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    Aminophenylbenzothiazole compounds
    3.
    发明申请
    Aminophenylbenzothiazole compounds 审中-公开
    氨基苯基苯并噻唑化合物

    公开(公告)号：US20050175554A1

    公开(公告)日：2005-08-11

    申请号：US10511852

    申请日：2003-04-14

    申请人： Barbara Wagner ,  Thomas Ehlis ,  Sebastien Mongiat ,  Kai Eichin

    发明人： Barbara Wagner ,  Thomas Ehlis ,  Sebastien Mongiat ,  Kai Eichin

    IPC分类号： A61K8/00 ,  A61K8/49 ,  A61K8/893 ,  A61K8/894 ,  A61K8/898 ,  A61K8/92 ,  A61K31/428 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/12 ,  A61Q5/02 ,  A61Q17/04 ,  A61Q19/00 ,  C07D277/66 ,  A61K7/42 ,  C07D277/60

    CPC分类号： A61K8/49 ,  A61K8/893 ,  A61K8/894 ,  A61Q17/04 ,  C07D277/66

    摘要： The Use, as a UV filter, of a compound of formula (I), wherein R1 and R2 are each independently of the other hydrogen; unsubstituted or halo-, amino-, mono- or di-C1-C5alkylamino-, cyano- or C1-C5alkoxy-substituted C1-C22alkyl, C5-C10cycloalkyl, carboxy-C1-C22alkyl, carboxy-C6-C10aryl, C6-C10aryl, C6-C10aryl-C1-C5alkyl; carbamoyl; or sulfamoyl; or R1 and R2, together with the nitrogen atom linking them, form a 5- to 7-membered heterocyclic radical; and R3 is hydrogen; or C1-C22alkyl; and R4 is hydrogen; hydroxy; C1-C22alkyl; or C1-C22alkoxy; is described. The compounds of formula (I) are suitable especially as UV filters in cosmetic preparations.

    摘要翻译： 用作UV过滤器的式（I）化合物，其中R 1和R 2各自独立于另一个氢; 未取代的或卤代，氨基 - ，单 - 或二-C 1 -C 5烷基氨基 - ，氰基 - 或C 1 -C 1 - C 5烷氧基取代的C 1 -C 22烷基，C 5 -C 10烷基，C 5 -C 20烷基， 环烷基，羧基-C 1 -C 22烷基，羧基-C 6 -C 10芳基，C 1 -C 6烷基， C 6 -C 10芳基，C 6 -C 10芳基-C 1 - C 5烷基; 氨基甲酰基; 或氨磺酰; 或R 1和R 2 2与连接它们的氮原子一起形成5-至7-元杂环基; 和R 3是氢; 或C 1 -C 22烷基; 并且R 4是氢; 羟基; C 1 -C 22烷基; C 1 -C 12烷基; 或C 1 -C 22烷氧基; 被描述。 式（I）的化合物特别适用于化妆品制剂中的UV过滤器。

    Use of benzotropolone derivatives as UV absorbers and antioxidants and their use in sunscreens and/or cosmetic compositions
    4.
    发明授权
    Use of benzotropolone derivatives as UV absorbers and antioxidants and their use in sunscreens and/or cosmetic compositions 有权

    公开(公告)号：US09707417B2

    公开(公告)日：2017-07-18

    申请号：US13000163

    申请日：2009-06-18

    申请人： Barbara Wagner ,  Reinhold Öhrlein ,  Bernd Herzog ,  Kai Eichin ,  Gabriele Baisch ,  Stephanie Portmann

    发明人： Barbara Wagner ,  Reinhold Öhrlein ,  Bernd Herzog ,  Kai Eichin ,  Gabriele Baisch ,  Stephanie Portmann

    IPC分类号： A61K8/49 ,  A61Q17/04 ,  A61K8/35 ,  A61Q19/08 ,  C07C49/747 ,  C07C62/38 ,  C07C69/712 ,  C07C69/757 ,  C07C305/18 ,  C07F9/40 ,  C07H15/18 ,  C07H15/203 ,  C07H15/26

    CPC分类号： A61Q17/04 ,  A61K8/35 ,  A61Q19/08 ,  C07C49/747 ,  C07C62/38 ,  C07C69/712 ,  C07C69/757 ,  C07C305/18 ,  C07C2602/12 ,  C07F9/4006 ,  C07H15/18 ,  C07H15/203 ,  C07H15/26

