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公开(公告)号：US20100075932A1
公开(公告)日：2010-03-25
申请号：US12625068
申请日：2009-11-24
IPC分类号： A61K31/609 , A61P3/04 , A61P25/00 , A61P1/00 , A61P35/00 , A61P9/10 , A61P9/12 , C07C235/56 , C07C255/50
CPC分类号： C07D333/60 , C07C235/64 , C07C255/60 , C07D333/38
摘要： Novel salicylic anilides are chemical uncouplers useful e.g. for the treatment of obesity.
摘要翻译： 新型水杨酸酯是化学解偶联剂，例如有用的。 用于治疗肥胖。
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公开(公告)号：US06242443B1
公开(公告)日：2001-06-05
申请号：US08877456
申请日：1997-06-17
申请人： Bernard Pirotte , Philippe Lebrun , Pascal De Tullio , Fabian Somers , Jacques Delarge , John Bondo Hansen , Flemming Elmelund Nielsen , Holger Claus Hansen , John Patrick Mogensen , Tina Møller-Tagmose
发明人： Bernard Pirotte , Philippe Lebrun , Pascal De Tullio , Fabian Somers , Jacques Delarge , John Bondo Hansen , Flemming Elmelund Nielsen , Holger Claus Hansen , John Patrick Mogensen , Tina Møller-Tagmose
IPC分类号： C07D28524
CPC分类号： A61K31/541 , A61K31/5415 , C07D285/24 , C07D453/02 , C07D453/06
摘要： 1,2,4-Benzothiadiazine derivatives represented by formula wherein D, R1, R2, R3, R4, R5, R12, R13, R14, R15 are defined in the description, composition thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system.
摘要翻译： 所述化合物的制备方法及其制备方法在本说明书中进行了说明，其中，式（Ⅳ）所示的1,2,4-苯并噻二嗪衍生物由式Ⅵ所示，D，R 1，R 2，R 3，R 4，R 5，R 12，R 13，R 14， 可用于治疗中枢神经系统疾病，心血管系统，肺系统，胃肠系统和内分泌系统。
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3.发明授权Pyrido-1,2,4-thiadiazine and pyrido-1,4-thiazine derivatives, their preparation and use 失效吡啶-1,2,4-噻二嗪和吡啶-1,4-噻嗪衍生物，其制备和用途
公开(公告)号：US5792764A
公开(公告)日：1998-08-11
申请号：US785435
申请日：1997-01-17
申请人： Bernard Pirotte , Philippe Lebrun , Pascal De Tullio , Fabian Somers , Jacques Delarge , Holger Claus Hansen , Flemming Elmelund Nielsen , John Bondo Hansen
发明人： Bernard Pirotte , Philippe Lebrun , Pascal De Tullio , Fabian Somers , Jacques Delarge , Holger Claus Hansen , Flemming Elmelund Nielsen , John Bondo Hansen
IPC分类号： A61K31/00 , A61K31/54 , A61K31/542 , A61K31/549 , A61P1/00 , A61P3/00 , A61P3/10 , A61P5/48 , A61P5/50 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P17/14 , A61P25/06 , A61P25/08 , A61P25/28 , C07D513/04
CPC分类号： C07D513/04
摘要： Pyrido-1,2,4-thiadiazine and pyrido-1,4-thiazine derivatives represented by the formula ##STR1## wherein A, B, D, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, pulmonary system, the gastrointestinal system and the endocrinologic system.
