Non-Invasive In-Situ Detection Of Malignant Skin Tissue And Other Abnormalities Using Laser Plasma Spectroscopy
    1.
    发明申请
    Non-Invasive In-Situ Detection Of Malignant Skin Tissue And Other Abnormalities Using Laser Plasma Spectroscopy 审中-公开
    使用激光等离子体光谱法对恶性皮肤组织和其他异常的非侵入性原位检测

    公开(公告)号:US20080269618A1

    公开(公告)日:2008-10-30

    申请号:US12110528

    申请日:2008-04-28

    IPC分类号: A61B6/00 A61B10/02

    摘要: Disclosed is a system and method for a non-invasive method for determining the presence or absence of cancerous cells in the skin and deeper tissue levels. The system includes a portable handheld laser coupled with a spectroscopy system to produce real-time material analysis of the presence of cancerous cells without sample preparation. The system focuses a high peak power laser pulse onto a targeted material to produce a laser spark or micro-plasma. Elemental line spectra emission is created, collected and analyzed by a spectrophotometer. The line spectra emission data is quickly displayed on a laptop computer. “Eye-safe” Class I lasers provide for practical in-situ laser plasma spectroscopy applications such as detection of cancerous skin tissues. The emission data can be used to detect changes in the levels of a series of elements that are associated with cancerous cells versus normal skin cells. The system also finds use during excisional biopsy procedures to ensure that all cancerous cells have been removed.

    摘要翻译: 公开了用于确定皮肤和深层组织水平中癌细胞存在或不存在的非侵入性方法的系统和方法。 该系统包括与光谱系统耦合的便携式手持式激光器,以在没有样品制备的情况下产生癌细胞的存在的实时材料分析。 该系统将高峰值功率激光脉冲聚焦到目标材料上以产生激光火花或微等离子体。 通过分光光度计产生,收集和分析元素线谱发射。 线谱发射数据快速显示在笔记本电脑上。 “眼睛安全”I类激光器提供实际的原位激光等离子体光谱应用,例如检测癌性皮肤组织。 发射数据可用于检测与癌细胞相对于正常皮肤细胞相关的一系列元件的水平的变化。 该系统还可以在切除活检过程中使用,以确保所有的癌细胞已被去除。

    Fiber laser with cladding-to-core energy migration
    2.
    发明授权
    Fiber laser with cladding-to-core energy migration 失效
    具有包层到核心能量迁移的光纤激光器

    公开(公告)号:US07042915B2

    公开(公告)日:2006-05-09

    申请号:US10433024

    申请日:2001-12-07

    IPC分类号: H01S3/30

    摘要: A method of transferring energy in an optical fiber (12) from the fiber's cladding element (16) of the fiber's core element (14) is disclosed. The core element (14) includes an active gain component and an energy migration component, and the cladding element (16), which surrounds the core element (14), includes the energy migration component. The method includes the steps of providing a pump (22) for producting energy and optically coupling the pump with the cladding element (16), such that the energy is absorbed and stored in the cladding element (16) by its energy migration component. A further step includes the active gain component in the core element (14) lasing or providing gain, when the transferring of energy from the cladding element's energy migration component to the core element's energy migration component takes place.

    摘要翻译: 公开了一种从光纤的芯元件(14)的光纤包层元件(16)向光纤(12)传输能量的方法。 核心元件(14)包括有源增益分量和能量迁移组件,并且围绕核心元件(14)的包层元件(16)包括能量迁移组件。 该方法包括以下步骤:提供用于产生能量并将泵与包层元件(16)光学耦合的泵(22),使得能量通过其能量迁移部件被吸收并存储在包层元件(16)中。 当能量从包层元件的能量迁移组件转移到核心元件的能量迁移组件时,另一步骤包括激励或提供增益的核心元件(14)中的有源增益分量。

    Optical fiber laser structure and system based on ASE pumping of cladding element
    3.
    发明授权
    Optical fiber laser structure and system based on ASE pumping of cladding element 失效
    光纤激光器结构和基于ASE泵浦包层元件的系统

    公开(公告)号:US06693924B2

    公开(公告)日:2004-02-17

    申请号:US10070036

    申请日:2002-06-07

    IPC分类号: H01S330

    摘要: An optical fiber laser structure and system are disclosed. The fiber laser structure includes a core, an inner cladding, and an outer cladding. The core has a first and second end and includes a combination of ytterbium and erbium as a first active gain component. The inner cladding, having a length defined between the first and second ends, surrounds the core. The inner cladding includes neodymium as a second active gain component that is different from the first active gain component. The system includes a pumping source coupled to the inner cladding to provide energy to the neodymium in the inner cladding. Upon being pumped, the neodymium achieves amplified spontaneous emission in the inner cladding along the length between the first and second ends. As a result, energy is efficiently transferred from the neodymium to the combination of the ytterbium and erbium in the core thereby providing laser activity at an eye-safe laser wavelength of 1535 nanometers.

