公开(公告)号：US20240358963A1

公开(公告)日：2024-10-31

申请号：US18526542

申请日：2023-12-01

Applicant: Fractyl Health, Inc.

Inventor： Harith RAJAGOPALAN ,  Jay CAPLAN ,  Craig M. GARDNER ,  J. Christopher FLAHERTY

IPC: A61M25/00 ,  A61B5/00 ,  A61B5/055 ,  A61B17/00 ,  A61B17/02 ,  A61B17/30 ,  A61B17/34 ,  A61B18/00 ,  A61B18/02 ,  A61B18/04 ,  A61B18/06 ,  A61B18/08 ,  A61B18/14 ,  A61B18/18 ,  A61B18/24 ,  A61B90/00 ,  A61F5/00 ,  A61M25/04 ,  A61N7/00 ,  A61N7/02

CPC classification number: A61M25/00 ,  A61B5/0036 ,  A61B5/0084 ,  A61B5/4255 ,  A61B5/4836 ,  A61B5/6852 ,  A61B5/6885 ,  A61B17/00234 ,  A61B18/02 ,  A61B18/082 ,  A61B18/1492 ,  A61B18/1815 ,  A61F5/0069 ,  A61F5/0079 ,  A61M25/04 ,  A61N7/00 ,  A61B5/0066 ,  A61B5/055 ,  A61B2017/00004 ,  A61B2017/00022 ,  A61B2017/00199 ,  A61B2017/00269 ,  A61B17/00491 ,  A61B2017/00818 ,  A61B17/0218 ,  A61B2017/306 ,  A61B17/3478 ,  A61B2018/00005 ,  A61B2018/00011 ,  A61B2018/00017 ,  A61B2018/00029 ,  A61B2018/00041 ,  A61B2018/0022 ,  A61B2018/00255 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00494 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00672 ,  A61B2018/00678 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00809 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00863 ,  A61B2018/00875 ,  A61B2018/00982 ,  A61B2018/0212 ,  A61B2018/046 ,  A61B18/06 ,  A61B2018/1861 ,  A61B18/24 ,  A61B2090/3908 ,  A61B2090/3933 ,  A61B2090/395 ,  A61B2218/002 ,  A61B2505/05 ,  A61B2560/0431 ,  A61B2562/227 ,  A61M25/0082 ,  A61M2210/1053 ,  A61M2210/1057 ,  A61M2210/1071 ,  A61M2210/1408 ,  A61N7/022

Abstract: A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat polycystic ovarian syndrome (PCOS).

公开(公告)号：US20230200883A1

公开(公告)日：2023-06-29

申请号：US17879222

申请日：2022-08-02

Applicant: Fractyl Health, Inc.

Inventor： Jay Caplan ,  Harith Rajagopalan ,  J. Christopher Flaherty

IPC: A61B18/14

CPC classification number: A61B18/14 ,  A61B18/1492 ,  A61B2018/00494

Abstract: A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

公开(公告)号：US20220354571A1

公开(公告)日：2022-11-10

申请号：US17868076

申请日：2022-07-19

Applicant: Fractyl Health, Inc.

Inventor： Jay Caplan ,  Harith Rajagopalan ,  Mark A. Manasas ,  Christopher James Kadamus ,  Andrew Coats ,  Philip S. Levin ,  J. Christopher Flaherty

IPC: A61B18/14 ,  A61M25/00 ,  A61M25/04 ,  A61B5/00 ,  A61M29/02 ,  A61M29/00 ,  A61B17/12

Abstract: A device for expanding tissue comprises at least one fluid delivery tube and at least one fluid delivery element in fluid communication with the at least one fluid delivery tube. The at least one fluid delivery tube comprises a proximal end, a distal end, and a lumen therebetween. The device is constructed and arranged to perform a near full circumferential expansion of luminal wall tissue. Systems and methods are also provided, including a system for expanding tissue layers and treating tissue proximate to the expanded tissue layers.

公开(公告)号：US20220265337A1

公开(公告)日：2022-08-25

申请号：US17490947

申请日：2021-09-30

Applicant: Fractyl Health, Inc.

