Solvent-free method for preparing sterically hindered phosphoramidates
    3.
    发明授权
    Solvent-free method for preparing sterically hindered phosphoramidates 有权
    制备空间位阻氨基磷酸酯的无溶剂方法

    公开(公告)号:US06277988B1

    公开(公告)日:2001-08-21

    申请号:US09515801

    申请日:2000-02-29

    CPC classification number: C07F9/2458 C07F9/650952 C07F9/6521

    Abstract: Sterically hindered phosphoramidates such as N,N′-bis[di-(2,6-xylenoxy)phosphinyl]piperazine are prepared by the reaction of a sterically hindered diaryl chlorophosphate, such as di-(2,6-xylyl) chlorophosphate, with a basic nitrogen compound containing at least two basic N—H groups, preferably a heterocyclic compound such as piperazine, in a predominantly liquid, solvent-free reaction mixture. The reaction may be conducted in the melt or in the presence of a non-solvent carrier, typically an aliphatic hydrocarbon. An excess of the basic nitrogen compound is employed as an acid acceptor.

    Abstract translation: 通过空间位阻的氯化磷酸二芳基酯如氯代磷酸二(2,6-二甲苯基)酯与二(2,6-二甲苯基)氧膦基]哌嗪的反应制备了N,N'-双[二 - (2,6-二甲苯氧基) 在主要是液体,无溶剂的反应混合物中含有至少两个碱性NH基团,优选杂环化合物如哌嗪的碱性氮化合物。 反应可以在熔体中或在非溶剂载体(通常为脂族烃)的存在下进行。 使用过量的碱性氮化合物作为酸受体。

Patent Agency Ranking