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    Insulin mimetic amino acid sequences
    4.
    发明申请
    Insulin mimetic amino acid sequences 审中-公开
    胰岛素模拟氨基酸序列

    公开(公告)号：US20050089969A1

    公开(公告)日：2005-04-28

    申请号：US10476184

    申请日：2002-10-07

    申请人： Josef Wissler ,  Gilda Georgi ,  Gunther Boehm

    发明人： Josef Wissler ,  Gilda Georgi ,  Gunther Boehm

    IPC分类号： C07K14/62 ,  A61K38/00 ,  A61K38/28 ,  A61K38/30 ,  A61P5/48 ,  C07K14/415 ,  C07K14/47 ,  C07K14/475 ,  C12N15/17 ,  C07H21/04

    CPC分类号： C07K14/415 ,  A61K38/00 ,  C07K14/4732

    摘要： The invention relates to exsulins or insulin mimetic amino acid sequences with a molecular weight of up to 55,000 daltons and with 1 to 50 basic units of following Formula (1): [−] L,V,I,A]-X1—X2-[L,V,I,A]-[D,E]-[N,Q,M]-X3—[C,H]—X4 [−], whereby; [L,V,I,A], [D,E], [N,Q,M], [C,H] and X1 to 4 represent peptidically linked amino acids; [L,V,I,A] represents leucine (L), valine (V), isoleucine (I) or alanine (A); [D,E] represents asparaginic acid (D) or glutamic acid (E); [N,Q,M] represents asparagine (N), glutamine (Q) or methionine (M); [C,H] represents cysteine (C) or histidine (H); both groups [L,V,I,A] in a basic unit can be identical or different; X1, X2, X3 and X4 represent any type of amino acid and the four amino acids X1 to 4 in a basic unit can be identical or different. The inventive exsulins can be used in dietetic and pharmaceutical agents, and to be precise, can be used for mimicking the properties and functions of members of the family of endogenous insulin and IGF proteohormones/mediators and for preventing, treating and influencing hormonal states and disturbances as well as various degenerative diseases of the body of mammals including various forms of hormonal metabolic disturbances, hormonal resistances, hormonal deficiencies, hyperinsulinemia, diabetes mellitus and autoimmune diseases as well as neurodegenerative and secondary diseases.

    摘要翻译： 本发明涉及分子量高达55,000道尔顿的exsulins或胰岛素模拟氨基酸序列，以及具有1至50个下式（1）的基本单位：[ - ] L，V，I，A] -X < 1 2 - [L，V，I，A] - [D，E] - [N，Q，M] -X 3 - [C，H] -X 4 - [ - ]，由此; [L，V，I，A]，[D，E]，[N，Q，M]，[C，H]和X 1〜4代表肽连接的氨基酸; [L，V，I，A]表示亮氨酸（L），缬氨酸（V），异亮氨酸（I）或丙氨酸（A） [D，E]表示天冬氨酸（D）或谷氨酸（E）; [N，Q，M]表示天冬酰胺（N），谷氨酰胺（Q）或甲硫氨酸（M）; [C，H]表示半胱氨酸（C）或组氨酸（H）; 基本单元中的两组[L，V，I，A]可以相同或不同; X 1，X 2，X 3和X 4代表任何类型的氨基酸，并且四个氨基酸 基本单元中的X 1〜4可以相同或不同。 本发明的exsulins可以用于饮食和药物，并且精确地可以用于模拟内源胰岛素和IGF蛋白激素/介体家族成员的性质和功能，并用于预防，治疗和影响荷尔蒙状态和干扰 以及哺乳动物身体的各种退行性疾病，包括各种形式的激素代谢紊乱，激素抵抗，激素缺乏症，高胰岛素血症，糖尿病和自身免疫疾病以及神经变性和继发性疾病。

    Oligosaccharide mixture
    5.
    发明授权
    Oligosaccharide mixture 有权
    寡糖混合物

    公开(公告)号：US07939118B2

    公开(公告)日：2011-05-10

    申请号：US10148193

    申请日：2000-12-07

    申请人： Bernd Stahl ,  Günther Böhm ,  Berndt Finke ,  Gilda Georgi ,  Jürgen Jelinek ,  Joachim J. Schmitt

    发明人： Bernd Stahl ,  Günther Böhm ,  Berndt Finke ,  Gilda Georgi ,  Jürgen Jelinek ,  Joachim J. Schmitt

    IPC分类号： C13K1/06

    CPC分类号： A61K45/06 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23V2002/00 ,  A61K31/702 ,  A61K35/20 ,  A61K2300/00 ,  A23V2250/28

    摘要： An oligosaccharide mixture based on oligosaccharides from one or several animal milks composed of two or more monosaccharide units. The oligosaccharide mixture comprises at least two oligosaccharide fractions which are each composed of at least two different oligosaccharides. Lactose does not pertain thereto and the total spectrum of the oligosaccharides in the oligosaccharide mixture differs from those present in animal milk or animal milks, wherefrom the oligosaccharide fractions are extracted and that a) if the oligosaccharides are extracted from only one animal milk, the proportion of neutral oligosaccharides to acidic oligosaccharides is 90-60:10-40 weight %, or b) if the oligosaccharides are extracted from at least two animal milks, the oligosaccharides extracted from two different animal milks each make up 10 weight % of the total amount of oligosaccharides present in the oligosaccharide mixture. The oligosaccharide mixture approximates human milk with respect to its positive properties.