Inventor： HARITH RAJAGOPALAN ,  DAVID MAGGS ,  J. CHRISTOPHER FLAHERTY

IPC: A61B18/06 ,  A61B18/20

Abstract: Provided herein are systems for treating a patient, the systems comprising: a treatment device for treating a minimum amount of mucosal tissue of the patient's small intestine. The system is configured to treat a medical condition of the patient. Methods of treating a patient are also provided.

公开(公告)号：US20220117658A1

公开(公告)日：2022-04-21

申请号：US17516503

申请日：2021-11-01

Applicant: Fractyl Health, Inc.

Inventor： Harith Rajagopalan ,  Jay Caplan ,  Craig M. Gardner ,  J. Christopher Flaherty

IPC: A61B18/14 ,  A61M29/02

Abstract: Systems, devices and methods treat target tissue to provide a therapeutic benefit to the patient. A tissue treatment device comprises a tissue treatment element constructed and arranged to treat target tissue, such as duodenal mucosa and/or submucosal tissue. Patients treated can safely eliminate or reduce their daily insulin intake.

公开(公告)号：US11986235B2

公开(公告)日：2024-05-21

申请号：US14917243

申请日：2014-09-12

Applicant: Fractyl Health, Inc.

Inventor： Jay Caplan ,  Philip S. Levin ,  R. Maxwell Flaherty ,  J. Christopher Flaherty

IPC: A61B18/14 ,  A61B8/12 ,  A61B18/00

CPC classification number: A61B18/1492 ,  A61B8/12 ,  A61B2018/00023 ,  A61B2018/00041 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00482 ,  A61B2018/00494 ,  A61B2018/00577 ,  A61B2018/00714

Abstract: A system for treating a patient comprises an elongate shaft, an expandable reservoir and a fluid delivery assembly. The elongate shaft comprises a distal portion and is constructed and arranged to be introduced into a gastrointestinal lumen. The expandable reservoir is positioned on the elongate shaft distal portion and is constructed and arranged to receive a first fixed amount of ablative fluid and to deliver a first thermal dose of energy to a first portion of target tissue. The fluid delivery assembly is in fluid communication with the expandable reservoir and is constructed and arranged to deliver the first fixed amount of ablative fluid to the expandable reservoir. Devices and methods for treating tissue of a patient are also provided.

公开(公告)号：US11878128B2

公开(公告)日：2024-01-23

申请号：US17384421

申请日：2021-07-23

Applicant: Fractyl Health, Inc.

Inventor： Harith Rajagopalan ,  Jay Caplan ,  Craig M. Gardner ,  J. Christopher Flaherty

IPC: A61B18/14 ,  A61M25/00 ,  A61B18/02 ,  A61F5/00 ,  A61B5/00 ,  A61B17/00 ,  A61B18/08 ,  A61B18/18 ,  A61M25/04 ,  A61N7/00 ,  A61B18/00 ,  A61B18/06 ,  A61B18/04 ,  A61N7/02 ,  A61B17/02 ,  A61B90/00 ,  A61B5/055 ,  A61B17/34 ,  A61B17/30 ,  A61B18/24

CPC classification number: A61M25/00 ,  A61B5/0036 ,  A61B5/0084 ,  A61B5/4255 ,  A61B5/4836 ,  A61B5/6852 ,  A61B5/6885 ,  A61B17/00234 ,  A61B18/02 ,  A61B18/082 ,  A61B18/1492 ,  A61B18/1815 ,  A61F5/0069 ,  A61F5/0079 ,  A61M25/04 ,  A61N7/00 ,  A61B5/0066 ,  A61B5/055 ,  A61B17/00491 ,  A61B17/0218 ,  A61B17/3478 ,  A61B18/06 ,  A61B18/24 ,  A61B2017/00004 ,  A61B2017/00022 ,  A61B2017/00199 ,  A61B2017/00269 ,  A61B2017/00818 ,  A61B2017/306 ,  A61B2018/00005 ,  A61B2018/00011 ,  A61B2018/00017 ,  A61B2018/0022 ,  A61B2018/00029 ,  A61B2018/00041 ,  A61B2018/00255 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00494 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00672 ,  A61B2018/00678 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00809 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00863 ,  A61B2018/00875 ,  A61B2018/00982 ,  A61B2018/0212 ,  A61B2018/046 ,  A61B2018/1861 ,  A61B2090/395 ,  A61B2090/3908 ,  A61B2090/3933 ,  A61B2218/002 ,  A61B2505/05 ,  A61B2560/0431 ,  A61B2562/227 ,  A61M25/0082 ,  A61M2210/1053 ,  A61M2210/1057 ,  A61M2210/1071 ,  A61M2210/1408 ,  A61N7/022

