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1.发明授权公开(公告)号：US10450600B2
公开(公告)日：2019-10-22
申请号：US12267421
申请日：2008-11-07
申请人： Tae Sun Kim , Keum Soo Song , Woon Yong Eoum , Chan Young Jung
发明人： Tae Sun Kim , Keum Soo Song , Woon Yong Eoum , Chan Young Jung
IPC分类号： C12Q1/68 , C12Q1/6837
摘要： The present invention relates to a method of designing DNA probe chip for room-temperature hybridization in order to solve the solvent evaporation problem occurring when carrying out said hybridization at a high temperature of 40° C.˜50° C. or higher, wherein the method is designed to allow genotyping through hybridizing at a room temperature of 20° C.˜30° C. The method of designing DNA probe chip comprises designing DNA probe to start at −10˜+5 position that is between −10 position which is overlapped 10 sequences with primer and +5 position which is 5 sequences far from the 3′-terminal of primer, based on 0 position which is 3′-terminal of primer.
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2.发明授权Modified glass fiber with monolayer of aminocalixarene derivatives and iminecalixarene derivatives 有权改性玻璃纤维与单分散的氨基焦虑衍生物和亚氨基癸烷衍生物公开(公告)号：US08288443B2
公开(公告)日：2012-10-16
申请号：US12266480
申请日：2008-11-06
申请人： Tae Sun Kim , Keum Soo Song , Hyung Sub Kim
发明人： Tae Sun Kim , Keum Soo Song , Hyung Sub Kim
CPC分类号： G01N33/552
摘要： Techniques for a surface-modified glass fiber with monolayer of aminocalixarene derivatives and iminecalixrene derivatives are provided.
摘要翻译： 提供了具有单层氨基焦虑衍生物和亚胺癸内酯衍生物的表面改性玻璃纤维的技术。
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3.发明申请NOVEL METHOD OF DESIGNING DNA PROBE CHIP FOR ROOM TEMPERATURE HYBRIDIZATION AND THE DNA PROBE CHIP 审中-公开设计用于室温杂交的DNA探针芯片的新方法和DNA探针芯片公开(公告)号：US20090203005A1
公开(公告)日：2009-08-13
申请号：US12267421
申请日：2008-11-07
申请人： Tae Sun Kim , Keum Soo Song , Woon Yong Eoum , Chan Young Jung
发明人： Tae Sun Kim , Keum Soo Song , Woon Yong Eoum , Chan Young Jung
CPC分类号： C12Q1/6837 , B01J2219/00527 , B01J2219/00596 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722
摘要： The present invention relates to a method of designing DNA probe chip for room-temperature hybridization in order to solve the solvent evaporation problem occurring when carrying out said hybridization at a high temperature of 40° C.˜50° C. or higher, wherein the method is designed to allow genotyping through hybridizing at a room temperature of 20° C.˜30° C. The method of designing DNA probe chip comprises designing DNA probe to start at −10˜+5 position that is between −10 position which is overlapped 10 sequences with primer and +5 position which is 5 sequences far from the 3′-terminal of primer, based on 0 position which is 3′-terminal of primer.
摘要翻译： 本发明涉及设计用于室温杂交的DNA探针芯片的方法，以解决在40℃〜50℃以上的高温下进行杂交时发生的溶剂蒸发问题，其中， 设计方法是通过在20°C〜30°C的室温下进行杂交进行基因分型。设计DNA探针芯片的方法包括设计DNA探针，在-10〜+ 5位置开始，位于-10位置之间 基于引物3'末端的0位，重叠10个具有引物和+5位的序列，其为远离引物3'末端的5个序列。
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4.发明申请MODIFIED GLASS FIBER WITH MONOLAYER OF AMINOCALIXARENE DERIVATIVES AND IMINECALIXARENE DERIVATIVES 有权改性玻璃纤维与单胺衍生物和亚胺基二烯衍生物单体公开(公告)号：US20090191554A1
公开(公告)日：2009-07-30
申请号：US12266480
申请日：2008-11-06
申请人： Tae Sun Kim , Keum Soo Song , Hyung Sub Kim
发明人： Tae Sun Kim , Keum Soo Song , Hyung Sub Kim
IPC分类号： C12Q1/68
CPC分类号： G01N33/552
摘要： Techniques for a surface-modified glass fiber with monolayer of aminocalixarene derivatives and iminecalixrene derivatives are provided.
