公开(公告)号：US06221836B1

公开(公告)日：2001-04-24

申请号：US09213968

申请日：1998-12-17

申请人： Paxton K. Beale ,  Donald O. Nickey ,  Millard F. Williamson

发明人： Paxton K. Beale ,  Donald O. Nickey ,  Millard F. Williamson

IPC分类号： A23L1305

CPC分类号： A61K31/19 ,  A61K31/195 ,  A61K31/415 ,  A61K2300/00

摘要： The present invention is based in part upon the discovery that the use of pyruvate in enteral formulations, in combination with an anabolic protein composition, produces a synergistic effect in increasing the lean body mass or muscle tissue of a mammal consuming same. The present invention also provides a method for increasing fat loss or decreasing the percent body fat in a mammal through the administration of an anabolic protein composition. The present invention relates generally to a composition for enhancing the protein concentration or muscle mass of a mammal and a method for enhancing the protein concentration or muscle mass in a mammal. More specifically, the present invention relates to a composition which comprises an anabolic protein composition and optionally pyruvate and/or derivatives thereof. The compositions according to the invention can take the form of powders, liquids, pills, capsules, tablets, food additives, candies or confections.

摘要翻译： 本发明部分地基于以下发现：肠内制剂中的丙酮酸与合成代谢蛋白质组合物的组合在增加消耗其的哺乳动物的瘦体重或肌肉组织中产生协同效应。 本发明还提供了通过施用合成代谢蛋白质组合物来增加哺乳动物的脂肪损失或减少体脂肪百分比的方法。 本发明一般涉及用于增强哺乳动物的蛋白质浓度或肌肉质量的组合物以及用于增强哺乳动物蛋白质浓度或肌肉质量的方法。 更具体地，本发明涉及包含合成代谢蛋白质组合物和任选的丙酮酸和/或其衍生物的组合物。 根据本发明的组合物可以采取粉末，液体，丸剂，胶囊，片剂，食品添加剂，糖果或糖果的形式。

公开(公告)号：US06646006B2

公开(公告)日：2003-11-11

申请号：US10060252

申请日：2002-02-01

申请人： John P. Cooke ,  Victor J. Dzau ,  Gary H. Gibbons

发明人： John P. Cooke ,  Victor J. Dzau ,  Gary H. Gibbons

IPC分类号： A23L1305

CPC分类号： A61K31/00 ,  A23L33/175 ,  A23V2002/00 ,  A61K31/195 ,  A61K31/198 ,  A61K38/063 ,  A61K45/06 ,  A61K48/00 ,  A61K48/0075 ,  C12N9/0044 ,  C12N9/0075 ,  C12N15/85 ,  C12N2800/107 ,  A23V2250/0606 ,  A23V2200/326 ,  A23V2200/3262 ,  A61K2300/00

摘要： Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes.

公开(公告)号：US06605590B1

公开(公告)日：2003-08-12

申请号：US09699946

申请日：2000-10-30

申请人： Stephen J. Lorbert ,  Charles S. Schasteen ,  Paul K. S. Nam ,  Daniel Forciniti ,  Mathur P. Rajesh ,  Shubhender Kapila

发明人： Stephen J. Lorbert ,  Charles S. Schasteen ,  Paul K. S. Nam ,  Daniel Forciniti ,  Mathur P. Rajesh ,  Shubhender Kapila

IPC分类号： A23L1305

CPC分类号： C07K7/06 ,  C12P21/00

摘要： An enzymatic synthesis and composition of &agr;-hydroxy carboxylic acid and &agr;-amino acid or peptide co-oligomers is disclosed wherein a residue of the &agr;-hydroxy carboxylic acid is linked to a residue of the &agr;-amino acid or peptide by an amide linkage. Proteolytic enzyme papain catalyzes co-oligomerization of the &agr;-hydroxy carboxylic acid and &agr;-amino acid. The degree and distribution of oligomerization varies upon the type and concentrations of different reaction mixtures utilized and upon the length of allowed reaction time. The resultant oligomers may be provided to ruminants as bioavailable amino acid supplements that are resistant to degradation in the rumen.

摘要翻译： 公开了α-羟基羧酸和α-氨基酸或肽共低聚物的酶合成和组合物，其中α-羟基羧酸的残基通过酰胺键连接到α-氨基酸或肽的残基 。 蛋白水解酶木瓜蛋白酶催化α-羟基羧酸和α-氨基酸的共低聚。 低聚度的程度和分布根据所使用的不同反应混合物的类型和浓度以及允许的反应时间长短而变化。 所得到的寡聚物可以提供给反刍动物作为抗瘤胃降解的生物可利用氨基酸补充剂。

公开(公告)号：US06458761B2

公开(公告)日：2002-10-01

申请号：US09766686

申请日：2001-01-22

申请人： Lore Maria Klett-Loch

发明人： Lore Maria Klett-Loch

IPC分类号： A23L1305

CPC分类号： A61K35/26 ,  A61K38/00 ,  Y10S930/18

摘要： Immunologically and/or endocrinologically active preparation containing as an active ingredient short-chain peptides with a weighted quantity ratio and a pattern of amino acids characteristic of thymus tissue.

