公开(公告)号：US08940315B2

公开(公告)日：2015-01-27

申请号：US12426031

申请日：2009-04-17

申请人： Christopher M. Hobot ,  Michael E. Benz ,  Keith R. Hildebrand ,  Bryant J. Pudil

发明人： Christopher M. Hobot ,  Michael E. Benz ,  Keith R. Hildebrand ,  Bryant J. Pudil

IPC分类号： A61F13/00 ,  A01N43/62 ,  A61K31/55 ,  A61K31/197 ,  A61K9/00 ,  A61K47/34

CPC分类号： A61K31/197 ,  A61K9/0024 ,  A61K47/34

摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

摘要翻译： 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。

公开(公告)号：US08822546B2

公开(公告)日：2014-09-02

申请号：US12325514

申请日：2008-12-01

申请人： Michael Eric Benz ,  Christopher M. Hobot ,  Phillip Edward McDonald ,  Lian Leon Luo ,  John Kramer

发明人： Michael Eric Benz ,  Christopher M. Hobot ,  Phillip Edward McDonald ,  Lian Leon Luo ,  John Kramer

IPC分类号： A61K31/045 ,  A61K47/34 ,  A61K31/4168 ,  A61K9/00 ,  A61K31/445

CPC分类号： A61K9/0024 ,  A61K31/4168 ,  A61K31/445 ,  A61K47/34

摘要： Flowable pharmaceutical depots are described. The flowable pharmaceutical depot includes a polyester, such as a polylactic acid or a poly(trimethylene carbonate) endcapped with a primary alcohol and a pain relieving therapeutic agent, such as a post operative pain relieving therapeutic agent. Method of making and using the same are also described.

摘要翻译： 描述了可流动药剂库。 可流动的药物贮库包括聚酯，例如聚乳酸或用伯醇封端的聚（碳酸三亚甲基酯）和缓痛治疗剂，如手术后疼痛缓解治疗剂。 还描述了制造和使用它们的方法。

公开(公告)号：US20090264472A1

公开(公告)日：2009-10-22

申请号：US12420177

申请日：2009-04-08

申请人： Amira Wohabrebbi ,  William F. McKay ,  Vanja Margareta King ,  Danielle L. Biggs ,  Katara Shaw ,  Christopher M. Hobot ,  Phillip Edward McDonald

发明人： Amira Wohabrebbi ,  William F. McKay ,  Vanja Margareta King ,  Danielle L. Biggs ,  Katara Shaw ,  Christopher M. Hobot ,  Phillip Edward McDonald

IPC分类号： A61K31/445

CPC分类号： A61K31/445 ,  A61K9/0024 ,  A61K9/146 ,  A61K9/1647 ,  A61K9/7007 ,  A61K31/4458

摘要： The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a polymer and a therapeutically effective amount of a local anesthetic or pharmaceutically acceptable salt thereof, wherein the drug depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the drug depot is capable of releasing (i) a bolus dose of the local anesthetic or pharmaceutically acceptable salt thereof at a site beneath the skin and (ii) a sustained release dose of an effective amount of the local anesthetic or pharmaceutically acceptable salt thereof over a period of at least 4 days.

摘要翻译： 本发明涉及可用于减少，预防或治疗需要这种治疗的患者的手术后疼痛的可植入药物储存库，所述可植入药物储库包含聚合物和治疗有效量的局部麻醉剂或药学上可接受的盐 其中所述药物储存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述药物储库能够释放（i）所述局部麻醉剂或其药学上可接受的盐的推注剂量 （ii）持续释放剂量的有效量的局部麻醉剂或其药学上可接受的盐在至少4天的时间内。

公开(公告)号：US20090263450A1

公开(公告)日：2009-10-22

申请号：US12422624

申请日：2009-04-13

申请人： John Myers ZANELLA ,  William F. McKay ,  Vanja Margareta King ,  Christopher M. Hobot ,  Keith R. Hildebrand

发明人： John Myers ZANELLA ,  William F. McKay ,  Vanja Margareta King ,  Christopher M. Hobot ,  Keith R. Hildebrand

IPC分类号： A61K31/4168 ,  A61F2/00 ,  A61P25/00 ,  A61P29/00

CPC分类号： A61K31/137 ,  A61K9/0024 ,  A61K9/14 ,  A61K31/415 ,  A61K31/4162

摘要： Effective treatments of pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist at or near a target site, one can reduce, prevent or treat pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease.

