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    Systems for providing neural markers for sensed autonomic nervous system activity
    1.
    发明授权
    Systems for providing neural markers for sensed autonomic nervous system activity 有权
    用于提供感觉到的自主神经系统活动的神经标记物的系统

    公开(公告)号：US09555252B2

    公开(公告)日：2017-01-31

    申请号：US12612494

    申请日：2009-11-04

    申请人： Imad Libbus ,  Andrew P. Kramer ,  William J. Linder ,  Jeffrey E. Stahmann

    发明人： Imad Libbus ,  Andrew P. Kramer ,  William J. Linder ,  Jeffrey E. Stahmann

    IPC分类号： A61N1/37 ,  A61B5/04 ,  A61N1/36 ,  A61N1/362 ,  A61N1/372 ,  A61B5/00

    CPC分类号： A61N1/37 ,  A61B5/04001 ,  A61B5/4035 ,  A61B5/4047 ,  A61B5/4052 ,  A61B5/726 ,  A61N1/36135 ,  A61N1/3627 ,  A61N1/3702 ,  A61N1/37217 ,  A61N1/37235

    摘要： In various method embodiments, a neural activity signal is sensed, a feature from the sensed neural activity signal is extracted, and a neural marker for the extracted feature is created. The neural marker includes information regarding the extracted feature. Various device embodiments comprise a port to receive a neural activity signal, and a feature extractor adapted to receive and process the neural activity signal to produce a neural marker that includes information for the neural activity signal. Various device embodiments comprise a display, a memory adapted to store a neural marker associated with a sensed neural activity signal, and a controller adapted to communicate with the memory and the display to provide a representation of the neural marker on the display.

    摘要翻译： 在各种方法实施例中，感测神经活动信号，提取来自所感测的神经活动信号的特征，并且创建用于提取的特征的神经标记。 神经标记包括关于提取的特征的信息。 各种装置实施例包括用于接收神经活动信号的端口，以及适于接收和处理所述神经活动信号以产生神经标记的特征提取器，所述神经标记包括所述神经活动信号的信息。 各种设备实施例包括显示器，适于存储与感测的神经活动信号相关联的神经标记的存储器，以及适于与存储器和显示器通信以提供显示器上的神经标记的表示的控制器。

    Systems and methods for treating supraventricular arrhythmias
    3.
    发明授权
    Systems and methods for treating supraventricular arrhythmias 有权
    用于治疗室上性心律失常的系统和方法

    公开(公告)号：US08965503B2

    公开(公告)日：2015-02-24

    申请号：US13555784

    申请日：2012-07-23

    申请人： Imad Libbus

    发明人： Imad Libbus

    IPC分类号： A61N1/00 ,  A61N1/36 ,  A61N1/362 ,  A61N1/39

    CPC分类号： A61N1/36114 ,  A61N1/3621 ,  A61N1/3962

    摘要： In various method embodiments, a supraventricular arrhythmia event is detected, and a supraventricular arrhythmia treatment, including neural stimulation to elicit a sympathetic response, is delivered in response to a detected supraventricular arrhythmia event. Some embodiments detect a precursor for a supraventricular arrhythmia episode, and deliver prophylactic neural stimulation to avoid the supraventricular arrhythmia event. Some embodiments detect a supraventricular arrhythmia episode, and deliver therapeutic neural stimulation for the supraventricular arrhythmia event.

    摘要翻译： 在各种方法实施例中，检测到室上性心律失常事件，并且响应于检测到的室上性心律失常事件递送室上性心律失常治疗，包括引起交感神经反应的神经刺激。 一些实施方案检测室上性心律失常发作的前体，并提供预防性神经刺激以避免室上性心律失常事件。 一些实施例检测室上性心律失常发作，并为室上性心律失常事件递送治疗性神经刺激。

    Transvascular neural stimulation device and method for treating hypertension
    4.
    发明授权
    Transvascular neural stimulation device and method for treating hypertension 有权
    血管神经刺激装置及治疗高血压的方法

    公开(公告)号：US08929990B2

    公开(公告)日：2015-01-06

    申请号：US12968831

    申请日：2010-12-15

    申请人： Julia Moffitt ,  Imad Libbus

    发明人： Julia Moffitt ,  Imad Libbus

    IPC分类号： A61N1/36 ,  A61N1/05 ,  A61N1/362

    CPC分类号： A61N1/37288 ,  A61M31/00 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/36053 ,  A61N1/3611 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/362 ,  A61N1/3627 ,  A61N1/37217