Abstract: A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat polycystic ovarian syndrome (PCOS).

公开(公告)号：US20230346451A1

公开(公告)日：2023-11-02

申请号：US18062331

申请日：2022-12-06

Applicant: Fractyl Health, Inc.

Inventor： Philip Levin ,  Jay Caplan ,  Charles Abele ,  Greg Dierksen ,  Andrew Hollett ,  Thomas Kochem ,  Adam Jaynes ,  Jeff Johnson ,  Jeff Lesica ,  Lionel Stewart Maclean ,  Sara Morneau ,  Bruno Piazzarolo ,  Len Rosberg ,  Jonathan Seidmann ,  R. Maxwell Flaherty ,  J. Christopher Flaherty

IPC: A61B18/04 ,  A61B18/02

CPC classification number: A61B18/04 ,  A61B18/02 ,  A61B2018/00642

Abstract: A system for performing a medical procedure in the intestine of a patient comprises a catheter for insertion into the intestine, a console, and a connector configured to operably attach the catheter to the console. The catheter comprises a shaft including a distal portion, and a functional assembly positioned on the distal portion of the shaft. The functional assembly is configured to receive fluid. The console comprises: a fluid reservoir configured to supply the fluid, a first syringe pump assembly configured to deliver the fluid to the functional assembly, a second syringe pump assembly configured to deliver the fluid to the functional assembly, a fluid heater configured to heat the fluid, and a waste fluid reservoir configured to receive the fluid. The system is configured to treat target tissue of the intestine of the patient. Methods of treating target tissue are also provided.

公开(公告)号：US20230165621A1

公开(公告)日：2023-06-01

申请号：US17859137

申请日：2022-07-07

Applicant: Fractyl Health, Inc.

Inventor： Michael Biasella ,  Sara Morneau ,  Jay Caplan ,  Michelle Riches ,  Philip Levin ,  Ryan Cahill ,  Keith Boudreau ,  Harith Rajagopalan ,  Brendan Zarechian ,  Jeffrey Lesica ,  R. Maxwell Flaherty ,  J. Christopher Flaherty

IPC: A61B18/04

CPC classification number: A61B18/04 ,  A61B2018/00494

Abstract: Systems, devices and methods for performing medical procedures in the intestine of a patient are provided. A medical device for performing a treatment and/or a diagnostic procedure can include an elongate shaft assembly comprising at least a shaft assembly first section comprising a distal section of the shaft assembly, and a shaft assembly second section proximal to the first section, and a functional assembly positioned on the shaft assembly first section. Additional sections of the shaft assembly can be included, and each section can comprise a different construction, such as to achieve a different stiffness as described herein. Variable stiffness along the length of the shaft assembly can be provided to aid in translation of the device through the patient's GI tract (e.g. through the stomach and into the small intestine), as described herein.

公开(公告)号：US12201342B2

公开(公告)日：2025-01-21

申请号：US17864855

申请日：2022-07-14

Applicant: Fractyl Health, Inc.

Inventor： Philip S. Levin ,  Jay Caplan ,  Harith Rajagopalan ,  Mark A. Manasas ,  Andrew Coats ,  J. Christopher Flaherty

IPC: A61B18/08 ,  A61B18/04 ,  A61B18/00 ,  A61B18/14 ,  A61M25/04 ,  A61M25/10

Abstract: A system for treatment target tissue comprises an ablation device and an energy delivery unit. The ablation device comprises an elongate tube with an expandable treatment element. The system delivers a thermal dose of energy to treat the target tissue. Methods of treating target tissue are also provided.