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公开(公告)号：US20100096763A1
公开(公告)日：2010-04-22
申请号：US12513423
申请日：2007-11-05
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the biopolymer matrix solution on the substrate, embedding a channel mold in the biopolymer matrix solution, drying the biopolymer matrix solution to solidify biopolymer optofluidic device, and extracting the embedded channel mold to provide a fluidic channel in the solidified biopolymer optofluidic device. In accordance with another aspect, an optofluidic device is provided that is made of a biopolymer and that has a channel therein for conveying fluid.
摘要翻译： 一种制备生物聚合物光流体装置的方法，包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，提供基材，将生物聚合物基质溶液浇铸在基材上，将通道模具嵌入生物聚合物基质溶液中，干燥生物聚合物基质 固化生物聚合物光流体装置的解决方案，以及提取嵌入式通道模具以在凝固的生物聚合物光流体装置中提供流体通道。 根据另一方面，提供了由生物聚合物制成并且在其中具有用于输送流体的通道的光流体装置。
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2.发明申请MICROFLUIDIC DEVICE WITH A CYLINDRICAL MICROCHANNEL AND A METHOD FOR FABRICATING SAME 审中-公开具有圆柱微通道的微流体装置及其制造方法公开(公告)号：US20100068740A1
公开(公告)日：2010-03-18
申请号：US12513416
申请日：2007-11-05
申请人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi , Hannah Perry
发明人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi , Hannah Perry
CPC分类号： B29D11/0074 , B01L3/502707 , B01L2300/0816 , B01L2300/12 , B01L2300/163 , B29C39/02 , B81B2201/058 , B81B2201/06 , B81C1/00071 , G01J3/02 , G01J3/0237 , G01J3/0256 , G01J3/06 , G01J3/10 , G01J3/1804 , G01J3/42 , G01N33/54386 , G01N2021/0346
摘要： A method of manufacturing a microfluidic device having at least one cylindrical microchannel includes providing a substrate, casting an uncured polymer matrix solution onto the substrate, embedding an elongated rod in the uncured polymer matrix solution, curing the polymer matrix solution to form a solidified body, and extracting the elongated rod to form the cylindrical microchannel in the solidified body. In another embodiment, the method includes forming an optical feature on a surface of the microfluidic device. A microfluidic device is also provided, the device including a polymer body, and at least one cylindrical microchannel in the polymer body, the cylindrical microchannel having a diameter between approximately 40 ?m and 250 ?m, inclusive. An additional microfluidic device is provided that functions as an optofluidic spectrometer. The optofluidic spectrometer includes a polymer body, a diffraction grating integrated within the polymer body, and a cylindrical microchannel behind the diffraction grating on the polymer body.
摘要翻译： 制造具有至少一个圆柱形微通道的微流体装置的方法包括提供基底，将未固化的聚合物基质溶液浇铸到基底上，将细长棒嵌入未固化的聚合物基质溶液中，固化聚合物基质溶液以形成凝固体， 并提取细长杆以在凝固体中形成圆柱形微通道。 在另一个实施例中，该方法包括在微流体装置的表面上形成光学特征。 还提供了一种微流体装置，该装置包括聚合物主体和聚合物主体中的至少一个圆柱形微通道，所述圆柱形微通道的直径在约40μm至250μm之间，包括端点在内。 提供额外的微流体装置，其用作光流体光谱仪。 光流体光谱仪包括聚合物体，集成在聚合物主体内的衍射光栅，以及聚合物主体上的衍射光栅后面的圆柱形微通道。
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3.发明授权
公开(公告)号：US5493444A
公开(公告)日：1996-02-20
申请号：US238032
申请日：1994-04-28
摘要： An all-optical nonlinear joint transform correlator has been implemented for the first time without using a spatial light modulator and digital processing in the Fourier plane. The correlator utilizes energy transfer from two-beam coupling in the Fourier plane. A compressional nonlinearity in the hard-clipped regime is implemented by pumping a weak plane wave with the intense joint spectrum of the reference and signal images. Operation of this device rivals or exceeds that of the phase-only filter for detecting objects in cluttered noise. Experimental results are compared with both plane wave and beam propagation simulations.
