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1.发明授权公开(公告)号：US06908748B2
公开(公告)日：2005-06-21
申请号：US10058518
申请日：2002-01-28
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译： 使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。 使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。 由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。 证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。 该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。
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2.发明授权公开(公告)号：US07279558B2
公开(公告)日：2007-10-09
申请号：US11051410
申请日：2005-02-04
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译： 使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。 使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。 由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。 证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。 该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。
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3.发明申请公开(公告)号：US20050164934A1
公开(公告)日：2005-07-28
申请号：US11051410
申请日：2005-02-04
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , C07K14/705 , C07K16/28
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译： 使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。 使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。 由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。 证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。 该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。
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4.发明授权Proteins comprising calmodulin- and actin-binding human caldesmon polypeptide fragments 失效蛋白质包含钙调蛋白和肌动蛋白结合的人钙二聚体多肽片段
公开(公告)号：US5532337A
公开(公告)日：1996-07-02
申请号：US285440
申请日：1994-08-04
申请人： Ken'ichiro Hayashi , Takashi Hashida , Kiyozo Asada , Hirokazu Kotani , Ikunoshin Kato , Kenji Sobue
发明人： Ken'ichiro Hayashi , Takashi Hashida , Kiyozo Asada , Hirokazu Kotani , Ikunoshin Kato , Kenji Sobue
IPC分类号： A61K38/00 , A61K31/00 , A61P35/00 , C07K14/435 , C07K14/47 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , G01N33/53 , C07K14/46 , C07K19/00
CPC分类号： C07K14/47
摘要： Provided are functional peptide fragments of human caldesmon having calmodulin and actin-binding activity, the amino acid sequences and nucleic acid sequences therefor.
摘要翻译： 提供具有钙调素和肌动蛋白结合活性的人钙调蛋白的功能性肽片段，其氨基酸序列及其核酸序列。
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5.发明申请公开(公告)号：US20080069826A1
公开(公告)日：2008-03-20
申请号：US11869267
申请日：2007-10-09
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译： 使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。 使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。 由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。 证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。 该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。
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6.发明授权公开(公告)号：US08110662B2
公开(公告)日：2012-02-07
申请号：US11869267
申请日：2007-10-09
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译： 使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。 使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。 由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。 证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。 该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。
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7.发明授权DNA encoding a protein comprising calmodulin-and actin-binding human caldesmon peptide fragment 失效编码包含钙调蛋白和与肌动蛋白结合的人钙蛋白多糖片段的蛋白质的DNA
公开(公告)号：US5739008A
公开(公告)日：1998-04-14
申请号：US630349
申请日：1996-04-10
申请人： Ken'ichiro Hayashi , Takashi Hashida , Kiyozo Asada , Hirokazu Kotani , Ikunoshin Kato , Kenji Sobue
发明人： Ken'ichiro Hayashi , Takashi Hashida , Kiyozo Asada , Hirokazu Kotani , Ikunoshin Kato , Kenji Sobue
IPC分类号： A61K38/00 , A61K31/00 , A61P35/00 , C07K14/435 , C07K14/47 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , G01N33/53 , C12N5/10 , C12N15/62 , C12N15/63
CPC分类号： C07K14/47
摘要： Provided are functional peptide fragments of human caldesmon having calmodulin and actin-binding activity, the amino acid sequences and nucleic acid sequences therefor.
摘要翻译： 提供具有钙调素和肌动蛋白结合活性的人钙调蛋白的功能性肽片段，其氨基酸序列及其核酸序列。
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