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公开(公告)号：US06312680B1
公开(公告)日：2001-11-06
申请号：US08464488
申请日：1995-06-05
IPC分类号： A61K3820
CPC分类号： C07K14/5428 , Y10S514/825 , Y10S514/885 , Y10S930/141
摘要： Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-&ggr;.
摘要翻译： 哺乳动物基因和蛋白质被命名为细胞因子合成抑制因子（CSIFs，现在称为白细胞介素-10（IL-10）），其能够抑制与延迟型超敏反应相关的细胞因子的合成，并且与拮抗剂一起， 可用于治疗与细胞因子失衡相关的疾病，例如利什曼病和其他寄生虫感染，以及某些免疫疾病，包括由过量产生干扰素-γ引起的MHC相关的自身免疫性疾病。
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2.发明授权Nucleic acids encoding cytokine synthesis inhibitory factor (Interleukin-10) 失效核酸编码细胞因子合成抑制因子（Interleukin-10）
公开(公告)号：US6018036A
公开(公告)日：2000-01-25
申请号：US463876
申请日：1995-06-05
CPC分类号： C07K14/5428 , Y10S514/825 , Y10S514/885 , Y10S930/141
摘要： Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-.gamma..
摘要翻译： 提供了哺乳动物基因和蛋白质，命名为细胞因子合成抑制因子（CSIF，现在称为白细胞介素-10（IL-10）），其能够抑制与延迟型超敏反应相关的细胞因子的合成，并且与拮抗剂 可用于治疗与细胞因子失衡相关的疾病，例如利什曼病和其他寄生虫感染，以及某些免疫疾病，包括由过量产生干扰素-γ引起的MHC相关的自身免疫性疾病。
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公开(公告)号：US06239260B1
公开(公告)日：2001-05-29
申请号：US08467365
申请日：1995-06-06
IPC分类号： C07K1624
CPC分类号： C07K14/5428 , Y10S514/825 , Y10S514/885 , Y10S930/141
摘要： Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs) or interleukin 10 (IL-10), as well as antibodies which specifically bind IL-10, are provided. These proteins, and antibodies, may be used to treat various disease states associated with cytokine imbalances.
摘要翻译： 提供哺乳动物基因和蛋白质，称为细胞因子合成抑制因子（CSIF）或白细胞介素10（IL-10），以及特异性结合IL-10的抗体。 这些蛋白质和抗体可用于治疗与细胞因子失衡相关的各种疾病状态。
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4.发明授权Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) 失效核酸编码细胞因子合成抑制因子（interleukin-10）
公开(公告)号：US5231012A
公开(公告)日：1993-07-27
申请号：US917806
申请日：1992-07-20
CPC分类号： C07K16/244 , C07K14/5428 , A61K38/00 , Y10S930/141
摘要： Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs) (now known as interleukin -10), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-.gamma..
摘要翻译： 提供哺乳动物基因和蛋白质，称为细胞因子合成抑制因子（CSIF）（现在称为白介素-10），其能够抑制与延迟型超敏反应相关的细胞因子的合成，并且其与拮抗剂一起可用于 治疗与细胞因子失衡相关的疾病，例如利什曼病和其他寄生虫感染，以及某些免疫疾病，包括由过量产生干扰素-γ引起的MHC相关的自身免疫性疾病。
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5.发明授权Methods of treatment using antagonists of cytokine synthesis inhibitory factor 失效使用拮抗剂的细胞因子合成抑制因子的治疗方法公开(公告)号：US06207154B1
公开(公告)日：2001-03-27
申请号：US08467374
申请日：1995-06-06
IPC分类号： A61K39395
CPC分类号： C07K14/5428 , Y10S514/825 , Y10S514/885 , Y10S930/141
摘要： Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-&ggr;.
摘要翻译： 提供了哺乳动物基因和蛋白质，命名为细胞因子合成抑制因子（CSIF，现在称为白细胞介素-10（IL-10）），其能够抑制与延迟型超敏反应相关的细胞因子的合成，并且与拮抗剂 可用于治疗与细胞因子失衡相关的疾病，例如利什曼病和其他寄生虫感染，以及某些免疫疾病，包括由过量产生干扰素-γ引起的MHC相关的自身免疫性疾病。
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6.发明授权Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof 失效细胞因子合成抑制因子（IL-10）及其药物组合物公开(公告)号：US06217857B1
公开(公告)日：2001-04-17
申请号：US08464110
申请日：1995-06-05
IPC分类号： A61K3820
CPC分类号： C07K14/5428 , A61K38/00 , C07K16/244 , Y02A50/409
摘要： Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIF's, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-&ggr;.
摘要翻译： 提供哺乳动物基因和蛋白质，称为细胞因子合成抑制因子（CSIF's，现在称为白细胞介素-10（IL-10）），其能够抑制与延迟型超敏反应相关的细胞因子的合成，并且与拮抗剂 可用于治疗与细胞因子失衡相关的疾病，例如利什曼病和其他寄生虫感染，以及某些免疫疾病，包括由过量产生干扰素-γ引起的MHC相关的自身免疫性疾病。
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7.发明授权Methods of treating insulin-dependent diabetes mellitus by administration of IL-10 失效通过施用IL-10治疗胰岛素依赖性糖尿病的方法
公开(公告)号：US5827513A
公开(公告)日：1998-10-27
申请号：US406929
申请日：1995-03-30
CPC分类号： A61K38/2066 , Y10S514/866
摘要： Disclosed is a method for treating an individual who is predisposed to develop insulin-dependent diabetes mellitus. To practice the method, an amount of interleukin-10 protein effective to maintain blood glucose levels at a non-diabetic level is administered to an individual predisposed to develop the disease.
摘要翻译： PCT No.PCT / US93 / 09030 Sec。 371日期1995年3月30日 102（e）1995年3月30日PCT PCT 1993年9月28日PCT公布。 公开号WO94 / 08606 日期1994年04月28日被公开是治疗倾向于发展胰岛素依赖性糖尿病的个体的方法。 为了实施该方法，将一定量的有效维持非糖尿病水平的血糖水平的白细胞介素-10蛋白施用于易于发展该疾病的个体。
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