-
1.发明申请公开(公告)号：US20100144733A1
公开(公告)日：2010-06-10
申请号：US12590977
申请日：2009-11-16
申请人： Kevin James Doyle , Graham Peter Jones , Michael Geoffrey Neil Russell , Sebastian Bruckner , Jacqueline Anne Macritchie , Joanne Peach
发明人： Kevin James Doyle , Graham Peter Jones , Michael Geoffrey Neil Russell , Sebastian Bruckner , Jacqueline Anne Macritchie , Joanne Peach
IPC分类号： A61K31/4245 , C07D271/06 , C07D413/12 , C07D413/14 , C07D253/06 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K31/53 , A61P15/00 , A61P9/00 , A61P1/12
CPC分类号： A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/4245 , A61K31/50 , C07D237/14 , C07D237/20 , C07D249/10 , C07D253/06 , C07D261/18 , C07D263/34 , C07D271/06 , C07D277/56 , C07D285/12 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
摘要翻译： 本发明涉及用于治疗动物疾病的组合物和方法，该疾病通过对有需要的哺乳动物施用有效量的本文定义的化合物来对功能性囊性纤维化跨膜传导调节因子（CFTR）多肽的抑制作出反应 包括表1-14所示或由式I-XII所包括的那些化合物）或其组合物，从而治疗疾病。 本发明特别涉及一种治疗腹泻和多囊肾病的方法。
-
公开(公告)号：US20090286828A1
公开(公告)日：2009-11-19
申请号：US11722219
申请日：2005-12-21
申请人： Andrea Bozzoli , Clive Leslie Branch , Jacqueline Anne Macritchie , Howard Robert Marshall , Roderick Alan Porter , Simone Spada
发明人： Andrea Bozzoli , Clive Leslie Branch , Jacqueline Anne Macritchie , Howard Robert Marshall , Roderick Alan Porter , Simone Spada
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/165 , C07D215/38 , C07C233/00 , C07D401/02
CPC分类号： C07C255/57 , C07C233/78 , C07C235/66 , C07C237/48 , C07C2601/08 , C07C2602/08 , C07D215/50 , C07D295/135 , C07D405/12
摘要： The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. wherein R1 is a group selected from:
摘要翻译： 本发明涉及式（I）化合物或其盐或溶剂化物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。 本发明还包括制备这些化合物及其药物制剂的方法。 其中R1是选自：
-
3.发明申请COMPOUNDS HAVING ACTIVITY AT THE GLYCINE TRANSPORTER GLYT1 AND USES THEREOF 审中-公开在GLYCINE TRANSPORTER GLYT1中具有活性的化合物及其用途公开(公告)号：US20090227629A1
公开(公告)日：2009-09-10
申请号：US12158761
申请日：2007-01-08
申请人： Clive Leslie Branch , Jacqueline Anne Macritchie , Howard Marshall , Roderick Alan Porter , Simone Spada
发明人： Clive Leslie Branch , Jacqueline Anne Macritchie , Howard Marshall , Roderick Alan Porter , Simone Spada
IPC分类号： A61K31/4545 , C07D213/70 , A61K31/44 , C07D401/12
CPC分类号： C07D333/38 , C07D213/70 , C07D261/18
摘要： The present invention relates to compounds of formula (I), salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. wherein R1, R2, R3, R4, R5, R6 and n are as defined in the description.
摘要翻译： 本发明涉及式（I）化合物，其盐或溶剂合物，它们在制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物中的用途。 本发明还包括制备这些化合物及其药物制剂的方法。 其中R1，R2，R3，R4，R5，R6和n如说明书中所定义。
-
公开(公告)号：US08778966B2
公开(公告)日：2014-07-15
申请号：US13617686
申请日：2012-09-14
申请人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thèrése Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
发明人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thèrése Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
IPC分类号： A61K31/04 , C07D413/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D215/227 , C07D417/06
CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6，R7，n，m和X具有 定义含义。
-
公开(公告)号：US20100216837A1
公开(公告)日：2010-08-26
申请号：US11722210
申请日：2005-12-21
申请人： Andrea Bozzoli , Daniel Marcus Bradley , Steven Coulton , Martin Leonard Gilpin , Jacqueline Anne MacRitchie , Roderick Alan Porter , Kevin Michael Thewlis
发明人： Andrea Bozzoli , Daniel Marcus Bradley , Steven Coulton , Martin Leonard Gilpin , Jacqueline Anne MacRitchie , Roderick Alan Porter , Kevin Michael Thewlis
IPC分类号： A61K31/4709 , C07C231/06 , A61K31/166 , C07D215/50 , A61K31/47 , C07D333/06 , A61K31/381 , C07D207/04 , A61K31/40 , A61P25/00
CPC分类号： C07C211/36 , C07C211/29 , C07C229/34 , C07C233/78 , C07C271/22 , C07C2601/08 , C07D215/50 , C07D295/13 , C07D333/20 , C07D409/12
摘要： The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
摘要翻译： 本发明涉及式（I）化合物或其盐或溶剂合物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。 本发明还包括制备这些化合物及其药物制剂的方法。
-
公开(公告)号：US20100168065A1
公开(公告)日：2010-07-01
申请号：US12529142
申请日：2008-03-07
申请人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Pilatte , Bruno Roux , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Francoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
发明人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Pilatte , Bruno Roux , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Francoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
