公开(公告)号：US07702388B2

公开(公告)日：2010-04-20

申请号：US10377257

申请日：2003-02-28

申请人： Haris J. Sih ,  Scott A. Meyer ,  Paul A. Haefner

发明人： Haris J. Sih ,  Scott A. Meyer ,  Paul A. Haefner

IPC分类号： A61N1/08 ,  A61N1/39

CPC分类号： A61N1/3962

摘要： The present disclosure provides methods and systems for tachyarrhythmia therapy involving pacing the heart to prior to the application of a cardioversion/defibrillation shock. One or more pace pulses are delivered to the arrhythmic chamber or chambers. The pace pulses may be delivered to the heart at an adaptable rate selected to organize the electrical activity of the heart. If the pace pulses produce capture, cardioversion/defibrillation stimulation is delivered.

摘要翻译： 本公开提供了用于在应用心脏复律/除颤休克之前心脏起搏的快速性心律失常治疗的方法和系统。 将一个或多个步速脉冲输送到心律失常室或腔室。 速度脉冲可以以选择用于组织心脏的电活动的适应速率递送到心脏。 如果速度脉冲产生捕获，则输送心脏复律/除颤刺激。

公开(公告)号：US20080154324A1

公开(公告)日：2008-06-26

申请号：US12008876

申请日：2008-01-15

申请人： Jaeho Kim ,  Joseph Bocek ,  Scott A. Meyer ,  Paul A. Haefner ,  Haris J. Sih

发明人： Jaeho Kim ,  Joseph Bocek ,  Scott A. Meyer ,  Paul A. Haefner ,  Haris J. Sih

IPC分类号： A61N1/37

CPC分类号： A61B5/7264 ,  A61B5/04525 ,  A61B5/7217 ,  A61N1/371

摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a plurality of classification windows relative to and following a pacing pulse. One or more characteristics of a cardiac signal sensed following the pacing pulse are detected within one or more particular classification windows. The characteristics may be compared to one or more references. Classification of the cardiac response may be performed based on the comparison of the one or more characteristics to the one or more references and the particular classification windows in which the one or more characteristics are detected.

摘要翻译： 用于将心脏反应分类为起搏的方法和装置涉及建立相对于起搏脉冲和起搏脉冲之后的多个分类窗口。 在一个或多个特定分类窗口中检测到在起搏脉冲之后感测的心脏信号的一个或多个特征。 特征可以与一个或多个参考进行比较。 心脏反应的分类可以基于一个或多个特征与一个或多个参考和检测到一个或多个特征的特定分类窗口的比较来执行。

公开(公告)号：US07574258B2

公开(公告)日：2009-08-11

申请号：US11300674

申请日：2005-12-14

申请人： Haris J. Sih ,  Scott A. Meyer ,  Paul A. Haefner

发明人： Haris J. Sih ,  Scott A. Meyer ,  Paul A. Haefner

IPC分类号： A61N1/08 ,  A61N1/39

CPC分类号： A61N1/3962

摘要： The present invention provides methods and systems for tachyarrhythmia therapy involving pacing the heart to prior to the application of a cardioversion/defibrillation shock. One or more pace pulses are delivered to the arrhythmic chamber or chambers. The pace pulses may be delivered to the heart at an adaptable rate selected to organize the electrical activity of the heart. If the pace pulses produce capture, cardioversion/defibrillation stimulation is delivered.

摘要翻译： 本发明提供了用于在应用心脏复律/除颤休克之前心脏起搏的快速性心律失常治疗的方法和系统。 将一个或多个步速脉冲输送到心律失常室或腔室。 速度脉冲可以以选择用于组织心脏的电活动的适应速率递送到心脏。 如果速度脉冲产生捕获，则输送心脏复律/除颤刺激。

公开(公告)号：US08831726B2

公开(公告)日：2014-09-09

申请号：US12008876

申请日：2008-01-15

申请人： Jaeho Kim ,  Joseph Bocek ,  Scott A. Meyer ,  Paul A. Haefner ,  Haris J. Sih

发明人： Jaeho Kim ,  Joseph Bocek ,  Scott A. Meyer ,  Paul A. Haefner ,  Haris J. Sih

IPC分类号： A61B5/0452 ,  A61B5/00 ,  A61N1/37

CPC分类号： A61B5/7264 ,  A61B5/04525 ,  A61B5/7217 ,  A61N1/371

摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a plurality of classification windows relative to and following a pacing pulse. One or more characteristics of a cardiac signal sensed following the pacing pulse are detected within one or more particular classification windows. The characteristics may be compared to one or more references. Classification of the cardiac response may be performed based on the comparison of the one or more characteristics to the one or more references and the particular classification windows in which the one or more characteristics are detected.