摘要翻译： 全光非线性联合变换相关器首次实现，而不使用空间光调制器和傅立叶平面中的数字处理。 相关器利用傅立叶平面中双光束耦合的能量传递。 通过用参考和信号图像的强烈联合频谱泵浦弱平面波来实现硬切割状态中的压缩非线性。 该设备的操作与相位滤波器的操作相当或超过用于检测杂乱噪声中的物体的操作。 实验结果与平面波和波束传播模拟进行比较。
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公开(公告)号：US08195021B2
公开(公告)日：2012-06-05
申请号：US12513387
申请日：2007-11-05
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method of manufacturing a biopolymer optical waveguide includes providing a biopolymer, unwinding the biopolymer progressively to extract individual biopolymer fibers, and putting the unwound fibers under tension. The tensioned fibers are then cast in a different polymer to form a biopolymer optical waveguide that guides light due to the difference in indices of refraction between the biopolymer and the different polymer. The optical fibers may be used in biomedical applications and can be inserted in the body as transmissive media. Printing techniques may be used to manufacture the biopolymer optical waveguides.
摘要翻译： 制造生物聚合物光波导的方法包括提供生物聚合物，逐渐解卷生物聚合物以提取单个生物聚合物纤维，以及将展开的纤维置于张力下。 然后将张紧的纤维浇铸在不同的聚合物中以形成由于生物聚合物和不同聚合物之间的折射率差异而引导光的生物聚合物光波导。 光纤可以用于生物医学应用，并且可以作为透射介质插入体内。 印刷技术可用于制造生物聚合物光波导。
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5.发明申请公开(公告)号：US20120121820A1
公开(公告)日：2012-05-17
申请号：US12741066
申请日：2008-11-05
申请人： David Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi , Luca Dal Negro
发明人： David Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi , Luca Dal Negro
CPC分类号： G03F7/0002 , B29D11/00 , B29D11/00346 , B82Y10/00 , B82Y20/00 , B82Y40/00 , C07K14/435 , G02B6/1225
摘要： A method of manufacturing a nanopatterned biophotonic structure includes forming a customized nanopattern mask on a substrate using E-beam lithography, providing a biopolymer matrix solution, depositing the biopolymer matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film. A surface of the film is formed with the nanopattern mask, or a nanopattern is machined directly on a surface of the film using E-beam lithograpy such that the biopolymer film exhibits a spectral signature corresponding to the E-beam lithograpy nanopattern. The resulting bio-compatible nanopatterned biophotonic structures may be made from silk, may be biodegradable, and may be bio-sensing devices. The biophotonic structures may employ nanopatterned masks based on non-periodic photonic lattices, and the biophotonic structures may be designed with specific spectral signatures for use in probing biological substances, including displaying optical activity in the form of opalescence.
摘要翻译： 制造纳米图案生物光子结构的方法包括使用电子束光刻在基底上形成定制的纳米图案掩模，提供生物聚合物基质溶液，将生物聚合物基质溶液沉积在基材上，以及干燥生物聚合物基质溶液以形成固化的生物聚合物膜 。 用纳米图案掩模形成膜的表面，或者使用电子束光刻直接在膜的表面上加工纳米图案，使得生物聚合物膜显示对应于电子束光刻纳米图案的光谱特征。 所得的生物相容纳米图案的生物光子结构可以由丝制成，可以是可生物降解的，并且可以是生物感测装置。 生物光子结构可以使用基于非周期性光子晶格的纳米图案掩模，并且生物光子结构可以被设计成用于探测生物物质的特定光谱特征，包括以乳光的形式显示光学活性。
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公开(公告)号：US4529273A
公开(公告)日：1985-07-16
申请号：US451849
申请日：1982-12-21
CPC分类号： G02F1/3538
摘要： A passive (self-pumped) phase conjugate mirror uses a third-order nonlinear polarization medium, either of the refractive type (effective nonlinear) or the actual nonlinear type, with an optical system of one or more mirrors to reflect back through the medium a coherent incident beam diffracted by the medium. With two mirrors, they may be aligned to form a linear optical cavity containing the nonlinear medium, or they may be so oriented on one side of the medium that the incident beam transmitted through the medium is reflected back through the medium at an angle with the incident beam, and diffracted light from the incident beam is reflected back through the medium in the opposite direction coincident with the incident beam. A passive phase conjugate mirror may replace an end mirror of an optical cavity for a laser gain medium. Phase distortions of the laser beam in the laser cavity are corrected by the passive phase conjugate mirror.
