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公开(公告)号：US20210147917A1
公开(公告)日：2021-05-20
申请号：US17144708
申请日：2021-01-08
IPC分类号： C12Q1/6825 , B01L3/00
摘要： This invention provides biochip cartridges and instrument devices for the detection and/or analysis of target analytes from patient samples.
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公开(公告)号：US10670591B2
公开(公告)日：2020-06-02
申请号：US15974605
申请日：2018-05-08
IPC分类号： G01N33/543 , C40B40/04
摘要： The invention, depending on aspect and embodiment, relates to capture probe controls, and capture and signal probe configurations and combinations of configurations that can facilitate accurate and efficient multiplex analyte detection, especially in electrochemical detection schemes.
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公开(公告)号：US20180180605A1
公开(公告)日：2018-06-28
申请号：US15857427
申请日：2017-12-28
IPC分类号： G01N33/543
CPC分类号： G01N33/5438
摘要： The present invention provides compositions and methods directed to an electrode initialization step for the electrochemical treatment of monolayers used in electrochemical detection of target analytes on the surface of a monolayer. Electrode initialization creates a more stable monolayer, and resolves variability within the electrochemical signal detected on the monolayer.
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公开(公告)号：US10005080B2
公开(公告)日：2018-06-26
申请号：US14538506
申请日：2014-11-11
发明人： Jon Faiz Kayyem , Sean Ford , Vamsee K. Pamula , Vijay Srinivasan , Scott Corey , Brian Murphy , David Walter Wright , Dominic Aiello
CPC分类号： B01L3/502 , B01L3/502792 , B01L3/52 , B01L7/525 , B01L2200/04 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/021 , B01L2300/04 , B01L2300/06 , B01L2300/0636 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2300/1822 , B01L2400/0427 , B01L2400/043 , B01L2400/0481 , B01L2400/0487 , B01L2400/0683
摘要： In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.
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公开(公告)号：US20180111119A1
公开(公告)日：2018-04-26
申请号：US15848049
申请日：2017-12-20
发明人： DAVID WALTER WRIGHT
CPC分类号： B01L3/505 , B01L3/502 , B01L3/52 , B01L2200/0621 , B01L2300/0816 , B01L2300/087 , B01L2300/12 , B01L2300/123 , B01L2300/126 , B01L2400/0481 , B65D81/3238
摘要： A module for processing fluids includes one or more collapsible fluid chambers supported on a substrate, a compression element supported on the substrate and configured to be movable with respect to the one or more chambers, and an actuating element coupled to the compression element and configured to effect movement of the compression element relative to the one or more fluid chambers to collapse each fluid chamber by compressing the fluid chamber between the compression element and the substrate as the compression element moves over the fluid chamber. A method for motivating a fluid out of a fluid chamber comprises the steps of providing a module that includes one or more collapsible fluid chambers supported on a substrate, a compression element supported on the substrate and configured to be movable with respect to the one or more chambers, and an actuating element coupled to the compression element and configured to effect movement of the compression element relative to the one or more fluid chambers and moving the actuator element to move the compression element across at least a portion of t substrate and compress the fluid chamber, thereby motivating the fluid out of the fluid chamber.
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公开(公告)号：US09598722B2
公开(公告)日：2017-03-21
申请号：US14538533
申请日：2014-11-11
CPC分类号： C12Q1/6825 , B01F7/00116 , B01F7/00133 , B01F7/00141 , B01F7/003 , B01F7/00341 , B01F13/0094 , B01F15/00006 , B01F15/00318 , B01F15/00538 , B01F2215/0037 , B01L3/502738 , B01L3/502784 , B01L7/525 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2200/10 , B01L2200/142 , B01L2200/147 , B01L2200/16 , B01L2300/021 , B01L2300/022 , B01L2300/044 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/161 , B01L2300/1822 , B01L2400/0427 , B01L2400/0481 , B01L2400/0683 , C12N15/1006
摘要： In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.
