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    Computer systems and methods for associating genes with traits using cross species data
    3.
    发明申请
    Computer systems and methods for associating genes with traits using cross species data 有权
    使用交叉物种数据将基因与性状相关联的计算机系统和方法

    公开(公告)号：US20070166707A1

    公开(公告)日：2007-07-19

    申请号：US10540405

    申请日：2003-12-24

    申请人： Eric Schadt ,  Stephanie Monks ,  John Lamb

    发明人： Eric Schadt ,  Stephanie Monks ,  John Lamb

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： C12Q1/6883 ,  C12Q1/6827 ,  C12Q2600/158 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24

    摘要： A method for confirming the association of a query QTL or a query gene in the genome of a second species with a clinical trait T exhibited by the second species. A first QTL or a first gene in a first species that is linked to a trait T′ is found. The trait T′ is indicative of trait T. A region of the genome of the first species that comprises the first QTL or the first gene is mapped to a particular region of the genome of the second species. A query QTL or a query gene in the second species that is potentially associated with the trait T is found. The potential association of the query QTL or the query gene with the clinical trait T is confirmed when the query QTL or the query gene is in the particular region of the genome of the second species.

    摘要翻译： 一种用于确认第二物种的基因组中的查询QTL或查询基因与由第二物种展示的临床特征T相关联的方法。 发现与性状T'相关联的第一种物种中的第一个QTL或第一个基因。 性状T'表示性状T.包含第一个QTL或第一个基因的第一个物种的基因组区域被映射到第二个物种的基因组的特定区域。 发现可能与性状T相关的第二种物种中的查询QTL或查询基因。 当查询QTL或查询基因位于第二物种的基因组的特定区域时，确认查询QTL或查询基因与临床特征T的潜在关联。

    REAL-TIME SEQUENCING METHODS AND SYSTEMS
    4.
    发明申请
    REAL-TIME SEQUENCING METHODS AND SYSTEMS 有权
    实时测序方法和系统

    公开(公告)号：US20100311061A1

    公开(公告)日：2010-12-09

    申请号：US12767673

    申请日：2010-04-26

    申请人： JONAS KORLACH ,  STEPHEN TURNER ,  ERIC SCHADT

    发明人： JONAS KORLACH ,  STEPHEN TURNER ,  ERIC SCHADT

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： C12Q1/6869 ,  C12Q1/702 ,  C12Q2565/518 ,  C12Q2547/101

    摘要： The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance or inhibit such reactions. In certain preferred embodiments, RNA templates are used in single-molecule real-time sequencing reactions.

    摘要翻译： 本发明一般涉及用于进行各种不同生物反应的单分子实时分析的组合物，方法和系统。 分析这些反应的能力提供了研究这些反应以及潜在鉴定影响这种反应的因素和/或方法的机会，例如增强或抑制这种反应。 在某些优选实施方案中，RNA模板用于单分子实时测序反应。

    Computer systems and methods for inferring causality from cellullar constituent abundance data
    5.
    发明申请
    Computer systems and methods for inferring causality from cellullar constituent abundance data 审中-公开
    计算机系统和方法，从细胞组成丰度数据推断因果关系

    公开(公告)号：US20060241869A1

    公开(公告)日：2006-10-26

    申请号：US11361871

    申请日：2006-02-23

    申请人： Eric Schadt ,  John Lamb

    发明人： Eric Schadt ,  John Lamb

    IPC分类号： G06F19/00

    CPC分类号： G01N33/5041 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/172 ,  G01N33/5023 ,  G01N2800/04 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/105 ,  G01N2800/108 ,  G01N2800/122 ,  G01N2800/301 ,  G01N2800/304 ,  G01N2800/323 ,  G16B20/00

    摘要： Methods for determining whether a molecule affects a disorder are provided. A cell from an organism is contacted with the molecule, or the molecule is expressed within the cell. A determination is made as to whether the RNA or protein expression in the cell of at least one open reading frame is changed relative to the expression of the reading frame in the absence of the molecule. Each such open reading frame is regulated by a promoter native to SEQ ID NOS: 5-9, 11-12, 14, 16, 18, 20-21, 23, 25, 27, 29, 31, 33 or homologs of the foregoing. A determination is made as to whether the molecule affects the disorder when the RNA or protein expression of the at least one reading frame is changed. Alternatively, a determination is made that the molecule does not affect the disorder when the RNA or protein expression of the at least one reading frame is unchanged.