    摘要： Described is the use of benzotropolone and their derivatives, especially the compounds of formula (1); wherein R2, R3, R4, R5 and R6 independently of one another are hydrogen; OH; C1-C30alkyl, C2-C30al-kenyl, C1-C30alkoxy, C3-C12cycloalkyl or C1C30hydroxyalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G, C2-C18alkenyl, C2-C18alkynyl, C7-C25aralkyl, CN, or —CO—R17; C1-C30mono- or dialkylamino; COR9; COOR9; CONR9R10; CN; SO2R9; OCOOR9; OCOR9; NHCOOR9; NR9COR10; NH2; *—(CO)—NH—(CH2)n1—(PO)—(OR11)2; —(CO)—O—(CH2)n1—(PO)—(OR11)2; sulphate; sulphonate; phosphate; phosphonate; —(CH2)n2—[O—(SO2)]n3—OR11; —O—(CH2)n4(CO)n5—R11; —(O)n6—(CH2)n7—(PO)—(OR9)2; —(O)n6—(CH2)n7—SO2—OR9; halogen; organosilanyl; organo-siloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n—(X1)1 or 0-benzotropolone system, wherein n=1-10 and X1═—O—; —(CO)—; —O—CO—; —COO—, —NH—; —S—; —SO2—); R1, R7 and R8 independently of one another are hydrogen; C1C12alkyl or C3-C12-cycloalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G, C2-C18alkenyl, C2-C18alkynyl, C7-C25aralkyl, or COOR9; COR9; CONR9R10; SO3R9; SO2R9; PO3(R9)2; PO2(R9)2; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n—(X2)1 or 0—*, wherein n=1-10 and X2═—C(═O)—; —O—CO—*); R9 and R10 independently from each other are hydrogen; C1C18alkyl or C3-C12-cycloalkyl which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n—*, wherein n=1-10); or R9 and R10 together form a five or six membered ring, R11 is hydrogen; or C1-C5alkyl; n1, n2, n4 and n7 independently from each other are a number from 1 to 5; n3, n5 and n6 independently from each other are a 0; or 1; D is —CO—; —COO—; —S—; —SO—; —SO2-; —O—; —NR14—; —S1R19R20—; —POR11—; —CR12═CR13—; or —C≡C—; and E is —OR18; —SR18; —NR14R15; —NR14COR15; —COR17; —COOR16; —CONR14R15; —CN; halogen; Or SO3R18; SO2R18; PO3(R18)2; PO2(R18)2; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n-(X1)1 or 0—*, wherein n=1-10 and X1=—O—; —C(═O)—; —O—CO—; —COO—; —NH—; —S—; —SO2—); G is E; C1-C18alkyl, which is optionally interrupted by D; C1-C18perfluoroalkyl; C1-C18alkoxy, which is optionally substituted by E and/or interrupted by D; wherein R12, R13, R14 and R15 independently of each other are hydrogen; C6-C18aryl which is optionally substituted by OH, C1-C18alkyl or C1-C18alkoxy; C1-C18alkyl, which is optionally interrupted by —O—; or Ri4 and Ri5 together form a five or six membered ring, Ri6 is hydrogen; C6-Ci8aryl which is optionally substituted by OH, C1-C18alkyl or d-C18alkoxy; C1-C18alkyl which is optionally interrupted by —O—; R17 is H; C6-C18aryl which is optionally substituted by OH, C1-C18alkyl or C1-C18alkoxy; or d-C18alkyl which is optionally interrupted by —O—; R18 is hydrogen; C6-C18aryl, which is optionally substituted by OH, C1-C18alkyl or d-C18alkoxy; C1-C18alkyl, which is optionally interrupted by —O—; R19 and R20 independently of each other are hydrogen; C1-C18alkyl; C6-C18aryl which is optionally substituted by C1-C18alkyl; and R21 is C1-C18alkyl; or C6-C18aryl, which is substituted by C1-C18alkyl; * means, that this radical is directed to the benzotropolone moiety; for the protection of human and animal hair and skin against UV radiation.

    USE OF BENZOTROPOLONE DERIVATIVES AS UV ABSORBERS AND ANTIOXIDANTS AND THEIR USE IN SUNSCREENS AND/OR COSMETIC COMPOSITIONS
    6.
    发明申请
    USE OF BENZOTROPOLONE DERIVATIVES AS UV ABSORBERS AND ANTIOXIDANTS AND THEIR USE IN SUNSCREENS AND/OR COSMETIC COMPOSITIONS 有权

    公开(公告)号：US20110123468A1

    公开(公告)日：2011-05-26

    申请号：US13000163

    申请日：2009-06-18

    申请人： Barbara Wagner ,  Reinhold Ohrlein ,  Bernd Herzog ,  Kai Eichin ,  Gabriele Baisch ,  Stephanie Portmann

    发明人： Barbara Wagner ,  Reinhold Ohrlein ,  Bernd Herzog ,  Kai Eichin ,  Gabriele Baisch ,  Stephanie Portmann

    IPC分类号： A61K8/49 ,  A61K8/37 ,  A61K31/235 ,  A61K31/351 ,  C07C69/76 ,  C07D307/34 ,  A61K31/375 ,  A61K31/665 ,  A61Q19/04 ,  A61P39/06