    摘要翻译: 公开了一种光纤激光器结构和系统。 光纤激光器结构包括芯,内包层和外包层。 芯具有第一和第二端,并且包括镱和铒的组合作为第一有源增益分量。 具有限定在第一和第二端之间的长度的内包层围绕芯。 内包层包括钕作为与第一有源增益分量不同的第二有源增益分量。 该系统包括耦合到内包层的泵浦源,以向内包层中的钕提供能量。 在被泵送时,钕在内包层中沿着第一和第二端之间的长度实现放大的自发发射。 结果,能量被有效地从钕转移到核心中的镱和铒的组合中,从而在1535纳米的眼睛安全的激光波长下提供激光活性。

    Ion-exchangeable phosphate glass compositions and strengthened optical
quality glass articles
    4.
    发明授权
    Ion-exchangeable phosphate glass compositions and strengthened optical quality glass articles 失效
    可离子交换的磷酸盐玻璃组合物和增强的光学质量玻璃制品

    公开(公告)号:US4875920A

    公开(公告)日:1989-10-24

    申请号:US128676

    申请日:1987-12-04

    申请人: John D. Myers

    发明人: John D. Myers

    IPC分类号: C03C3/17

    CPC分类号: C03C3/17

    摘要: Ion-exchangeable phosphate glass compositions containing in mole percent from about 50 to 70% P.sub.2 O.sub.5, from about 5 to 30 % Li.sub.2 O, from about 5 to 25% MO, where M is selected from the group consisting of Be, Mg, Ca, Sr, Ba, and Zn, and about 5 to 30% X.sub.2 O.sub.3, where X is selected from the group consisting of Al, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu are provided. In another aspect, the phosphate glass compositions of the present invention also contain in mole percent up to 10% R.sub.2 O, where R is selected from the group consisting of Na, K, Rb and Cs. Solarization inhibitors and minor amounts of anhydrous fluorides and chlorides are also included in some embodiments. Optical quality phosphate glass articles formed of the phosphate glass compositions of the present invention are readily ion- exchangeable when contacted with certain salts. Optical quality phosphate glass articles are also provided having good thermal shock resistance. These glass articles have an inner tension region and an outer compressive surface layer formed using an ion exchange process. In some embodiments, laser rods and similar active optical elements are formed from the strengthened phosphate glass articles of the present invention where the optical elements are doped with an amount of a suitable dopant effective for laser activity.

    摘要翻译: 可离子交换的磷酸盐玻璃组合物,其含有摩尔百分数为约50至70%的P2O5,约5至30%的Li2O,约5至25%的MO,其中M选自Be,Mg,Ca,Sr ,Ba和Zn以及约5〜30%的X2O3,其中X选自Al,Y,La,Ce,Pr,Nd,Pm,Sm,Eu,Gd,Tb,Dy,Ho,Er ,Tm,Yb和Lu。 另一方面,本发明的磷酸盐玻璃组合物还含有多至10%的R 2 O,其中R选自Na,K,Rb和Cs。 在一些实施方案中还包括减光剂和少量的无水氟化物和氯化物。 由本发明的磷酸盐玻璃组合物形成的光学质量磷酸盐玻璃制品在与某些盐接触时容易离子交换。 还提供具有良好耐热冲击性的光学品质磷酸盐玻璃制品。 这些玻璃制品具有内部张力区域和使用离子交换工艺形成的外部压缩表面层。 在一些实施例中,激光棒和类似的有源光学元件由本发明的加强的磷酸盐玻璃制品形成,其中光学元件掺杂一定量的适合于激光活性的掺杂剂。

    Methods and assemblies for liquid-phase reactions
    5.
    发明授权
    Methods and assemblies for liquid-phase reactions 有权
    液相反应的方法和装配

