公开(公告)号：US07135555B2

公开(公告)日：2006-11-14

申请号：US10145014

申请日：2002-05-14

申请人： Barbara Dalie ,  Xuedong Fan ,  Daniel Lundell ,  Charles A. Lunn ,  Jimmy C. Tan ,  Paul J. Zavodny

发明人： Barbara Dalie ,  Xuedong Fan ,  Daniel Lundell ,  Charles A. Lunn ,  Jimmy C. Tan ,  Paul J. Zavodny

IPC分类号： C07K16/00 ,  A61K39/395 ,  G01N33/53 ,  C12P21/04

CPC分类号： C12N9/6489 ,  C12N9/6424 ,  C12Q1/37 ,  C12Y304/24086 ,  G01N2333/525 ,  G01N2333/96486

摘要： The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-α. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-α convertases, and for identifying nucleic acids encoding such convertases.

公开(公告)号：US06531290B2

公开(公告)日：2003-03-11

申请号：US09982308

申请日：2001-10-17

申请人： Barbara Dalie ,  Xuedong Fan ,  Daniel Lundell ,  Charles A. Lunn ,  Jimmy C. Tan ,  Paul J. Zavodny

发明人： Barbara Dalie ,  Xuedong Fan ,  Daniel Lundell ,  Charles A. Lunn ,  Jimmy C. Tan ,  Paul J. Zavodny

IPC分类号： G01N33573

CPC分类号： C12N9/6489 ,  C12N9/6424 ,  C12Q1/37 ,  C12Y304/24086 ,  G01N2333/525 ,  G01N2333/96486

摘要： The present invention provides isolated human and bovine TNF-&agr; convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-&agr;. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-&agr; convertases, and for identifying nucleic acids encoding such convertases.

摘要翻译： 本发明提供分离的人和牛TNF-α转化酶，编码它们的核酸和重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备转化酶的方法。 本发明进一步提供与转化酶特异性结合的抗体及其抗原结合片段，可用于治疗由TNF-α引起或介导的医学病症。 还提供了用于鉴定哺乳动物TNF-α转化酶的特异性抑制剂的筛选方法，以及用于鉴定编码这种转化酶的核酸。

公开(公告)号：US06423500B1

公开(公告)日：2002-07-23

申请号：US09439672

申请日：1999-11-15

申请人： Kevin W. Moore ,  Ying Liu ,  Alice Suk-Yue Ho ,  Di-Hwei Hsu ,  Bazan Fernando J. ,  Jimmy C. Tan ,  Chuan-Chu Chou

发明人： Kevin W. Moore ,  Ying Liu ,  Alice Suk-Yue Ho ,  Di-Hwei Hsu ,  Bazan Fernando J. ,  Jimmy C. Tan ,  Chuan-Chu Chou

IPC分类号： G01N3353

CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K14/5428 ,  C07K2319/00

摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.

摘要翻译： 分离和表征IL-10的受体组分。 公开了编码受体的各种变体的氨基酸序列和核酸。 公开了纯化的受体基因和多肽的用途，包括用于筛选受体配体的激动剂和拮抗剂，用于产生诊断或治疗试剂以及产生抗体的手段。 还提供治疗或诊断试剂和试剂盒。

公开(公告)号：US5985828A

公开(公告)日：1999-11-16

申请号：US472097

申请日：1995-06-07

申请人： Kevin W. Moore ,  Ying Liu ,  Alice Suk-Yue Ho ,  Di-Hwei Hsu ,  J. Fernando Bazan ,  Jimmy C. Tan ,  Chuan-Chu Chou

发明人： Kevin W. Moore ,  Ying Liu ,  Alice Suk-Yue Ho ,  Di-Hwei Hsu ,  J. Fernando Bazan ,  Jimmy C. Tan ,  Chuan-Chu Chou

IPC分类号： G01N33/577 ,  A61K38/00 ,  A61K39/395 ,  A61P31/04 ,  A61P37/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/715 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  A61K38/16

CPC分类号： C07K14/7155 ,  C07K14/5428 ,  A61K38/00 ,  C07K2319/00

摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.

摘要翻译： 分离和表征IL-10的受体组分。 公开了编码受体的各种变体的氨基酸序列和核酸。 公开了纯化的受体基因和多肽的用途，包括用于筛选受体配体的激动剂和拮抗剂，用于产生诊断或治疗试剂以及产生抗体的手段。 还提供治疗或诊断试剂和试剂盒。

公开(公告)号：US5789192A

公开(公告)日：1998-08-04

申请号：US110683

申请日：1993-08-23

申请人： Kevin W. Moore ,  Ying Liu ,  Alice Suk-Yue Ho ,  Di-Hwei Hsu ,  J. Fernando Bazan ,  Jimmy C. Tan ,  Chuan-Chu Chou

发明人： Kevin W. Moore ,  Ying Liu ,  Alice Suk-Yue Ho ,  Di-Hwei Hsu ,  J. Fernando Bazan ,  Jimmy C. Tan ,  Chuan-Chu Chou

IPC分类号： G01N33/577 ,  A61K38/00 ,  A61K39/395 ,  A61P31/04 ,  A61P37/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/715 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91

CPC分类号： C07K14/7155 ,  C07K14/5428 ,  A61K38/00 ,  C07K2319/00

摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.

