公开(公告)号：US08357113B2

公开(公告)日：2013-01-22

申请号：US12562730

申请日：2009-09-18

Applicant: Robert W. Childers ,  David S. Brown ,  Ramesh Wariar ,  Sujatha Karoor ,  Shahid Din ,  Leo Martis ,  Cody Buckmann ,  Paul Soltys

Inventor： Robert W. Childers ,  David S. Brown ,  Ramesh Wariar ,  Sujatha Karoor ,  Shahid Din ,  Leo Martis ,  Cody Buckmann ,  Paul Soltys

IPC: A61M1/00

CPC classification number: A61M1/1696 ,  A61M1/1656 ,  A61M1/1658 ,  A61M1/166 ,  A61M1/28 ,  A61M1/284 ,  A61M1/285 ,  A61M1/287 ,  A61M1/288 ,  A61M2202/0413 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2205/3327

Abstract: A regenerative peritoneal dialysis system includes a dialysis fluid loop; a filter located in the dialysis fluid loop, a first portion of the dialysis fluid sent to the filter rejected by the filter and returned upstream of the filter, a second portion of the dialysis fluid sent to the filter forming permeate, the permeate being rich in urea; and a urea removing apparatus located in the dialysis fluid loop downstream from the filter to receive the permeate and absorb urea from the permeate.

公开(公告)号：US20090218288A1

公开(公告)日：2009-09-03

申请号：US12465214

申请日：2009-05-13

Applicant: Sujatha Karoor ,  Brian Donovan ,  Ton That Hai ,  Mari Katada ,  Luis Lu ,  Leo Martis ,  Stavroula Morti ,  Salim Mujais ,  Paul J. Sanders ,  Paul J. Soltys ,  Rahul Tandon

Inventor： Sujatha Karoor ,  Brian Donovan ,  Ton That Hai ,  Mari Katada ,  Luis Lu ,  Leo Martis ,  Stavroula Morti ,  Salim Mujais ,  Paul J. Sanders ,  Paul J. Soltys ,  Rahul Tandon

IPC: B01D61/26 ,  B01D15/00 ,  B01D39/06 ,  B01J8/00 ,  B01D61/30

CPC classification number: A61M1/1696 ,  A61M1/284 ,  A61M1/287 ,  B01D15/00 ,  B01J20/0211 ,  B01J20/0292 ,  B01J20/06 ,  B01J20/20 ,  B01J20/22 ,  B01J20/28052 ,  B01J39/10 ,  B01J39/12 ,  B01J41/10

Abstract: Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.

Abstract translation: 提供了提供透析治疗的方法和装置。 该装置包括含有磷酸锆，氧化锆和脲酶的树脂床。

公开(公告)号：US07118857B2

公开(公告)日：2006-10-10

申请号：US10789320

申请日：2004-02-27

Applicant: Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

Inventor： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

IPC: C12Q1/00

CPC classification number: A61K31/716 ,  C12Q1/04 ,  G01N2333/4722 ,  Y10S436/815

Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

公开(公告)号：US20060182814A1

公开(公告)日：2006-08-17

申请号：US11343977

申请日：2006-01-30

Applicant: Leo Martis ,  Lee Henderson

Inventor： Leo Martis ,  Lee Henderson

IPC: A61K33/00 ,  A61K31/70

CPC classification number: A61K33/14 ,  A61K33/00 ,  A61K45/06 ,  A61M1/287 ,  A61K33/10 ,  A61K31/7004 ,  A61K31/19 ,  A61K2300/00

Abstract: A peritoneal dialysis solution that is biochemically balanced to correct metabolic acidosis associated with chronic renal failure in a more physiological manner. The peritoneal dialysis solution has a physiological pH, e.g. pH of 70 to 74 and contains bicarbonate at a concentration that is found in normal blood. Additionally, the solution contains carbon dioxide at a partial pressure that is similar to partial pressure of carbon dioxide found in normal blood. The peritoneal dialysis solution also contains a weak acid with a pKa of less than 5.0.

