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    Method and apparatus for neural stimulation with respiratory feedback
    1.
    发明授权
    Method and apparatus for neural stimulation with respiratory feedback 有权
    呼吸反馈神经刺激的方法和装置

    公开(公告)号：US08554323B2

    公开(公告)日：2013-10-08

    申请号：US13363198

    申请日：2012-01-31

    申请人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    发明人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36053 ,  A61B5/08 ,  A61B5/4035 ,  A61B5/4818 ,  A61N1/3601 ,  A61N1/36114

    摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.

    摘要翻译： 神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。 呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。 在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。 在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

    Systems and methods for providing neural stimulation transitions
    2.
    发明授权
    Systems and methods for providing neural stimulation transitions 有权
    用于提供神经刺激过渡的系统和方法

    公开(公告)号：US08249717B2

    公开(公告)日：2012-08-21

    申请号：US11779764

    申请日：2007-07-18

    申请人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfavesus

    发明人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfavesus

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36114 ,  A61N1/36117

    摘要： A method embodiment comprises generating a neural stimulation signal for a neural stimulation therapy. The signal is generated during a duty cycle of a stimulation period to provide the neural stimulation therapy with an intensity at a therapy level for a portion of the duty cycle. In various embodiments, a ramp up protocol is implemented to begin the duty cycle, a ramp down protocol is implemented to end the duty cycle, or both the ramp up protocol and the ramp down protocol are implemented. The ramp up protocol includes ramping up the intensity from a non-zero first subthreshold level for the neural stimulation therapy at the beginning of the duty cycle to the therapy level. The ramp down protocol includes ramping down the intensity from the therapy intensity level to a non-zero second subthreshold level for the neural stimulation therapy at the end of the duty cycle.

    摘要翻译： 方法实施例包括产生用于神经刺激治疗的神经刺激信号。 在刺激期的占空比期间产生信号，以在占空比的一部分的治疗水平上提供具有强度的神经刺激治疗。 在各种实施例中，实现斜坡上升协议以开始占空比，实现斜降协议以结束占空比，或者实现升温协议和斜降协议两者。 加速协议包括在占空比开始时到神经刺激治疗的非零第一亚阈值水平上升到治疗水平。 斜坡协议包括在占空比结束时将神经刺激治疗的强度从治疗强度水平向下降至非零秒次阈值水平。

    Respiration Measurements and Dosimetry Control in Inhalation Testing Systems
    3.
    发明申请
    Respiration Measurements and Dosimetry Control in Inhalation Testing Systems 有权
    吸入测量系统中的呼吸测量和剂量控制

    公开(公告)号：US20110218450A1

    公开(公告)日：2011-09-08

    申请号：US12715503

    申请日：2010-03-02

    申请人： Paul A. Haefner ,  Loell Boyce Moon ,  Steve Hachtman ,  Scott R. Tiesma ,  Gary Pritchard

    发明人： Paul A. Haefner ,  Loell Boyce Moon ,  Steve Hachtman ,  Scott R. Tiesma ,  Gary Pritchard

    IPC分类号： A61B5/085

    CPC分类号： A61B5/091 ,  A61B5/085 ,  A61M31/00

    摘要： Inhalation measurement systems and methods enable, during inhalant exposure, substantially real-time respiratory measurements of a test subject using techniques that obtain measurements of respiration directly from that test subject, instead of from inhalation chamber parameter measurements. Direct test subject respiratory measurements may be, by way of example only, impedance measurements. These respiratory measurements taken directly from the test subject may be transmitted, wirelessly for example, for processing during the course of the test to a processing system to determine a cumulative volume of inhalant inspired by the test subject. From that, a cumulative amount of inhalant (or dose) inspired by the test subject may be determined during the course of the inhalation compound test. In addition, a calibration procedure may be performed before the inhalant exposure to provide correlation needed to translate chest and/or abdominal wall expansion measurements, made during the test, into lung volume measurements.

