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1.
公开(公告)号:US08598338B2
公开(公告)日:2013-12-03
申请号:US12718713
申请日:2010-03-05
申请人: Robert Jackson Bair , Kristen Campbell Benedict , Wendy J. Kivens , Robert W. Kwiatkowski, Jr. , Kim Paulsen , Daniel A. Strom , John M. Wages
发明人: Robert Jackson Bair , Kristen Campbell Benedict , Wendy J. Kivens , Robert W. Kwiatkowski, Jr. , Kim Paulsen , Daniel A. Strom , John M. Wages
IPC分类号: C07H21/04
CPC分类号: C07H21/04 , C12N15/1003 , C12N15/1006
摘要: The present disclosure provides methods for isolating substantially pure and undegraded DNA from biological material via a solid support. The methods may use a DNA lysing solution that comprises a surfactant, a DNA-complexing salt (e.g., a lithium salt), and a buffer. Alternatively, the methods may use a solid support pre-treated with the DNA lysing solution.
摘要翻译: 本公开提供了通过固体支持物从生物材料中分离基本上纯的和未降解的DNA的方法。 该方法可以使用包含表面活性剂,DNA络合盐(例如锂盐)和缓冲液的DNA裂解溶液。 或者,所述方法可以使用用DNA裂解溶液预处理的固体支持物。
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2.Compact apparatus, compositions and methods for purifying nucleic acids 审中-公开
标题翻译: 用于纯化核酸的紧凑装置,组合物和方法公开(公告)号:US20070092403A1
公开(公告)日:2007-04-26
申请号:US11255807
申请日:2005-10-21
申请人: Alan Wirbisky , Tim Quinn , Nick Lught , Nate Morken , Rebecca Johnson , Kim Paulsen , Dan Strom , Jim Baldrica
发明人: Alan Wirbisky , Tim Quinn , Nick Lught , Nate Morken , Rebecca Johnson , Kim Paulsen , Dan Strom , Jim Baldrica
IPC分类号: G01N35/00
CPC分类号: G01N1/34 , C12N1/06 , C12N15/1006 , C12N15/1013 , G01N35/0098
摘要: The invention features an apparatus, materials and methods for isolating RNA or DNA from a sample.
摘要翻译: 本发明的特征在于用于从样品中分离RNA或DNA的装置,材料和方法。
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3.
公开(公告)号:US20070043216A1
公开(公告)日:2007-02-22
申请号:US11589364
申请日:2006-10-30
申请人: Robert Bair , Ellen Heath , Heather Meehan , Kim Paulsen , John Wages
发明人: Robert Bair , Ellen Heath , Heather Meehan , Kim Paulsen , John Wages
IPC分类号: C07H21/02
CPC分类号: C12N15/1003 , C12N15/1006
摘要: Reagents, methods and kits for the purification of RNA from biological materials are provided.
摘要翻译: 提供了用于从生物材料中纯化RNA的试剂,方法和试剂盒。
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4.Compositions and methods for purifying nucleic acids from stabilization reagents 审中-公开
标题翻译: 用于从稳定试剂中纯化核酸的组合物和方法公开(公告)号:US20060105372A1
公开(公告)日:2006-05-18
申请号:US11265996
申请日:2005-11-03
申请人: Robert Bair , Kim Paulsen
发明人: Robert Bair , Kim Paulsen
CPC分类号: C12N15/1006
摘要: The invention features reagents, methods and kits for the purification of RNA, or DNA, or both, from a sample.
摘要翻译: 本发明具有用于从样品中纯化RNA或DNA或两者的试剂,方法和试剂盒。
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公开(公告)号:US20050171333A1
公开(公告)日:2005-08-04
申请号:US11012527
申请日:2004-12-15
申请人: Kim Paulsen
发明人: Kim Paulsen
CPC分类号: C07H21/00 , C12N9/99 , C12N15/1006 , Y10S435/814 , Y10T436/255
摘要: Reagents, methods and kits for denaturation of protein are provided.
