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    NOVEL FUNGAL ENZYMES
    2.
    发明申请
    NOVEL FUNGAL ENZYMES 审中-公开
    新型真菌酶

    公开(公告)号：US20140329292A1

    公开(公告)日：2014-11-06

    申请号：US14020054

    申请日：2013-09-06

    Applicant: DYADIC INTERNATIONAL, INC.

    Inventor： Mark A. EMARLFARB ,  Alexander Vasilievich Gusakov ,  Peter J. Punt ,  Jan Cornelis Verdoes ,  Arkady Panteleimonovich Sinitsyn ,  Elena Vlasenko ,  Sandra Wihelmina Agnes Hinz ,  Mark Gosink ,  Zhijie Jiang

    IPC: C12N9/24 ,  C12N9/42 ,  C12N9/26

    CPC classification number: C12N9/248 ,  C07H21/00 ,  C12N9/2402 ,  C12N9/2408 ,  C12N9/2434 ,  C12N9/2471 ,  C12Y301/01072 ,  C12Y302/01023 ,  C12Y302/01037 ,  C12Y302/01055 ,  C12Y302/01139 ,  C12Y302/01151 ,  C12Y302/01155 ,  Y02E50/16 ,  Y02E50/17

    Abstract: This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method to convert lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass. The invention also relates to a method to release cellular content by degradation of cell walls. The invention also relates to methods to use the novel enzymes and compositions of such enzymes in a variety of other processes, including washing of clothing, detergent processes, biorefining, deinking and biobleaching of paper and pulp, and treatment of waste streams.

    Abstract translation: 本发明涉及新型酶及其生产方法。 更具体地，本发明涉及各种真菌酶。 描述了编码这种酶，组合物，重组和遗传修饰的宿主细胞的核酸分子和使用方法。 本发明还涉及将木质纤维素生物质转化为可发酵糖的方法，该酶用于降解木质纤维素材料和酶的新组合，包括提供来自植物生物质的糖的协同释放的酶。 本发明还涉及通过细胞壁降解释放细胞内容物的方法。 本发明还涉及在各种其它方法中使用新型酶和这些酶的组合物的方法，包括洗涤衣物，洗涤剂方法，生物精制，纸和纸浆的脱墨和生物漂白以及废物流的处理。

    EXPRESSION AND HIGH-THROUGHPUT SCREENING OF COMPLEX EXPRESSED DNA LIBRARIES IN FILAMENTOUS FUNGI
    3.
    发明申请
    EXPRESSION AND HIGH-THROUGHPUT SCREENING OF COMPLEX EXPRESSED DNA LIBRARIES IN FILAMENTOUS FUNGI 有权
    FILAMENTOUS FUNGI中复合表达的DNA文库的表达和高通量筛选

    公开(公告)号：US20170037417A9

    公开(公告)日：2017-02-09

    申请号：US14167292

    申请日：2014-01-29

    Applicant: Dyadic International, Inc.

    Inventor： Mark A. EMALFARB ,  Peter J. PUNT ,  Cornelia VAN ZEIJL ,  Cornelius VAN DEN HONDEL ,  Jan Cornelis VERDOES ,  Richard P. BURLINGAME

    IPC: C12N15/80 ,  G01N33/561 ,  C12P21/00

    CPC classification number: C12N15/80 ,  C12P21/00 ,  C40B40/06 ,  G01N33/561

    Abstract: The invention is generally directed to modified filamentous fungal host cells comprising one or more nucleic acids encoding one or more polypeptides under the control of one or more promoters that are functional in said cells. Methods of using the modified cells to express one or more polypeptides are also disclosed, including methods of screening cells transformed with one or more expression vectors comprising nucleic acids derived from synthetic or genomic nucleic acids including, cDNAs. Methods of purifying one or more polypeptides or complexes comprising one or more polypeptides expressed in the modified cells, intended for use as substrates in structure/function studies, as therapeutic agents, as diagnostic reagents, or as human or animal vaccines, are also disclosed.

    Abstract translation: 本发明通常涉及修饰的丝状真菌宿主细胞，其包含编码一种或多种在一种或多种在所述细胞中起作用的启动子控制的多肽的核酸。 还公开了使用修饰细胞表达一种或多种多肽的方法，包括筛选用一种或多种包含衍生自包括cDNA的合成或基因组核酸的核酸的表达载体转化的细胞的方法。 还公开了纯化一种或多种包含在修饰细胞中表达的多肽或复合物的多肽或复合物的方法，其用作结构/功能研究中的底物，作为治疗剂，作为诊断试剂，或作为人或动物疫苗。

    EXPRESSION AND HIGH-THROUGHPUT SCREENING OF COMPLEX EXPRESSED DNA LIBRARIES IN FILAMENTOUS FUNGI
    8.
    发明申请
    EXPRESSION AND HIGH-THROUGHPUT SCREENING OF COMPLEX EXPRESSED DNA LIBRARIES IN FILAMENTOUS FUNGI 有权
    FILAMENTOUS FUNGI中复合表达的DNA文库的表达和高通量筛选

    公开(公告)号：US20150211013A1

    公开(公告)日：2015-07-30

    申请号：US14167292

    申请日：2014-01-29

    Applicant: Dyadic International, Inc.

    Inventor： Mark A. EMALFARB ,  Peter J. PUNT ,  Cornelia VAN ZEIJL ,  Cornelius VAN DEN HONDEL ,  Jan Cornelis VERDOES ,  Richard P. BURLINGAME

    IPC: C12N15/80 ,  G01N33/561 ,  C12P21/00

    CPC classification number: C12N15/80 ,  C12P21/00 ,  C40B40/06 ,  G01N33/561

    Abstract: The invention is generally directed to modified filamentous fungal host cells comprising one or more nucleic acids encoding one or more polypeptides under the control of one or more promoters that are functional in said cells. Methods of using the modified cells to express one or more polypeptides are also disclosed, including methods of screening cells transformed with one or more expression vectors comprising nucleic acids derived from synthetic or genomic nucleic acids including, cDNAs. Methods of purifying one or more polypeptides or complexes comprising one or more polypeptides expressed in the modified cells, intended for use as substrates in structure/function studies, as therapeutic agents, as diagnostic reagents, or as human or animal vaccines, are also disclosed.

    Abstract translation: 本发明通常涉及修饰的丝状真菌宿主细胞，其包含编码一种或多种在一种或多种在所述细胞中起作用的启动子控制的多肽的核酸。 还公开了使用修饰细胞表达一种或多种多肽的方法，包括筛选用一种或多种包含衍生自包括cDNA的合成或基因组核酸的核酸的表达载体转化的细胞的方法。 还公开了纯化一种或多种包含在修饰细胞中表达的多肽或复合物的多肽或复合物的方法，其用作结构/功能研究中的底物，作为治疗剂，作为诊断试剂，或作为人或动物疫苗。

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