    CPC分类号： A61Q17/04 ,  A61K8/35 ,  A61Q19/08 ,  C07C49/747 ,  C07C62/38 ,  C07C69/712 ,  C07C69/757 ,  C07C305/18 ,  C07C2602/12 ,  C07F9/4006 ,  C07H15/18 ,  C07H15/203 ,  C07H15/26

    摘要： Described is the use of benzotropolone and their derivatives, especially the compounds of formula (1); wherein R2, R3, R4, R5 and R6 independently of one another are hydrogen; OH; C1-C30alkyl, C2-C30al-kenyl, C1-C30alkoxy, C3-C12cycloalkyl or C1C30hydroxyalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G, C2-C18alkenyl, C2-C18alkynyl, C7-C25aralkyl, CN, or —CO—R17; C1-C30mono- or dialkylamino; COR9; COOR9; CONR9R10; CN; SO2R9; OCOOR9; OCOR9; NHCOOR9; NR9COR10; NH2; *—(CO)—NH—(CH2)n1—(PO)—(OR11)2; —(CO)—O—(CH2)n1—(PO)—(OR11)2; sulphate; sulphonate; phosphate; phosphonate; —(CH2)n2—[O—(SO2)]n3—OR11; —O—(CH2)n4(CO)n5—R11; —(O)n6—(CH2)n7—(PO)—(OR9)2; —(O)n6—(CH2)n7—SO2—OR9; halogen; organosilanyl; organo-siloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n—(X1)1 or 0-benzotropolone system, wherein n=1-10 and X1=—O—; —(CO)—; —O—CO—; —COO—, —NH—; —S—; —SO2—); R1, R7 and R8 independently of one another are hydrogen; C1C12alkyl or C3-C12-cycloalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G, C2-C18alkenyl, C2-C18alkynyl, C7-C25aralkyl, or COOR9; COR9; CONR9R10; SO3R9; SO2R9; PO3(R9)2; PO2(R9)2; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n—(X2)1 or 0—*, wherein n=1-10 and X2=—C(═O)—; —O—CO—*); R9 and R10 independently from each other are hydrogen; C1C18alkyl or C3-C12-cycloalkyl which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n—*, wherein n=1-10); or R9 and R10 together form a five or six membered ring, R11 is hydrogen; or C1-C5alkyl; n1, n2, n4 and n7 independently from each other are a number from 1 to 5; n3, n5 and n6 independently from each other are a 0; or 1; D is —CO—; —COO—; —S—; —SO—; —SO2-; —O—; —NR14—; —S1R19R20—; —POR11—; —CR12═CR13—; or —C≡C—; and E is —OR18; —SR18; —NR14R15; —NR14COR15; —COR17; —COOR16; —CONR14R15; —CN; halogen; Or SO3R18; SO2R18; PO3(R18)2; PO2(R18)2; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n-(X1)1 or 0—*, wherein n=1-10 and X1=—O—; —C(═O)—; —O—CO—; —COO—; —NH—; —S—; —SO2—); G is E; C1-C18alkyl, which is optionally interrupted by D; C1-C18perfluoroalkyl; C1-C18alkoxy, which is optionally substituted by E and/or interrupted by D; wherein R12, R13, R14 and R15 independently of each other are hydrogen; C6-C18aryl which is optionally substituted by OH, C1-C18alkyl or C1-C18alkoxy; C1-C18alkyl, which is optionally interrupted by —O—; or Ri4 and Ri5 together form a five or six membered ring, Ri6 is hydrogen; C6-Ci8aryl which is optionally substituted by OH, C1-C18alkyl or d-C18alkoxy; C1-C18alkyl which is optionally interrupted by —O—; R17 is H; C6-C18aryl which is optionally substituted by OH, C1-C18alkyl or C1-C18alkoxy; or d-C18alkyl which is optionally interrupted by —O—; R18 is hydrogen; C6-C18aryl, which is optionally substituted by OH, C1-C18alkyl or d-C18alkoxy; C1-C18alkyl, which is optionally interrupted by —O—; R19 and R20 independently of each other are hydrogen; C1-C18alkyl; C6-C18aryl which is optionally substituted by C1-C18alkyl; and R21 is C1-C18alkyl; or C6-C18aryl, which is substituted by C1-C18alkyl; * means, that this radical is directed to the benzotropolone moiety; for the protection of human and animal hair and skin against UV radiation.

