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1.发明申请公开(公告)号：US20110218450A1
公开(公告)日：2011-09-08
申请号：US12715503
申请日：2010-03-02
IPC分类号： A61B5/085
摘要： Inhalation measurement systems and methods enable, during inhalant exposure, substantially real-time respiratory measurements of a test subject using techniques that obtain measurements of respiration directly from that test subject, instead of from inhalation chamber parameter measurements. Direct test subject respiratory measurements may be, by way of example only, impedance measurements. These respiratory measurements taken directly from the test subject may be transmitted, wirelessly for example, for processing during the course of the test to a processing system to determine a cumulative volume of inhalant inspired by the test subject. From that, a cumulative amount of inhalant (or dose) inspired by the test subject may be determined during the course of the inhalation compound test. In addition, a calibration procedure may be performed before the inhalant exposure to provide correlation needed to translate chest and/or abdominal wall expansion measurements, made during the test, into lung volume measurements.
摘要翻译： 吸入测量系统和方法在吸入式暴露过程中可以使用直接从该测试对象而不是从吸入室参数测量获得呼吸测量值的技术，使测试对象基本上实时呼吸测量。 直接测试对象呼吸测量可能仅作为示例，阻抗测量。 直接从测试对象取得的这些呼吸测量可以以无线方式传送，例如用于在测试过程中进行处理以处理系统以确定由测试对象启发的吸入剂的累积体积。 由此可以在吸入化合物测试过程中确定受试者启发的吸入剂（或剂量）的累积量。 此外，可以在吸入剂暴露之前进行校准程序，以提供在测试期间将胸部和/或腹壁扩张测量值转换成肺容量测量所需的相关性。
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公开(公告)号：US20120029372A1
公开(公告)日：2012-02-02
申请号：US13271717
申请日：2011-10-12
申请人： Paul A. Haefner , Loell Boyce Moon
发明人： Paul A. Haefner , Loell Boyce Moon
IPC分类号： A61B5/0452 , A61M5/168 , A61B5/02
CPC分类号： A61M37/00 , A61B5/021 , A61B5/0402 , A61B5/4839
摘要： Drug delivery methods and systems that include a determination of whether a cardiac condition is normal or abnormal, so that a drug may be administered in accordance with that determination. In one implementation, a drug delivery device may be controlled to reduce or stop the drug administration when a normal cardiac condition is detected. In another implementation, a patient monitoring device determines the duration that a cardiac condition is normal and provides an output indicative of the determination so that the patient may alter a therapy accordingly.
摘要翻译： 包括确定心脏病状是正常还是异常的药物递送方法和系统，以便可以根据该测定来施用药物。 在一个实施方案中，当检测到正常心脏病状时，可以控制药物递送装置以减少或停止药物施用。 在另一实现中，患者监视装置确定心脏状况正常的持续时间，并提供指示确定的输出，使得患者可以相应地改变治疗。
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公开(公告)号：US20090326387A1
公开(公告)日：2009-12-31
申请号：US12165415
申请日：2008-06-30
IPC分类号： A61B5/02
CPC分类号： A61B5/0402 , A61B5/0006 , A61B5/053 , A61B5/0809 , A61B5/0816 , A61B5/6805 , A61B5/721 , A61B2503/40 , A61B2560/06
摘要： An ambulatory animal monitoring system includes a wearable structure constructed to be worn about a body of a non-human animal to be monitored. The system includes a plurality of electrical signal conduits each associated with the wearable structure and each connectable to a different one of a plurality of surface electrode components. The system includes processing and control device adapted to be worn with the wearable structure, the processing and control device comprising a) an ECG monitoring component and b) an impedance level monitoring component that generates data indicative of electrical impedance levels of the animal over time.
摘要翻译： 动态动物监测系统包括被构造为佩戴在被监测的非人动物身体周围的可穿戴结构。 该系统包括多个电信号导管，每个电信号导管与可佩戴结构相关联并且各自可连接到多个表面电极部件中的不同的一个。 该系统包括适于与可穿戴式结构一起磨损的处理和控制装置，所述处理和控制装置包括a）ECG监测部件，以及b）产生指示动物随时间变化的电阻抗水平的数据的阻抗电平监视部件。
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4.发明授权公开(公告)号：US08491491B2
公开(公告)日：2013-07-23
申请号：US12715503
申请日：2010-03-02
摘要： Inhalation measurement systems and methods enable, during inhalant exposure, substantially real-time respiratory measurements of a test subject using techniques that obtain measurements of respiration directly from that test subject, instead of from inhalation chamber parameter measurements. Direct test subject respiratory measurements may be, by way of example only, impedance measurements. These respiratory measurements taken directly from the test subject may be transmitted, wirelessly for example, for processing during the course of the test to a processing system to determine a cumulative volume of inhalant inspired by the test subject. From that, a cumulative amount of inhalant (or dose) inspired by the test subject may be determined during the course of the inhalation compound test. In addition, a calibration procedure may be performed before the inhalant exposure to provide correlation needed to translate chest and/or abdominal wall expansion measurements, made during the test, into lung volume measurements.