Abstract translation: 腹膜透析液，其生物化学平衡，以更生理的方式纠正与慢性肾衰竭相关的代谢性酸中毒。 腹膜透析溶液具有生理pH，例如， pH值为70至74，并含有在正常血液中发现的浓度的碳酸氢盐。 此外，该溶液含有与正常血液中发现的二氧化碳分压相似的分压下的二氧化碳。 腹膜透析液还含有pKa小于5.0的弱酸。

公开(公告)号：US20050020507A1

公开(公告)日：2005-01-27

申请号：US10628065

申请日：2003-07-25

Applicant: Paul Zieske ,  Leo Martis ,  Carolyn Choo

Inventor： Paul Zieske ,  Leo Martis ,  Carolyn Choo

IPC: A61J1/00 ,  A61J1/20 ,  A61K9/00 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61M1/16 ,  A61M1/28 ,  A61K31/70

CPC classification number: A61J1/2093 ,  A61J1/10 ,  A61J1/2024 ,  A61J1/2027 ,  A61K9/0019 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61M1/1668 ,  A61M1/28 ,  A61M1/287

Abstract: Dialysis solutions with enhanced biocompatibility are provided. The dialysis solutions include a first acidic solution and a second acidic solution that are admixed to form a ready-to-use dialysis solution with reduced levels of glucose degradation products prior to use. The first acidic solution includes a dextrose concentrate, and the second acidic solution includes a buffer concentrate, such as a lactate-based buffer. The first and second acid solutions are separately sterilized prior to mixing to form the ready-to-use dialysis solutions. The dialysis solutions can be used in a variety of different applications, such as infusion into a patient during peritoneal dialysis.

Abstract translation: 提供具有增强的生物相容性的透析溶液。 透析溶液包括第一酸性溶液和第二酸性溶液，其混合以形成使用前葡萄糖降解产物水平降低的即用型透析溶液。 第一酸性溶液包括葡萄糖浓缩物，第二酸性溶液包括缓冲浓缩物，例如基于乳酸盐的缓冲液。 将第一和第二酸溶液在混合之前分开灭菌以形成即用型透析溶液。 透析溶液可用于各种不同的应用，例如在腹膜透析期间输注到患者体内。

公开(公告)号：US06475529B2

公开(公告)日：2002-11-05

申请号：US09918328

申请日：2001-07-30

Applicant: Annick Duponchelle ,  Dirk Faict ,  Patrick Balteau ,  Jean-Pierre Hartman ,  Leo Martis ,  Francesco Peluso

Inventor： Annick Duponchelle ,  Dirk Faict ,  Patrick Balteau ,  Jean-Pierre Hartman ,  Leo Martis ,  Francesco Peluso

IPC: A61K3300

CPC classification number: A61M1/287 ,  A61K33/14 ,  A61M1/1654 ,  A61K33/10 ,  A61K2300/00

Abstract: The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts—an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.

公开(公告)号：US06380163B1

公开(公告)日：2002-04-30

申请号：US07995106

申请日：1992-12-22

Applicant: Leo Martis ,  Ron Burke ,  Dirk Faict

Inventor： Leo Martis ,  Ron Burke ,  Dirk Faict

IPC: A61K3808

CPC classification number: A61K38/018 ,  A61K38/02 ,  A61M1/287

Abstract: The present invention provides an improved dialysis solution. The improved dialysis solution provides for the use of specific polypeptides as an osmotic agent with an additional osmotic agent such as dextrose. To this end, the present invention provides, in an embodiment, a peritoneal dialysis solution comprising as osmotic agents approximately 0.25 to about 4.0% (w/v) polypeptides and approximately 0.5% to about 4.0% (w/v) dextrose. The polypeptides have well defined characteristics.