摘要翻译： 其中A，B，D，R 1，R 2，R 3和R 4表示的吡咯并-1,2,4-噻二嗪和吡啶并-1,4-噻嗪衍生物在其描述中的定义，其组成和方法 描述了制备化合物。 该化合物可用于治疗中枢神经系统疾病，心血管系统，肺系统，胃肠系统和内分泌系统。
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4.发明授权2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes 失效用于治疗肥胖和糖尿病的2-（2-羟基苯基）苯并咪唑公开(公告)号：US07915299B2
公开(公告)日：2011-03-29
申请号：US12515049
申请日：2007-11-15
申请人： Anders Klarskov Petersen , Preben Houlberg Olesen , Lise Brown Christiansen , Holger Claus Hansen , Flemming Elmelund Nielsen
发明人： Anders Klarskov Petersen , Preben Houlberg Olesen , Lise Brown Christiansen , Holger Claus Hansen , Flemming Elmelund Nielsen
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： C07D235/18
摘要： The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
摘要翻译： 本发明涉及用作化学解偶联剂的新型化合物。 本发明的化合物尤其可用于治疗，包括预防肥胖症，糖尿病和与其相关的许多疾病或病症。
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5.发明授权Compounds and uses thereof for decreasing activity of hormone-sensitive lipase 失效用于降低激素敏感性脂肪酶活性的化合物及其用途公开(公告)号：US07279470B2
公开(公告)日：2007-10-09
申请号：US10319885
申请日：2002-12-13
IPC分类号： C07D401/12 , C07D401/14 , A61K31/496 , A61K31/4523
CPC分类号： C07D207/404 , C07C39/367 , C07C233/25 , C07C233/26 , C07C233/60 , C07C307/06 , C07C311/04 , C07C311/17 , C07C311/21 , C07C311/29 , C07C311/40 , C07C317/22 , C07C323/20 , C07C2601/14 , C07D209/08 , C07D209/32 , C07D209/48 , C07D211/88 , C07D213/61 , C07D213/63 , C07D213/64 , C07D213/643 , C07D213/68 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/84 , C07D215/20 , C07D215/22 , C07D217/24 , C07D231/12 , C07D231/16 , C07D233/54 , C07D233/56 , C07D235/18 , C07D235/26 , C07D237/14 , C07D239/22 , C07D241/18 , C07D241/44 , C07D249/04 , C07D249/08 , C07D249/18 , C07D253/04 , C07D257/04 , C07D261/12 , C07D263/52 , C07D277/24 , C07D277/68 , C07D285/01 , C07D295/205 , C07D295/26 , C07D307/16 , C07D307/52 , C07D307/89 , C07D311/16 , C07D311/18 , C07D333/16 , C07D333/32 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/06 , C07D491/10
摘要： Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.
摘要翻译： 使用化合物抑制激素敏感性脂肪酶，包含化合物的药物组合物，使用这些化合物和组合物的治疗方法以及新化合物。 本发明化合物是激素敏感性脂肪酶的抑制剂，并且可用于治疗和/或预防需要激素敏感性脂肪酶活性降低的医学病症。
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公开(公告)号：US06225310B1
公开(公告)日：2001-05-01
申请号：US09539242
申请日：2000-03-30
申请人： Flemming Elmelund Nielsen , John Bondo Hansen , Holger Claus Hansen , Tina Møller Tagmose , John Patrick Mogensen
发明人： Flemming Elmelund Nielsen , John Bondo Hansen , Holger Claus Hansen , Tina Møller Tagmose , John Patrick Mogensen
IPC分类号： C07D49804
CPC分类号： C07D513/04
摘要： 1,2,4-Thiadiazine and 1,4-thiazine derivates represented by formula (I): wherein A, B, D, R1, R2, R3 and R4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system.
摘要翻译： 由式（I）表示的1,2,4-噻二嗪和1,4-噻嗪衍生物：其中A，B，D，R 1，R 2，R 3和R 4在说明书中定义，其组成及其制备方法为 所述化合物可用于治疗中枢神经系统，心血管系统，肺系统，胃肠系统和内分泌系统的疾病。
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7.发明授权Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use 失效熔融的1,2,4-噻二嗪和稠合的1,4-噻嗪衍生物，其制备和用途
公开(公告)号：US5889002A
公开(公告)日：1999-03-30
申请号：US785438
申请日：1997-01-17
申请人： Flemming Elmelund Nielsen , Holger Claus Hansen , John Bondo Hansen , Tina M.o slashed.ller Tagmose
发明人： Flemming Elmelund Nielsen , Holger Claus Hansen , John Bondo Hansen , Tina M.o slashed.ller Tagmose
IPC分类号： A61K31/54 , A61K31/542 , A61K31/549 , A61P1/12 , A61P3/00 , A61P3/08 , A61P3/10 , A61P9/08 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P25/04 , A61P25/08 , A61P25/28 , A61P43/00 , C07D513/04 , A61K31/535 , C07D498/04
CPC分类号： C07D513/04
摘要： 1,2,4-Thiadiazine and 1,4-thiazine derivatives represented by the formula ##STR1## wherein A, B, D, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinologic system.