摘要翻译： 提供了具有单层氨基焦虑衍生物和亚胺癸内酯衍生物的表面改性玻璃纤维的技术。
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5.发明申请Novel Iminecalixarene Derivatives and Aminocalixarene Derivatives, Method of Preparation Thereof, and Self-Assembled Monolayer Prepared by the Method, Fixing Method of Oligo-Dna By Using the Self-Assembled Monolayer, and Oligo-Dna Chip Prepared By the Method 有权新型咪唑烷衍生物和氨基焦虑衍生物及其制备方法，以及通过使用自组装单层的方法制备寡聚-Dna的固定方法和通过该方法制备的寡聚-Dna芯片制备的自组装单层公开(公告)号：US20080305477A1
公开(公告)日：2008-12-11
申请号：US11816022
申请日：2006-05-11
申请人： Tae Sun Kim , Keum Soo Song , Jung Hoon Kim , Hyung Sub Kim
发明人： Tae Sun Kim , Keum Soo Song , Jung Hoon Kim , Hyung Sub Kim
IPC分类号： C07C215/80 , C07C229/52 , C07C227/00 , C12Q1/68
CPC分类号： C07C251/24 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C07C2603/92
摘要： The present invention relates to novel iminecalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method. Also, the present invention relates to novel aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA wherein the oligo-DNA is voluntarily fixed by molecular recognition on said self-assembled monolayer in a liquid phase, and oligo-DNA chip prepared by the method.
摘要翻译： 本发明涉及新颖的亚氨基癸烷衍生物，其制备方法和通过该方法制备的自组装单层，通过使用自组装单层固定寡DNA的方法，以及通过该方法制备的寡核苷酸芯片。 此外，本发明涉及新型氨基焦虑衍生物，其制备方法和通过该方法制备的自组装单层，其中通过分子识别在所述自组装单层上自愿固定寡DNA的寡DNA的固定方法 液相和通过该方法制备的寡核苷酸芯片。
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6.发明授权Iminecalixarene derivatives and aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method 有权咪草胺衍生物和氨基焦虑衍生物，其制备方法和通过该方法制备的自组装单层，通过使用自组装单层固定寡DNA的方法，以及通过该方法制备的寡核苷酸芯片公开(公告)号：US08013188B2
公开(公告)日：2011-09-06
申请号：US11816022
申请日：2006-05-11
申请人： Tae Sun Kim , Keum Soo Song , Jung Hoon Kim , Hyung Sub Kim
发明人： Tae Sun Kim , Keum Soo Song , Jung Hoon Kim , Hyung Sub Kim
IPC分类号： C07C211/00
CPC分类号： C07C251/24 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C07C2603/92
摘要： The present invention relates to novel iminecalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method. Also, the present invention relates to novel aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA wherein the oligo-DNA is voluntarily fixed by molecular recognition on said self-assembled monolayer in a liquid phase, and oligo-DNA chip prepared by the method.
摘要翻译： 本发明涉及新颖的亚氨基癸烷衍生物，其制备方法和通过该方法制备的自组装单层，通过使用自组装单层固定寡DNA的方法，以及通过该方法制备的寡核苷酸芯片。 此外，本发明涉及新型氨基焦虑衍生物，其制备方法和通过该方法制备的自组装单层，其中通过分子识别在所述自组装单层上自愿固定寡DNA的寡DNA的固定方法 液相和通过该方法制备的寡核苷酸芯片。
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7.发明申请Novel Iminecalixarene Derivatives, Method for Preparing the Same, Self-Assembled Monolayer Prepared by Using the Iminecalixarene Derivatives or Aminocalixarene, and Protein Chip Using the Self-Assembled Monolayer 审中-公开新型咪唑烷衍生物，其制备方法，使用咪唑烷衍生物或氨基焦虑剂制备的自组装单层和使用自组装单层的蛋白芯片公开(公告)号：US20080194798A1
公开(公告)日：2008-08-14
申请号：US11910164
申请日：2006-06-14
申请人： Tae Sun Kim , Keum Soo Song , Jung Hoon Kim
发明人： Tae Sun Kim , Keum Soo Song , Jung Hoon Kim
IPC分类号： C07K16/00 , C07C211/40
CPC分类号： G01N33/54353 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C07C251/24 , C07C2603/92 , G01N2610/00
摘要： The present invention relates to iminecalixarene derivatives, iminecalixarene derivative monolayers prepared as a monolayer on a solid substrate by using said iminecalixarene derivatives, a protein chip substrate prepared by fixing all kinds of proteins on a chip substrate in a solution phase without any treatment, while ammonium groups on the surface of the proteins are irreversibly recognized by said iminecalixarene derivative monolayer, and protein chips prepared by using the protein fixation on said substrate.
