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    Design of Hydrolytically Releasable Prodrugs for Sustained Release Nanoparticle Formulations
    1.
    发明申请
    Design of Hydrolytically Releasable Prodrugs for Sustained Release Nanoparticle Formulations 有权
    用于缓释纳米颗粒配方的水解可释放前药的设计

    公开(公告)号：US20130296285A1

    公开(公告)日：2013-11-07

    申请号：US13976776

    申请日：2011-12-28

    申请人： Ivan Alferiev ,  Michael Chorny ,  Robert J. Levy

    发明人： Ivan Alferiev ,  Michael Chorny ,  Robert J. Levy

    IPC分类号： A61K47/48

    CPC分类号： A61K47/48123 ,  A61K47/551 ,  A61K47/554 ,  A61K47/645 ,  C08B37/0021

    摘要： A prodrug according to formula (I) wherein R2 is a residue of a drug, said drug having a hydroxyl group by which the COOR2 group is formed; Z is O or NH; m is 0 or 1; and R3 is an organic moiety comprising a lipophilic group or a residue of a polymer, provided that Z is 0 if the polymer is carboxymethyl dextran. A system includes a plurality of magnetic nanoparticles including a prodrug as described above, a stent and a source of uniform magnetic field capable of producing temporary magnetization of the stent and/or the magnetic nanoparticles. A method of treating a medical condition with a drug includes administering to a patient in need of the drug a prodrug as described above, the prodrug being capable of releasing the drug in the patient after the administration step.

    摘要翻译： 根据式（I）的前药，其中R2是药物的残基，所述药物具有形成COOR 2基团的羟基; Z是O或NH; m为0或1; 并且R3是包含亲油基团或聚合物残基的有机部分，条件是如果聚合物是羧甲基葡聚糖，则Z为0。 一种系统包括多个磁性纳米颗粒，包括如上所述的前体药物，能够产生支架和/或磁性纳米颗粒的暂时磁化的支架和均匀磁场源。 用药物治疗医学病症的方法包括向需要该药物的患者施用如上所述的前药，该前药能够在施用步骤后释放患者的药物。

    Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex
    3.
    发明授权
    Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex 有权
    用表面附着的聚阳离子络合物配制的磁驱动的可生物降解的基因递送纳米颗粒

    公开(公告)号：US07846201B2

    公开(公告)日：2010-12-07

    申请号：US11250948

    申请日：2005-10-14

    申请人： Michael Chorny ,  Boris Polyak ,  Ilia Fishbein ,  Ivan Alferiev ,  Robert J. Levy

    发明人： Michael Chorny ,  Boris Polyak ,  Ilia Fishbein ,  Ivan Alferiev ,  Robert J. Levy

    IPC分类号： A61F2/02

    CPC分类号： A61K9/5146 ,  A61K9/5094 ,  A61K9/5153 ,  A61K47/59 ,  A61K47/6923 ,  A61K47/6929

    摘要： A particle including a matrix-forming agent and a polyelectrolyte-amphiphilic agent adduct wherein the polyelectrolyte-amphiphilic agent adduct is in physical communication with the matrix-forming agent. The particle further includes a coated magnetic field-responsive agent and a biomaterial. Methods of making the particle are provided. Also provided are methods of delivery of the biomaterial to a target cell or a target tissue including administering the particle having the matrix-forming agent, polyelectrolyte-amphiphilic agent adduct, the coated magnetic field-responsive agent and the biomaterial; providing a magnetic device associated with the target cell or the target tissue; applying a magnetic force to the particle; and guiding the particle toward the magnetic device by the magnetic force.

    摘要翻译： 包括基质形成剂和聚电解质 - 两亲加合物的颗粒，其中聚电解质 - 两亲性加合物与基质形成剂物理连通。 颗粒还包括涂覆的磁场响应剂和生物材料。 提供制造颗粒的方法。 还提供了将生物材料递送到靶细胞或靶组织的方法，包括施用具有基质形成剂的颗粒，聚电解质 - 两亲剂加合物，包被的磁场响应剂和生物材料; 提供与所述靶细胞或所述靶组织相关联的磁性装置; 向颗粒施加磁力; 并通过磁力将粒子引向磁性装置。

    Gene and Cell Delivery Self Expanding Polymer Stents
    4.
    发明申请
    Gene and Cell Delivery Self Expanding Polymer Stents 审中-公开
    基因和细胞递送自扩张聚合物支架

    公开(公告)号：US20070293927A1

    公开(公告)日：2007-12-20

    申请号：US10589711

    申请日：2004-04-16

    申请人： Ko Frank ,  Robert Levy ,  Ivan Alferiev ,  Ilia Fishbein

    发明人： Ko Frank ,  Robert Levy ,  Ivan Alferiev ,  Ilia Fishbein

    IPC分类号： A61F2/06

    CPC分类号： A61F2/90 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/80

    摘要： A device having polymeric filaments, wherein at least one of the filaments includes at least one groove for slidably retaining at least one other filament, such that the device is adapted to revert to a tubular lattice structure when allowed to expand from a collapsed state. A device as described above and further including a biologically active function, wherein the polymeric filaments of the device include an agent having a reactive group or a fiber adapted to covalently react with a biomaterial. Thus, the device of the invention has an active structural function such as the ability to regain a shape and, optionally, a biologically active function such as the ability to deliver a biomaterial to an organism or a cell. A process of manufacturing the device is also described.

