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公开(公告)号：US08598338B2
公开(公告)日：2013-12-03
申请号：US12718713
申请日：2010-03-05
申请人： Robert Jackson Bair , Kristen Campbell Benedict , Wendy J. Kivens , Robert W. Kwiatkowski, Jr. , Kim Paulsen , Daniel A. Strom , John M. Wages
发明人： Robert Jackson Bair , Kristen Campbell Benedict , Wendy J. Kivens , Robert W. Kwiatkowski, Jr. , Kim Paulsen , Daniel A. Strom , John M. Wages
IPC分类号： C07H21/04
CPC分类号： C07H21/04 , C12N15/1003 , C12N15/1006
摘要： The present disclosure provides methods for isolating substantially pure and undegraded DNA from biological material via a solid support. The methods may use a DNA lysing solution that comprises a surfactant, a DNA-complexing salt (e.g., a lithium salt), and a buffer. Alternatively, the methods may use a solid support pre-treated with the DNA lysing solution.
摘要翻译： 本公开提供了通过固体支持物从生物材料中分离基本上纯的和未降解的DNA的方法。 该方法可以使用包含表面活性剂，DNA络合盐（例如锂盐）和缓冲液的DNA裂解溶液。 或者，所述方法可以使用用DNA裂解溶液预处理的固体支持物。
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2.发明申请公开(公告)号：US20070092403A1
公开(公告)日：2007-04-26
申请号：US11255807
申请日：2005-10-21
申请人： Alan Wirbisky , Tim Quinn , Nick Lught , Nate Morken , Rebecca Johnson , Kim Paulsen , Dan Strom , Jim Baldrica
发明人： Alan Wirbisky , Tim Quinn , Nick Lught , Nate Morken , Rebecca Johnson , Kim Paulsen , Dan Strom , Jim Baldrica
IPC分类号： G01N35/00
CPC分类号： G01N1/34 , C12N1/06 , C12N15/1006 , C12N15/1013 , G01N35/0098
摘要： The invention features an apparatus, materials and methods for isolating RNA or DNA from a sample.
摘要翻译： 本发明的特征在于用于从样品中分离RNA或DNA的装置，材料和方法。
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公开(公告)号：US20100130495A1
公开(公告)日：2010-05-27
申请号：US12613935
申请日：2009-11-06
IPC分类号： A61K31/5377 , A61K31/519 , A61K31/506 , A61K31/445 , A61K31/421 , A61K31/4172 , A61K31/4155 , A61K31/4015 , A61K31/382 , A61K31/351 , A61K31/155 , A61K31/121 , C07D413/04 , C07D491/052 , C07D471/04 , C07D401/10 , C07D211/94 , C07D263/30 , C07D233/60 , C07D231/12 , C07D405/06 , C07D335/02 , C07D309/02 , C07D309/10 , C07C281/16 , A61P25/16 , A61P25/28
CPC分类号： C07D471/04 , C07D403/12 , C07D491/052 , C07D495/04
摘要： The present invention relates to novel compounds of formula I and therapeutically acceptable salts thereof, their pharmaceutical compositions, processes for making them and their use as therapeutic methods for treatment and/or prevention of various diseases. In particular the invention relates to compounds, which inhibit the Aβ40 and Aβ42 production, increase the Aβ37 and Aβ38 production and maintain the Notch signaling and will be used for treatment and/or prevention of Aβ-related pathologies such as Alzheimer's disease, Downs syndrome and β-amyloid angiopathy, such as but not limited to cerebral amyloid angiopathy, hereditary cerebral hemorrhage, disorders associated with cognitive impairment, such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
摘要翻译： 本发明涉及式I的新化合物及其治疗上可接受的盐，其药物组合物，其制备方法及其作为治疗和/或预防各种疾病的治疗方法。 特别地，本发明涉及抑制A＆bgr 40和A＆bgr 42生产的化合物，增加A＆bgr 37和A＆bgr 38产量并维持Notch信号，并将用于治疗和/或预防A＆bgr相关 诸如阿尔茨海默氏病，唐氏综合征和淀粉样血管病的病态，例如但不限于脑淀粉样血管病，遗传性脑出血，与认知障碍相关的病症，例如但不限于MCI（“轻度认知障碍”）， 阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与诸如阿尔茨海默病或痴呆的疾病相关的神经变性，包括混合血管和退行性起源的痴呆，老年痴呆，老年痴呆和与帕金森病相关的痴呆，进行性核上性麻痹 或皮质基底变性。
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公开(公告)号：US20070043216A1
公开(公告)日：2007-02-22
申请号：US11589364
申请日：2006-10-30
申请人： Robert Bair , Ellen Heath , Heather Meehan , Kim Paulsen , John Wages
发明人： Robert Bair , Ellen Heath , Heather Meehan , Kim Paulsen , John Wages
IPC分类号： C07H21/02
CPC分类号： C12N15/1003 , C12N15/1006
摘要： Reagents, methods and kits for the purification of RNA from biological materials are provided.
