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    Aminophenylbenzothiazole compounds
    2.
    发明申请
    Aminophenylbenzothiazole compounds 审中-公开
    氨基苯基苯并噻唑化合物

    公开(公告)号：US20050175554A1

    公开(公告)日：2005-08-11

    申请号：US10511852

    申请日：2003-04-14

    申请人： Barbara Wagner ,  Thomas Ehlis ,  Sebastien Mongiat ,  Kai Eichin

    发明人： Barbara Wagner ,  Thomas Ehlis ,  Sebastien Mongiat ,  Kai Eichin

    IPC分类号： A61K8/00 ,  A61K8/49 ,  A61K8/893 ,  A61K8/894 ,  A61K8/898 ,  A61K8/92 ,  A61K31/428 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/12 ,  A61Q5/02 ,  A61Q17/04 ,  A61Q19/00 ,  C07D277/66 ,  A61K7/42 ,  C07D277/60

    CPC分类号： A61K8/49 ,  A61K8/893 ,  A61K8/894 ,  A61Q17/04 ,  C07D277/66

    摘要： The Use, as a UV filter, of a compound of formula (I), wherein R1 and R2 are each independently of the other hydrogen; unsubstituted or halo-, amino-, mono- or di-C1-C5alkylamino-, cyano- or C1-C5alkoxy-substituted C1-C22alkyl, C5-C10cycloalkyl, carboxy-C1-C22alkyl, carboxy-C6-C10aryl, C6-C10aryl, C6-C10aryl-C1-C5alkyl; carbamoyl; or sulfamoyl; or R1 and R2, together with the nitrogen atom linking them, form a 5- to 7-membered heterocyclic radical; and R3 is hydrogen; or C1-C22alkyl; and R4 is hydrogen; hydroxy; C1-C22alkyl; or C1-C22alkoxy; is described. The compounds of formula (I) are suitable especially as UV filters in cosmetic preparations.

    摘要翻译： 用作UV过滤器的式（I）化合物，其中R 1和R 2各自独立于另一个氢; 未取代的或卤代，氨基 - ，单 - 或二-C 1 -C 5烷基氨基 - ，氰基 - 或C 1 -C 1 - C 5烷氧基取代的C 1 -C 22烷基，C 5 -C 10烷基，C 5 -C 20烷基， 环烷基，羧基-C 1 -C 22烷基，羧基-C 6 -C 10芳基，C 1 -C 6烷基， C 6 -C 10芳基，C 6 -C 10芳基-C 1 - C 5烷基; 氨基甲酰基; 或氨磺酰; 或R 1和R 2 2与连接它们的氮原子一起形成5-至7-元杂环基; 和R 3是氢; 或C 1 -C 22烷基; 并且R 4是氢; 羟基; C 1 -C 22烷基; C 1 -C 12烷基; 或C 1 -C 22烷氧基; 被描述。 式（I）的化合物特别适用于化妆品制剂中的UV过滤器。

    Aminophenylbenzothiazole compounds
    3.
    发明申请
    Aminophenylbenzothiazole compounds 审中-公开
    氨基苯基苯并噻唑化合物

    公开(公告)号：US20090068129A1

    公开(公告)日：2009-03-12

    申请号：US12284043

    申请日：2008-09-18

    申请人： Barbara Wagner ,  Thomas Ehlis ,  Sebastien Mongiat ,  Kai Eichin

    发明人： Barbara Wagner ,  Thomas Ehlis ,  Sebastien Mongiat ,  Kai Eichin

    IPC分类号： A61K8/49 ,  C07D277/66

    CPC分类号： A61K8/49 ,  A61K8/893 ,  A61K8/894 ,  A61Q17/04 ,  C07D277/66

    摘要： The Use, as a UV filter, of a compound of formula R1 and R2 are each independently of the other hydrogen; unsubstituted or halo-, amino-, mono- or di-C1-C5alkylamino-, cyano- or C1-C5alkoxy-substituted C1-C22alkyl, C5-C10cycloalkyl, carboxy-C1-C22alkyl, carboxy-C6-C10aryl, C6-C10aryl, C6-C10aryl-C1-C5alkyl; carbamoyl; or sulfamoyl; or R1 and R2, together with the nitrogen atom linking them, form a 5- to 7-membered heterocyclic radical; and R3 is hydrogen; or C1-C22alkyl; and R4 is hydrogen; hydroxy; C1-C22alkyl; or C1-C22alkoxy; is described. The compounds of formula (1) are suitable especially as UV filters in cosmetic preparations.

