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1.发明申请Nucleic acid molecules encoding serine protease 16, the encoded polypeptides and methods based thereon 审中-公开编码丝氨酸蛋白酶16的核酸分子，编码的多肽和基于其的方法公开(公告)号：US20050112579A1
公开(公告)日：2005-05-26
申请号：US10612466
申请日：2003-07-01
Applicant: Edwin Madison , Edgar Ong , Jiunn- Chern Yeh
Inventor： Edwin Madison , Edgar Ong , Jiunn- Chern Yeh
CPC classification number: C12N9/6424 , A01K2217/05 , A01K2217/075 , A61K2039/505
Abstract: Provided herein are serine proteases designated CVSP16. CVSP16 polypeptides exhibit protease activity as a single chain or as a multi-chain form. Methods using the polypeptides to identify compounds that modulate the protease activity thereof are provided. The polypeptides also serve as tumor markers.
Abstract translation: 本文提供了称为CVSP16的丝氨酸蛋白酶。 CVSP16多肽表现出作为单链或多链形式的蛋白酶活性。 提供了使用多肽来鉴定调节其蛋白酶活性的化合物的方法。 多肽也用作肿瘤标志物。
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公开(公告)号：US20060171884A1
公开(公告)日：2006-08-03
申请号：US11303608
申请日：2005-12-16
Applicant: Ian Foltz , Chadwick King , Peter Ling , Jaspal Kang , Kathy Manchulenko , Francine Chen , Caroline Scatena , Bruce Keyt , Edwin Madison , Wayne Godfrey , Stanislaw Morkowski , Jennifer Richardson
Inventor： Ian Foltz , Chadwick King , Peter Ling , Jaspal Kang , Kathy Manchulenko , Francine Chen , Caroline Scatena , Bruce Keyt , Edwin Madison , Wayne Godfrey , Stanislaw Morkowski , Jennifer Richardson
IPC: A61K51/00 , C07H21/04 , C12P21/06 , A61K39/395 , C12N5/06
CPC classification number: C07K16/40 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N2500/04
Abstract: Binding proteins, such as fully human monoclonal antibodies and fragments thereof, directed to the antigen Matriptase and uses of such binding proteins are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising heavy and light chain immunoglobulin molecules capable of binding to Matriptase are also disclosed. The invention also discloses cell lines expressing such immunoglobulin molecules and monoclonal antibodies to Matriptase. The antibodies can be used to detect, prevent, and treat diseases such as cancer.
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公开(公告)号：US20070093443A1
公开(公告)日：2007-04-26
申请号：US11584776
申请日：2006-10-20
Applicant: Edwin Madison , Jack Nguyen , Sandra Ruggles , Christopher Thanos
Inventor： Edwin Madison , Jack Nguyen , Sandra Ruggles , Christopher Thanos
CPC classification number: A61K38/482 , A61K38/49 , C07K2319/00 , C12N9/6421 , C12N9/6424 , C12N9/6467 , C12Y304/21109
Abstract: Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorder.
Abstract translation: 提供了用于调节补体系统的方法和化合物。 特别地，提供抑制补体活化的化合物，并提供促进补体活化的化合物。 这些化合物由于其对补体系统的作用而成为治疗剂。 因此，抑制补体活化的化合物可用于治疗缺血和再灌注障碍，包括心肌梗死和中风，败血症，自身免疫性疾病，炎性疾病和具有炎性成分的疾病，包括阿尔茨海默氏病和其他神经变性疾病。
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Patent Agency Ranking
公开(公告)号：US20050164945A1
公开(公告)日：2005-07-28
申请号：US10969719
申请日：2004-10-20
Applicant: Andrew Nixon , Edwin Madison
Inventor： Andrew Nixon , Edwin Madison
CPC classification number: C07K14/001 , A61K38/00
Abstract: The disclosure describes compounds that can include a peptide or Kunitz domain that binds endotheliase 1 (ET1). The compounds can be used, e.g., to reduce angiogenesis in a subject having or at risk for a neoplastic disorder, modulate the activity of an ET1-expressing cell, modulate proteolysis of a biological structure, detect endotheliase activity or protein in a sample, and detect ET1 protein in a subjects.
