公开(公告)号：US20170065293A1

公开(公告)日：2017-03-09

申请号：US15354898

申请日：2016-11-17

Applicant: Michael H. ROSENTHAL ,  Michael ZUNG ,  Nicholas J. SPINELLI ,  Charles W. McNALL ,  John B. SIMPSON ,  John F. BLACK

Inventor： Michael H. ROSENTHAL ,  Michael ZUNG ,  Nicholas J. SPINELLI ,  Charles W. McNALL ,  John B. SIMPSON ,  John F. BLACK

IPC: A61B17/3207 ,  A61B90/00

CPC classification number: A61B17/320758 ,  A61B17/32075 ,  A61B90/361 ,  A61B2017/2927 ,  A61B2017/320064 ,  A61B2017/320766 ,  A61B2017/320791 ,  A61B2090/3614 ,  A61M25/0074 ,  A61M25/0133

Abstract: Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.

Abstract translation: 这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。 将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。 环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。 这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。 描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。

公开(公告)号：US20130096589A1

公开(公告)日：2013-04-18

申请号：US13654357

申请日：2012-10-17

Applicant: Maegan K. Spencer ,  Nicholas J. Spinelli

Inventor： Maegan K. Spencer ,  Nicholas J. Spinelli

IPC: A61B17/3207

CPC classification number: A61B17/320758 ,  A61B2017/00057 ,  A61B2017/00398 ,  A61B2017/00876 ,  A61B2017/22039 ,  A61B2017/22094 ,  A61B2017/2927 ,  A61B2017/320791 ,  A61B2090/0813 ,  A61B2090/3614 ,  A61B2090/3735

Abstract: An atherectomy catheter includes a deflectable distal tip, a rotatable cutter proximal to the distal tip, a cutter drive shaft configured to rotate the rotatable cutter, and a pull shaft concentric with the drive shaft and coupled to the distal tip. The pull shaft is configured such that pulling the pull shaft deflects the distal tip, thereby exposing the rotatable cutter. Also disclosed herein is a magnetic drive system configured for non-contact actuation of a catheter.

Abstract translation: 粥样斑块切除术导管包括可偏转的远侧末端，靠近远侧末端的可旋转刀具，被配置为使可旋转切割器旋转的切割器驱动轴以及与驱动轴同心并联接到远侧末端的牵引轴。 拉动轴构造成使得拉动拉动轴使远侧末端偏转，从而暴露可旋转切割器。 本文还公开了一种配置用于非接触致动导管的磁驱动系统。

公开(公告)号：US09498600B2

公开(公告)日：2016-11-22

申请号：US12829277

申请日：2010-07-01

Applicant: Michael H. Rosenthal ,  Michael Zung ,  Nicholas J. Spinelli ,  Charles W. McNall ,  John B. Simpson ,  John F. Black

Inventor： Michael H. Rosenthal ,  Michael Zung ,  Nicholas J. Spinelli ,  Charles W. McNall ,  John B. Simpson ,  John F. Black

IPC: A61M25/01 ,  A61M25/00 ,  A61B17/3207 ,  A61B17/29

CPC classification number: A61B17/320758 ,  A61B17/32075 ,  A61B90/361 ,  A61B2017/2927 ,  A61B2017/320064 ,  A61B2017/320766 ,  A61B2017/320791 ,  A61B2090/3614 ,  A61M25/0074 ,  A61M25/0133

Abstract: Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.

Abstract translation: 这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。 将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。 环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。 这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。 描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。

公开(公告)号：US20180256039A1

公开(公告)日：2018-09-13

申请号：US15854579

申请日：2017-12-26

Applicant: Peter H. SMITH ,  Manish KANKARIA ,  Priyanshu GUPTA ,  Nicholas J. SPINELLI ,  Charles W. MCNALL

Inventor： Peter H. SMITH ,  Manish KANKARIA ,  Priyanshu GUPTA ,  Nicholas J. SPINELLI ,  Charles W. MCNALL

IPC: A61B5/02 ,  A61B5/00 ,  A61B1/005 ,  A61B1/04 ,  A61B17/3207 ,  A61B17/32 ,  A61B1/313 ,  A61B1/07 ,  A61B90/00 ,  A61B17/22

Abstract: An imaging device includes a hollow flexible shaft having a central longitudinal axis and an imaging window therein. An optical fiber extends within the hollow flexible shaft substantially along the central axis. A distal tip of the optical fiber is attached to the hollow flexible shaft and aligned with the imaging window so as to transfer an optical coherence tomography signal through the imaging window. A handle is attached to the hollow flexible shaft configured rotate the hollow flexible shaft at speeds of greater than 1,000 rpm.