    摘要翻译： 使用式R 1和R 2的化合物作为UV过滤器各自独立于另一个氢; 未取代或卤代，氨基 - ，单 - 或二-C 1 -C 5烷基氨基 - ，氰基 - 或C 1 -C 5烷氧基取代的C 1 -C 22烷基，C 5 -C 10环烷基，羧基-C 1 -C 22烷基，羧基-C 6 -C 10芳基，C 6 -C 10芳基， C 6 -C 10芳基-C 1 -C 5烷基; 氨基甲酰基; 或氨磺酰; 或R 1和R 2与连接它们的氮原子一起形成5-至7-元杂环基; 并且R 3是氢; 或C 1 -C 22烷基; R4为氢; 羟基; C 1 -C 22烷基; 或C 1 -C 22烷氧基; 被描述。 式（1）的化合物特别适用于化妆品制剂中的UV过滤器。

    Merocyanine derivatives for cosmetic use
    5.
    发明授权
    Merocyanine derivatives for cosmetic use 有权

    公开(公告)号：US07407648B2

    公开(公告)日：2008-08-05

    申请号：US10520840

    申请日：2003-07-01

    申请人： Barbara Wagner ,  Thomas Ehlis ,  Kai Eichin

    发明人： Barbara Wagner ,  Thomas Ehlis ,  Kai Eichin

    IPC分类号： A61Q17/04 ,  A61K8/37 ,  A61K31/21 ,  A61K31/235 ,  A61K31/10 ,  A61K31/04 ,  A61K8/04 ,  A61Q1/10 ,  A01N37/00 ,  A01N31/235 ,  A01N41/10 ,  A01N33/24

    CPC分类号： C07D239/54 ,  A61K8/4906 ,  A61Q17/04 ,  C07C255/30 ,  C07C255/31 ,  C07C2601/16 ,  C07D207/20 ,  C07D231/36 ,  C07D263/14 ,  C07D277/10 ,  C07D295/145 ,  C07D295/155 ,  C07D319/06

    摘要： The use is described of merocyanine derivatives of formula (1), wherein R1 and R2 are each independently of the other hydrogen; C1-C22alkyl; cyclo-C3C8alkyl; or unsubstituted or C1-C5alkyl- or C1-C5alkoxy-substituted C6-C20aryl; orl; or R1 and R2 together with the nitrogen atom linking them form a —(CH2)m— ring which is uninterrupted or, interrupted by —O— or by —NH—; R3 is a cyano group; —COOR5; —CONHR5; —COR5; or —SO2R5; R4 is a cyano group; —COOR6; —CONHR6; —COR6; or —SO2R6; R5 and R6 are each independently of the other C1-C22alkyl; or unsubstituted or C1-C5alkyl substituted C6-C20aryl; or R3 and R4 together or R5 and R6 together form in a 5- to 7-membered, monocyclic, carbocyclic or heterocyclic ring; Z1, and Z2 are each independently of the other a —(CH2)n— group which is uninterrupted or interrupted by —O—, —S—, or by —NR7—, and/or is unsubstituted or substituted by C1-C5alkyl; R7 is (ClC5alkyl; 1 is from 1 to 4; m is from 1 to 7; n is from 1 to 4; when n=2, R1, R5 or R6 is a bivalent alkyl group; or R1, and R2 together with the 2 nitrogen atoms linking them form a —(CH2)m— ring; when n=3, R1, R5 or R6 is a trivalent alkyl group; when n=4, R1, R5 or R6 is a tetravalent alkyl group; and R1, and R2 in formula (1) are not simultaneously hydrogen, in protecting human and animal hair and skin from UV radiation.

    Use of benzotropolone derivatives as UV absorbers and antioxidants and their use in sunscreens and/or cosmetic compositions
    7.
    发明授权
    Use of benzotropolone derivatives as UV absorbers and antioxidants and their use in sunscreens and/or cosmetic compositions 有权

    公开(公告)号：US09707417B2

    公开(公告)日：2017-07-18

    申请号：US13000163

    申请日：2009-06-18

    申请人： Barbara Wagner ,  Reinhold Öhrlein ,  Bernd Herzog ,  Kai Eichin ,  Gabriele Baisch ,  Stephanie Portmann

    发明人： Barbara Wagner ,  Reinhold Öhrlein ,  Bernd Herzog ,  Kai Eichin ,  Gabriele Baisch ,  Stephanie Portmann

    IPC分类号： A61K8/49 ,  A61Q17/04 ,  A61K8/35 ,  A61Q19/08 ,  C07C49/747 ,  C07C62/38 ,  C07C69/712 ,  C07C69/757 ,  C07C305/18 ,  C07F9/40 ,  C07H15/18 ,  C07H15/203 ,  C07H15/26

    CPC分类号： A61Q17/04 ,  A61K8/35 ,  A61Q19/08 ,  C07C49/747 ,  C07C62/38 ,  C07C69/712 ,  C07C69/757 ,  C07C305/18 ,  C07C2602/12 ,  C07F9/4006 ,  C07H15/18 ,  C07H15/203 ,  C07H15/26