    摘要翻译： 基于由两个或更多个单糖单元组成的一个或几个动物奶的寡糖的寡糖混合物。 寡糖混合物包含至少两种各自由至少两种不同寡糖组成的寡糖部分。 乳糖与其无关，低聚糖混合物中寡糖的总光谱与动物乳或动物奶中存在的低聚糖的总光谱不同，其中提取寡糖部分，并且a）如果寡糖仅从一种动物乳提取，则比例 的中性寡糖与酸性寡糖的比例为90-60：10-40重量％，或b）如果从至少两只动物奶中提取低聚糖，则从两种不同动物奶中提取的寡糖各自占总量的10重量％ 的寡糖混合物中存在的寡糖。 寡糖混合物相对于其正性质接近人乳。

    Infant formula
    7.
    发明授权
    Infant formula 有权
    婴幼儿配方奶粉

    公开(公告)号：US06190724B1

    公开(公告)日：2001-02-20

    申请号：US09401611

    申请日：1999-09-22

    申请人： Günther Sawatzki ,  Günther Böhm ,  Gilda Georgi ,  Friedrich Schweikhardt

    发明人： Günther Sawatzki ,  Günther Böhm ,  Gilda Georgi ,  Friedrich Schweikhardt

    IPC分类号： A23L1305

    CPC分类号： A23J3/08 ,  A23C11/04 ,  A23J3/10 ,  A23L33/17 ,  A23L33/19 ,  Y10S426/801

    摘要： A protein composition and a baby food (infant formula) containing this are provided. The protein composition is characterised in that it contains at least 15 wt % (based on the total amount of the proteins) modified proteins, the course of whose digestion is slowed compared to the unmodified, normal proteins serving as starting materials. Such a protein composition and a baby food containing this create just as good metabolic conditions for the normal development of a child as feeding with human milk proteins.

    摘要翻译： 提供了含有这种蛋白质组合物和婴儿食品（婴儿配方食品）。 蛋白质组合物的特征在于，其含有至少15重量％（基于蛋白质的总量）修饰的蛋白质，与用作起始材料的未修饰的正常蛋白质相比，其消化过程减慢。 这样的蛋白质组合物和含有这种婴儿食品对于喂养人乳蛋白质的孩子的正常发育创造出同样好的代谢条件。

    Baby food stimulating growth of the thymus
    9.
    发明授权
    Baby food stimulating growth of the thymus 失效
    婴儿食品刺激生长的胸腺

    公开(公告)号：US06656903B1

    公开(公告)日：2003-12-02

    申请号：US09856483

    申请日：2001-07-16

    申请人： Gunther Sawatzki ,  Gunther Bohm ,  Gilda Georgi

    发明人： Gunther Sawatzki ,  Gunther Bohm ,  Gilda Georgi

    IPC分类号： A23L100

    CPC分类号： A23L33/19 ,  A23L33/16 ,  A23L33/175 ,  A23L33/18 ,  Y10S426/801

    摘要： A thymus growth stimulating baby food is provided, substantially composed of a fat component, as well as a carbohydrate component and a protein component of animal or vegetable or animal and vegetable but not human origin, whereby the protein component is composed of intact proteins, hydrolyzed proteins, peptides or the constituents thereof, or of amino acids or a mixture thereof not bound to peptides or proteins. This type of baby food is characterized in that the total amount of arginine is at least 3.7 g per 100 g of the amino acids present in toto, and that it contains zinc (calculated as elementary zinc) in an amount of at least 40 mg per 100 g of the amino acids present in toto.

    摘要翻译： 提供了一种刺激婴儿食品的婴儿食品，其基本上由脂肪组分组成，以及动物或植物或动植物的蛋白质组分，但不是人源的蛋白质组分，由此完成蛋白质，水解 蛋白质，肽或其组分，或氨基酸或其结合肽或蛋白质的混合物。 这种婴儿食品的特征在于，精氨酸的总量至少为每100g存在于toto中的氨基酸至少3.7g，并且其含有至少40mg的锌（以基本锌计）） 100g存在于toto的氨基酸。

    Protein component for dietetic food
    10.
    发明授权
    Protein component for dietetic food 失效
    饮食食品的蛋白质成分

    公开(公告)号：US06355297B1

    公开(公告)日：2002-03-12

    申请号：US09774189

    申请日：2001-02-06

    申请人： Günther Sawatzki ,  Gilda Georgi ,  Günther Böhm

    发明人： Günther Sawatzki ,  Gilda Georgi ,  Günther Böhm

    IPC分类号： A23J310

    CPC分类号： A23J3/344 ,  A23J3/10 ,  A23L33/19 ,  Y10S426/801

    摘要： The invention relates to the use of a protein component based on conventional proteins used for the production of foods, at least 20 wt-% thereof having a phosphate residue, which is covalently bound to the protein, whereby 50 to 100 wt-% of the proteins including at least one covalently bound phosphate residue, are subjected to a dephosphorylation reaction wherein 20 to 100% of the covalently bound phosphate residues were removed, for a treatment of adult and adolescent patients, as well as of babies and small children suffering from a disturbed gastrointestinal motility and of reflux-predisposed patients. The use of said protein component not only allows for a sufficient protein supply but it also passes rapidly through the stomach and prevents the stomach contents from flowing back into the oesophagus.

    摘要翻译： 本发明涉及基于用于生产食品的常规蛋白质的蛋白质组分的用途，其至少20重量％具有与蛋白质共价结合的磷酸盐残基，由此将50至100重量％ 蛋白质包括至少一个共价结合的磷酸盐残基，进行去磷酸化反应，其中除去20-100％共价结合的磷酸盐残留物，用于治疗成年和青少年患者以及患有 紊乱的胃肠蠕动和反流易感患者。 所述蛋白质组分的使用不仅允许足够的蛋白质供应，而且还快速通过胃并防止胃内容物流回食道。