    Aminophenylbenzothiazole compounds
    8.
    发明申请
    Aminophenylbenzothiazole compounds 审中-公开
    氨基苯基苯并噻唑化合物

    公开(公告)号：US20090068129A1

    公开(公告)日：2009-03-12

    申请号：US12284043

    申请日：2008-09-18

    申请人： Barbara Wagner ,  Thomas Ehlis ,  Sebastien Mongiat ,  Kai Eichin

    发明人： Barbara Wagner ,  Thomas Ehlis ,  Sebastien Mongiat ,  Kai Eichin

    IPC分类号： A61K8/49 ,  C07D277/66

    CPC分类号： A61K8/49 ,  A61K8/893 ,  A61K8/894 ,  A61Q17/04 ,  C07D277/66

    摘要： The Use, as a UV filter, of a compound of formula R1 and R2 are each independently of the other hydrogen; unsubstituted or halo-, amino-, mono- or di-C1-C5alkylamino-, cyano- or C1-C5alkoxy-substituted C1-C22alkyl, C5-C10cycloalkyl, carboxy-C1-C22alkyl, carboxy-C6-C10aryl, C6-C10aryl, C6-C10aryl-C1-C5alkyl; carbamoyl; or sulfamoyl; or R1 and R2, together with the nitrogen atom linking them, form a 5- to 7-membered heterocyclic radical; and R3 is hydrogen; or C1-C22alkyl; and R4 is hydrogen; hydroxy; C1-C22alkyl; or C1-C22alkoxy; is described. The compounds of formula (1) are suitable especially as UV filters in cosmetic preparations.

    摘要翻译： 使用式R 1和R 2的化合物作为UV过滤器各自独立于另一个氢; 未取代或卤代，氨基 - ，单 - 或二-C 1 -C 5烷基氨基 - ，氰基 - 或C 1 -C 5烷氧基取代的C 1 -C 22烷基，C 5 -C 10环烷基，羧基-C 1 -C 22烷基，羧基-C 6 -C 10芳基，C 6 -C 10芳基， C 6 -C 10芳基-C 1 -C 5烷基; 氨基甲酰基; 或氨磺酰; 或R 1和R 2与连接它们的氮原子一起形成5-至7-元杂环基; 并且R 3是氢; 或C 1 -C 22烷基; R4为氢; 羟基; C 1 -C 22烷基; 或C 1 -C 22烷氧基; 被描述。 式（1）的化合物特别适用于化妆品制剂中的UV过滤器。

    Merocyanine derivatives for cosmetic use
    10.
    发明授权
    Merocyanine derivatives for cosmetic use 有权

    公开(公告)号：US07407648B2

    公开(公告)日：2008-08-05

    申请号：US10520840

    申请日：2003-07-01

    申请人： Barbara Wagner ,  Thomas Ehlis ,  Kai Eichin

    发明人： Barbara Wagner ,  Thomas Ehlis ,  Kai Eichin

    IPC分类号： A61Q17/04 ,  A61K8/37 ,  A61K31/21 ,  A61K31/235 ,  A61K31/10 ,  A61K31/04 ,  A61K8/04 ,  A61Q1/10 ,  A01N37/00 ,  A01N31/235 ,  A01N41/10 ,  A01N33/24

    CPC分类号： C07D239/54 ,  A61K8/4906 ,  A61Q17/04 ,  C07C255/30 ,  C07C255/31 ,  C07C2601/16 ,  C07D207/20 ,  C07D231/36 ,  C07D263/14 ,  C07D277/10 ,  C07D295/145 ,  C07D295/155 ,  C07D319/06

    摘要： The use is described of merocyanine derivatives of formula (1), wherein R1 and R2 are each independently of the other hydrogen; C1-C22alkyl; cyclo-C3C8alkyl; or unsubstituted or C1-C5alkyl- or C1-C5alkoxy-substituted C6-C20aryl; orl; or R1 and R2 together with the nitrogen atom linking them form a —(CH2)m— ring which is uninterrupted or, interrupted by —O— or by —NH—; R3 is a cyano group; —COOR5; —CONHR5; —COR5; or —SO2R5; R4 is a cyano group; —COOR6; —CONHR6; —COR6; or —SO2R6; R5 and R6 are each independently of the other C1-C22alkyl; or unsubstituted or C1-C5alkyl substituted C6-C20aryl; or R3 and R4 together or R5 and R6 together form in a 5- to 7-membered, monocyclic, carbocyclic or heterocyclic ring; Z1, and Z2 are each independently of the other a —(CH2)n— group which is uninterrupted or interrupted by —O—, —S—, or by —NR7—, and/or is unsubstituted or substituted by C1-C5alkyl; R7 is (ClC5alkyl; 1 is from 1 to 4; m is from 1 to 7; n is from 1 to 4; when n=2, R1, R5 or R6 is a bivalent alkyl group; or R1, and R2 together with the 2 nitrogen atoms linking them form a —(CH2)m— ring; when n=3, R1, R5 or R6 is a trivalent alkyl group; when n=4, R1, R5 or R6 is a tetravalent alkyl group; and R1, and R2 in formula (1) are not simultaneously hydrogen, in protecting human and animal hair and skin from UV radiation.