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18 条记录 (耗时 0.015 秒)

    Image processing apparatus, image forming apparatus, image processing method, and computer-readable medium
    1.
    发明授权
    Image processing apparatus, image forming apparatus, image processing method, and computer-readable medium 有权
    图像处理装置，图像形成装置，图像处理方法以及计算机可读介质

    公开(公告)号：US08724174B2

    公开(公告)日：2014-05-13

    申请号：US13361474

    申请日：2012-01-30

    申请人： Toru Misaizu ,  Kenji Hara ,  Shigeru Arai ,  Koichi Matsubara ,  Kouta Matsuo

    发明人： Toru Misaizu ,  Kenji Hara ,  Shigeru Arai ,  Koichi Matsubara ,  Kouta Matsuo

    IPC分类号： G06K1/00 ,  G06F15/00 ,  H04N1/46

    CPC分类号： H04N1/4072

    摘要： An image processing apparatus includes an edge-portion detector, an edge-width detector, and a tone correction unit. The edge-portion detector detects a pixel of an edge portion by determining whether or not each of pixels constituting image data which has been input is a pixel which is included in the edge portion. The edge-width detector detects, for the pixel of the edge portion detected by the edge-portion detector, an edge width which is a width of the edge portion. When the edge width detected by the edge-width detector is smaller than a value which is set in advance, the tone correction unit performs tone correction differently in accordance with the detected edge width.

    摘要翻译： 图像处理装置包括边缘部分检测器，边缘宽度检测器和色调校正单元。 边缘部分检测器通过确定构成已经输入的图像数据的每个像素是否包括在边缘部分中的像素来检测边缘部分的像素。 对于由边缘部分检测器检测的边缘部分的像素，边缘宽度检测器检测作为边缘部分的宽度的边缘宽度。 当由边缘检测器检测到的边缘宽度小于预先设置的值时，色调校正单元根据检测到的边缘宽度进行不同的色调校正。

    Method of Proliferating Plasma Cells
    2.
    发明申请
    Method of Proliferating Plasma Cells 失效
    增殖血浆细胞的方法

    公开(公告)号：US20120015402A1

    公开(公告)日：2012-01-19

    申请号：US13187677

    申请日：2011-07-21

    申请人： Masayuki Tsuchiya ,  Masami Suzuki ,  Kenji Yoshida ,  Etsuko Fujii ,  Miho Watanabe ,  Koichi Matsubara ,  Yu Jau Chen ,  Juliana Sim

    发明人： Masayuki Tsuchiya ,  Masami Suzuki ,  Kenji Yoshida ,  Etsuko Fujii ,  Miho Watanabe ,  Koichi Matsubara ,  Yu Jau Chen ,  Juliana Sim

    IPC分类号： C12P21/00 ,  C12N5/071

    CPC分类号： A01K67/027 ,  A01K2267/01 ,  A61K35/16 ,  C07K16/00 ,  C07K16/30

    摘要： An objective of the present invention is to facilitate the acquisition of antibody-producing cells that are infiltrating virus-infected cells, cancer cells, abnormal cells forming a benign hyperplasia, and the like, and to improve the efficiency of the production of antibodies as well as nucleic acids encoding them from the antibody-producing cells.The present inventors discovered that, when cancer tissues comprising infiltrating lymphocytes are transplanted into highly immunodeficient animals that do not have T cells, B cells, and NK cells and further exhibit a low IFN production ability, the differentiation and proliferation of infiltrating lymphocytes are unexpectedly promoted, and the number of plasma cells that produce antibodies recognizing cancer tissues increases dramatically, plasma cells can be separated easily, and antibodies or nucleic acids encoding them can be easily prepared from the plasma cells.

    摘要翻译： 本发明的目的是便于获得渗透病毒感染细胞的抗体产生细胞，癌细胞，形成良性增生的异常细胞等，以及提高抗体生产的效率 作为从抗体产生细胞编码它们的核酸。 本发明人发现，当将包含浸润性淋巴细胞的癌组织移植到不具有T细胞，B细胞和NK细胞的高度免疫缺陷的动物中并且进一步表现出低的IFN产生能力时，意外地促进了浸润性淋巴细胞的分化和增殖 并且产生识别癌组织的抗体的浆细胞的数量急剧增加，可以容易地分离浆细胞，并且可以容易地从浆细胞制备抗体或编码它们的核酸。

    Methods of generating and using antibody-producing cells
    8.
    发明授权
    Methods of generating and using antibody-producing cells 失效
    产生和使用抗体产生细胞的方法

    公开(公告)号：US08343761B2

    公开(公告)日：2013-01-01

    申请号：US13187677

    申请日：2011-07-21

    申请人： Masayuki Tsuchiya ,  Masami Suzuki ,  Kenji Yoshida ,  Etsuko Fujii ,  Miho Watanabe ,  Koichi Matsubara ,  Yu Jau Chen ,  Juliana Sim

    发明人： Masayuki Tsuchiya ,  Masami Suzuki ,  Kenji Yoshida ,  Etsuko Fujii ,  Miho Watanabe ,  Koichi Matsubara ,  Yu Jau Chen ,  Juliana Sim

    IPC分类号： C12N5/06 ,  A01K67/00 ,  C12N5/00

    CPC分类号： A01K67/027 ,  A01K2267/01 ,  A61K35/16 ,  C07K16/00 ,  C07K16/30

    摘要： An objective of the present invention is to facilitate the acquisition of antibody-producing cells that are infiltrating virus-infected cells, cancer cells, abnormal cells forming a benign hyperplasia, and the like, and to improve the efficiency of the production of antibodies as well as nucleic acids encoding them from the antibody-producing cells.The present inventors discovered that, when cancer tissues comprising infiltrating lymphocytes are transplanted into highly immunodeficient animals that do not have T cells, B cells, and NK cells and further exhibit a low IFN production ability, the differentiation and proliferation of infiltrating lymphocytes are unexpectedly promoted, and the number of plasma cells that produce antibodies recognizing cancer tissues increases dramatically, plasma cells can be separated easily, and antibodies or nucleic acids encoding them can be easily prepared from the plasma cells.

    摘要翻译： 本发明的目的是便于获得渗透病毒感染细胞的抗体产生细胞，癌细胞，形成良性增生的异常细胞等，以及提高抗体生产的效率 作为从抗体产生细胞编码它们的核酸。 本发明人发现，当将包含浸润性淋巴细胞的癌组织移植到不具有T细胞，B细胞和NK细胞的高度免疫缺陷的动物中并且进一步表现出低的IFN产生能力时，意外地促进了浸润性淋巴细胞的分化和增殖 并且产生识别癌组织的抗体的浆细胞的数量急剧增加，可以容易地分离浆细胞，并且可以容易地从浆细胞制备抗体或编码它们的核酸。