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    IMPLANT DEVICES FOR MODULATING BIOACTIVE AGENT RELEASE PROFILES
    1.
    发明申请
    IMPLANT DEVICES FOR MODULATING BIOACTIVE AGENT RELEASE PROFILES 审中-公开
    用于调节生物活性剂释放特性的植入装置

    公开(公告)号：US20110086083A1

    公开(公告)日：2011-04-14

    申请号：US12887877

    申请日：2010-09-22

    申请人： Danielle Biggs

    发明人： Danielle Biggs

    IPC分类号： A61F2/00

    CPC分类号： A61K9/0024 ,  A61K9/0092

    摘要： Described herein are implant devices comprising at least one exposed biodegradable inner core surface, the inner core being surrounding partially by a membrane sheath which comprises a biocompatible polymer. A bioactive agent can be released from the inner core.

    摘要翻译： 本文描述的是包括至少一个暴露的可生物降解的内芯表面的植入装置，所述内芯部分地由包含生物相容性聚合物的膜护套包围。 生物活性剂可以从内核释放。

    IMPLANT DEVICES HAVING VARYING BIOACTIVE AGENT LOADING CONFIGURATIONS
    2.
    发明申请
    IMPLANT DEVICES HAVING VARYING BIOACTIVE AGENT LOADING CONFIGURATIONS 审中-公开
    具有变化的生物活性剂负载配置的植入装置

    公开(公告)号：US20110091518A1

    公开(公告)日：2011-04-21

    申请号：US12887893

    申请日：2010-09-22

    申请人： Danielle Biggs

    发明人： Danielle Biggs

    IPC分类号： A61F2/00

    CPC分类号： A61K9/0092 ,  A61K9/0024

    摘要： Described herein are implant devices comprising various configurations of bioactive agent loading which can be selected and used to tailor a particular bioactive agent release profile from the implant device.

    摘要翻译： 本文描述了包含生物活性剂加载的各种构型的植入装置，其可被选择并用于从植入装置调整特定的生物活性剂释放曲线。

    Sulindac formulations in a biodegradable material
    5.
    发明授权
    Sulindac formulations in a biodegradable material 有权
    舒林酸配方可生物降解材料

    公开(公告)号：US09289409B2

    公开(公告)日：2016-03-22

    申请号：US12413236

    申请日：2009-03-27

    申请人： John Myers Zanella ,  Vanja M King ,  Christopher M Hobot ,  S Mark Cox ,  Danielle Biggs ,  Katara Shaw ,  William F McKay ,  Kathy L Remsen

    发明人： John Myers Zanella ,  Vanja M King ,  Christopher M Hobot ,  S Mark Cox ,  Danielle Biggs ,  Katara Shaw ,  William F McKay ,  Kathy L Remsen

    IPC分类号： A01N43/00 ,  A61K31/33 ,  A61K31/255 ,  A61K9/00 ,  A61K9/20

    CPC分类号： A61K31/255 ,  A61K9/0024 ,  A61K9/204

    摘要： Effective treatments of pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulindac or a pharmaceutically acceptable salt thereof at or near a target site, one can relieve pain and/or inflammation caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days, at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长时间疼痛和/或炎症的有效治疗。 通过在目标部位处或附近施用有效量的舒林酸或其药学上可接受的盐，可以减轻由不同来源引起的疼痛和/或炎症，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位， 狭窄，恶性背痛和关节疼痛以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天，至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。