抵抗颈内静脉施加的力，由此通过向引线施加扭矩来允许引线的引导和取向的旋转。 导管具有尺寸适于可滑动地接收医疗电引线并且被配置为提供从经皮粘连部位进入颈内静脉的内腔。 将医用电导线递送到患者的颈内静脉的方法。

    Left ventricular lead shapes
    3.
    发明授权
    Left ventricular lead shapes 有权
    左心室铅形

    公开(公告)号：US07747334B2

    公开(公告)日：2010-06-29

    申请号：US11277326

    申请日：2006-03-23

    申请人： Mark J. Bly ,  Brian D. Soltis ,  Bruce A. Tockman ,  Avram Scheiner

    发明人： Mark J. Bly ,  Brian D. Soltis ,  Bruce A. Tockman ,  Avram Scheiner

    IPC分类号： A61N1/372

    CPC分类号： A61N1/056 ,  A61N2001/0585

    摘要： A lead for sensing and pacing a left ventricle of the heart includes a lead body having a proximal portion and a distal portion, a lumen extending through the lead body, a conductor extending through the lead body from the proximal end to the distal end and an electrode disposed on the distal portion of the lead body and electrically coupled to the conductor. A distal tip of the lead body is continuously deflectable upon advancement and withdrawal of a stylet through the lumen at the distal portion to access a selected branch of the coronary sinus. The distal tip of the lead body may be offset before or after continuously deflecting the distal tip.

    摘要翻译： 用于感测和起搏心脏左心室的引线包括具有近端部分和远端部分的引线体，延伸穿过引线主体的内腔，从近端延伸穿过引线主体到远端的导体，以及 电极，其设置在引线体的远端部分上并电耦合到导体。 引导体的远侧末端在通过远端部分的内腔前进和取出探针时可连续偏转，以进入冠状窦的选定分支。 引线体的远端可以在连续偏转远端之前或之后偏移。

    ELECTRODE CONFIGURATIONS FOR TRANSVASCULAR NERVE STIMULATION
    5.
    发明申请
    ELECTRODE CONFIGURATIONS FOR TRANSVASCULAR NERVE STIMULATION 审中-公开
    用于透视神经刺激的电极配置

    公开(公告)号：US20080183264A1

    公开(公告)日：2008-07-31

    申请号：US11668957

    申请日：2007-01-30

    申请人： Mark J. Bly ,  David J. Smith ,  Imad Libbus

    发明人： Mark J. Bly ,  David J. Smith ,  Imad Libbus

    IPC分类号： A61N1/05

    CPC分类号： A61N1/057

    摘要： An intravascular lead adapted to be deployed to a stimulation site within a vessel adjacent a nerve to be stimulated includes at least a first electrode adapted to deliver an electrical pulse across a vessel wall. The first electrode includes an electrically active surface having one or more surface features adapted to focus current. The first electrode is disposed on the distal portion that the electrically active surface can be directed towards the nerve to be stimulated.

    摘要翻译： 适于部署到邻近被刺激的神经的血管内的刺激部位的血管内线包括至少第一电极，其适于将电脉冲传送穿过血管壁。 第一电极包括具有适于聚焦电流的一个或多个表面特征的电活性表面。 第一电极设置在远端部分上，电活性表面可以被引导到被刺激的神经。

    ADHERENT DEVICE FOR SLEEP DISORDERED BREATHING
    9.
    发明申请
    ADHERENT DEVICE FOR SLEEP DISORDERED BREATHING 有权
    用于睡眠障碍呼吸的附属装置

    公开(公告)号：US20120277549A1

    公开(公告)日：2012-11-01

    申请号：US13543660

    申请日：2012-07-06

    申请人： Imad Libbus ,  Yatheendhar D. Manicka ,  Mark J. Bly

    发明人： Imad Libbus ,  Yatheendhar D. Manicka ,  Mark J. Bly

    IPC分类号： A61B5/0492 ,  A61B5/08 ,  A61B5/0408 ,  A61B5/01 ,  A61B5/053 ,  A61B5/11

    CPC分类号： A61B5/4818 ,  A61B5/0002 ,  A61B5/0205 ,  A61B5/02055 ,  A61B5/04085 ,  A61B5/0809 ,  A61B5/11 ,  A61B5/14551 ,  A61B5/6832 ,  A61B5/6833 ,  A61B5/7282 ,  A61B2560/0412 ,  A61B2562/164

