知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

25 records (took 0.017 seconds)

    DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS
    2.
    发明申请
    DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS 审中-公开
    用于预测和预防保留的装置和方法

    公开(公告)号：US20140005534A1

    公开(公告)日：2014-01-02

    申请号：US14019466

    申请日：2013-09-05

    Applicant: Xuanmin HE ,  John B. SIMPSON ,  Michael H. ROSENTHAL ,  John F. BLACK

    Inventor： Xuanmin HE ,  John B. SIMPSON ,  Michael H. ROSENTHAL ,  John F. BLACK

    IPC: A61B5/02 ,  A61B17/22 ,  A61F2/06 ,  A61B5/00 ,  A61M31/00

    CPC classification number: A61B5/02007 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/4836 ,  A61B17/22 ,  A61F2/06 ,  A61M31/005 ,  G06T7/0012 ,  G06T2207/10068 ,  G06T2207/30101

    Abstract: The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.

    Abstract translation: 本发明涉及用于预测再狭窄的方法和装置，以及用于治疗动脉粥样硬化以预防或减少再狭窄发生率的方法和装置。 预测狭窄外周动脉再狭窄的方法可能包括血管的定量组织学。 例如，治疗狭窄动脉（特别是外周动脉）的方法可包括确定组织中炎症细胞包涵体的超细胞程度和一种或多种脂质丰富度和程度的步骤。 可以确定基于组织中炎症细胞包涵体的超细胞性和脂质丰富性和/或程度的再狭窄指数。 用于治疗或预防再狭窄的系统可以包括用于成像组织区域的一种或多种成像模式，并且确定超细胞程度的水平以及组织区域中炎症细胞包含的脂质丰富程度和程度的一个或多个。

    Trans-Catheter / Trans-Endoscope Drug and Stem Cell Delivery
    3.
    发明申请
    Trans-Catheter / Trans-Endoscope Drug and Stem Cell Delivery 审中-公开
    跨导管/跨内窥镜药物和干细胞递送

    公开(公告)号：US20120215098A1

    公开(公告)日：2012-08-23

    申请号：US13402562

    申请日：2012-02-22

    Applicant: John F Black ,  Jayakumar Rajadas ,  Geoffrey Gurtner

    Inventor： John F Black ,  Jayakumar Rajadas ,  Geoffrey Gurtner

    IPC: A61B6/00 ,  A61B1/04 ,  A61M5/00

    CPC classification number: A61M37/00

    Abstract: An apparatus and method are provided for very precise and efficient delivery of e.g. viscous nutritive cell matrices and/or drugs into an exact point in the human body using minimally-invasive surgical techniques. Embodiments are compatible with modern catheter access and endoscopic techniques and a disposable-plus-capital-equipment business model separating the cost of the procedure between a reusable and a disposable component. It also represents a substantial step forward in terms of safety with no high voltage or high pressure components present in the body. The inherent risk of using this design to deliver substances into the human body is significantly reduced compared to standard hydraulic methods. Mechanical trauma associated with needles is avoided with this invention, and the method is also compatible with tortuous anatomy such as the coronary or brain arteries.

    Abstract translation: 提供了一种设备和方法，用于非常精确和有效地传递例如。 粘性营养细胞基质和/或药物使用微创手术技术进入人体的精确点。 实施例与现代导管接近和内窥镜技术以及将可再次使用和一次性部件之间的程序成本分开的一次性加资本设备业务模型相兼容。 它也代表了在安全性方面向前迈出的重要一步，没有高压或高压组件存在于体内。 与标准液压方法相比，使用这种设计将物质运送到人体内部的固有风险显着降低。 用本发明避免与针相关的机械创伤，并且该方法还与曲折的解剖结构如冠状动脉或脑动脉相兼容。

    ATHERECTOMY CATHETER WITH LATERALLY-DISPLACEABLE TIP
    5.
    发明申请
    ATHERECTOMY CATHETER WITH LATERALLY-DISPLACEABLE TIP 有权
    ATHERECTOMY导管与侧向放置提示

    公开(公告)号：US20110004107A1

    公开(公告)日：2011-01-06

    申请号：US12829277

    申请日：2010-07-01

    Applicant: Michael H. Rosenthal ,  Michael Zung ,  Nicholas J. Spinelli ,  Charles W. McNall ,  John B. Simpson ,  John F. Black

    Inventor： Michael H. Rosenthal ,  Michael Zung ,  Nicholas J. Spinelli ,  Charles W. McNall ,  John B. Simpson ,  John F. Black

    IPC: A61B17/22 ,  A61B6/00

    CPC classification number: A61B17/320758 ,  A61B17/32075 ,  A61B90/361 ,  A61B2017/2927 ,  A61B2017/320064 ,  A61B2017/320766 ,  A61B2017/320791 ,  A61B2090/3614 ,  A61M25/0074 ,  A61M25/0133

    Abstract: Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.