公开(公告)号：US20130296695A1

公开(公告)日：2013-11-07

申请号：US13939161

申请日：2013-07-10

Applicant: Maegan K. SPENCER ,  Christopher B. WHITE ,  Charles W. MCNALL ,  Dennis W. JACKSON ,  Michael ZUNG ,  Nicholas J. SPINELLI ,  Benjamin NGO ,  Evangeline LUMABAS ,  Kin F. CHAN ,  John F. BLACK ,  Michael H. ROSENTHAL ,  John B. SIMPSON

Inventor： Maegan K. SPENCER ,  Christopher B. WHITE ,  Charles W. MCNALL ,  Dennis W. JACKSON ,  Michael ZUNG ,  Nicholas J. SPINELLI ,  Benjamin NGO ,  Evangeline LUMABAS ,  Kin F. CHAN ,  John F. BLACK ,  Michael H. ROSENTHAL ,  John B. SIMPSON

IPC: A61B5/00

Abstract: A system for imaging a body lumen includes a controller and a display. The controller is configured to connect to a proximal end of a catheter having an optical fiber extending along the length of an elongate catheter body. The controller is further configured to rotate a distal end of the optical fiber from a location near a proximal end of the elongate catheter body, acquire optical coherence tomography (OCT) images using the optical fiber as the distal end of the optical fiber rotates, and determine a rotational lag of the distal end of the optical fiber. The display is configured to display one or more OCT images corrected for the rotational lag.

Abstract translation: 用于对体腔成像的系统包括控制器和显示器。 控制器被配置为连接到具有沿着细长导管主体的长度延伸的光纤的导管的近端。 所述控制器进一步构造成从所述细长导管主体的近端附近的位置旋转所述光纤的远端，当所述光纤的远端旋转时，使用所述光纤采集光学相干断层摄影（OCT）图像;以及 确定光纤远端的旋转滞后。 显示器被配置为显示针对旋转滞后校正的一个或多个OCT图像。

公开(公告)号：US09125562B2

公开(公告)日：2015-09-08

申请号：US12829267

申请日：2010-07-01

Applicant: Maegan K. Spencer ,  Christopher B. White ,  Charles W. McNall ,  Dennis W. Jackson ,  Michael Zung ,  Nicholas J. Spinelli ,  Benjamin Ngo ,  Evangeline Lumabas ,  Kin F. Chan ,  John F. Black ,  Michael H. Rosenthal ,  John B. Simpson

Inventor： Maegan K. Spencer ,  Christopher B. White ,  Charles W. McNall ,  Dennis W. Jackson ,  Michael Zung ,  Nicholas J. Spinelli ,  Benjamin Ngo ,  Evangeline Lumabas ,  Kin F. Chan ,  John F. Black ,  Michael H. Rosenthal ,  John B. Simpson

IPC: A61B5/00 ,  A61B5/02

CPC classification number: A61B5/0066 ,  A61B5/0062 ,  A61B5/0073 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/6852 ,  A61B5/7257

Abstract: Catheter-based Optical Coherence Tomography (OCT) systems utilizing an optical fiber that is positioned off-axis of the central longitudinal axis of the catheter have many advantage over catheter-based OCT systems, particularly those having centrally-positioned optical fibers or fibers that rotate independently of the elongate body of the catheter. An OCT system having an off-axis optical fiber for visualizing the inside of a body lumen may be rotated with the body of the elongate catheter, relative to a handle portion. The handle may include a fiber management pathway for the optical fiber that permits the off-axis optical fiber to rotate with the catheter body relative to the handle. The system may also include optical processing elements adapted to prepare and process the OCT image collected by the off-axis catheter systems described herein.