摘要翻译： 无源（自泵浦）相位共轭反射镜使用三阶非线性偏振介质，折射型（有效非线性）或实际非线性类型中的任一者与一个或多个反射镜的光学系统反射回介质a 相干入射光束被介质衍射。 使用两个反射镜，它们可以对准以形成包含非线性介质的线性光学腔，或者它们可以在介质的一侧上定向，使得透射通过介质的入射光束通过介质以与 入射光束和来自入射光束的衍射光在与入射光束重合的相反方向上通过介质反射回来。 无源相位共轭反射镜可以替代用于激光增益介质的光学腔的端镜。 激光腔中激光束的相位失真由无源相位共轭反射镜校正。
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7.发明授权Electroactive biopolymer optical and electro-optical devices and method of manufacturing the same 有权电活性生物聚合物光学和电光器件及其制造方法公开(公告)号：US08574461B2
公开(公告)日：2013-11-05
申请号：US12513392
申请日：2007-11-05
IPC分类号： H01B1/12
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
摘要翻译： 制造生物聚合物光学器件的方法包括提供聚合物，提供基底，将聚合物浇注到基底上，以及将有机化合物酶促聚合以在所提供的聚合物和基底之间产生导电聚合物。 聚合物可以是诸如丝的生物聚合物，并且可以使用有机化合物如酪氨酸进行改性，以通过酪氨酸 - 酶聚合提供生物聚合物光学器件的所提供的本体生物聚合物与底物或其它导电层之间的分子水平界面。 酶促聚合可包括用过氧化物酶反应催化有机化合物。 结果是碳 - 碳共轭骨架提供用于聚合物和生物聚合物光学器件的聚合物“丝线”。 由此提供了提供光学功能和特征的全部有机生物聚合物电活性材料。
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公开(公告)号：US20100063404A1
公开(公告)日：2010-03-11
申请号：US12513387
申请日：2007-11-05
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method of manufacturing a biopolymer optical waveguide includes providing a biopolymer, unwinding the biopolymer progressively to extract individual biopolymer fibers, and putting the unwound fibers under tension. The tensioned fibers are then cast in a different polymer to form a biopolymer optical waveguide that guides light due to the difference in indices of refraction between the biopolymer and the different polymer. The optical fibers may be used in biomedical applications and can be inserted in the body as transmissive media. Printing techniques may be used to manufacture the biopolymer optical waveguides.
摘要翻译： 制造生物聚合物光波导的方法包括提供生物聚合物，逐渐解卷生物聚合物以提取单个生物聚合物纤维，以及将展开的纤维置于张力下。 然后将张紧的纤维浇铸在不同的聚合物中以形成由于生物聚合物和不同聚合物之间的折射率差异而引导光的生物聚合物光波导。 光纤可以用于生物医学应用，并且可以作为透射介质插入体内。 印刷技术可用于制造生物聚合物光波导。
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公开(公告)号：US5018801A
公开(公告)日：1991-05-28
申请号：US531623
申请日：1990-06-01
CPC分类号： G03H1/0248 , G03H1/06
摘要： Achromatic volume holograms are attained for broad band phase conjugation and image reconstruction having bandwidths of 250 nanometers. The holograms are generated by means of a diffraction grating having a predetermined angle of tilt. Achromaticity is achieved by tilting the holographic recording medium at the same predetermined angle.
摘要翻译： 获得宽带相位共轭和具有250纳米带宽的图像重建的消色体积全息图。 全息图通过具有预定倾斜角的衍射光栅产生。 通过以相同的预定角度倾斜全息记录介质来实现消色差。
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公开(公告)号：US09969134B2
公开(公告)日：2018-05-15
申请号：US12513394
申请日：2007-11-05
摘要： A method of manufacturing a nanopatterned biopolymer optical device includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate with a nanopatterned surface, casting the biopolymer matrix solution on the nanopatterned surface of the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film on the substrate, where the solidified biopolymer film is formed with a surface having a nanopattern thereon. In another embodiment, the method also includes annealing the solidified biopolymer film. A nanopatterned biopolymer optical device includes a solidified biopolymer film with a surface having a nanopattern is also provided.
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