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7.发明授权Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system 有权用于在封闭的样品制备和反应系统中进行测定的处理滤芯的仪器公开(公告)号：US09498778B2
公开(公告)日：2016-11-22
申请号：US14538565
申请日：2014-11-11
发明人： Scott Corey , Brian Murphy , Eric Schneider , David Walter Wright , Dominic Aiello , Andrew Fish , Jay Srinivasan , George Maltezos
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L3/502792 , B01L3/505 , B01L2200/027 , B01L2200/0668 , B01L2200/0673 , B01L2200/0684 , B01L2200/10 , B01L2200/14 , B01L2300/021 , B01L2300/022 , B01L2300/0609 , B01L2300/0636 , B01L2300/0645 , B01L2300/0663 , B01L2300/0681 , B01L2300/0809 , B01L2300/0858 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/123 , B01L2300/18 , B01L2300/1805 , B01L2300/1827 , B01L2400/0427 , B01L2400/043 , B01L2400/0481 , B01L2400/0487 , C12Q1/6846 , C12Q2563/113 , C12Q2563/143 , C12Q2563/159 , C12Q2565/629
摘要： In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.
摘要翻译： 在一个实施例中，多重流体处理盒包括样品阱，可变形流体室，与其中设置的混合器的混合井，包括裂解混合器的裂解室，用于微滴操作的电润湿栅格，以及配置成检测分析物的电传感器阵列 出于兴趣。 用于处理盒的装置被配置为接收盒并且选择性地将热能，磁力和电连接施加到盒上的一个或多个离散位置，并且还被配置成以指定的顺序压缩可变形室 。
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公开(公告)号：US09410663B2
公开(公告)日：2016-08-09
申请号：US14206817
申请日：2014-03-12
CPC分类号： B01L3/50273 , B01L3/502 , B01L3/502715 , B01L3/505 , B01L3/523 , B01L2200/0689 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , B01L2300/123 , B01L2400/0481 , B01L2400/0683 , B65D35/28 , B65D35/30 , B65D35/56 , B65D83/0055 , F17D1/08 , Y10T137/0318 , Y10T137/87917
摘要： An apparatus for processing a fluid module, including a collapsible vessel supported on a planar substrate, comprises a first actuator component configured to be movable in a first direction is generally parallel to the plane of the substrate, a second actuator component configured to be movable in a second direction having a component that is normal to the plane of the substrate, and a motion conversion mechanism coupling the first actuator component with the second actuator component and configured to convert movement of the first actuator component in the first direction into movement of the second actuator component in the second direction.
摘要翻译： 一种用于处理流体模块的装置，包括支撑在平面基板上的可折叠容器，包括构造成可在第一方向上移动的第一致动器部件大致平行于所述基板的平面，第二致动器部件构造成可在 具有与所述基板平面垂直的分量的第二方向，以及将所述第一致动器部件与所述第二致动器部件联接并被配置为将所述第一致动器部件沿所述第一方向的运动转换成所述第二方向的运动的运动转换机构， 致动器部件沿第二方向。
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公开(公告)号：US20150323555A1
公开(公告)日：2015-11-12
申请号：US14807000
申请日：2015-07-23
IPC分类号： G01N35/00
CPC分类号： G01N35/00722 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L7/525 , B01L2200/0621 , B01L2200/0631 , B01L2200/10 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/123 , B01L2400/0427 , B01L2400/0481 , B01L2400/0683 , G01N35/00732 , G01N2035/00019 , G01N2035/00366 , G01N2035/00752 , G01N2035/0091
摘要： This invention provides biochip cartridges and instrument devices for the detection and/or analysis of target analytes from patient samples.
摘要翻译： 本发明提供用于从患者样品检测和/或分析目标分析物的生物芯片盒和仪器装置。
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公开(公告)号：US20140323326A1
公开(公告)日：2014-10-30
申请号：US14218615
申请日：2014-03-18
IPC分类号： C12Q1/68
CPC分类号： G01N33/5438
摘要： The present invention provides compositions and methods directed to an electrode initialization step for the electrochemical treatment of monolayers used in electrochemical detection of target analytes on the surface of a monolayer. Electrode initialization creates a more stable monolayer, and resolves variability within the electrochemical signal detected on the monolayer.
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