摘要翻译： 吸入测量系统和方法在吸入式暴露过程中可以使用直接从该测试对象而不是从吸入室参数测量获得呼吸测量值的技术，使测试对象基本上实时呼吸测量。 直接测试对象呼吸测量可能仅作为示例，阻抗测量。 直接从测试对象取得的这些呼吸测量可以以无线方式传送，例如用于在测试过程中进行处理以处理系统以确定由测试对象启发的吸入剂的累积体积。 由此可以在吸入化合物测试过程中确定受试者启发的吸入剂（或剂量）的累积量。 此外，可以在吸入剂暴露之前进行校准程序，以提供在测试期间将胸部和/或腹壁扩张测量值转换成肺容量测量所需的相关性。
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公开(公告)号：US20090326510A1
公开(公告)日：2009-12-31
申请号：US12165328
申请日：2008-06-30
申请人： Paul A. Haefner , Loell Boyce Moon
发明人： Paul A. Haefner , Loell Boyce Moon
CPC分类号： A61M37/00 , A61B5/021 , A61B5/0402 , A61B5/4839
摘要： Drug delivery methods and systems that include a determination of whether a cardiac condition is normal or abnormal, so that a drug may be administered in accordance with that determination. In one implementation, a drug delivery device may be controlled to reduce or stop the drug administration when a normal cardiac condition is detected. In another implementation, a patient monitoring device determines the duration that a cardiac condition is normal and provides an output indicative of the determination so that the patient may alter a therapy accordingly.
摘要翻译： 包括确定心脏病状是正常还是异常的药物递送方法和系统，以便可以根据该测定来施用药物。 在一个实施方案中，当检测到正常心脏病状时，可以控制药物递送装置以减少或停止药物施用。 在另一实现中，患者监视装置确定心脏状况正常的持续时间，并提供指示确定的输出，使得患者可以相应地改变治疗。
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公开(公告)号：US20090326408A1
公开(公告)日：2009-12-31
申请号：US12165430
申请日：2008-06-30
申请人： Loell Boyce Moon
发明人： Loell Boyce Moon
IPC分类号： A61B5/053
CPC分类号： A61B5/0809 , A61B5/0538 , A61B2503/40
摘要： A method of measuring lung impedance of a subject can include positioning current-injection electrodes on or within the subject in a configuration such that a current injected between the current-injection electrodes propagates substantially through a first lung of the subject, and not through a heart and a second lung of the subject; positioning voltage-measurement electrodes on or within the subject in a configuration such that voltage measuring fields propagate substantially through the first lung and the second lung of the subject, but not through the heart of the subject; and injecting a current between the current-injection electrodes, as positioned, and measuring a resulting voltage between the voltage-measurement electrodes, as positioned, to obtain an impedance measure across lung tissue. The method can further include injecting current and measuring the resulting voltage multiple times over a time period to monitor respiration of the subject over the time period.
摘要翻译： 测量受试者的肺阻抗的方法可以包括在被配置中或内部定位电流注入电极，使得注入电流注入电极之间的电流基本上传播通过受试者的第一肺而不通过心脏 和受试者的第二肺; 将电压测量电极定位在受试者内部或内部，使得电压测量场基本上通过受试者的第一肺和第二肺传播，但不通过受试者的心脏; 并且在定位的电流注入电极之间注入电流，并测量定位的电压测量电极之间的所得电压，以获得横跨肺组织的阻抗测量值。 该方法还可以包括在一段时间内多次注入电流并测量所得到的电压，以监测受试者在该时间段内的呼吸。
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公开(公告)号：US20120245475A1
公开(公告)日：2012-09-27
申请号：US13479967
申请日：2012-05-24
IPC分类号： A61B5/0205
CPC分类号： A61B5/0535 , A61B5/0809 , A61B5/7207 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： Implantable medical devices and techniques are implemented that use bio-impedance to measure aspects of patient physiology. A signal separation method is performed at least in part in an implantable device. The method involves detecting a plurality of impedance signals using a plurality of implantable electrodes coupled to the implantable device. The method further involves separating one or more signals from the plurality of impedance signals using a signal separation technique, such as an algorithm-based separation technique.
