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    Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
    1.
    发明申请
    Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon 审中-公开
    编码跨膜丝氨酸蛋白酶的核酸分子，编码的蛋白质和基于其的方法

    公开(公告)号：US20110105731A1

    公开(公告)日：2011-05-05

    申请号：US12927372

    申请日：2010-11-12

    申请人： Edwin L. Madison ,  Edgar O. Ong ,  Jiunn-Chern Yeh

    发明人： Edwin L. Madison ,  Edgar O. Ong ,  Jiunn-Chern Yeh

    IPC分类号： C07K16/40

    CPC分类号： C12N9/6424 ,  C07K2319/00

    摘要： Provided herein are antibodies, fragments and derivatives of an antibody containing a binding domain thereof, where the antibody, fragment or derivative specifically binds to a single chain protease domain of a type II transmembrane serine protease (MTSP). Methods using the antibodies to modulate the protease activity of an MTSP are provided. Also provided are antibodies that bind to MTSPs designated MTSP3 and MTSP4 and to a form of an MTSP designated MTSP6.

    摘要翻译： 本文提供了抗体，片段和含有其结合结构域的抗体的衍生物，其中抗体，片段或衍生物特异性结合II型跨膜丝氨酸蛋白酶（MTSP）的单链蛋白酶结构域。 提供了使用抗体调节MTSP的蛋白酶活性的方法。 还提供了结合指定为MTSP3和MTSP4的MTSP以及指定为MTSP6的MTSP形式的抗体。

    .beta.-1-6-N-acetylglucosaminyltransferase that forms core 2, core 4 and I branches
    3.
    发明授权
    .beta.-1-6-N-acetylglucosaminyltransferase that forms core 2, core 4 and I branches 失效
    形成核心2核心4和1分支的β-1-N-N-乙酰葡糖胺基转移酶

    公开(公告)号：US6136580A

    公开(公告)日：2000-10-24

    申请号：US233506

    申请日：1999-01-19

    申请人： Minoru Fukuda ,  Jiunn-Chern Yeh

    发明人： Minoru Fukuda ,  Jiunn-Chern Yeh

    IPC分类号： C12N9/10 ,  C12P19/18 ,  A61K16/00

    CPC分类号： C12N9/1051

    摘要： The present invention provides a substantially pure C2GnT-M polypeptide or a functional fragment or derivative thereof, wherein C2GnT-M is characterized as a polypeptide having core 2, core 4 and I branching .beta.-1.fwdarw.6-N-acetylglucosaminyltransferase activities. The invention also provides a substantially pure C2GnT-M peptide, wherein the peptide is immunogenic. Also provided is a method of modifying an acceptor molecule by contacting the acceptor molecule with a substantially pure C2GnT-M polypeptide or a functional fragment under conditions that allow addition of core 2, core 4 or I GlcNAc linkages to the acceptor molecule, and an acceptor molecule produced by the method. Also provided is a substantially pure nucleic acid molecule having substantially the nucleic acid sequence designated SEQ ID NO: 1, or the complement thereof. The invention also provides a substantially pure nucleic acid molecule encoding C2GnT-M or a functional fragment or derivative thereof, or the complement of the nucleic acid molecule, wherein C2GnT-M is characterized as a polypeptide having core 2, core 4 and I branching P-1.fwdarw.6-N-acetylglucosaminyltransferase activities. Also provided are vectors and host cells containing nucleic acid molecules encoding C2GnT-M or a functional fragment or derivative thereof. A substantially pure oligonucleotide having a nucleotide sequence corresponding to or complementary to at least 15 nucleotides from SEQ ID NO: 1, SEQ ID NO: 9 or SEQ ID NO: 13 is also provided. The invention further provides an antibody or antigen binding fragment thereof that is specifically reactive with C2GnT-M or with a functional fragment or derivative hereof. Methods of detecting the presence of C2GnT-M in sample are also provided.