    Abstract translation: 这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。 将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。 环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。 这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。 描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。

    Atherectomy catheter with laterally-displaceable tip
    7.
    发明授权
    Atherectomy catheter with laterally-displaceable tip 有权
    动脉粥样硬化切除导管具有横向位移尖端

    公开(公告)号：US09498600B2

    公开(公告)日：2016-11-22

    申请号：US12829277

    申请日：2010-07-01

    Applicant: Michael H. Rosenthal ,  Michael Zung ,  Nicholas J. Spinelli ,  Charles W. McNall ,  John B. Simpson ,  John F. Black

    Inventor： Michael H. Rosenthal ,  Michael Zung ,  Nicholas J. Spinelli ,  Charles W. McNall ,  John B. Simpson ,  John F. Black

    IPC: A61M25/01 ,  A61M25/00 ,  A61B17/3207 ,  A61B17/29

    CPC classification number: A61B17/320758 ,  A61B17/32075 ,  A61B90/361 ,  A61B2017/2927 ,  A61B2017/320064 ,  A61B2017/320766 ,  A61B2017/320791 ,  A61B2090/3614 ,  A61M25/0074 ,  A61M25/0133

    Abstract: Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.

    Abstract translation: 这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。 将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。 环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。 这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。 描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。

    Fire suppressing materials and systems and methods of use
    8.
    发明授权
    Fire suppressing materials and systems and methods of use 有权
    消防材料及系统及使用方法

    公开(公告)号：US08920668B2

    公开(公告)日：2014-12-30

    申请号：US13594738

    申请日：2012-08-24

    Applicant: Mark D. Mitchell ,  John F. Black ,  Kurt Mills

    Inventor： Mark D. Mitchell ,  John F. Black ,  Kurt Mills

    IPC: A62D1/08 ,  A62C3/08 ,  A62C35/02 ,  A62D1/00

    CPC classification number: A62D1/0092 ,  A62C35/02 ,  A62D1/00

    Abstract: A fire suppressant mixture comprising: an organic or supplemental organic fire suppressant compound; a halogen element, and an organic compound, wherein the organic fire suppressant compound, the halogen element and the organic compound are combined such that a boiling point of the mixture is lower than the boiling point of the organic fire suppressant. In some embodiments, the organic fire suppressant compound is FK 5-1-12 and the organic compound is carbon dioxide. In other embodiments, the mixture is supplemented with an additional organic compound such as CF3I or 2,2-Dichloro-1,1,1-trifluoroethane (R123), or an halogen element. In some embodiments an inorganic pressurizing gas, such as nitrogen, is also added.

    Abstract translation: 一种灭火剂混合物，其包含：有机或补充的有机灭火剂化合物; 卤素元素和有机化合物，其中组合有机灭火剂化合物，卤素元素和有机化合物使得混合物的沸点低于有机灭火剂的沸点。 在一些实施方案中，有机灭火剂化合物为FK 5-1-12，有机化合物为二氧化碳。 在其它实施方案中，混合物补充有另外的有机化合物如CF 3 I或2,2-二氯-1,1,1-三氟乙烷（R123）或卤素元素。 在一些实施方案中，还加入无机加压气体，例如氮气。

    ATHERECTOMY CATHETER WITH LATERALLY-DISPLACEABLE TIP
    10.
    发明申请
    ATHERECTOMY CATHETER WITH LATERALLY-DISPLACEABLE TIP 审中-公开
    ATHERECTOMY导管与侧向放置提示

    公开(公告)号：US20170065293A1

    公开(公告)日：2017-03-09

    申请号：US15354898

    申请日：2016-11-17

    Applicant: Michael H. ROSENTHAL ,  Michael ZUNG ,  Nicholas J. SPINELLI ,  Charles W. McNALL ,  John B. SIMPSON ,  John F. BLACK

    Inventor： Michael H. ROSENTHAL ,  Michael ZUNG ,  Nicholas J. SPINELLI ,  Charles W. McNALL ,  John B. SIMPSON ,  John F. BLACK

    IPC: A61B17/3207 ,  A61B90/00

    CPC classification number: A61B17/320758 ,  A61B17/32075 ,  A61B90/361 ,  A61B2017/2927 ,  A61B2017/320064 ,  A61B2017/320766 ,  A61B2017/320791 ,  A61B2090/3614 ,  A61M25/0074 ,  A61M25/0133

    Abstract: Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.

    Abstract translation: 这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。 将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。 环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。 这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。 描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。

Patent Agency Ranking