    摘要翻译： 提供了确定分子是否影响病症的方法。 来自生物体的细胞与分子接触，或者分子在细胞内表达。 确定在不存在分子的情况下，至少一个开放阅读框的细胞中的RNA或蛋白质表达是否相对于阅读框的表达而改变。 每个这样的开放阅读框架由SEQ ID NOS：5-9,11-12,14,16,18,20-21,23,25,27,29,31,33天然的启动子或前述同源物调节 。 当改变至少一个阅读框的RNA或蛋白质表达时，确定分子是否影响病症。 或者，当至少一个阅读框的RNA或蛋白质表达不变时，确定分子不影响病症。

    Computer systems and methods for identifying surrogate markers
    7.
    发明申请
    Computer systems and methods for identifying surrogate markers 有权
    用于识别替代标记的计算机系统和方法

    公开(公告)号：US20070185656A1

    公开(公告)日：2007-08-09

    申请号：US10558928

    申请日：2004-05-28

    申请人： Eric Schadt

    发明人： Eric Schadt

    IPC分类号： G06F19/00

    CPC分类号： G01N33/5023 ,  G01N33/5082 ,  G01N33/6803 ,  G01N2500/00

    摘要： Methods, computer program products and systems for identifying cellular constituents in a secondary tissue that serve as surrogate markers for a target gene expressed in a primary tissue of a species are provided. A classifier is constructed using cellular constituent abundances of cellular constituents in a first plurality of cellular constituents measured in the secondary tissue in a population. This population comprises a first and second subgroup. The classifier is based on a second plurality of cellular constituents that comprises all or a portion of the first plurality of cellular constituents. Abundance levels of each cellular constituent in the second plurality of cellular constituents varies between the first and second subgroup. All or portion of the population is classified into a plurality of subtypes using the classifier. Then, one or more cellular constituents that can discriminate members of the population between a first subtype and a second subtype in the plurality of subtypes are identified.

    摘要翻译： 提供了用于鉴定作为在物种的初级组织中表达的靶基因的替代标记物的次级组织中的细胞成分的计算机程序产品和系统。 在群体中的次级组织中测量的第一多个细胞成分中，使用细胞组分的细胞组成丰度构建分类器。 该群体包括第一和第二子群。 分类器基于包含第一多个细胞成分的全部或一部分的第二多个细胞成分。 第二多个细胞组分中每个细胞成分的丰度水平在第一和第二亚组之间变化。 使用分类器将全部或部分群体分类为多个亚型。 然后，识别可以区分多个亚型中的第一亚型和第二亚型之间的群体成员的一个或多个细胞组分。

    Computer systems and methods for inferring casuality from cellular constituent abundance data
    8.
    发明申请
    Computer systems and methods for inferring casuality from cellular constituent abundance data 审中-公开
    用于从细胞成分丰度数据推断随机性的计算机系统和方法

    公开(公告)号：US20070038386A1

    公开(公告)日：2007-02-15

    申请号：US10567282

    申请日：2004-06-04

    申请人： Eric Schadt ,  John Lamb

    发明人： Eric Schadt ,  John Lamb

    IPC分类号： G06F19/00

    CPC分类号： G01N33/5041 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/172 ,  G01N33/5023 ,  G01N2800/04 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/105 ,  G01N2800/108 ,  G01N2800/122 ,  G01N2800/301 ,  G01N2800/304 ,  G01N2800/323 ,  G16B20/00

    摘要： Methods, computer program products, and systems are provided for associating a cellular constituent with a trait T exhibited by a species. A cellular constituent i that has at least one abundance quantitative trait locus (eQTL) coincident with a respective clinical quantitative trait locus (cQTL) for the trait of interest T is identified. For each eQTL, a determination is made as to whether (i) the genetic variation of the eQTL and (ii) the variation of the trait of interest T across the plurality of organisms are correlated conditional on an abundance pattern of the cellular constituent i across the plurality of organisms. When the genetic variation of (i) one of the eQTL and (ii) the variation of the trait of interest T across the plurality of organisms are uncorrelated conditional on the abundance pattern of the cellular constituent i, the cellular constituent i is considered causal for, and is therefore associated with, the trait of interest T.

