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公开(公告)号：US20120107313A1
公开(公告)日：2012-05-03
申请号：US13350641
申请日：2012-01-13
IPC分类号： A61K39/395 , A61K31/7088 , A61P37/08 , A61P17/00 , A61P11/00 , A61P11/06 , A61P1/00 , A61P17/06 , G01N33/566 , A61P19/02
CPC分类号： A61K38/20 , A61K31/7088 , A61K38/1793 , A61K48/00 , C07K14/54 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K16/2866 , C07K2319/00 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12Q1/6876 , G01N33/6869 , G01N33/6893
摘要： Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
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公开(公告)号：US08110378B2
公开(公告)日：2012-02-07
申请号：US13149643
申请日：2011-05-31
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00 , Y10S435/975
摘要： Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
摘要翻译： 编码哺乳动物，例如灵长类，受体，纯化受体蛋白及其片段的核酸。 还提供了抗体，包括多克隆和单克隆抗体。 描述了用于诊断和治疗用途的组合物的方法。
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公开(公告)号：US20110021412A1
公开(公告)日：2011-01-27
申请号：US12902001
申请日：2010-10-11
IPC分类号： A61K38/02 , C12N5/10 , C12N5/071 , C12N1/21 , C12N1/19 , A61K31/7088 , C07K14/435 , C07K16/28 , C07H21/00
CPC分类号： C07K14/7056 , Y10S930/142
摘要： Nucleic acids encoding mammalian, e.g., primate or rodent receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
摘要翻译： 编码哺乳动物，例如灵长类或啮齿动物受体的核酸，纯化的受体蛋白及其片段。 还提供了抗体，包括多克隆和单克隆抗体。 提供了用于诊断和治疗用途的组合物的方法。
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公开(公告)号：US20100278825A1
公开(公告)日：2010-11-04
申请号：US12834728
申请日：2010-07-12
IPC分类号： A61K39/395 , A61K38/17 , A61K31/7052 , G01N33/53 , A61P37/06 , A61P19/02 , A61P29/00 , A61P1/00
CPC分类号： A61K38/20 , A61K31/7088 , A61K38/1793 , A61K48/00 , C07K14/54 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K16/2866 , C07K2319/00 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12Q1/6876 , G01N33/6869 , G01N33/6893
摘要： Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
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公开(公告)号：US07754214B2
公开(公告)日：2010-07-13
申请号：US12181152
申请日：2008-07-28
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00
CPC分类号： A61K38/20 , A61K31/7088 , A61K38/1793 , A61K48/00 , C07K14/54 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K16/2866 , C07K2319/00 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12Q1/6876 , G01N33/6869 , G01N33/6893
摘要： Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
摘要翻译： 编码哺乳动物，例如灵长类动物，受体，纯化受体蛋白及其片段的核酸。 还提供了抗体，包括多克隆和单克隆抗体。 描述了用于诊断和治疗用途的组合物的方法。
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公开(公告)号：US07510853B2
公开(公告)日：2009-03-31
申请号：US10667289
申请日：2003-09-18
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00 , Y10S435/975
摘要： Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
摘要翻译： 编码哺乳动物，例如灵长类动物，受体，纯化受体蛋白及其片段的核酸。 还提供了抗体，包括多克隆和单克隆抗体。 描述了用于诊断和治疗用途的组合物的方法。
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公开(公告)号：US06294347B1
公开(公告)日：2001-09-25
申请号：US09232218
申请日：1999-01-19
申请人： Gary A. Peltz , Kevin W. Moore
发明人： Gary A. Peltz , Kevin W. Moore
IPC分类号： G01N33567
CPC分类号： G01N33/566 , A61K38/00 , C07K14/70535 , C12N13/00 , G01N33/564
摘要： Soluble and membrane-bound forms of human Fc&ggr;RIII are provided, together with nucleic acids capable of encoding the same. Soluble Fc&ggr;RIIIs are useful in ameliorating the serum platelet deficiency associated with immune thrombocytopenic prupura. Cells expressing membrane-bound Fc&ggr;RIIIs are useful components in assays for serum immune complexes.
摘要翻译： 提供人FcgammaRIII的可溶性和膜结合形式以及能够编码它们的核酸。 可溶性FcgammaRIIIs可用于改善与免疫血小板减少性早发性相关的血小板缺陷。 表达膜结合FcgammaRIII的细胞是血清免疫复合物测定中的有用成分。
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8.发明授权Methods of treatment using antagonists of cytokine synthesis inhibitory factor 失效使用拮抗剂的细胞因子合成抑制因子的治疗方法公开(公告)号：US06207154B1
公开(公告)日：2001-03-27
申请号：US08467374
申请日：1995-06-06
IPC分类号： A61K39395
CPC分类号： C07K14/5428 , Y10S514/825 , Y10S514/885 , Y10S930/141
摘要： Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-&ggr;.
摘要翻译： 提供了哺乳动物基因和蛋白质，命名为细胞因子合成抑制因子（CSIF，现在称为白细胞介素-10（IL-10）），其能够抑制与延迟型超敏反应相关的细胞因子的合成，并且与拮抗剂 可用于治疗与细胞因子失衡相关的疾病，例如利什曼病和其他寄生虫感染，以及某些免疫疾病，包括由过量产生干扰素-γ引起的MHC相关的自身免疫性疾病。
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9.发明授权Antibodies which specifically bind mammalian receptors for interleukin-10 (IL-10) 失效特异性结合哺乳动物受体的白细胞介素-10（IL-10）
公开(公告)号：US5863796A
公开(公告)日：1999-01-26
申请号：US477166
申请日：1995-06-07
申请人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
发明人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
IPC分类号： G01N33/577 , A61K38/00 , A61K39/395 , A61P31/04 , A61P37/00 , C07H21/04 , C07K14/54 , C07K14/715 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , C07K16/28 , C12N5/12 , G01N33/53
CPC分类号： C07K14/7155 , C07K14/5428 , A61K38/00 , C07K2319/00
摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
摘要翻译： 分离和表征IL-10的受体组分。 公开了编码受体的各种变体的氨基酸序列和核酸。 公开了纯化的受体基因和多肽的用途，包括用于筛选受体配体的激动剂和拮抗剂，用于产生诊断或治疗试剂以及产生抗体的手段。 还提供治疗或诊断试剂和试剂盒。
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公开(公告)号：US5252584A
公开(公告)日：1993-10-12
申请号：US801998
申请日：1991-12-03
IPC分类号： A61K31/47 , A61P25/00 , A61P25/08 , A61P25/28 , C07D401/04 , C07D215/56
CPC分类号： C07D401/04
摘要： A class of 4-hydroxy-2(1H)-quinolone derivatives, substituted at the 3-position by an N-linked heteroaromatic ring system, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and or AMPA receptor antagonist.
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