公开(公告)号：US07358352B2

公开(公告)日：2008-04-15

申请号：US11598469

申请日：2006-11-13

申请人： Barbara Dalie ,  Xuedong Fan ,  Daniel Lundell ,  Charles A. Lunn ,  Jimmy C. Tan ,  Paul J. Zavodny

发明人： Barbara Dalie ,  Xuedong Fan ,  Daniel Lundell ,  Charles A. Lunn ,  Jimmy C. Tan ,  Paul J. Zavodny

IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N5/00 ,  C12N15/00 ,  A61K39/395 ,  C07K1/02 ,  C07K16/00 ,  G01N33/53

CPC分类号： C12N9/6489 ,  C12N9/6424 ,  C12Q1/37 ,  C12Y304/24086 ,  G01N2333/525 ,  G01N2333/96486

摘要： The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and; recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-α. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-α convertases, and for identifying nucleic acids encoding such convertases.

摘要翻译： 本发明提供分离的人和牛TNF-α转化酶，核酸和 编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备转化酶的方法。 本发明进一步提供与转化酶特异性结合的抗体及其抗原结合片段，可用于治疗由TNF-α引起或介导的医学病症。 还提供了用于鉴定哺乳动物TNF-α转化酶的特异性抑制剂的筛选方法，以及用于鉴定编码这种转化酶的核酸。

公开(公告)号：US06319681B1

公开(公告)日：2001-11-20

申请号：US09156163

申请日：1998-09-17

申请人： Barbara Dalie ,  Xuedong Fan ,  Daniel Lundell ,  Charles A. Lunn ,  Jimmy C. Tan ,  Paul J. Zavodny

发明人： Barbara Dalie ,  Xuedong Fan ,  Daniel Lundell ,  Charles A. Lunn ,  Jimmy C. Tan ,  Paul J. Zavodny

IPC分类号： C12Q137

CPC分类号： C12N9/6489 ,  C12N9/6424 ,  C12Q1/37 ,  C12Y304/24086 ,  G01N2333/525 ,  G01N2333/96486

摘要： The present invention provides isolated human and bovine TNF-&agr; convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-&agr;. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-&agr; convertases, and for identifying nucleic acids encoding such convertases.

摘要翻译： 本发明提供分离的人和牛TNF-α转化酶，编码它们的核酸和重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备转化酶的方法。 本发明进一步提供与转化酶特异性结合的抗体及其抗原结合片段，可用于治疗由TNF-α引起或介导的医学病症。 还提供了用于鉴定哺乳动物TNF-α转化酶的特异性抑制剂的筛选方法，以及用于鉴定编码这种转化酶的核酸。

公开(公告)号：US5863796A

公开(公告)日：1999-01-26

申请号：US477166

申请日：1995-06-07

申请人： Kevin W. Moore ,  Ying Liu ,  Alice Suk-Yue Ho ,  Di-Hwei Hsu ,  J. Fernando Bazan ,  Jimmy C. Tan ,  Chuan-Chu Chou

发明人： Kevin W. Moore ,  Ying Liu ,  Alice Suk-Yue Ho ,  Di-Hwei Hsu ,  J. Fernando Bazan ,  Jimmy C. Tan ,  Chuan-Chu Chou

IPC分类号： G01N33/577 ,  A61K38/00 ,  A61K39/395 ,  A61P31/04 ,  A61P37/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/715 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  C07K16/28 ,  C12N5/12 ,  G01N33/53

CPC分类号： C07K14/7155 ,  C07K14/5428 ,  A61K38/00 ,  C07K2319/00

摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.

摘要翻译： 分离和表征IL-10的受体组分。 公开了编码受体的各种变体的氨基酸序列和核酸。 公开了纯化的受体基因和多肽的用途，包括用于筛选受体配体的激动剂和拮抗剂，用于产生诊断或治疗试剂以及产生抗体的手段。 还提供治疗或诊断试剂和试剂盒。

公开(公告)号：US5853977A

公开(公告)日：1998-12-29

申请号：US889909

申请日：1997-07-10

申请人： Barbara Dalie ,  Xuedong Fan ,  Daniel Lundell ,  Charles A. Lunn ,  Jimmy C. Tan ,  Paul J. Zavodny

发明人： Barbara Dalie ,  Xuedong Fan ,  Daniel Lundell ,  Charles A. Lunn ,  Jimmy C. Tan ,  Paul J. Zavodny

IPC分类号： C12N9/64 ,  C12Q1/37 ,  C12Q1/00 ,  C12N9/48 ,  C12N9/50

CPC分类号： C12N9/6489 ,  C12N9/6424 ,  C12Q1/37 ,  C12Y304/24086 ,  G01N2333/525 ,  G01N2333/96486

摘要： The present invention provides isolated human and bovine TNF-.alpha. convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-.alpha.. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-.alpha. convertases, and for identifying nucleic acids encoding such convertases.

摘要翻译： 本发明提供分离的人和牛TNF-α转化酶，编码它们的核酸和重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备转化酶的方法。 本发明进一步提供了与转化酶特异性结合并且可用于治疗由TNF-α引起或介导的医学病症的抗体及其抗原结合片段。 还提供了用于鉴定哺乳动物TNF-α转化酶的特异性抑制剂的筛选方法，以及用于鉴定编码这种转化酶的核酸。