    摘要翻译： 提供了方法，计算机程序产品和系统，用于将细胞成分与物种展示的性状T相关联。 鉴定了具有与感兴趣的性状T的相应临床数量性状位点（cQTL）一致的至少一个丰度数量性状基因座（eQTL）的细胞成分i。 对于每个eQTL，确定是否（i）eQTL的遗传变异和（ii）跨多个生物体的感兴趣T的性状的变化是相互关联的，其依赖于细胞成分i的丰度模式 多种生物体。 当（i）eQTL中的一个的遗传变异和（ii）多个生物体的感兴趣的性状T的变化在细胞成分i的丰度模式下是不相关的，细胞成分i被认为是因果 ，因此与感兴趣的特征T相关联。

    Computer systems and methods for subdividing a complex disease into component diseases
    9.
    发明申请
    Computer systems and methods for subdividing a complex disease into component diseases 有权
    将复杂疾病细分为成分疾病的计算机系统和方法

    公开(公告)号：US20060122816A1

    公开(公告)日：2006-06-08

    申请号：US10515804

    申请日：2003-05-20

    申请人： Eric Schadt ,  Stephanie Monks

    发明人： Eric Schadt ,  Stephanie Monks

    IPC分类号： G06G7/48 ,  G06G7/58

    CPC分类号： G06F19/18 ,  G06F19/20 ,  G06F19/24

    摘要： A method for identifying a quantitative trait loci for a complex trait that is exhibited by a plurality of organisms in a population. The population is divided into a plurality of sub-populations using a classification scheme. Depending on what is known about the population, either a supervised or unsupervised classification is used. The classification scheme is derived from a plurality of cellular constituent measurements obtained from each organism in the population. For each sub-population in the plurality of sub-populations, a quantitative genetic analysis is performed on the sub-population in order to identify one or more quantitative trait loci for the complex trait.

    摘要翻译： 用于鉴定由群体中的多种生物体展现的复杂性状的数量性状位点的方法。 使用分类方案将群体分成多个子群体。 根据已知的人口，使用监督或无监督分类。 分类方案来源于从群体中的每个生物获得的多个细胞成分测量。 对于多个子群体中的每个子群体，对子群体进行定量遗传分析，以便鉴定复杂性状的一个或多个数量性状位点。

    Single-molecule real-time analysis of protein synthesis
    10.
    发明授权
    Single-molecule real-time analysis of protein synthesis 有权
    单分子实时分析蛋白质合成

    公开(公告)号：US08609421B2

    公开(公告)日：2013-12-17

    申请号：US12813968

    申请日：2010-06-11

    申请人： Benjamin Flusberg ,  Stephen Turner ,  Jonas Korlach ,  Eric Schadt

    发明人： Benjamin Flusberg ,  Stephen Turner ,  Jonas Korlach ,  Eric Schadt

    IPC分类号： G01N37/00

    CPC分类号： G01N33/542 ,  G01N33/6818 ,  Y10T436/13 ,  Y10T436/143333

    摘要： The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of analytical reactions in which protein synthesis is occurring. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance, inhibit, or otherwise affect such reactions including, but not limited to, affecting the reaction rate, processivity, fidelity, duration, and the like.

    摘要翻译： 本发明一般涉及用于进行蛋白质合成发生的分析反应的单分子实时分析的组合物，方法和系统。 分析这种反应的能力提供了研究这些反应的机会，并且潜在地鉴定影响这些反应的因素和/或方法，例如增强，抑制或以其他方式影响这些反应，包括但不限于影响 反应速度，持续性，持续时间等。