知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

43 条记录 (耗时 0.059 秒)

    Devices and methods for predicting and preventing restenosis
    2.
    发明授权
    Devices and methods for predicting and preventing restenosis 有权
    用于预测和预防再狭窄的装置和方法

    公开(公告)号：US08548571B2

    公开(公告)日：2013-10-01

    申请号：US12963536

    申请日：2010-12-08

    申请人： Xuanmin He ,  John B. Simpson ,  Michael H. Rosenthal ,  John F. Black

    发明人： Xuanmin He ,  John B. Simpson ,  Michael H. Rosenthal ,  John F. Black

    IPC分类号： A61B1/07 ,  A61B6/00

    CPC分类号： A61B5/02007 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/4836 ,  A61B17/22 ,  A61F2/06 ,  A61M31/005 ,  G06T7/0012 ,  G06T2207/10068 ,  G06T2207/30101

    摘要： The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.

    摘要翻译： 本发明涉及用于预测再狭窄的方法和装置，以及用于治疗动脉粥样硬化以预防或减少再狭窄发生率的方法和装置。 预测狭窄外周动脉再狭窄的方法可能包括血管的定量组织学。 例如，治疗狭窄动脉（特别是外周动脉）的方法可包括确定组织中炎症细胞包涵体的超细胞程度和一种或多种脂质丰富度和程度的步骤。 可以确定基于组织中炎症细胞包涵体的超细胞性和脂质丰富性和/或程度的再狭窄指数。 用于治疗或预防再狭窄的系统可以包括用于成像组织区域的一种或多种成像模式，并且确定超细胞程度的水平以及组织区域中炎症细胞包含的脂质丰富程度和程度的一个或多个。

    DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS
    3.
    发明申请
    DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS 有权
    用于预测和预防保留的装置和方法

    公开(公告)号：US20110263936A1

    公开(公告)日：2011-10-27

    申请号：US12963536

    申请日：2010-12-08

    申请人： Xuanmin He ,  John B. Simpson ,  Michael H. Rosenthal ,  John F. Black

    发明人： Xuanmin He ,  John B. Simpson ,  Michael H. Rosenthal ,  John F. Black

    IPC分类号： A61B1/04

    CPC分类号： A61B5/02007 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/4836 ,  A61B17/22 ,  A61F2/06 ,  A61M31/005 ,  G06T7/0012 ,  G06T2207/10068 ,  G06T2207/30101

    摘要： The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.

    摘要翻译： 本发明涉及用于预测再狭窄的方法和装置，以及用于治疗动脉粥样硬化以预防或减少再狭窄发生率的方法和装置。 预测狭窄外周动脉再狭窄的方法可能包括血管的定量组织学。 例如，治疗狭窄动脉（特别是外周动脉）的方法可包括确定组织中炎症细胞包涵体的超细胞程度和一种或多种脂质丰富度和程度的步骤。 可以确定基于组织中炎症细胞包涵体的超细胞性和脂质丰富性和/或程度的再狭窄指数。 用于治疗或预防再狭窄的系统可以包括用于成像组织区域的一种或多种成像模式，并且确定超细胞程度的水平以及组织区域中炎症细胞包含的脂质丰富程度和程度的一个或多个。

    ATHERECTOMY CATHETER WITH LATERALLY-DISPLACEABLE TIP
    8.
    发明申请
    ATHERECTOMY CATHETER WITH LATERALLY-DISPLACEABLE TIP 审中-公开
    ATHERECTOMY导管与侧向放置提示

    公开(公告)号：US20170065293A1

    公开(公告)日：2017-03-09

    申请号：US15354898

    申请日：2016-11-17

    申请人： Michael H. ROSENTHAL ,  Michael ZUNG ,  Nicholas J. SPINELLI ,  Charles W. McNALL ,  John B. SIMPSON ,  John F. BLACK

    发明人： Michael H. ROSENTHAL ,  Michael ZUNG ,  Nicholas J. SPINELLI ,  Charles W. McNALL ,  John B. SIMPSON ,  John F. BLACK

    IPC分类号： A61B17/3207 ,  A61B90/00

    CPC分类号： A61B17/320758 ,  A61B17/32075 ,  A61B90/361 ,  A61B2017/2927 ,  A61B2017/320064 ,  A61B2017/320766 ,  A61B2017/320791 ,  A61B2090/3614 ,  A61M25/0074 ,  A61M25/0133

    摘要： Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.