Abstract translation: 本发明提供了一种改进的透析溶液。 改进的透析溶液提供使用特定多肽作为渗透剂与另外的渗透剂如葡萄糖。 为此，在一个实施方案中，本发明提供包含约0.25至约4.0％（w / v）多肽和约0.5％至约4.0％（w / v）葡萄糖的渗透剂的腹膜透析溶液。 多肽具有明确的特征。

公开(公告)号：US08597227B2

公开(公告)日：2013-12-03

申请号：US13213707

申请日：2011-08-19

Applicant: Robert W. Childers ,  David S. Brown ,  Ramesh Wariar ,  Sujatha Karoor ,  Shahid Din ,  Leo Martis ,  Cody Buchmann ,  Paul Soltys

Inventor： Robert W. Childers ,  David S. Brown ,  Ramesh Wariar ,  Sujatha Karoor ,  Shahid Din ,  Leo Martis ,  Cody Buchmann ,  Paul Soltys

IPC: A61M1/00

CPC classification number: A61M1/1696 ,  A61M1/1656 ,  A61M1/1658 ,  A61M1/166 ,  A61M1/28 ,  A61M1/284 ,  A61M1/285 ,  A61M1/287 ,  A61M1/288 ,  A61M2202/0413 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2205/3327

Abstract: A hemodialysis system including (i) a dialyzer; (ii) a blood circuit including a blood pump in fluid communication with the dialyzer; (iii) a dialysate circuit including a dialysate circulation pump in fluid communication with the dialyzer, the dialysate circuit further including a sorbent cartridge for cleaning used dialysate; (iv) a container holding an initial supply of dialysate; (v) a container pump in fluid communication with the dialysate circuit and the container; (vi) a supply of concentrate; and (vii) an electronic weight balance positioned and arranged to weigh the supply of concentrate.

Abstract translation: 一种血液透析系统，包括（i）透析器; （ii）包括与所述透析器流体连通的血液泵的血液回路; （iii）透析液回路，其包括与所述透析器流体连通的透析液循环泵，所述透析液回路还包括用于清洗使用过的透析液的吸附剂盒; （iv）容纳初始供应透析液的容器; （v）与透析液回路和容器流体连通的容器泵; （vi）精矿供应; 和（vii）定位和布置成对浓缩物供应进行称重的电子重量平衡。

公开(公告)号：US08546097B2

公开(公告)日：2013-10-01

申请号：US12618442

申请日：2009-11-13

Applicant: Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

Inventor： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

IPC: C12G1/00

CPC classification number: A61K31/716 ,  C12Q1/04 ,  G01N2333/4722 ,  Y10S436/815

Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

Abstract translation: 提供了用于检测腹膜透析溶液中微生物污染物的方法和组合物。 方法和组合物采用修饰的生物负载测试和肽聚糖的检测。 提供无菌性腹膜炎的新原因 - 与透析溶液的革兰氏阳性微生物污染相关的无菌性腹膜炎。 肽聚糖是革兰氏阳性细菌细胞壁的主要成分，因此可以作为革兰氏阳性菌的标记物。 在这方面，可以利用肽聚糖的测试来有效地预防使用腹膜透析溶液的患者腹膜炎，例如含有包含icodextrin等的葡萄糖聚合物的腹膜透析溶液。

公开(公告)号：US20120037558A1

公开(公告)日：2012-02-16

申请号：US13281675

申请日：2011-10-26

Applicant: Sujatha Karoor ,  Brian Donovan ,  Ton That Hai ,  Mari Katada ,  Luis Lu ,  Leo Martis ,  Stavroula Morti ,  Salim Mujais ,  Paul J. Sanders ,  Paul J. Soltys ,  Rahul Tandon

Inventor： Sujatha Karoor ,  Brian Donovan ,  Ton That Hai ,  Mari Katada ,  Luis Lu ,  Leo Martis ,  Stavroula Morti ,  Salim Mujais ,  Paul J. Sanders ,  Paul J. Soltys ,  Rahul Tandon

IPC: B01D15/08 ,  B01D61/30

CPC classification number: A61M1/1696 ,  A61M1/284 ,  A61M1/287 ,  B01D15/00 ,  B01J20/0211 ,  B01J20/0292 ,  B01J20/06 ,  B01J20/20 ,  B01J20/22 ,  B01J20/28052 ,  B01J39/10 ,  B01J39/12 ,  B01J41/10

Abstract: Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.

Abstract translation: 提供了提供透析治疗的方法和装置。 该装置包括含有磷酸锆，氧化锆和脲酶的树脂床。