摘要翻译： 其中A，B，D，R 1，R 2，R 3和R 4如式IV所定义，其组成及其制备方法如下式 描述。 该化合物可用于治疗中枢神经系统疾病，心血管系统，肺系统，胃肠系统和内分泌系统。
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8.发明授权2-(2-hydroxyphenyl) benzothiadiazines useful for treating obesity and diabetes 失效可用于治疗肥胖和糖尿病的2-（2-羟基苯基）苯并噻二嗪公开(公告)号：US08022066B2
公开(公告)日：2011-09-20
申请号：US12515056
申请日：2007-11-15
申请人： Anders Klarskov Petersen , Preben Houlberg Olesen , Lise Brown Christiansen , Holger Claus Hansen , Flemming Elmelund Nielsen
发明人： Anders Klarskov Petersen , Preben Houlberg Olesen , Lise Brown Christiansen , Holger Claus Hansen , Flemming Elmelund Nielsen
IPC分类号： C07D285/24 , A61K31/549
CPC分类号： C07D285/24
摘要： The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
摘要翻译： 本发明涉及用作化学解偶联剂的新型化合物。 本发明的化合物尤其可用于治疗，包括预防肥胖症，糖尿病和与其相关的许多疾病或病症。
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9.发明申请HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES 审中-公开用于治疗肥胖和糖尿病的HALOALKYLSULFONE替代化合物公开(公告)号：US20100041657A1
公开(公告)日：2010-02-18
申请号：US11913720
申请日：2006-05-11
申请人： Preben Houlberg Olesen , Holger Claus Hansen , Lise Brown Christiansen , Flemming Elmelund Nielsen , Anders Klarskov Petersen
发明人： Preben Houlberg Olesen , Holger Claus Hansen , Lise Brown Christiansen , Flemming Elmelund Nielsen , Anders Klarskov Petersen
IPC分类号： A61K31/5375 , C07C233/64 , A61K31/165 , C07D333/38 , A61K31/381 , C07D295/00 , C07C69/76 , A61K31/24 , C07C311/15 , A61K31/18 , A61P3/04 , A61P3/10
CPC分类号： C07C317/46 , C07C317/40 , C07C317/50 , C07C323/42 , C07C323/62 , C07C2602/08 , C07C2602/10 , C07C2603/72 , C07D295/26 , C07D307/79 , C07D317/60 , C07D333/38
摘要： The present invention relates to compounds of formula I, in which at least one of R5, R6 and R7 is SR12, S(O)R12 or S(O)2R12 group where R12 is a C1-6haloalkyl group, that act, as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
摘要翻译： 本发明涉及式I化合物，其中R 5，R 6和R 7中的至少一个是SR 12，S（O）R 12或S（O）2 R 12基团，其中R 12是C 1-6卤代烷基，其作为化学 解偶联 本发明的化合物可用于治疗，包括预防肥胖症，糖尿病以及与其相关的许多疾病或病症。
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10.发明申请NOVEL 2-(2-HYDROXYPHENYL) BENZOTHIADIAZINES USEFUL FOR TREATING OBESITY AND DIABETES 失效新的2-（2-羟基苯基）苯并二氮杂用于治疗糖尿病和糖尿病公开(公告)号：US20090325941A1
公开(公告)日：2009-12-31
申请号：US12515056
申请日：2007-11-15
申请人： Anders Klarskov Petersen , Preben Houlberg Olesen , Lise Brown Christiansen , Holger Claus Hansen , Flemming Elmelund Nielsen
发明人： Anders Klarskov Petersen , Preben Houlberg Olesen , Lise Brown Christiansen , Holger Claus Hansen , Flemming Elmelund Nielsen
IPC分类号： A61K31/5415 , C07D285/24
CPC分类号： C07D285/24
摘要： The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
摘要翻译： 本发明涉及用作化学解偶联剂的新型化合物。 本发明的化合物尤其可用于治疗，包括预防肥胖症，糖尿病和与其相关的许多疾病或病症。
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