    摘要： Described is the use of benzotropolone and their derivatives, especially the compounds of formula (1); wherein R2, R3, R4, R5 and R6 independently of one another are hydrogen; OH; C1-C30alkyl, C2-C30al-kenyl, C1-C30alkoxy, C3-C12cycloalkyl or C1C30hydroxyalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G, C2-C18alkenyl, C2-C18alkynyl, C7-C25aralkyl, CN, or —CO—R17; C1-C30mono- or dialkylamino; COR9; COOR9; CONR9R10; CN; SO2R9; OCOOR9; OCOR9; NHCOOR9; NR9COR10; NH2; *—(CO)—NH—(CH2)n1—(PO)—(OR11)2; —(CO)—O—(CH2)n1—(PO)—(OR11)2; sulphate; sulphonate; phosphate; phosphonate; —(CH2)n2—[O—(SO2)]n3—OR11; —O—(CH2)n4(CO)n5—R11; —(O)n6—(CH2)n7—(PO)—(OR9)2; —(O)n6—(CH2)n7—SO2—OR9; halogen; organosilanyl; organo-siloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n—(X1)1 or 0-benzotropolone system, wherein n=1-10 and X1═—O—; —(CO)—; —O—CO—; —COO—, —NH—; —S—; —SO2—); R1, R7 and R8 independently of one another are hydrogen; C1C12alkyl or C3-C12-cycloalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G, C2-C18alkenyl, C2-C18alkynyl, C7-C25aralkyl, or COOR9; COR9; CONR9R10; SO3R9; SO2R9; PO3(R9)2; PO2(R9)2; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n—(X2)1 or 0—*, wherein n=1-10 and X2═—C(═O)—; —O—CO—*); R9 and R10 independently from each other are hydrogen; C1C18alkyl or C3-C12-cycloalkyl which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n—*, wherein n=1-10); or R9 and R10 together form a five or six membered ring, R11 is hydrogen; or C1-C5alkyl; n1, n2, n4 and n7 independently from each other are a number from 1 to 5; n3, n5 and n6 independently from each other are a 0; or 1; D is —CO—; —COO—; —S—; —SO—; —SO2-; —O—; —NR14—; —S1R19R20—; —POR11—; —CR12═CR13—; or —C≡C—; and E is —OR18; —SR18; —NR14R15; —NR14COR15; —COR17; —COOR16; —CONR14R15; —CN; halogen; Or SO3R18; SO2R18; PO3(R18)2; PO2(R18)2; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n-(X1)1 or 0—*, wherein n=1-10 and X1=—O—; —C(═O)—; —O—CO—; —COO—; —NH—; —S—; —SO2—); G is E; C1-C18alkyl, which is optionally interrupted by D; C1-C18perfluoroalkyl; C1-C18alkoxy, which is optionally substituted by E and/or interrupted by D; wherein R12, R13, R14 and R15 independently of each other are hydrogen; C6-C18aryl which is optionally substituted by OH, C1-C18alkyl or C1-C18alkoxy; C1-C18alkyl, which is optionally interrupted by —O—; or Ri4 and Ri5 together form a five or six membered ring, Ri6 is hydrogen; C6-Ci8aryl which is optionally substituted by OH, C1-C18alkyl or d-C18alkoxy; C1-C18alkyl which is optionally interrupted by —O—; R17 is H; C6-C18aryl which is optionally substituted by OH, C1-C18alkyl or C1-C18alkoxy; or d-C18alkyl which is optionally interrupted by —O—; R18 is hydrogen; C6-C18aryl, which is optionally substituted by OH, C1-C18alkyl or d-C18alkoxy; C1-C18alkyl, which is optionally interrupted by —O—; R19 and R20 independently of each other are hydrogen; C1-C18alkyl; C6-C18aryl which is optionally substituted by C1-C18alkyl; and R21 is C1-C18alkyl; or C6-C18aryl, which is substituted by C1-C18alkyl; * means, that this radical is directed to the benzotropolone moiety; for the protection of human and animal hair and skin against UV radiation.

    USE OF BENZOTROPOLONE DERIVATIVES AS UV ABSORBERS AND ANTIOXIDANTS AND THEIR USE IN SUNSCREENS AND/OR COSMETIC COMPOSITIONS
    8.
    发明申请
    USE OF BENZOTROPOLONE DERIVATIVES AS UV ABSORBERS AND ANTIOXIDANTS AND THEIR USE IN SUNSCREENS AND/OR COSMETIC COMPOSITIONS 有权

    公开(公告)号：US20110123468A1

    公开(公告)日：2011-05-26

    申请号：US13000163

    申请日：2009-06-18

    申请人： Barbara Wagner ,  Reinhold Ohrlein ,  Bernd Herzog ,  Kai Eichin ,  Gabriele Baisch ,  Stephanie Portmann