Abstract translation: 本公开描述了可以包括结合内皮酶1（ET1）的肽或Kunitz结构域的化合物。 所述化合物可用于减少患有或具有肿瘤性疾病风险的受试者的血管生成，调节表达ET1的细胞的活性，调节生物结构的蛋白水解，检测样品中的内皮酶活性或蛋白质，以及 检测受试者中的ET1蛋白。
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公开(公告)号：US07572444B2
公开(公告)日：2009-08-11
申请号：US11303608
申请日：2005-12-16
Applicant: Ian Foltz , Chadwick King , Peter Koon Bong Ling , Jaspal Singh Kang , Kathy Manchulenko , Francine Chen , Caroline Darne Scatena , Bruce A. Keyt , Edwin Madison , Wayne R. Godfrey , Stanislaw K. Morkowski , Jennifer H. Richardson
Inventor： Ian Foltz , Chadwick King , Peter Koon Bong Ling , Jaspal Singh Kang , Kathy Manchulenko , Francine Chen , Caroline Darne Scatena , Bruce A. Keyt , Edwin Madison , Wayne R. Godfrey , Stanislaw K. Morkowski , Jennifer H. Richardson
IPC: A61K39/395 , A61K51/00 , C07H21/04 , C12N5/06 , C12P21/06
CPC classification number: C07K16/40 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N2500/04
Abstract: Binding proteins, such as fully human monoclonal antibodies and fragments thereof, directed to the antigen Matriptase and uses of such binding proteins are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising heavy and light chain immunoglobulin molecules capable of binding to Matriptase are also disclosed. The invention also discloses cell lines expressing such immunoglobulin molecules and monoclonal antibodies to Matriptase. The antibodies can be used to detect, prevent, and treat diseases such as cancer.
Abstract translation: 公开了涉及抗原Matriptase的结合蛋白，例如完全人单克隆抗体及其片段，以及这些结合蛋白的用途。 还公开了编码和包含能够结合Matriptase的重链和轻链免疫球蛋白分子的氨基酸序列的核苷酸序列。 本发明还公开了表达这种免疫球蛋白分子的细胞系和对Matriptase的单克隆抗体。 抗体可用于检测，预防和治疗诸如癌症的疾病。
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6.发明申请公开(公告)号：US20060029590A1
公开(公告)日：2006-02-09
申请号：US11149513
申请日：2005-06-10
Applicant: Christopher Thanos , Edwin Madison
Inventor： Christopher Thanos , Edwin Madison
CPC classification number: C12N9/6421 , A61K38/00 , C12N9/6494 , C12Y304/24011
Abstract: Administration of recombinant, truncated mammalian NEP or certain bacterial homologues of this protein is therapeutically effective in the treatment of inflammatory bowel disease.
Abstract translation: 重组，截短的哺乳动物NEP或该蛋白质的某些细菌同系物的施用在治疗炎症性肠病中是治疗有效的。
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公开(公告)号：US20080019962A1
公开(公告)日：2008-01-24
申请号：US11838677
申请日：2007-08-14
Applicant: Andrew Nixon , Edwin Madison
Inventor： Andrew Nixon , Edwin Madison
IPC: A61K39/395 , A61P43/00 , C12N5/00
CPC classification number: C07K16/40 , A61K2039/505 , C07K2317/55 , C07K2317/56 , C07K2317/76
Abstract: Proteins that bind to ET2, such as immunoglobulins that inhibit ET2 with high affinity and selectivity, are provided. The ET2 binding proteins can be used to treat a variety of disorders, including angiogenesis-associated disorders.
Abstract translation: 提供了结合ET2的蛋白质，例如以高亲和力和选择性抑制ET2的免疫球蛋白。 ET2结合蛋白可用于治疗多种疾病，包括血管发生相关疾病。
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公开(公告)号：US20050180977A1
公开(公告)日：2005-08-18
申请号：US10916758
申请日：2004-08-12
Applicant: Andrew Nixon , Edwin Madison
Inventor： Andrew Nixon , Edwin Madison
IPC: A61K39/395 , C07H21/04 , C07K16/40 , C12N5/06
CPC classification number: C07K16/40 , A61K2039/505 , C07K2317/55 , C07K2317/56 , C07K2317/76
Abstract: This disclosure provides, inter alia, proteins that bind to ET2, e.g., immunoglobulins that inhibit ET2 with high affinity and selectivity. The ET2 binding proteins can be used to treat a variety of disorders including angiogenesis-associated disorders.
Abstract translation: 本公开尤其提供结合ET2的蛋白质，例如以高亲和力和选择性抑制ET2的免疫球蛋白。 ET2结合蛋白可用于治疗多种疾病，包括血管发生相关疾病。
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