    摘要： This document discusses, among other things, apparatus, systems, and methods for transvascularly stimulation of a nerve or nerve trunk. In an example, an apparatus is configured to transvascularly stimulate a nerve trunk through a blood vessel. The apparatus includes an expandable electrode that is chronically implantable in a blood vessel proximate a nerve trunk. The expandable electrode is configured to abut a predetermined surface area of the vessel wall along a predetermined length of the vessel. An electrical lead is coupled to the expandable electrode. An implantable pulse generator is coupled to the lead and configured to deliver an electrical stimulation signal to the electrode through the lead. In an example method, an electrical signal is delivered from an implanted medical device to an electrode chronically implanted in a blood vessel proximate a nerve trunk to transvascularly deliver neural stimulation from the electrode to the nerve trunk.

    摘要翻译： 本文件还讨论了用于神经或神经干的经血管刺激的装置，系统和方法。 在一个实例中，一种装置构造成通过血管经血管刺激神经干。 该装置包括可长期植入在靠近神经干的血管中的可扩张电极。 可膨胀电极构造成沿容器的预定长度邻接容器壁的预定表面积。 电引线耦合到可扩张电极。 可植入脉冲发生器耦合到引线并且被配置为通过引线将电刺激信号传递到电极。 在一个示例性方法中，将电信号从植入的医疗装置输送到长期植入在靠近神经干的血管中的电极，从而将神经刺激从电极转移到神经干。

    Neural stimulation system to prevent simultaneous energy discharges
    5.
    发明授权
    Neural stimulation system to prevent simultaneous energy discharges 有权
    神经刺激系统防止同时释放能量

    公开(公告)号：US08831718B2

    公开(公告)日：2014-09-09

    申请号：US13007739

    申请日：2011-01-17

    申请人： Imad Libbus ,  Andrew P. Kramer ,  William J. Linder ,  Jeffrey E. Stahmann

    发明人： Imad Libbus ,  Andrew P. Kramer ,  William J. Linder ,  Jeffrey E. Stahmann

    IPC分类号： A61N1/18 ,  A61N1/39 ,  A61N1/36

    CPC分类号： A61N1/36114 ,  A61N1/3962

    摘要： Various aspects of the present subject matter relate to a system. Various embodiments of the system comprise at least one port to connect to at least one lead with at least one electrode, at least one stimulator circuit and at least one controller. The at least one stimulator circuit is connected to the at least one port and is adapted to deliver neural stimulation to a neural stimulation target using the at least one electrode. The at least one controller is adapted to determine when another energy discharge other than the neural stimulation to the neural stimulation target is occurring and to prevent delivery of the neural stimulation simultaneously with the other energy discharge. Other aspects and embodiments are provided herein.

    摘要翻译： 本主题的各个方面涉及系统。 系统的各种实施例包括至少一个端口，以连接至少一个引线与至少一个电极，至少一个刺激器电路和至少一个控制器。 所述至少一个刺激器电路连接到所述至少一个端口，并且适于使用所述至少一个电极将神经刺激递送到神经刺激靶。 所述至少一个控制器适于确定何时发生除了对神经刺激靶的神经刺激以外的其他能量放电，并且防止神经刺激与另一能量放电同时传送。 本文提供了其它方面和实施例。

    Cardiac stimulation device for sinus rate modulation
    6.
    发明授权
    Cardiac stimulation device for sinus rate modulation 有权
    用于窦速调制的心脏刺激装置

    公开(公告)号：US08798749B2

    公开(公告)日：2014-08-05

    申请号：US11610821

    申请日：2006-12-14

    申请人： Barun Maskara ,  Jiang Ding ,  Imad Libbus

    发明人： Barun Maskara ,  Jiang Ding ,  Imad Libbus

    IPC分类号： A61N1/365

    CPC分类号： A61N1/0587 ,  A61N1/36514 ,  A61N1/3956

    摘要： A system comprising an implantable electrical cardiac signal sensing circuit, an implantable sinoatrial cardiac action potential detector circuit, and an implantable electrical stimulation circuit in electrical communication with the electrical cardiac signal sensing circuit and the sinoatrial cardiac action potential detector circuit. The electrical cardiac signal sensing circuit is configured to receive one or more intrinsic heart signals from one or more respective electrodes configured for placement in a vicinity of a sinoatrial node of a subject. The implantable electrical stimulation circuit is configured to initiate delivery of at least one inhibitory electrical stimulation pulse in a vicinity of the sinoatrial node in a timed relationship to a sensed sinoatrial cardiac action potential. Other systems and methods are disclosed.