摘要翻译： 提供了用于从生物材料中纯化RNA的试剂，方法和试剂盒。
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公开(公告)号：US08188101B2
公开(公告)日：2012-05-29
申请号：US12613935
申请日：2009-11-06
IPC分类号： A61K31/519
CPC分类号： C07D471/04 , C07D403/12 , C07D491/052 , C07D495/04
摘要： Dihydropyridopyrimidine compounds of formula (Ia) and therapeutically acceptable salts thereof, wherein R1, R2 and Z are as defined in the specification; processes for making them and methods for using them in the treatment of Aβ-related pathologies.
摘要翻译： 式（Ia）的二氢吡啶并嘧啶化合物及其治疗上可接受的盐，其中R1，R2和Z如说明书中所定义; 制备它们的过程和使用它们在治疗A＆bgr相关病变中的方法。
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公开(公告)号：US20100292210A1
公开(公告)日：2010-11-18
申请号：US12777602
申请日：2010-05-11
IPC分类号： A61K31/553 , C07D267/08 , A61P25/28
CPC分类号： C07D498/04 , C07D471/04
摘要： The present invention relates to novel compounds of formulae I and II and therapeutically acceptable salts thereof, their pharmaceutical compositions processes for making them and their use in therapeutic methods for treatment and/or prevention of various diseases. In particular, the invention relates to compounds which interfere with γ-secretase and/or its substrate and hence modulate the formation of Aβ peptides.
摘要翻译： 本发明涉及式I和II的新化合物及其治疗上可接受的盐，它们的药物组合物制备方法及其用于治疗和/或预防各种疾病的治疗方法。 特别地，本发明涉及干扰γ-分泌酶和/或其底物并因此调节A＆bgr的形成的化合物; 肽。
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公开(公告)号：US20100160619A1
公开(公告)日：2010-06-24
申请号：US12718713
申请日：2010-03-05
申请人： Robert Jackson Bair , Kristen Campbell Benedict , Wendy J. Kivens , Robert W. Kwiatkowski, JR. , Kim Paulsen , Daniel A. Strom , John M. Wages
发明人： Robert Jackson Bair , Kristen Campbell Benedict , Wendy J. Kivens , Robert W. Kwiatkowski, JR. , Kim Paulsen , Daniel A. Strom , John M. Wages
IPC分类号： C07H21/00
CPC分类号： C07H21/04 , C12N15/1003 , C12N15/1006
摘要： Reagents, methods and kits for the purification of DNA from biological materials are provided.
摘要翻译： 提供了用于从生物材料中纯化DNA的试剂，方法和试剂盒。
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8.发明申请Compositions and methods for purifying nucleic acids from stabilization reagents 审中-公开用于从稳定试剂中纯化核酸的组合物和方法公开(公告)号：US20060105372A1
公开(公告)日：2006-05-18
申请号：US11265996
申请日：2005-11-03
申请人： Robert Bair , Kim Paulsen
发明人： Robert Bair , Kim Paulsen
CPC分类号： C12N15/1006
摘要： The invention features reagents, methods and kits for the purification of RNA, or DNA, or both, from a sample.
摘要翻译： 本发明具有用于从样品中纯化RNA或DNA或两者的试剂，方法和试剂盒。
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公开(公告)号：US20050171333A1
公开(公告)日：2005-08-04
申请号：US11012527
申请日：2004-12-15
申请人： Kim Paulsen
发明人： Kim Paulsen
CPC分类号： C07H21/00 , C12N9/99 , C12N15/1006 , Y10S435/814 , Y10T436/255
摘要： Reagents, methods and kits for denaturation of protein are provided.
摘要翻译： 提供了用于蛋白质变性的试剂，方法和试剂盒。
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10.发明申请公开(公告)号：US20120122843A1
公开(公告)日：2012-05-17
申请号：US13292582
申请日：2011-11-09
申请人： István MACSÁRI , Kim PAULSEN , Laszlo RAKOS , Britt-Marie SWAHN , Magnus WALDMAN , Didier ROTTICCI , Stefan VON BERG
发明人： István MACSÁRI , Kim PAULSEN , Laszlo RAKOS , Britt-Marie SWAHN , Magnus WALDMAN , Didier ROTTICCI , Stefan VON BERG
IPC分类号： A61K31/553 , A61P25/18 , A61P25/28 , C07D498/04 , A61P29/00
CPC分类号： A61K31/553 , C07D498/04
摘要： The present invention relates to novel compounds of formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said compounds, processes for making said compounds, and their use as medicaments for treatment and/or prevention of Aβ-related diseases.
摘要翻译： 本发明涉及式（I）的新化合物及其药学上可接受的盐，包含所述化合物的药物组合物，制备所述化合物的方法及其作为用于治疗和/或预防与疾病有关的疾病的药物的用途。
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