摘要翻译： 提供了对肌腱炎，腕管综合征，t疮综合征，骨关节炎，滑囊炎和/或口腔面部疾病的疼痛和/或炎症的有效治疗。 通过在目标部位处或附近施用有效量的至少一种α肾上腺素能激动剂，可以减少，预防或治疗由腱炎，腕管综合征，t疮综合征，骨关节炎，滑囊炎和/或 口腔疾病。

公开(公告)号：US20090081273A1

公开(公告)日：2009-03-26

申请号：US12234011

申请日：2008-09-19

申请人： Phillip Edward McDonald ,  Christopher M. Hobot

发明人： Phillip Edward McDonald ,  Christopher M. Hobot

IPC分类号： A61F2/04 ,  A61K38/18

CPC分类号： A61K38/1875 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/45 ,  A61L2300/602

摘要： Medical devices and methods including polymers having biologically active agents therein are disclosed. The medical devices can be useful as implantable devices such as orthopedic implants.

摘要翻译： 公开了包括其中具有生物活性剂的聚合物的医疗装置和方法。 医疗设备可用作诸如矫形植入物之类的可植入装置。

公开(公告)号：US20080069856A1

公开(公告)日：2008-03-20

申请号：US11523841

申请日：2006-09-20

申请人： SuPing Lyu ,  Christopher M. Hobot ,  Sean M. Haddock ,  Brian Loy ,  Randall V. Sparer ,  K. Matthew Kinnane ,  Jeffrey M. Gross

发明人： SuPing Lyu ,  Christopher M. Hobot ,  Sean M. Haddock ,  Brian Loy ,  Randall V. Sparer ,  K. Matthew Kinnane ,  Jeffrey M. Gross

IPC分类号： A61K35/12 ,  A61F2/02 ,  B27N3/00

CPC分类号： A61L27/3608 ,  A61L27/18 ,  A61L27/3683 ,  A61L27/58 ,  C08L67/04

摘要： A process for making an implantable material comprising a composite of a biocompatible polymer and a bioactive agent. The composite combines desirable mechanical properties of polymers and the bioactivity of tissue or one or more component of tissue. More particularly, but not exclusively, the invention relates to methods for the manufacture of implantable materials, devices and components via a powder molding process.

摘要翻译： 一种用于制造可植入材料的方法，其包括生物相容性聚合物和生物活性剂的复合物。 该复合物结合聚合物的所需机械性能和组织的生物活性或组织的一种或多种组分。 更具体地但不排他地，本发明涉及通过粉末成型工艺制造可植入材料，装置和部件的方法。

公开(公告)号：US4873308A

公开(公告)日：1989-10-10

申请号：US251418

申请日：1988-09-30

申请人： Arthur J. Coury ,  Christopher M. Hobot ,  Kurt Carlson

发明人： Arthur J. Coury ,  Christopher M. Hobot ,  Kurt Carlson

IPC分类号： A61L27/00 ,  C08G18/10 ,  C08G18/32 ,  C08G18/38 ,  C08G18/65 ,  C08G18/66 ,  C08G18/73 ,  C08G18/75

CPC分类号： C08G18/3206 ,  C08G18/3212 ,  C08G18/3831 ,  C08G18/75

摘要： Highly stable, segmented, aliphatic polyurethanes prepared by particular processes are disclosed. The segmented polyurethanes of this invention are substantially free of ester and ether linkages and are found to be particularly hydrolytically and oxidatively stable. The polyurethanes of this invention are prepared by a particular two stage process involving the formation of a prepolymer and subsequent reaction with simultaneously or sequentially added diisocyanate and diol monomers.