摘要翻译: 提供了用于蛋白质变性的试剂,方法和试剂盒。
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6.COMPACT APPARATUS, COMPOSITIONS AND METHODS FOR PURIFYING NUCLEIC ACIDS 审中-公开
标题翻译: 紧凑的装置,用于净化核酸的组合物和方法公开(公告)号:US20120058011A1
公开(公告)日:2012-03-08
申请号:US13224200
申请日:2011-09-01
申请人: Alan Wirbisky , Tim Quinn , Nick Van Der Lught , Nate Morken , Rebecca Johnson , Kim Paulsen , Dan Strom , Jim Baldrica
发明人: Alan Wirbisky , Tim Quinn , Nick Van Der Lught , Nate Morken , Rebecca Johnson , Kim Paulsen , Dan Strom , Jim Baldrica
IPC分类号: G01N35/00
CPC分类号: G01N1/34 , C12N1/06 , C12N15/1006 , C12N15/1013 , G01N35/0098
摘要: The invention features an apparatus, materials and methods for isolating RNA or DNA from a sample.
摘要翻译: 本发明的特征在于用于从样品中分离RNA或DNA的装置,材料和方法。
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7.
公开(公告)号:US20050032105A1
公开(公告)日:2005-02-10
申请号:US10909724
申请日:2004-08-02
申请人: Robert Bair , Kristen Benedict , Wendy Kivens , Robert Kwiatkowski , Kim Paulsen , Daniel Strom , John Wages
发明人: Robert Bair , Kristen Benedict , Wendy Kivens , Robert Kwiatkowski , Kim Paulsen , Daniel Strom , John Wages
CPC分类号: C07H21/04 , C12N15/1003 , C12N15/1006
摘要: Reagents, methods and kits for the purification of DNA from biological materials are provided.
摘要翻译: 提供了用于从生物材料中纯化DNA的试剂,方法和试剂盒。
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8.
公开(公告)号:US08188101B2
公开(公告)日:2012-05-29
申请号:US12613935
申请日:2009-11-06
IPC分类号: A61K31/519
CPC分类号: C07D471/04 , C07D403/12 , C07D491/052 , C07D495/04
摘要: Dihydropyridopyrimidine compounds of formula (Ia) and therapeutically acceptable salts thereof, wherein R1, R2 and Z are as defined in the specification; processes for making them and methods for using them in the treatment of Aβ-related pathologies.
摘要翻译: 式(Ia)的二氢吡啶并嘧啶化合物及其治疗上可接受的盐,其中R1,R2和Z如说明书中所定义; 制备它们的过程和使用它们在治疗A&bgr相关病变中的方法。
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公开(公告)号:US20100292210A1
公开(公告)日:2010-11-18
申请号:US12777602
申请日:2010-05-11
IPC分类号: A61K31/553 , C07D267/08 , A61P25/28
CPC分类号: C07D498/04 , C07D471/04
摘要: The present invention relates to novel compounds of formulae I and II and therapeutically acceptable salts thereof, their pharmaceutical compositions processes for making them and their use in therapeutic methods for treatment and/or prevention of various diseases. In particular, the invention relates to compounds which interfere with γ-secretase and/or its substrate and hence modulate the formation of Aβ peptides.
摘要翻译: 本发明涉及式I和II的新化合物及其治疗上可接受的盐,它们的药物组合物制备方法及其用于治疗和/或预防各种疾病的治疗方法。 特别地,本发明涉及干扰γ-分泌酶和/或其底物并因此调节A&bgr的形成的化合物; 肽。
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10.
公开(公告)号:US20100160619A1
公开(公告)日:2010-06-24
申请号:US12718713
申请日:2010-03-05
申请人: Robert Jackson Bair , Kristen Campbell Benedict , Wendy J. Kivens , Robert W. Kwiatkowski, JR. , Kim Paulsen , Daniel A. Strom , John M. Wages
发明人: Robert Jackson Bair , Kristen Campbell Benedict , Wendy J. Kivens , Robert W. Kwiatkowski, JR. , Kim Paulsen , Daniel A. Strom , John M. Wages
IPC分类号: C07H21/00
CPC分类号: C07H21/04 , C12N15/1003 , C12N15/1006
摘要: Reagents, methods and kits for the purification of DNA from biological materials are provided.
摘要翻译: 提供了用于从生物材料中纯化DNA的试剂,方法和试剂盒。
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