    摘要翻译： 一种包括可植入电气心脏信号感测电路，可植入窦房心脏动作电位检测器电路和与电心脏信号感测电路和窦房心脏动作电位检测器电路电通信的可植入电刺激电路的系统。 电心脏信号感测电路被配置为从被配置为放置在受试者的窦房结附近的一个或多个相应电极接收一个或多个固有心脏信号。 可植入电刺激电路被配置为以与所感测的窦房心脏动作电位的定时关系开始在窦房结附近发送至少一个抑制性电刺激脉冲。 公开了其它系统和方法。

    System and method for delivering myocardial and autonomic neural stimulation
    9.
    发明授权
    System and method for delivering myocardial and autonomic neural stimulation 有权
    用于输送心肌和自主神经刺激的系统和方法

    公开(公告)号：US08639322B2

    公开(公告)日：2014-01-28

    申请号：US13484060

    申请日：2012-05-30

    申请人： Ronald W. Heil, Jr. ,  Avram Scheiner ,  Imad Libbus

    发明人： Ronald W. Heil, Jr. ,  Avram Scheiner ,  Imad Libbus

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36117 ,  A61N1/3627 ,  A61N1/36564

    摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.

    摘要翻译： 本主题的各个方面提供可植入医疗装置。 在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。 脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。 引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。 引线包括位于心脏中或靠近心脏的电极以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。 传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。 控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。 本文提供了其他方面。

    IMPLANTABLE NEUROSTIMULATOR-IMPLEMENTED METHOD FOR MANAGING BRADYCARDIA THROUGH VAGUS NERVE STIMULATION
    10.
    发明申请
    IMPLANTABLE NEUROSTIMULATOR-IMPLEMENTED METHOD FOR MANAGING BRADYCARDIA THROUGH VAGUS NERVE STIMULATION 有权
    通过VAGUS神经刺激治疗弓形虫的可植入神经细胞实现方法

    公开(公告)号：US20140025132A1

    公开(公告)日：2014-01-23

    申请号：US13554656

    申请日：2012-07-20

    申请人： Imad LIBBUS ,  Badri AMURTHUR ,  Bruce H. KENKNIGHT

    发明人： Imad LIBBUS ,  Badri AMURTHUR ,  Bruce H. KENKNIGHT

    IPC分类号： A61N1/365

    CPC分类号： A61N1/365 ,  A61B5/0464 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/36167 ,  A61N1/36171 ,  A61N1/36175

    摘要： A method for managing bradycardia through vagus nerve stimulation is provided. An implantable neurostimulator configured to deliver electrical therapeutic stimulation in both afferent and efferent directions of a patient's cervical vagus nerve is provided. An operating mode is stored, which includes parametrically defining a maintenance dose of the electrical therapeutic stimulation tuned to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses. The maintenance dose is delivered via a pulse generator through a pair of helical electrodes via an electrically coupled nerve stimulation therapy lead independent of cardiac cycle. The patient's physiology is monitored, and upon sensing a condition indicative of bradycardia, the delivery of the maintenance dose is suspended. A progressively increasing amount of time is spent waiting via a controller and, upon sensing a condition indicative of an absence or termination of the bradycardia, a progressively increasing partial maintenance dose is delivered via the pulse generator.

    摘要翻译： 提供了通过迷走神经刺激来控制心动过缓的方法。 提供了一种可植入神经刺激器，其被配置为在患者的颈部迷走神经的传入方向和传出方向上递送电疗治疗刺激。 存储操作模式，其包括参数地定义通过连续循环，间歇和周期性电脉冲来恢复心脏自主平衡的电治疗刺激的维持剂量。 维持剂量通过脉冲发生器通过一对螺旋电极通过电耦合的神经刺激治疗导联而独立于心动周期递送。 监测患者的生理状态，并且在感测到指示心动过缓的状况时，停止维持剂量的递送。 通过控制器花费等待时间的逐渐增加，并且在感测到指示不存在或终止心动过缓的状况时，通过脉冲发生器递送逐渐增加的部分维持剂量。