IPC分类号： A61K31/675 , C07D215/227 , A61K31/4704 , C07D413/12 , A61K31/5377 , C07D401/12 , A61K31/496 , A61K31/506 , C07F9/38 , A61K31/502 , A61K31/498 , C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6，R7，n，m和X具有 定义含义。
-
7.发明申请OXYGEN CONTAINING HETEROCYCLES AS GLYCINE TRANSPORTER INHIBITING COMPOUNDS 审中-公开含氧化合物作为甘氨酸运输抑制剂的含氧化合物公开(公告)号：US20100137428A1
公开(公告)日：2010-06-03
申请号：US11722216
申请日：2005-12-21
申请人： Andrea Bozzoli , Clive Leslie Branch , Jacqueline Anne MacRitchie , Howard Robert Marshall , Roderick Alan Porter , Simone Spada
发明人： Andrea Bozzoli , Clive Leslie Branch , Jacqueline Anne MacRitchie , Howard Robert Marshall , Roderick Alan Porter , Simone Spada
IPC分类号： A61K31/36 , C07D307/87 , A61K31/343 , C07D317/46 , A61P25/18 , A61P25/28 , A61P25/00
CPC分类号： C07D307/84 , C07D317/48
摘要： The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. wherein R1 is a group selected from:
摘要翻译： 本发明涉及式（I）化合物或其盐或溶剂合物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。 本发明还包括制备这些化合物及其药物制剂的方法。 其中R1是选自：
-
8.发明申请公开(公告)号：US20090318429A1
公开(公告)日：2009-12-24
申请号：US12430834
申请日：2009-04-27
申请人： Kevin James Doyle , Graham Peter Jones , Michael Geoffrey Neil Russell , Sebastian Bruckner , Jacqueline Anne Macritchie , Joanne Peach
发明人： Kevin James Doyle , Graham Peter Jones , Michael Geoffrey Neil Russell , Sebastian Bruckner , Jacqueline Anne Macritchie , Joanne Peach
IPC分类号： A61K31/5415 , C07D413/02 , C07D253/06 , C07D417/12 , A61K31/497 , A61K31/53 , C12N5/06 , A61P13/12
CPC分类号： C07D271/06 , A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/4245 , A61K31/50 , C07D237/14 , C07D249/10 , C07D253/06 , C07D263/34 , C07D277/56 , C07D285/12
摘要： The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
摘要翻译： 本发明涉及用于治疗动物疾病的组合物和方法，该疾病通过对有需要的哺乳动物施用有效量的本文定义的化合物来对功能性囊性纤维化跨膜传导调节因子（CFTR）多肽的抑制作出反应 包括表1-14所示或由式I-XII所包括的那些化合物）或其组合物，从而治疗疾病。 本发明特别涉及一种治疗腹泻和多囊肾病的方法。
-
公开(公告)号：US20130018017A1
公开(公告)日：2013-01-17
申请号：US13617686
申请日：2012-09-14
申请人： Jorge Eduardo VIALARD , Patrick René ANGIBAUD , Laurence Anne MEVELLEC , Christophe MEYER , Eddy Jean Edgard FREYNE , Isabelle Noëlle Constance PILATTE , Bruno ROUX , Elizabeth Thérèse Jeanne PASQUIER , Xavier Marc BOURDREZ , Christophe Denis ADELINET , Laurence Françoise Bernadette MARCONNET-DECRANE , Jacqueline Anne MACRITCHIE , James Edward Stewart DUFFY , Andrew Pate OWENS , Pierre-Henri STORCK , Virginie Sophie PONCELET
发明人： Jorge Eduardo VIALARD , Patrick René ANGIBAUD , Laurence Anne MEVELLEC , Christophe MEYER , Eddy Jean Edgard FREYNE , Isabelle Noëlle Constance PILATTE , Bruno ROUX , Elizabeth Thérèse Jeanne PASQUIER , Xavier Marc BOURDREZ , Christophe Denis ADELINET , Laurence Françoise Bernadette MARCONNET-DECRANE , Jacqueline Anne MACRITCHIE , James Edward Stewart DUFFY , Andrew Pate OWENS , Pierre-Henri STORCK , Virginie Sophie PONCELET
IPC分类号： A61K31/4704 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/675 , A61K31/4709 , A61K31/501 , A61K31/475 , A61P25/00 , A61P25/28 , A61P9/00 , A61P21/00 , A61P29/00 , A61P19/06 , A61P19/02 , A61P9/10 , A61P37/00 , A61P35/00 , A61P1/00 , A61P19/10 , A61P3/10 , A61P13/12 , A61K31/695
CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6，R7，n，m和X具有 定义含义。
-
公开(公告)号：US20090270510A1
公开(公告)日：2009-10-29
申请号：US11722213
申请日：2005-12-21
申请人： Daniel Marcus Bradley , Clive Leslie Branch , Wai Ngor Chan , Steven Coulton , Martin Leonard Gilpin , Andrew Jonathan Harris , Justine Yeun Quai Lai , Jacqueline Anne Macritchie , Howard Robert Marshall , David John Nash , Roderick Alan Porter , Simone Spada , Kevin Michael Thewlis , Simon Edward Ward
发明人： Daniel Marcus Bradley , Clive Leslie Branch , Wai Ngor Chan , Steven Coulton , Martin Leonard Gilpin , Andrew Jonathan Harris , Justine Yeun Quai Lai , Jacqueline Anne Macritchie , Howard Robert Marshall , David John Nash , Roderick Alan Porter , Simone Spada , Kevin Michael Thewlis , Simon Edward Ward
IPC分类号： A61K31/166 , C07C321/10 , C07C233/78 , C07C211/27
CPC分类号： C07C235/60 , C07C211/27 , C07C233/78 , C07C235/50 , C07C323/62
摘要： The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
摘要翻译： 本发明涉及式（I）化合物或其盐或溶剂合物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。 本发明还包括制备这些化合物及其药物制剂的方法。
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.026 秒)
