发明授权
- 专利标题： Protease screening methods and proteases identified thereby
- 专利标题（中）： 因此鉴定出蛋白酶筛选方法和蛋白酶
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申请号： US13507480申请日： 2012-07-02
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公开(公告)号： US08663633B2公开(公告)日： 2014-03-04
- 发明人: Edwin L. Madison
- 申请人： Edwin L. Madison
- 申请人地址： US CA San Diego US CA South San Francisco
- 专利权人： Torrey Pines Institute for Molecular Studies,Catalyst Biosciences, Inc.
- 当前专利权人： Torrey Pines Institute for Molecular Studies,Catalyst Biosciences, Inc.
- 当前专利权人地址： US CA San Diego US CA South San Francisco
- 代理机构： McKenna Long & Aldridge LLP
- 代理商 Stephanie Seidman
- 主分类号： A61K38/48
- IPC分类号： A61K38/48 ; C12Q1/37 ; C07H21/04
摘要：
Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.
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