Abstract translation: 使用位于导管的中心纵向轴线离轴的光纤的基于导管的光学相干断层扫描（OCT）系统具有优于基于导管的OCT系统的许多优点，特别是具有中心定位的光纤或旋转的光纤 独立于导管的细长主体。 具有用于可视化体腔内部的离轴光纤的OCT系统可以相对于手柄部分与细长导管的主体一起旋转。 手柄可以包括用于光纤的光纤管理路径，其允许离轴光纤相对于手柄与导管主体一起旋转。 该系统还可以包括适于制备和处理由本文所述的离轴导管系统收集的OCT图像的光学处理元件。

公开(公告)号：US20110021926A1

公开(公告)日：2011-01-27

申请号：US12829267

申请日：2010-07-01

Applicant: Maegan K. SPENCER ,  Christopher B. White ,  Charles W. McNall ,  Dennis W. Jackson ,  Michael Zung ,  Nicholas J. Spinelli ,  Benjamin Ngo ,  Evangeline Lumabas ,  Kin F. Chan ,  John F. Black ,  Michael H. Rosenthal ,  John B. Simpson

Inventor： Maegan K. SPENCER ,  Christopher B. White ,  Charles W. McNall ,  Dennis W. Jackson ,  Michael Zung ,  Nicholas J. Spinelli ,  Benjamin Ngo ,  Evangeline Lumabas ,  Kin F. Chan ,  John F. Black ,  Michael H. Rosenthal ,  John B. Simpson

IPC: A61B6/00

CPC classification number: A61B5/0066 ,  A61B5/0062 ,  A61B5/0073 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/6852 ,  A61B5/7257

Abstract: Catheter-based Optical Coherence Tomography (OCT) systems utilizing an optical fiber that is positioned off-axis of the central longitudinal axis of the catheter have many advantage over catheter-based OCT systems, particularly those having centrally-positioned optical fibers or fibers that rotate independently of the elongate body of the catheter. An OCT system having an off-axis optical fiber for visualizing the inside of a body lumen may be rotated with the body of the elongate catheter, relative to a handle portion. The handle may include a fiber management pathway for the optical fiber that permits the off-axis optical fiber to rotate with the catheter body relative to the handle. The system may also include optical processing elements adapted to prepare and process the OCT image collected by the off-axis catheter systems described herein.

Abstract translation: 使用位于导管的中心纵向轴线离轴的光纤的基于导管的光学相干断层扫描（OCT）系统具有优于基于导管的OCT系统的许多优点，特别是具有中心定位的光纤或旋转的光纤 独立于导管的细长主体。 具有用于可视化体腔内部的离轴光纤的OCT系统可以相对于手柄部分与细长导管的主体一起旋转。 手柄可以包括用于光纤的光纤管理路径，其允许离轴光纤相对于手柄与导管主体一起旋转。 该系统还可以包括适于制备和处理由本文所述的离轴导管系统收集的OCT图像的光学处理元件。

公开(公告)号：US20110004107A1

公开(公告)日：2011-01-06

申请号：US12829277

申请日：2010-07-01

Applicant: Michael H. Rosenthal ,  Michael Zung ,  Nicholas J. Spinelli ,  Charles W. McNall ,  John B. Simpson ,  John F. Black

Inventor： Michael H. Rosenthal ,  Michael Zung ,  Nicholas J. Spinelli ,  Charles W. McNall ,  John B. Simpson ,  John F. Black

IPC: A61B17/22 ,  A61B6/00

CPC classification number: A61B17/320758 ,  A61B17/32075 ,  A61B90/361 ,  A61B2017/2927 ,  A61B2017/320064 ,  A61B2017/320766 ,  A61B2017/320791 ,  A61B2090/3614 ,  A61M25/0074 ,  A61M25/0133

Abstract: Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.

Abstract translation: 这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。 将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。 环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。 这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。 描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。