摘要翻译： 含有作为活性成分的具有加权量比例和胸腺组织特征性氨基酸模式的短链肽的免疫学和/或内分泌活性制剂。

公开(公告)号：US06645543B2

公开(公告)日：2003-11-11

申请号：US10266029

申请日：2002-10-07

申请人： Sharon Gohman ,  Carol Jo Lowry

发明人： Sharon Gohman ,  Carol Jo Lowry

IPC分类号： A23L1305

CPC分类号： A23L33/18 ,  A23L33/115 ,  A23L33/175 ,  A23L33/40 ,  Y10S426/801

摘要： A fat-rich powder provides the complete nutritional needs of an at-risk infant no more than one year old, who has acquired a milk allergy, such as cow's milk allergy (“CMA”), and/or an allergy to protein in “soy milk”, as well as digestive or absorption problems resulting in a damaged gut. Because such an infant must derive all its protein from amino acids it is not fed any ingredient derived from mammalian milk, but a combination of amino acids with nucleotides in specified amounts along with free L-glutamine, maintaining specified ratios of their relative amounts, which ratios in the ranges stated are found to be beneficial for healing of the infant's damaged gut, and for promoting cell division to assure its normal growth. A typical feeding of 32.6 gm of the powder delivers 160 cals; the powder, including triglycerides of relatively long chain fatty acids which contribute about 50% of the total caloric content of the powder, is nevertheless solubilized when the powder is manually shaken at 35° C. in a bottle containing 240 ml (8 fl oz) of water.

公开(公告)号：US06511696B2

公开(公告)日：2003-01-28

申请号：US09735884

申请日：2000-12-13

申请人： Sharon Gohman ,  Carol Jo Lowry

发明人： Sharon Gohman ,  Carol Jo Lowry

IPC分类号： A23L1305

CPC分类号： A23L33/18 ,  A23L33/115 ,  A23L33/175 ,  A23L33/40 ,  Y10S426/801

摘要： A fat-rich powder provides the complete nutritional needs of an at-risk infant no more than one year old, who has acquired a milk allergy, such as cow's milk allergy (“CMA”), and/or an allergy to protein in “soy milk”, as well as digestive or absorption problems resulting in a damaged gut. Because such an infant must derive all its protein from amino acids it is not fed any ingredient derived from mammalian milk, but a combination of amino acids with nucleotides in specified amounts along with free L-glutamine, maintaining specified ratios of their relative amounts, which ratios in the ranges stated are found to be beneficial for healing of the infant's damaged gut, and for promoting cell division to assure its normal growth. A typical feeding of 32.6 gm of the powder delivers 160 cals; the powder, including triglycerides of relatively long chain fatty acids which contribute about 50% of the total caloric content of the powder, is nevertheless solubilized when the powder is manually shaken at 35° C. in a bottle containing 240 ml (8 fl oz) of water.

公开(公告)号：US06190724B1

公开(公告)日：2001-02-20

申请号：US09401611

申请日：1999-09-22

申请人： Günther Sawatzki ,  Günther Böhm ,  Gilda Georgi ,  Friedrich Schweikhardt

发明人： Günther Sawatzki ,  Günther Böhm ,  Gilda Georgi ,  Friedrich Schweikhardt

IPC分类号： A23L1305

CPC分类号： A23J3/08 ,  A23C11/04 ,  A23J3/10 ,  A23L33/17 ,  A23L33/19 ,  Y10S426/801

摘要： A protein composition and a baby food (infant formula) containing this are provided. The protein composition is characterised in that it contains at least 15 wt % (based on the total amount of the proteins) modified proteins, the course of whose digestion is slowed compared to the unmodified, normal proteins serving as starting materials. Such a protein composition and a baby food containing this create just as good metabolic conditions for the normal development of a child as feeding with human milk proteins.

摘要翻译： 提供了含有这种蛋白质组合物和婴儿食品（婴儿配方食品）。 蛋白质组合物的特征在于，其含有至少15重量％（基于蛋白质的总量）修饰的蛋白质，与用作起始材料的未修饰的正常蛋白质相比，其消化过程减慢。 这样的蛋白质组合物和含有这种婴儿食品对于喂养人乳蛋白质的孩子的正常发育创造出同样好的代谢条件。