摘要翻译： 用于将心脏反应分类为起搏的方法和装置涉及建立相对于起搏脉冲和起搏脉冲之后的多个分类窗口。 在一个或多个特定分类窗口中检测到在起搏脉冲之后感测的心脏信号的一个或多个特征。 特征可以与一个或多个参考进行比较。 心脏反应的分类可以基于一个或多个特征与一个或多个参考和检测到一个或多个特征的特定分类窗口的比较来执行。

公开(公告)号：US08521284B2

公开(公告)日：2013-08-27

申请号：US10735519

申请日：2003-12-12

申请人： Jaeho Kim ,  Joseph Bocek ,  Scott A. Meyer ,  Paul A. Haefner ,  Haris J. Sih

发明人： Jaeho Kim ,  Joseph Bocek ,  Scott A. Meyer ,  Paul A. Haefner ,  Haris J. Sih

IPC分类号： A61N1/36

CPC分类号： A61N1/371 ,  A61B5/04525 ,  A61B5/7217 ,  A61B5/7264 ,  A61N1/368

摘要： Methods and devices for classifying a cardiac pacing response involve using a first electrode combination for pacing and a second electrode combination for sensing a cardiac signal following pacing. The cardiac response to pacing may be classified using the sensed cardiac signal. One process involves using the sensed cardiac signal to detect the cardiac response as a fusion/pseudofusion beat. Another process involves using the sensed cardiac signal to classify the cardiac response to pacing as one of at least three cardiac response types.

摘要翻译： 用于分类心脏起搏反应的方法和装置涉及使用用于起搏的第一电极组合和用于感测起搏后的心脏信号的第二电极组合。 可以使用感测到的心脏信号来分类对起搏的心脏反应。 一个过程涉及使用感测到的心脏信号来检测作为融合/假融合搏动的心脏反应。 另一个过程涉及使用所感测到的心脏信号将心脏起搏应答分为至少三种心脏反应类型之一。

公开(公告)号：US07979124B2

公开(公告)日：2011-07-12

申请号：US11600569

申请日：2006-11-16

申请人： Scott A. Meyer ,  Haris J. Sih ,  Paul A. Haefner

发明人： Scott A. Meyer ,  Haris J. Sih ,  Paul A. Haefner

IPC分类号： A61N1/37 ,  A61N1/362

CPC分类号： A61N1/3712 ,  A61N1/3714

摘要： A method and device provide for determining capture in multiple chambers of a patient's heart using an electrode inserted into a coronary vein of the patient's heart. The coronary vein electrode is positioned adjacent to multiple heart chambers and is responsive to cardiac signals originating in the multiple chambers. The coronary vein electrode may be coupled to a single sense amplifier to detect the cardiac signals. Pace pulses may be applied to multiple heart chambers simultaneously or according to a phased timing sequence. Cardiac signals responsive to the pace pulses sensed using the coronary vein electrode may be used to verify capture in the multiple chambers of the heart.

摘要翻译： 一种方法和装置用于使用插入到患者心脏的冠状静脉中的电极来确定在患者心脏的多个腔室中的捕获。 冠状静脉电极位于多个心室附近，并且响应于源自多个腔室的心脏信号。 冠状静脉电极可以耦合到单个读出放大器以检测心脏信号。 步态脉冲可以同时或根据定相序列施加到多个心室。 可以使用响应于使用冠状静脉电极感测到的步速脉冲的心脏信号来验证心脏的多个腔室中的捕获。

公开(公告)号：US07319900B2

公开(公告)日：2008-01-15

申请号：US10733869

申请日：2003-12-11

申请人： Jaeho Kim ,  Joseph Bocek ,  Scott A. Meyer ,  Paul A. Haefner ,  Haris J. Sih