    摘要翻译： 一种具有聚合物长丝的装置，其中至少一根长丝包括至少一个用于可滑动地保持至少一个其它细丝的凹槽，使得该装置适于在允许从折叠状态膨胀时回复到管状格子结构。 如上所述的装置并且还包括生物活性功能，其中所述装置的聚合长丝包括具有反应性基团的试剂或适于与生物材料共价反应的纤维。 因此，本发明的装置具有活性结构功能，例如恢复形状和任选的生物活性功能的能力，例如将生物材料递送到生物体或细胞的能力。 还描述了制造该装置的过程。

    Thiol activation of polyurethanes and methods of making the same
    6.
    发明授权
    Thiol activation of polyurethanes and methods of making the same 有权
    聚氨酯的硫醇活化及其制备方法

    公开(公告)号：US06890998B2

    公开(公告)日：2005-05-10

    申请号：US10672893

    申请日：2003-09-26

    申请人： Ivan Alferiev ,  Ilia Fishbein ,  Robert J. Levy

    发明人： Ivan Alferiev ,  Ilia Fishbein ,  Robert J. Levy

    IPC分类号： A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  C08G18/44 ,  C08G18/48 ,  C08G18/81 ,  C08G18/82 ,  C08G18/83 ,  G01N21/64

    CPC分类号： A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  C08G18/44 ,  C08G18/4854 ,  C08G18/838 ,  G01N21/6428 ,  C08L75/04

    摘要： A polyurethane having a thiol substituent pendant from at least one nitrogen and/or at least one carbon atom of the polyurethane.A polyurethane having a thiol substituent pendant from at least one nitrogen and/or at least one carbon atom of the polyurethane, wherein the thiol substituent has a formula: —RL—(S—R1)n wherein n is an integer from 1 to 3; RL is an (n+1)-valent organic radical having at least one carbon atom; and R1 is a member selected from the group consisting of H, C(O)R3, and SR4, wherein R3 is a member selected from the group consisting of C1 to C6 alkyl and R4 is a heterocyclic group or an electron deficient aromatic group.

    摘要翻译： 具有聚氨酯的至少一个氮原子和/或至少一个碳原子的硫醇取代基的聚氨酯。 聚氨酯，其具有来自聚氨酯的至少一个氮原子和/或至少一个碳原子的硫醇取代基，其中所述硫醇取代基具有下式：<？in-line-formula description =“In-line Formulas”end =“ （“1”）在线公式描述=“在线公式”结束 =“尾”→其中n是1至3的整数; R L是具有至少一个碳原子的（n + 1）价有机基团; 和R 1是选自H，C（O）R 3和SR 4的成员，其中R SUP > 3 是选自C 1至C 6烷基的基团，R 4是杂环基或 电子缺乏芳族基团。

    Biodegradable linkers for molecular therapies
    7.
    发明授权
    Biodegradable linkers for molecular therapies 有权
    用于分子疗法的生物可降解接头

    公开(公告)号：US08580545B2

    公开(公告)日：2013-11-12

    申请号：US13306459

    申请日：2011-11-29

    申请人： Ivan Alferiev ,  Robert J. Levy ,  Ilia Fishbein

    发明人： Ivan Alferiev ,  Robert J. Levy ,  Ilia Fishbein

    IPC分类号： C12N11/06 ,  C12N11/00

    CPC分类号： A61K47/6957 ,  A61K47/6901 ,  C12N2799/022

    摘要： A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.

    摘要翻译： 用于将生物材料递送到动物细胞或组织的方法和组合物，所述组合物包括（a）生物材料; （b）具有可水解键的可生物降解的交联剂部分，其中所述可生物降解的交联剂部分与所述生物材料共价结合; 并且（c）底物，其中所述底物共价结合到所述可生物降解的交联剂部分，条件是所述可生物降解的交联剂适于通过破坏所述可水解键从而水解，从而释放和递送所述生物材料。 还提供了制备组合物的方法。

    Photochemical activation of surfaces for attaching biomaterial
    9.
    发明授权
    Photochemical activation of surfaces for attaching biomaterial 有权
    用于附着生物材料的表面的光化学活化

    公开(公告)号：US07635734B2

    公开(公告)日：2009-12-22

    申请号：US11250877

    申请日：2005-10-14

    申请人： Ivan Alferiev ,  Ilia Fishbein ,  Michael Chorny ,  Robert J. Levy ,  Benjamin Yellen ,  Darryl Williams

    发明人： Ivan Alferiev ,  Ilia Fishbein ,  Michael Chorny ,  Robert J. Levy ,  Benjamin Yellen ,  Darryl Williams

    IPC分类号： A61K47/48

    CPC分类号： C08G63/91 ,  A61K31/765 ,  A61K31/785 ,  A61L27/50 ,  A61L2400/18 ,  C07K17/02 ,  C08F8/10 ,  C08F8/32 ,  C08F8/34 ,  C08F226/02 ,  C08F271/02 ,  C08F290/00 ,  C08F291/00 ,  C08J7/18 ,  C08L75/04 ,  C08F120/06 ,  C08F126/02

    摘要： A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.

    摘要翻译： 一种水溶性可光活化聚合物，其包括：适于被辐照源活化并在所述水溶性可光活化聚合物与具有至少一个碳的基质之间形成共价键的可光致活化基团; 适于与生物材料共价反应的反应性基团，用于随后将生物材料递送至细胞; 亲水基团; 和聚合物前体。 一种组合物，其包含水溶性可光活化聚合物的单分子层和具有至少一个碳的基质，其中单分子层通过可光致活化基团和至少一个碳之间的共价键共价连接到基质上 。 组合物还包括具有多个活性基团的生物材料，其中生物材料通过活性基团和反应性基团之间的共价键共价连接到单分子层上。 还提供了将生物材料递送到细胞的方法。