公开(公告)号：US09132085B2

公开(公告)日：2015-09-15

申请号：US12420110

申请日：2009-04-08

申请人： Phillip E. McDonald ,  Amira Wohabrebbi ,  Christopher M. Hobot ,  Vanja M. King

发明人： Phillip E. McDonald ,  Amira Wohabrebbi ,  Christopher M. Hobot ,  Vanja M. King

IPC分类号： A61K51/00 ,  A61K9/00 ,  A61K9/20

CPC分类号： A61K9/0024 ,  A61K9/204 ,  A61K31/4168 ,  A61K31/445 ,  A61K45/06

摘要： Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and clonidine at or near a target site, one can alleviate or prevent pain. This administration of bupivacaine and clonidine or pharmaceutically acceptable salts thereof is particularly useful following surgery.

摘要翻译： 提供了伴随手术后手术的有效治疗疼痛。 通过在目标部位或其附近施用有效量的布比卡因和可乐定的组合，可以缓解或预防疼痛。 布比卡因和可乐定或其药学上可接受的盐的施用在手术后是特别有用的。

公开(公告)号：US08956636B2

公开(公告)日：2015-02-17

申请号：US12388635

申请日：2009-02-19

申请人： Amira Wohabrebbi ,  William F. McKay ,  Christopher M. Hobot ,  Keith R. Hildebrand ,  Edward Phillip McDonald

发明人： Amira Wohabrebbi ,  William F. McKay ,  Christopher M. Hobot ,  Keith R. Hildebrand ,  Edward Phillip McDonald

IPC分类号： A61F13/00 ,  A61K9/14 ,  A61K31/407 ,  A61K9/00 ,  A61K9/16 ,  A61K49/04

CPC分类号： A61K31/407 ,  A61K9/0024 ,  A61K9/1647 ,  A61K49/0404 ,  A61K49/0419

摘要： Methods and compositions are provided for reducing, treating or preventing postoperative pain or inflammation in a patient in need of such treatment, the methods and compositions comprising administering one or more biodegradable drug depots comprising a therapeutically effective amount of ketorolac or pharmaceutically acceptable salt thereof to a target tissue site, wherein the drug depot releases an effective amount of ketorolac or pharmaceutically acceptable salt thereof over a period of 3 to 10 days.

摘要翻译： 提供了用于在需要这种治疗的患者中减少，治疗或预防术后疼痛或炎症的方法和组合物，所述方法和组合物包括给予包含治疗有效量的酮咯酸或其药学上可接受的盐的一种或多种可生物降解的药物宿主 靶组织部位，其中药物库在3至10天的时间内释放有效量的酮咯酸或其药学上可接受的盐。

公开(公告)号：US08946277B2

公开(公告)日：2015-02-03

申请号：US12420197

申请日：2009-04-08

申请人： John Myers Zanella ,  Christopher M. Hobot ,  Danielle L. Biggs ,  Katara Shaw ,  Phillip Edward McDonald ,  Vanja Margareta King ,  William F. McKay ,  Kathy L. Remsen

发明人： John Myers Zanella ,  Christopher M. Hobot ,  Danielle L. Biggs ,  Katara Shaw ,  Phillip Edward McDonald ,  Vanja Margareta King ,  William F. McKay ,  Kathy L. Remsen

IPC分类号： A01N43/00 ,  A61K31/33 ,  A01N43/50 ,  A61K31/415 ,  A61K31/4162 ,  A61K9/00 ,  A61K9/20 ,  A61K47/34

CPC分类号： A61K31/4168 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/4162 ,  A61K47/34

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位处或附近施用有效量的可乐定，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节疼痛，如 以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。