发明人： Jaeho Kim ,  Joseph Bocek ,  Scott A. Meyer ,  Paul A. Haefner ,  Haris J. Sih

IPC分类号： A61N1/37

CPC分类号： A61B5/7264 ,  A61B5/04525 ,  A61B5/7217 ,  A61N1/371

摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a plurality of classification windows relative to and following a pacing pulse. One or more characteristics of a cardiac signal sensed following the pacing pulse are detected within one or more particular classification windows. The characteristics may be compared to one or more references. Classification of the cardiac response may be performed based on the comparison of the one or more characteristics to the one or more references and the particular classification windows in which the one or more characteristics are detected.

公开(公告)号：US07203543B2

公开(公告)日：2007-04-10

申请号：US10278732

申请日：2002-10-23

申请人： Scott A. Meyer ,  Haris J. Sih ,  Paul A. Haefner

发明人： Scott A. Meyer ,  Haris J. Sih ,  Paul A. Haefner

IPC分类号： A61N1/37 ,  A61N1/362

CPC分类号： A61N1/3712 ,  A61N1/3714

摘要： A method and device provide for determining capture in multiple chambers of a patient's heart using an electrode inserted into a coronary vein of the patient's heart. The coronary vein electrode is positioned adjacent to multiple heart chambers and is responsive to cardiac signals originating in the multiple chambers. The coronary vein electrode may be coupled to a single sense amplifier to detect the cardiac signals. Pace pulses may be applied to multiple heart chambers simultaneously or according to a phased timing sequence. Cardiac signals responsive to the pace pulses sensed using the coronary vein electrode may be used to verify capture in the multiple chambers of the heart.

摘要翻译： 一种方法和装置用于使用插入到患者心脏的冠状静脉中的电极来确定在患者心脏的多个腔室中的捕获。 冠状静脉电极位于多个心室附近，并且响应于源自多个腔室的心脏信号。 冠状静脉电极可以耦合到单个读出放大器以检测心脏信号。 步态脉冲可以同时或根据定相序列施加到多个心室。 可以使用响应于使用冠状静脉电极感测到的步速脉冲的心脏信号来验证心脏的多个腔室中的捕获。

公开(公告)号：US08554323B2

公开(公告)日：2013-10-08

申请号：US13363198

申请日：2012-01-31

申请人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

发明人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

IPC分类号： A61N1/365

CPC分类号： A61N1/36053 ,  A61B5/08 ,  A61B5/4035 ,  A61B5/4818 ,  A61N1/3601 ,  A61N1/36114

摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.

摘要翻译： 神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。 呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。 在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。 在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

公开(公告)号：US08249717B2

公开(公告)日：2012-08-21

申请号：US11779764

申请日：2007-07-18

申请人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfavesus

发明人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfavesus

IPC分类号： A61N1/00

CPC分类号： A61N1/36114 ,  A61N1/36117

摘要： A method embodiment comprises generating a neural stimulation signal for a neural stimulation therapy. The signal is generated during a duty cycle of a stimulation period to provide the neural stimulation therapy with an intensity at a therapy level for a portion of the duty cycle. In various embodiments, a ramp up protocol is implemented to begin the duty cycle, a ramp down protocol is implemented to end the duty cycle, or both the ramp up protocol and the ramp down protocol are implemented. The ramp up protocol includes ramping up the intensity from a non-zero first subthreshold level for the neural stimulation therapy at the beginning of the duty cycle to the therapy level. The ramp down protocol includes ramping down the intensity from the therapy intensity level to a non-zero second subthreshold level for the neural stimulation therapy at the end of the duty cycle.

摘要翻译： 方法实施例包括产生用于神经刺激治疗的神经刺激信号。 在刺激期的占空比期间产生信号，以在占空比的一部分的治疗水平上提供具有强度的神经刺激治疗。 在各种实施例中，实现斜坡上升协议以开始占空比，实现斜降协议以结束占空比，或者实现升温协议和斜降协议两者。 加速协议包括在占空比开始时到神经刺激治疗的非零第一亚阈值水平上升到治疗水平。 斜坡协议包括在占空比结束时将神经刺激治疗的强度从治疗强度水平向下降至非零秒次阈值水平。