摘要:
Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and for other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable.
摘要:
Methods and compositions comprising combinations of one or more anti-connexin agents and one or more other agents useful for the promotion and/or improvement of wound healing and/or tissue repair.
摘要:
Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and for other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable.
摘要:
A sensor (80) for sensing the position of a ferromagnetic target (82) relative to the sensor includes a Hall effect device (184) responsive to a change in a magnetic field (240) acting on the Hall effect device. A magnet (182) produces a magnetic field (240) that acts on the Hall effect device (184). The target (82) changes the magnetic field (240) acting on the Hall effect device (184) as the position of the target relative to the sensor (80) changes. First and second flux collectors (186 and 190) are located on one side (194) of the magnet (182) for concentrating the magnetic field (240) on the Hall effect device (184). A third flux collector (192) is located on a second side (196) of the magnet (182) opposite the one side (194) for reducing the reluctance of a magnetic flux path through the target (82).
摘要:
A code wheel (32) is rotatable with a vehicle steering wheel (12). A magnet (78) mounted on a rotatable driven component (34) indicates the number of revolutions of the code wheel (32). A sensing device (74) is provided to sense a flux field provided by the magnet (78). The magnetic flux field varies relative to the sensing device (74) as the driven component (34) is rotated by the code wheel (32).
摘要:
A ferromagnetic latch (42) is moveable from a first position to a second position in which the latch locks a lockable element (16) against movement in a passage (22) in a buckle (12). The buckle (12) also includes a switch (60) which includes a ferromagnetic support member (62). The switch (60) also includes a ferromagnetic flux collecting member (70), a Hall effect device (72), and a magnet (74) fixed to the support member (62). The magnet (74) creates a magnetic field that is conducted by the flux collecting member (70) and the latch (42) away from the Hall effect device (72) when the latch is in the first position. The magnetic field is conducted by the flux collecting member (70) and the support member (62) towards the Hall effect device (72) when the latch (42) is moved away from the switch (60) to the second position. The Hall effect device (72) senses a first flux density when the latch (42) is in the first position which causes the Hall effect device (72) to provide a first output signal. The Hall effect device (72) senses a second flux density when the latch (42) is in the second position which causes the Hall effect device to provide a second output signal.
摘要:
An apparatus includes a lockable element (16) and a buckle (12). The buckle (12) includes a base (28) that defines a passage (32) for receiving the lockable element (16), a latch (42), a Hall effect device (60), and a magnet (62). The latch (42) is movable from a non-locking position to a locking position in which it engages the lockable element (16). The magnet (62) is fixed to and moves with the latch (42). In the non-locking position, the latch (42) conducts low density magnetic flux from the magnet (62) to the Hall effect device (60). In the locking position, the latch (42) and the lockable element (16) conduct high density magnetic flux from the magnet (62) to the Hall effect device (60). The Hall effect device (60) thus has a first output when the latch (42) is in the non-locking position, and a second, different output when the latch (42) is in the locking position.
摘要:
A method of testing concrete in a structure in situ, by: directing a succession of pulses of laser radiation at a point on the structure so that each pulse effects removal of a quantity of concrete and transfers energy to the concrete; detecting a characteristic of energy which has been transferred to the concrete; determining, separately from the detecting step, the total quantity of concrete removed by the succession of pulses; and calculating a property of the concrete on the basis of the detected energy characteristic and the determined total quantity of concrete removed.
摘要:
A combined bearing/diaphragm seal for use in a solenoid valve assembly or the like is disclosed which provides a flexible fluid seal between the solenoid sub-assembly and the valve sub-assembly. The solenoid and valve sub-assemblies communicate mechanically via a portion of a solenoid armature which translates through the combined bearing/diaphragm seal and controls elements of the valve sub-assembly for regulating outlet fluid pressure. The bearing portion of the combined bearing/diaphragm seal comprises a flat spring-plate that is adapted to resiliently deflect in response to movement of the solenoid armature. The diaphragm portion of the combined bearing/diaphragm seal is an elastomeric seal material applied to at least one side of the spring plate.