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公开(公告)号：US09145552B2
公开(公告)日：2015-09-29
申请号：US13815768
申请日：2013-03-15
CPC分类号： C12N9/6432 , A61K38/36 , A61K38/482 , A61K38/4846
摘要： Modified therapeutic proteins are provided. In particular modified Factor X polypeptides, which includes the Factor X zymogen, Factor Xa and other forms of Factor X, and uses thereof are provided.
摘要翻译： 提供了修饰的治疗蛋白质。 提供了包括因子X酶原，因子Xa和其他形式的因子X的修饰的因子X多肽及其用途。
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公开(公告)号：US20140322191A1
公开(公告)日：2014-10-30
申请号：US14267754
申请日：2014-05-01
IPC分类号： C12N9/64
CPC分类号： C12N9/644 , A61K38/4846 , A61K48/00 , C12Y304/21022
摘要： Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰因子IX（FIX）多肽及其用途。 这种修饰的FIX多肽包括FIXa和其它形式的FIX。 提供的修饰的FIX多肽中的那些是具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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公开(公告)号：US08778870B2
公开(公告)日：2014-07-15
申请号：US13373118
申请日：2011-11-03
CPC分类号： C12N9/644 , A61K38/4846 , A61K48/00 , C12Y304/21022
摘要： Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰因子IX（FIX）多肽及其用途。 这种修饰的FIX多肽包括FIXa和其它形式的FIX。 提供的修饰的FIX多肽中的那些是具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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公开(公告)号：US08663633B2
公开(公告)日：2014-03-04
申请号：US13507480
申请日：2012-07-02
申请人： Edwin L. Madison
发明人： Edwin L. Madison
CPC分类号： C12N15/1037 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/23 , C07K2319/30 , C07K2319/41 , C07K2319/42 , C12N9/50 , C12N9/6408 , C12N9/6462 , C12Q1/37 , C12Y304/21073 , C12Y304/21109 , G01N33/6842
摘要： Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.
摘要翻译： 提供用于鉴定修饰的底物特异性或其它性质的修饰蛋白酶的方法。 通过使筛选候选物和修饰的蛋白酶与底物（例如丝氨酸蛋白酶抑制剂，α巨球蛋白或p35家族蛋白质或修饰的丝氨酸蛋白酶和修饰的p35家族成员或修饰的α巨球蛋白）接触来筛选候选物和修饰的蛋白酶，在基底切割时， 蛋白酶通过形成稳定的复合物。 还提供了修饰的蛋白酶。
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公开(公告)号：US20120308551A1
公开(公告)日：2012-12-06
申请号：US13507480
申请日：2012-07-02
申请人： Edwin L. Madison
发明人： Edwin L. Madison
CPC分类号： C12N15/1037 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/23 , C07K2319/30 , C07K2319/41 , C07K2319/42 , C12N9/50 , C12N9/6408 , C12N9/6462 , C12Q1/37 , C12Y304/21073 , C12Y304/21109 , G01N33/6842
摘要： Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.
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公开(公告)号：US20120244139A1
公开(公告)日：2012-09-27
申请号：US13506603
申请日：2012-04-30
CPC分类号： A61K38/482 , A61K38/49 , C07K2319/00 , C12N9/6421 , C12N9/6424 , C12N9/6467 , C12Y304/21109
摘要： Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorder.
摘要翻译： 提供了用于调节补体系统的方法和化合物。 特别地，提供抑制补体活化的化合物，并提供促进补体活化的化合物。 这些化合物由于其对补体系统的作用而成为治疗剂。 因此，抑制补体活化的化合物可用于治疗缺血和再灌注障碍，包括心肌梗死和中风，败血症，自身免疫性疾病，炎性疾病和具有炎性成分的疾病，包括阿尔茨海默氏病和其他神经变性疾病。
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7.发明申请Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon 审中-公开编码跨膜丝氨酸蛋白酶的核酸分子，编码的蛋白质和基于其的方法公开(公告)号：US20110105731A1
公开(公告)日：2011-05-05
申请号：US12927372
申请日：2010-11-12
申请人： Edwin L. Madison , Edgar O. Ong , Jiunn-Chern Yeh
发明人： Edwin L. Madison , Edgar O. Ong , Jiunn-Chern Yeh
IPC分类号： C07K16/40
CPC分类号： C12N9/6424 , C07K2319/00
摘要： Provided herein are antibodies, fragments and derivatives of an antibody containing a binding domain thereof, where the antibody, fragment or derivative specifically binds to a single chain protease domain of a type II transmembrane serine protease (MTSP). Methods using the antibodies to modulate the protease activity of an MTSP are provided. Also provided are antibodies that bind to MTSPs designated MTSP3 and MTSP4 and to a form of an MTSP designated MTSP6.