    摘要： An adherent device is configured to adhere to the skin of the patient with an adherent patch, for example breathable tape, coupled to at least four electrodes. The device comprises impedance circuitry coupled to the at least four electrodes and configured to measure respiration of the patient to detect sleep apnea and/or hypopnea. The impedance circuitry may be used to measure hydration of the patient. An accelerometer can be mechanically coupled to the adherent patch such that the accelerometer can be coupled to and move with the skin of the patient. Electrocardiogram circuitry to generate an electrocardiogram signal may be coupled to at least two of the at least four electrodes to detect the sleep apnea and/or hypopnea.

    摘要翻译： 贴附装置被配置为使用与至少四个电极耦合的粘附贴片（例如透气带）粘附到患者的皮肤。 该装置包括耦合到至少四个电极并被配置为测量患者的呼吸以检测睡眠呼吸暂停和/或呼吸不足的阻抗电路。 阻抗电路可以用于测量患者的水合。 加速度计可以机械耦合到粘附贴片，使得加速度计可以耦合到患者皮肤并与患者的皮肤一起移动。 用于产生心电图信号的心电图电路可以耦合到至少四个电极中的至少两个，以检测睡眠呼吸暂停和/或呼吸不足。

    Retrograde pressure regulated infusion
    10.
    发明授权
    Retrograde pressure regulated infusion 有权
    逆行压力调节输液

    公开(公告)号：US08182463B2

    公开(公告)日：2012-05-22

    申请号：US11609143

    申请日：2006-12-11

    申请人： Jessica Chiu ,  Gregory Waimong Chan ,  Hongzhi Bai ,  Nianjiong J. Bei ,  Mark J. Bly ,  Srinivasan Sridharan ,  Tom Hatten

    发明人： Jessica Chiu ,  Gregory Waimong Chan ,  Hongzhi Bai ,  Nianjiong J. Bei ,  Mark J. Bly ,  Srinivasan Sridharan ,  Tom Hatten

    IPC分类号： A61M31/00

    CPC分类号： A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

    摘要： A delivery catheter that includes a flexible shaft having a proximal end and a distal end, the distal end having an outer diameter less than about 13 mm; a delivery lumen having a proximal end and a distal end, the delivery lumen within the flexible shaft, the delivery lumen having at least an outlet port or at least one side hole at the distal end of the delivery lumen, the delivery lumen having a cross-sectional area at least about 5 mm2; a pressure monitoring lumen having a proximal end and a distal end, the pressure monitoring lumen within the flexible shaft; a pressure port adjacent to and connected to the distal end of the pressure monitoring lumen; a balloon inflation lumen having a proximal end and a distal end, the balloon inflation lumen within the flexible shaft; a soft tip at the distal end of the flexible shaft; a balloon at the distal end of the flexible shaft, the balloon connected to the distal end of the balloon inflation lumen, the balloon includes at least one of the following materials, polyether block amide resin, polyetheramide, polyurethane, silicone, natural latex, or synthetic latex; wherein the balloon is adapted to inflate to a diameter range of about 4 to about 15 mm.

    摘要翻译： 输送导管，其包括具有近端和远端的柔性轴，所述远端具有小于约13mm的外径; 输送腔，其具有近端和远端，所述输送腔在所述柔性轴内，所述输送腔至少具有出口端口或至少一个在所述输送腔的远端处的侧孔，所述输送腔具有交叉 截面面积至少约5 mm2; 具有近端和远端的压力监测管腔，所述柔性轴内的所述压力监测腔; 与所述压力监视管腔的远端相邻并连接的压力口; 具有近端和远端的球囊充气腔，所述气囊膨胀腔在所述柔性轴内; 在柔性轴的远端处的软尖端; 在柔性轴的远端处的气囊，气囊连接到球囊充气腔的远端，气囊包括以下材料中的至少一种：聚醚嵌段酰胺树脂，聚醚酰胺，聚氨酯，硅氧烷，天然胶乳或 合成胶乳 其中所述气囊适于膨胀至约4至约15mm的直径范围。