    摘要翻译： 吸入测量系统和方法在吸入式暴露过程中可以使用直接从该测试对象而不是从吸入室参数测量获得呼吸测量值的技术，使测试对象基本上实时呼吸测量。 直接测试对象呼吸测量可能仅作为示例，阻抗测量。 直接从测试对象取得的这些呼吸测量可以以无线方式传送，例如用于在测试过程中进行处理以处理系统以确定由测试对象启发的吸入剂的累积体积。 由此可以在吸入化合物测试过程中确定受试者启发的吸入剂（或剂量）的累积量。 此外，可以在吸入剂暴露之前进行校准程序，以提供在测试期间将胸部和/或腹壁扩张测量值转换成肺容量测量所需的相关性。

    Cardiac therapy triggered by capture verification
    4.
    发明授权
    Cardiac therapy triggered by capture verification 有权
    通过捕获验证触发心脏治疗

    公开(公告)号：US07702388B2

    公开(公告)日：2010-04-20

    申请号：US10377257

    申请日：2003-02-28

    申请人： Haris J. Sih ,  Scott A. Meyer ,  Paul A. Haefner

    发明人： Haris J. Sih ,  Scott A. Meyer ,  Paul A. Haefner

    IPC分类号： A61N1/08 ,  A61N1/39

    CPC分类号： A61N1/3962

    摘要： The present disclosure provides methods and systems for tachyarrhythmia therapy involving pacing the heart to prior to the application of a cardioversion/defibrillation shock. One or more pace pulses are delivered to the arrhythmic chamber or chambers. The pace pulses may be delivered to the heart at an adaptable rate selected to organize the electrical activity of the heart. If the pace pulses produce capture, cardioversion/defibrillation stimulation is delivered.

    摘要翻译： 本公开提供了用于在应用心脏复律/除颤休克之前心脏起搏的快速性心律失常治疗的方法和系统。 将一个或多个步速脉冲输送到心律失常室或腔室。 速度脉冲可以以选择用于组织心脏的电活动的适应速率递送到心脏。 如果速度脉冲产生捕获，则输送心脏复律/除颤刺激。

    Cardiac response classification using multiple classification windows
    5.
    发明申请
    Cardiac response classification using multiple classification windows 有权
    使用多个分类窗口的心脏反应分类

    公开(公告)号：US20080154324A1

    公开(公告)日：2008-06-26

    申请号：US12008876

    申请日：2008-01-15

    申请人： Jaeho Kim ,  Joseph Bocek ,  Scott A. Meyer ,  Paul A. Haefner ,  Haris J. Sih

    发明人： Jaeho Kim ,  Joseph Bocek ,  Scott A. Meyer ,  Paul A. Haefner ,  Haris J. Sih

    IPC分类号： A61N1/37

    CPC分类号： A61B5/7264 ,  A61B5/04525 ,  A61B5/7217 ,  A61N1/371

    摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a plurality of classification windows relative to and following a pacing pulse. One or more characteristics of a cardiac signal sensed following the pacing pulse are detected within one or more particular classification windows. The characteristics may be compared to one or more references. Classification of the cardiac response may be performed based on the comparison of the one or more characteristics to the one or more references and the particular classification windows in which the one or more characteristics are detected.

    摘要翻译： 用于将心脏反应分类为起搏的方法和装置涉及建立相对于起搏脉冲和起搏脉冲之后的多个分类窗口。 在一个或多个特定分类窗口中检测到在起搏脉冲之后感测的心脏信号的一个或多个特征。 特征可以与一个或多个参考进行比较。 心脏反应的分类可以基于一个或多个特征与一个或多个参考和检测到一个或多个特征的特定分类窗口的比较来执行。

    Linear amplifier
    6.
    发明授权
    Linear amplifier 失效
    线性放大器

    公开(公告)号：US5699014A

    公开(公告)日：1997-12-16

    申请号：US627403

    申请日：1996-04-04

    申请人： Paul A. Haefner ,  William J. Linder

    发明人： Paul A. Haefner ,  William J. Linder

    IPC分类号： H03F1/32 ,  H03F3/45

    CPC分类号： H03F1/3211 ,  H03F1/3205 ,  H03F2200/162 ,  H03F2200/372

    摘要： A low-noise, low-power complementary metal-oxide-semiconductor (CMOS) integrated circuit common source differential amplifier is disclosed which is capable of amplifying low amplitude cardiac signals such as those produced by atrial depolarization of the heart. The amplifier has a pair of large area p-channel input field-effect transistors (FETs) biased in weak inversion. The amplifier also has active load FETs biased in the nonsaturation (linear) region by means of a varying gate terminal voltage applied by a dynamic bias circuit. The gate terminal voltage is varied to match the temperature dependence of the output conductance of the load FETs to the temperature dependence of the transconductance of the input FETs. The gate terminal voltage also sets a dc bias point which uses the nonlinearity in the load FET output conductance to cancel nonlinearity in the input FET transconductance.