    摘要翻译： 这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。 将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。 环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。 这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。 描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。

    Apparatus and methods for nipple formation via collapsible devices
    9.
    发明授权
    Apparatus and methods for nipple formation via collapsible devices 有权
    用于通过可折叠装置形成乳头的装置和方法

    公开(公告)号：US09308081B2

    公开(公告)日：2016-04-12

    申请号：US13606517

    申请日：2012-09-07

    申请人： Kenneth N. Horne ,  Sergio Salinas ,  Geoffrey C. Gurtner ,  Michael H. Rosenthal ,  Christopher S. Jones ,  Joseph Rimsa

    发明人： Kenneth N. Horne ,  Sergio Salinas ,  Geoffrey C. Gurtner ,  Michael H. Rosenthal ,  Christopher S. Jones ,  Joseph Rimsa

    IPC分类号： A61F2/12 ,  A61B19/00

    CPC分类号： A61H9/0057 ,  A61B90/02 ,  A61F2/12 ,  A61H2205/082

    摘要： Apparatus and methods for nipple and breast formation are described where devices precondition or expand a target nipple tissue to reduce the pressure exerted by the skin on an eventual implant. Generally, the apparatus comprises a mold having a contact surface which is curved in conformance with a breast upon which the mold is positionable, the contact surface having an adhesive for securement upon the breast, and the mold defining a cavity along the contact surface which conforms to a size of a nipple to be formed upon the breast and where the cavity further comprises the adhesive for securement to the nipple. A breast enlargement device comprises a cup larger than the target breast and further defines an inner surface which adheres to the breast when contacted.

    摘要翻译： 描述了用于乳头和乳房形成的装置和方法，其中装置预处理或扩大目标乳头组织，以减少最终植入时由皮肤施加的压力。 通常，该装置包括具有接触表面的模具，该接触表面与模具可定位在其上的乳房一致地弯曲，接触表面具有用于固定在乳房上的粘合剂，并且模具沿着接触表面限定空腔， 到乳房上形成的乳头的尺寸，并且其中腔还包括用于固定到乳头的粘合剂。 乳房放大装置包括比目标乳房大的杯子，并进一步限定了当接触时粘附到乳房的内表面。

    APPARATUS AND METHODS FOR NIPPLE FORMATION VIA COLLAPSIBLE DEVICES
    10.
    发明申请
    APPARATUS AND METHODS FOR NIPPLE FORMATION VIA COLLAPSIBLE DEVICES 有权
    用于通过可拆卸装置形成的装置和方法

    公开(公告)号：US20130116782A1

    公开(公告)日：2013-05-09

    申请号：US13606517

    申请日：2012-09-07

    申请人： Kenneth N. HORNE ,  Sergio SALINAS ,  Geoffrey C. GURTNER ,  Michael H. ROSENTHAL ,  Christopher S. JONES ,  Joseph RIMSA

    发明人： Kenneth N. HORNE ,  Sergio SALINAS ,  Geoffrey C. GURTNER ,  Michael H. ROSENTHAL ,  Christopher S. JONES ,  Joseph RIMSA

    IPC分类号： A61F2/12

    CPC分类号： A61H9/0057 ,  A61B90/02 ,  A61F2/12 ,  A61H2205/082

    摘要： Apparatus and methods for nipple and breast formation are described where devices precondition or expand a target nipple tissue to reduce the pressure exerted by the skin on an eventual implant. Generally, the apparatus comprises a mold having a contact surface which is curved in conformance with a breast upon which the mold is positionable, the contact surface having an adhesive for securement upon the breast, and the mold defining a cavity along the contact surface which conforms to a size of a nipple to be formed upon the breast and where the cavity further comprises the adhesive for securement to the nipple. A breast enlargement device comprises a cup larger than the target breast and further defines an inner surface which adheres to the breast when contacted.

    摘要翻译： 描述了用于乳头和乳房形成的装置和方法，其中装置预处理或扩大目标乳头组织，以减少最终植入时由皮肤施加的压力。 通常，该装置包括具有接触表面的模具，该接触表面与模具可定位在其上的乳房一致地弯曲，接触表面具有用于固定在乳房上的粘合剂，并且模具沿着接触表面限定空腔， 到乳房上形成的乳头的尺寸，并且其中腔还包括用于固定到乳头的粘合剂。 乳房放大装置包括比目标乳房大的杯子，并进一步限定了当接触时粘附到乳房的内表面。