    摘要翻译： 本发明提供了基本上纯的C2GnT-M多肽或其功能性片段或衍生物，其中C2GnT-M被表征为具有核心2，核心核苷4和核苷酸4和核苷酸4的支链β-1-N-乙酰葡糖胺基转移酶活性的多肽。 本发明还提供了基本上纯的C2GnT-M肽，其中肽是免疫原性的。 还提供了一种通过使受体分子与基本上纯的C2GnT-M多肽或功能片段在允许加入核心2，核心4或I GlcNAc连接至受体分子的条件下接受来修饰受体分子的方法，以及受体 通过该方法制备的分子。 还提供了基本上纯的具有基本上指定为SEQ ID NO：1的核酸序列或其补体的核酸分子。 本发明还提供了编码C2GnT-M或其功能片段或衍生物或核酸分子的补体的基本上纯的核酸分子，其中C2GnT-M被表征为具有核心2，核心4和核苷酸I支链P -1-> 6-N-乙酰葡糖胺基转移酶活性。 还提供含有编码C2GnT-M或其功能片段或衍生物的核酸分子的载体和宿主细胞。 还提供了具有与SEQ ID NO：1，SEQ ID NO：9或SEQ ID NO：13至少15个核苷酸对应或互补的核苷酸序列的基本上纯的寡核苷酸。 本发明还提供了与C2GnT-M或其功能片段或衍生物特异性反应的抗体或其抗原结合片段。 还提供了检测样品中C2GnT-M存在的方法。

    Homotrimeric extended OBG3 globular head and uses thereof
    5.
    发明授权
    Homotrimeric extended OBG3 globular head and uses thereof 失效
    同源三聚体延伸OBG3球状头及其用途

    公开(公告)号：US07459433B2

    公开(公告)日：2008-12-02

    申请号：US10515033

    申请日：2003-05-26

    申请人： John Lucas ,  Jiunn-chern Yeh ,  Deno Dialynas

    发明人： John Lucas ,  Jiunn-chern Yeh ,  Deno Dialynas

    IPC分类号： C07K14/00 ,  A61K38/00

    CPC分类号： A61K38/17 ,  C07K14/5759

    摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, homotrimer of OBG3 polypeptide fragment comprising globular domain and all or part of OBG3 collagen-like region, has been identified that has utility for reducing body mass, for maintaining weight loss, and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.

    摘要翻译： 本发明涉及肥胖研究领域。 肥胖是一个严重而广泛的公共卫生问题。 已经鉴定了包含球状结构域和全部或部分OBG3胶原样区域的OBG3多肽片段的同三聚物，其具有用于减少体重，用于维持体重减轻和用于治疗肥胖相关疾病和病症的效用。 这些肥胖相关的疾病和病症包括高脂血症，动脉粥样硬化，糖尿病和高血压。

    Homotrimeric extended obg3 globular head and uses thereof
    7.
    发明申请
    Homotrimeric extended obg3 globular head and uses thereof 失效
    同源三聚体延长的obg3球形头及其用途

    公开(公告)号：US20060252678A1

    公开(公告)日：2006-11-09

    申请号：US10515033

    申请日：2003-05-26

    申请人： John Lucas ,  Jiunn-chern Yeh ,  Deno Dialynas

    发明人： John Lucas ,  Jiunn-chern Yeh ,  Deno Dialynas

    IPC分类号： A61K38/17 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06 ,  A61K48/00

    CPC分类号： A61K38/17 ,  C07K14/5759

    摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, homotrimer of OBG3 polypeptide fragment comprising globular domain and all or part of OBG3 collagen-like region, has been identified that has utility for reducing body mass, for maintaining weight loss, and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.

    摘要翻译： 本发明涉及肥胖研究领域。 肥胖是一个严重而广泛的公共卫生问题。 已经鉴定了包含球状结构域和全部或部分OBG3胶原样区域的OBG3多肽片段的同三聚物，其具有用于减少体重，用于维持体重减轻和用于治疗肥胖相关疾病和病症的效用。 这些肥胖相关的疾病和病症包括高脂血症，动脉粥样硬化，糖尿病和高血压。