    摘要翻译： 公开了一种低噪声，低功率互补金属氧化物半导体（CMOS）集成电路公共源差分放大器，其能够放大低振幅心脏信号，例如通过心脏去极化产生的心脏信号。 放大器具有一对在弱反相中偏置的大面积p沟道输入场效应晶体管（FET）。 放大器还通过由动态偏置电路施加的变化的栅极端子电压而在非饱和（线性）区域中偏置有有源负载FET。 栅极端子电压变化以匹配负载FET的输出电导的温度依赖性与输入FET的跨导的温度依赖性。 栅极端子电压还设置直流偏置点，其使用负载FET输出电导中的非线性来消除输入FET跨导中的非线性。

    Drug Delivery Methods and Systems
    7.
    发明申请
    Drug Delivery Methods and Systems 审中-公开
    药物递送方法和系统

    公开(公告)号：US20120029372A1

    公开(公告)日：2012-02-02

    申请号：US13271717

    申请日：2011-10-12

    申请人： Paul A. Haefner ,  Loell Boyce Moon

    发明人： Paul A. Haefner ,  Loell Boyce Moon

    IPC分类号： A61B5/0452 ,  A61M5/168 ,  A61B5/02

    CPC分类号： A61M37/00 ,  A61B5/021 ,  A61B5/0402 ,  A61B5/4839

    摘要： Drug delivery methods and systems that include a determination of whether a cardiac condition is normal or abnormal, so that a drug may be administered in accordance with that determination. In one implementation, a drug delivery device may be controlled to reduce or stop the drug administration when a normal cardiac condition is detected. In another implementation, a patient monitoring device determines the duration that a cardiac condition is normal and provides an output indicative of the determination so that the patient may alter a therapy accordingly.

    摘要翻译： 包括确定心脏病状是正常还是异常的药物递送方法和系统，以便可以根据该测定来施用药物。 在一个实施方案中，当检测到正常心脏病状时，可以控制药物递送装置以减少或停止药物施用。 在另一实现中，患者监视装置确定心脏状况正常的持续时间，并提供指示确定的输出，使得患者可以相应地改变治疗。

    Variable voltage compliance for current output generator
    9.
    发明授权
    Variable voltage compliance for current output generator 有权
    电流输出发生器的可变电压一致性

    公开(公告)号：US08014866B2

    公开(公告)日：2011-09-06

    申请号：US11457385

    申请日：2006-07-13

    申请人： Paul A. Haefner

    发明人： Paul A. Haefner

    IPC分类号： A61N1/08

    CPC分类号： A61N1/36114 ,  A61N1/0556 ,  A61N1/056 ,  A61N1/36053 ,  A61N1/3615 ,  A61N1/36521 ,  A61N1/3706

    摘要： A system for providing stimulation current in implantable medical devices is provided. One aspect of this disclosure relates to an apparatus including a power supply terminal adapted to be connected to a power supply. The apparatus embodiment also includes circuitry connected to the power supply terminal and adapted to detect a parameter dependent on tissue/electrode impedance. The apparatus embodiment further includes a current output pulse generator adapted to deliver electrical therapy. The current generator includes an adjustable compliance voltage source connected to the power supply terminal. The compliance voltage source has a programmable amplitude and is adapted to provide different potentials for different tissue/electrode interface impedances. According to various embodiments, the apparatus embodiment also includes at least one stimulating electrode, and the current generator is adapted to deliver electrical therapy using the electrode. Other aspects and embodiments are provided herein.

    摘要翻译： 提供了一种用于在可植入医疗装置中提供刺激电流的系统。 本公开的一个方面涉及一种包括适于连接到电源的电源端子的装置。 装置实施例还包括连接到电源端子并适于检测取决于组织/电极阻抗的参数的电路。 该装置实施例还包括适于递送电疗法的电流输出脉冲发生器。 电流发生器包括连接到电源端子的可调整的顺应性电压源。 顺应性电压源具有可编程幅度，并且适于为不同的组织/电极界面阻抗提供不同的电位。 根据各种实施例，装置实施例还包括至少一个刺激电极，并且电流发生器适于使用电极递送电疗法。 本文提供了其它方面和实施例。