    公开(公告)号:US08859830B2

    公开(公告)日:2014-10-14

    申请号:US12717800

    申请日:2010-03-04

    申请人: John D. Myers

    发明人: John D. Myers

    摘要: Methods and assemblies for improving the reaction kinetics of, conserving reactants utilized in, and/or producing a more pure reaction product of, liquid-phase reactions that involve volatile reactants and products are provided. The methods and assemblies herein provide for a feed of reaction liquid to two or more absorption zones, wherein the temperature and/or feed rate of the liquid is independently adjusted prior to introduction into at least one of the two or more absorption zones. More particularly, the temperature and feed rate of the liquid as delivered to each absorption zone can be adjusted independently to optimize the absorption of at least a portion of any gaseous reactants and byproducts from the gaseous product stream and/or to optimize reaction zone conditions. Reaction kinetics may thus be improved, or substantially maintained.

    摘要翻译: 提供了用于改善用于和/或生产涉及挥发性反应物和产物的液相反应的更纯的反应产物的反应动力学的保护反应动力学的方法和装置。 本文的方法和组件提供了将反应液体进料到两个或更多个吸收区域,其中在引入两个或更多个吸收区域中的至少一个吸收区域之前,液体的温度和/或进料速率被独立地调节。 更具体地,可以独立地调节输送到每个吸收区域的液体的温度和进料速率,以优化来自气态产物流的至少一部分气态反应物和副产物的吸收和/或优化反应区条件。 反应动力学因此可以得到改善或基本维持。

    Contact method to allow benign failure in ceramic capacitor having self-clearing feature
    6.
    发明授权
    Contact method to allow benign failure in ceramic capacitor having self-clearing feature 有权
    具有自清除功能的陶瓷电容器的良性故障接触方法

    公开(公告)号:US08208239B2

    公开(公告)日:2012-06-26

    申请号:US12469087

    申请日:2009-05-20

    IPC分类号: H01G2/00 H01G4/015

    CPC分类号: H01G4/015 H01G4/1218

    摘要: A capacitor exhibiting a benign failure mode has a first electrode layer, a first ceramic dielectric layer deposited on a surface of the first electrode, and a second electrode layer disposed on the ceramic dielectric layer, wherein selected areas of the ceramic dielectric layer have additional dielectric material of sufficient thickness to exhibit a higher dielectric breakdown voltage than the remaining majority of the dielectric layer. The added thickness of the dielectric layer in selected areas allows lead connections to be made at the selected areas of greater dielectric thickness while substantially eliminating a risk of dielectric breakdown and failure at the lead connections, whereby the benign failure mode is preserved.

    摘要翻译: 表现出良性破坏模式的电容器具有第一电极层,沉积在第一电极的表面上的第一陶瓷电介质层和设置在陶瓷介电层上的第二电极层,其中陶瓷介电层的选定区域具有额外的电介质 足够厚度的材料表现出比绝缘层的剩余大部分更高的介电击穿电压。 在选择的区域中增加的电介质层的厚度允许在较大电介质厚度的选定区域进行引线连接,同时基本消除引线连接处的介电击穿和故障的风险,从而保持良性故障模式。

    SHAPEABLE SHORT-RESISTANT CAPACITOR
    10.
    发明申请
    SHAPEABLE SHORT-RESISTANT CAPACITOR 有权
    形状短路电容

    公开(公告)号:US20110002081A1

    公开(公告)日:2011-01-06

    申请号:US12498025

    申请日:2009-07-06

    IPC分类号: H01G4/002 B32B43/00 B05D5/12

    摘要: A method that employs a novel combination of conventional fabrication techniques provides a ceramic short-resistant capacitor that is bendable and/or shapeable to provide a multiple layer capacitor that is extremely compact and amenable to desirable geometries. The method allows thinner and more flexible ceramic capacitors to be made. The method includes forming a first thin metal layer on a substrate; depositing a thin, ceramic dielectric layer over the metal layer; depositing a second thin metal layer over the dielectric layer to form a capacitor exhibiting a benign failure mode; and separating the capacitor from the substrate.

    摘要翻译: 使用常规制造技术的新颖组合的方法提供了可弯曲和/或可成形的陶瓷短路电容器,以提供非常紧凑和适合所需几何形状的多层电容器。 该方法允许制造更薄和更柔性的陶瓷电容器。 该方法包括在衬底上形成第一薄金属层; 在所述金属层上沉积薄的陶瓷介电层; 在所述介​​电层上沉积第二薄金属层以形成呈现良性故障模式的电容器; 并将电容器与衬底分离。