    发明人： Barbara Wagner ,  Reinhold Ohrlein ,  Bernd Herzog ,  Kai Eichin ,  Gabriele Baisch ,  Stephanie Portmann

    IPC分类号： A61K8/49 ,  A61K8/37 ,  A61K31/235 ,  A61K31/351 ,  C07C69/76 ,  C07D307/34 ,  A61K31/375 ,  A61K31/665 ,  A61Q19/04 ,  A61P39/06

    CPC分类号： A61Q17/04 ,  A61K8/35 ,  A61Q19/08 ,  C07C49/747 ,  C07C62/38 ,  C07C69/712 ,  C07C69/757 ,  C07C305/18 ,  C07C2602/12 ,  C07F9/4006 ,  C07H15/18 ,  C07H15/203 ,  C07H15/26

    摘要： Described is the use of benzotropolone and their derivatives, especially the compounds of formula (1); wherein R2, R3, R4, R5 and R6 independently of one another are hydrogen; OH; C1-C30alkyl, C2-C30al-kenyl, C1-C30alkoxy, C3-C12cycloalkyl or C1C30hydroxyalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G, C2-C18alkenyl, C2-C18alkynyl, C7-C25aralkyl, CN, or —CO—R17; C1-C30mono- or dialkylamino; COR9; COOR9; CONR9R10; CN; SO2R9; OCOOR9; OCOR9; NHCOOR9; NR9COR10; NH2; *—(CO)—NH—(CH2)n1—(PO)—(OR11)2; —(CO)—O—(CH2)n1—(PO)—(OR11)2; sulphate; sulphonate; phosphate; phosphonate; —(CH2)n2—[O—(SO2)]n3—OR11; —O—(CH2)n4(CO)n5—R11; —(O)n6—(CH2)n7—(PO)—(OR9)2; —(O)n6—(CH2)n7—SO2—OR9; halogen; organosilanyl; organo-siloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n—(X1)1 or 0-benzotropolone system, wherein n=1-10 and X1=—O—; —(CO)—; —O—CO—; —COO—, —NH—; —S—; —SO2—); R1, R7 and R8 independently of one another are hydrogen; C1C12alkyl or C3-C12-cycloalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G, C2-C18alkenyl, C2-C18alkynyl, C7-C25aralkyl, or COOR9; COR9; CONR9R10; SO3R9; SO2R9; PO3(R9)2; PO2(R9)2; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n—(X2)1 or 0—*, wherein n=1-10 and X2=—C(═O)—; —O—CO—*); R9 and R10 independently from each other are hydrogen; C1C18alkyl or C3-C12-cycloalkyl which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n—*, wherein n=1-10); or R9 and R10 together form a five or six membered ring, R11 is hydrogen; or C1-C5alkyl; n1, n2, n4 and n7 independently from each other are a number from 1 to 5; n3, n5 and n6 independently from each other are a 0; or 1; D is —CO—; —COO—; —S—; —SO—; —SO2-; —O—; —NR14—; —S1R19R20—; —POR11—; —CR12═CR13—; or —C≡C—; and E is —OR18; —SR18; —NR14R15; —NR14COR15; —COR17; —COOR16; —CONR14R15; —CN; halogen; Or SO3R18; SO2R18; PO3(R18)2; PO2(R18)2; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an α- or β-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH2)n-(X1)1 or 0—*, wherein n=1-10 and X1=—O—; —C(═O)—; —O—CO—; —COO—; —NH—; —S—; —SO2—); G is E; C1-C18alkyl, which is optionally interrupted by D; C1-C18perfluoroalkyl; C1-C18alkoxy, which is optionally substituted by E and/or interrupted by D; wherein R12, R13, R14 and R15 independently of each other are hydrogen; C6-C18aryl which is optionally substituted by OH, C1-C18alkyl or C1-C18alkoxy; C1-C18alkyl, which is optionally interrupted by —O—; or Ri4 and Ri5 together form a five or six membered ring, Ri6 is hydrogen; C6-Ci8aryl which is optionally substituted by OH, C1-C18alkyl or d-C18alkoxy; C1-C18alkyl which is optionally interrupted by —O—; R17 is H; C6-C18aryl which is optionally substituted by OH, C1-C18alkyl or C1-C18alkoxy; or d-C18alkyl which is optionally interrupted by —O—; R18 is hydrogen; C6-C18aryl, which is optionally substituted by OH, C1-C18alkyl or d-C18alkoxy; C1-C18alkyl, which is optionally interrupted by —O—; R19 and R20 independently of each other are hydrogen; C1-C18alkyl; C6-C18aryl which is optionally substituted by C1-C18alkyl; and R21 is C1-C18alkyl; or C6-C18aryl, which is substituted by C1-C18alkyl; * means, that this radical is directed to the benzotropolone moiety; for the protection of human and animal hair and skin against UV radiation.