摘要翻译： 本发明涉及通过使用所述亚氨基癸烷衍生物在固体底物上制备为单层的亚氨基癸烷衍生物单层，通过在溶液相中将各种蛋白质固定在芯片基底上而不进行任何处理制备的蛋白质芯片底物，而铵 所述蛋白质表面上的基团不可逆地被所述亚氨基二环衍生物单层识别，并且通过使用蛋白质固定在所述底物上制备的蛋白质芯片。
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8.发明授权Iminecalixarene derivatives and aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method 有权咪草胺衍生物和氨基焦虑衍生物，其制备方法和通过该方法制备的自组装单层，通过使用自组装单层固定寡DNA的方法，以及通过该方法制备的寡核苷酸芯片公开(公告)号：US08501996B2
公开(公告)日：2013-08-06
申请号：US13192268
申请日：2011-07-27
申请人： Tae Sun Kim , Keum Soo Song , Jung Hoon Kim , Hyung Sub Kim
发明人： Tae Sun Kim , Keum Soo Song , Jung Hoon Kim , Hyung Sub Kim
IPC分类号： C07C211/00
CPC分类号： C07C251/24 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C07C2603/92
摘要： The present invention relates to novel iminecalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method. Also, the present invention relates to novel aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA wherein the oligo-DNA is voluntarily fixed by molecular recognition on said self-assembled monolayer in a liquid phase, and oligo-DNA chip prepared by the method.
摘要翻译： 本发明涉及新颖的亚氨基癸烷衍生物，其制备方法和通过该方法制备的自组装单层，通过使用自组装单层固定寡DNA的方法，以及通过该方法制备的寡核苷酸芯片。 此外，本发明涉及新型氨基焦虑衍生物，其制备方法和通过该方法制备的自组装单层，其中通过分子识别在所述自组装单层上自愿固定寡DNA的寡DNA的固定方法 液相和通过该方法制备的寡核苷酸芯片。
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9.发明申请NOVEL IMINECALIXARENE DERIVATIVES AND AMINOCALIXARENE DERIVATIVES, METHOD OF PREPARATION THEREOF, AND SELF-ASSEMBLED MONOLAYER PREPARED BY THE METHOD, FIXING METHOD OF OLIGO-DNA BY USING THE SELF-ASSEMBLED MONOLAYER, AND OLIGO-DNA CHIP PREPARED BY THE METHOD 有权新方法衍生物及其制备方法及其制备方法，通过使用自组装单体的OLIGO-DNA的固定方法和通过该方法制备的寡核苷酸芯片制备的自由基衍生物和氨基胆碱衍生物公开(公告)号：US20120202711A1
公开(公告)日：2012-08-09
申请号：US13192268
申请日：2011-07-27
申请人： Tae Sun Kim , Keum Soo Song , Jung Hoon Kim , Hyung Sub Kim
发明人： Tae Sun Kim , Keum Soo Song , Jung Hoon Kim , Hyung Sub Kim
CPC分类号： C07C251/24 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C07C2603/92
摘要： The present invention relates to novel iminecalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method. Also, the present invention relates to novel aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA wherein the oligo-DNA is voluntarily fixed by molecular recognition on said self-assembled monolayer in a liquid phase, and oligo-DNA chip prepared by the method.
摘要翻译： 本发明涉及新颖的亚氨基癸烷衍生物，其制备方法和通过该方法制备的自组装单层，通过使用自组装单层固定寡DNA的方法，以及通过该方法制备的寡核苷酸芯片。 此外，本发明涉及新型氨基焦虑衍生物，其制备方法和通过该方法制备的自组装单层，其中通过分子识别在所述自组装单层上自愿固定寡DNA的寡DNA的固定方法 液相和通过该方法制备的寡核苷酸芯片。
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