摘要翻译： 本文提供了抗体，片段和含有其结合结构域的抗体的衍生物，其中抗体，片段或衍生物特异性结合II型跨膜丝氨酸蛋白酶（MTSP）的单链蛋白酶结构域。 提供了使用抗体调节MTSP的蛋白酶活性的方法。 还提供了结合指定为MTSP3和MTSP4的MTSP以及指定为MTSP6的MTSP形式的抗体。
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8.发明申请Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon 有权编码跨膜丝氨酸蛋白酶的核酸分子，编码的蛋白质和基于其的方法公开(公告)号：US20100105121A1
公开(公告)日：2010-04-29
申请号：US12590011
申请日：2009-10-30
申请人： Edwin L. Madison , Edgar O. Ong , Jiunn-Chern Yeh
发明人： Edwin L. Madison , Edgar O. Ong , Jiunn-Chern Yeh
CPC分类号： C12N9/6424 , C07K2319/00
摘要： Provided herein is are polypeptides that include the protease domain of a type II transmembrane serine protease (MTSP) as a single chain. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP are provided. Also provided are MTSPs designated MTSP3 and MTSP4 and a form of an MTSP designated MTSP6.
摘要翻译： 本文提供的是包含作为单链的II型跨膜丝氨酸蛋白酶（MTSP）的蛋白酶结构域的多肽。 提供了使用多肽来鉴定调节MTSP的蛋白酶活性的化合物的方法。 还提供了指定为MTSP3和MTSP4的MTSP以及指定为MTSP6的MTSP形式。
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公开(公告)号：US20090123452A1
公开(公告)日：2009-05-14
申请号：US11825627
申请日：2007-07-05
申请人： Edwin L. Madison
发明人： Edwin L. Madison
IPC分类号： A61K38/48 , C40B20/04 , C40B30/04 , C40B20/06 , C40B40/10 , C12N15/63 , C07K14/00 , A61P9/00 , A61P25/00 , A61P7/02 , C12N1/00 , C07H21/00 , C12N9/48 , C12N9/72 , A61K38/49
CPC分类号： C12N15/1037 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/23 , C07K2319/30 , C07K2319/41 , C07K2319/42 , C12N9/50 , C12N9/6408 , C12N9/6462 , C12Q1/37 , C12Y304/21073 , C12Y304/21109 , G01N33/6842
摘要： Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.
摘要翻译： 提供用于鉴定修饰的底物特异性或其它性质的修饰蛋白酶的方法。 通过使筛选候选物和修饰的蛋白酶与底物（例如丝氨酸蛋白酶抑制剂，α巨球蛋白或p35家族蛋白质或修饰的丝氨酸蛋白酶和修饰的p35家族成员或修饰的α巨球蛋白）接触来筛选候选物和修饰的蛋白酶，在基底切割时， 蛋白酶通过形成稳定的复合物。 还提供了修饰的蛋白酶。
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公开(公告)号：US07276364B1
公开(公告)日：2007-10-02
申请号：US09717473
申请日：2000-11-20
申请人： Edwin L. Madison , Edgar O. Ong
发明人： Edwin L. Madison , Edgar O. Ong
CPC分类号： C12N9/6424 , C07K2319/00
摘要： Provided herein are endotheliases and portions, particularly, the protease domains, and nucleic acids that encode the endotheliases. The endotheliases are transmembrane proteases expressed in endothelial cells. The nucleic acids and encoded proteins and protease domain portions thereof are used in a variety of prognostic, diagnostic, therapeutic and screening methods, including methods for screening for compounds that modulate angiogenesis.
摘要翻译： 本文提供了内皮酶和部分，特别是蛋白酶结构域和编码内皮酶的核酸。 内皮酶是内皮细胞中表达的跨膜蛋白酶。 核酸和其编码的蛋白质和蛋白酶结构域部分用于各种预后，诊断，治疗和筛选方法，包括筛选调节血管生成的化合物的方法。
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