摘要翻译： 实施了可植入的医疗设备和技术，其使用生物阻抗来测量患者生理学的方面。 信号分离方法至少部分地在可植入装置中进行。 该方法包括使用耦合到可植入装置的多个可植入电极来检测多个阻抗信号。 该方法还包括使用诸如基于算法的分离技术之类的信号分离技术来分离来自多个阻抗信号的一个或多个信号。
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公开(公告)号：US07848811B2
公开(公告)日：2010-12-07
申请号：US11314170
申请日：2005-12-21
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/1116 , A61N1/36535 , A61N1/36542
摘要： A system and method determines the posture of a body. The system is first calibrated by attaching it to, or implanted it into, a body, placing the body in particular postures, and generating spectral signatures for each of those postures. Thereafter, the system generates spectral signatures for particular instants in time, correlates these instant signatures with the stored signatures, from which the posture of the body at that instant in time is determined.
摘要翻译： 系统和方法确定身体的姿势。 该系统首先通过将身体附着或植入体内进行校准，将身体放置在特定姿势中，并为每个姿势产生光谱特征。 此后，系统及时地为特定时刻生成频谱特征，将这些即时签名与所存储的签名相关联，从而确定在该时刻的身体姿势。
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公开(公告)号：US20090118626A1
公开(公告)日：2009-05-07
申请号：US11933872
申请日：2007-11-01
IPC分类号： A61B5/0205
CPC分类号： A61B5/0535 , A61B5/0809
摘要： A method of determining a value for a respiration parameter in a test subject can include capturing—using a fully implanted system that includes a wireless transmitter and at least a first lead wire having a first electrode disposed thereon and a second lead wire having a second electrode disposed thereon—information indicative of an impedance measure between the first and second electrodes and across a thoracic region of the test subject; wirelessly transmitting, from the implanted system and to external equipment, the captured information; and determining a respiration parameter of the test subject based on the captured information. The at least first and second lead wires can be positioned in the test subject subcutaneously and external of any cranial, thoracic, abdominal and pelvic cavities of the test subject
摘要翻译： 确定测试对象中的呼吸参数的值的方法可以包括捕获 - 使用完全植入的系统，其包括无线发射器和至少第一引线，其具有设置在其上的第一电极和具有第二电极的第二引线 布置在其上的信息 - 指示所述第一和第二电极之间以及穿过所述测试对象的胸部区域的阻抗测量值的信息; 从植入系统和外部设备无线传输所捕获的信息; 以及基于所捕获的信息确定所述测试对象的呼吸参数。 至少第一和第二引线可以被测试对象的皮下和外部位于测试对象的任何颅脑，胸部，腹部和盆腔内
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公开(公告)号：US20080234773A1
公开(公告)日：2008-09-25
申请号：US11690700
申请日：2007-03-23
IPC分类号： A61N1/05
CPC分类号： A61N1/36521 , A61B5/0031 , A61B5/053 , A61B5/0538 , A61B5/11 , A61B5/686 , A61B5/6869 , A61N1/3627 , A61N1/3684
摘要： An apparatus comprises a first impedance sensing circuit, a second sensing circuit, and an impedance-based cardiac dyssynchrony detector. The impedance sensing circuit senses an intracardiac local impedance signal that is indicative of a cardiac local wall motion of a first cardiac region from an implantable first bipolar pair of impedance sensing electrodes. The second sensing circuit is configured to produce a second sensor signal indicative of cardiovascular activity. The impedance-based cardiac dyssynchrony detector is configured for detecting cardiac dyssynchrony using a relationship between the first intracardiac local impedance signal and the second sensor signal. Other apparatuses and methods are disclosed.
摘要翻译： 一种装置包括第一阻抗感测电路，第二感测电路和基于阻抗的心脏不同步检测器。 阻抗感测电路感测指示来自可植入的第一双极对阻抗感测电极的第一心脏区域的心脏局部壁运动的心内局部阻抗信号。 第二感测电路被配置为产生指示心血管活动的第二传感器信号。 基于阻抗的心脏不同步检测器被配置为使用第一心内局部阻抗信号和第二传感器信号之间的关系来检测心脏不同步。 公开了其他装置和方法。
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